PE20051129A1 - Piperazinas derivadas de urea para el tratamiento de la endometriosis - Google Patents
Piperazinas derivadas de urea para el tratamiento de la endometriosisInfo
- Publication number
- PE20051129A1 PE20051129A1 PE2005000217A PE2005000217A PE20051129A1 PE 20051129 A1 PE20051129 A1 PE 20051129A1 PE 2005000217 A PE2005000217 A PE 2005000217A PE 2005000217 A PE2005000217 A PE 2005000217A PE 20051129 A1 PE20051129 A1 PE 20051129A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- endometriosis
- treatment
- piperazines
- urea
- Prior art date
Links
- 201000009273 Endometriosis Diseases 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- HQLNLEFFXBXJIW-HNNXBMFYSA-N 2-(4-chlorophenoxy)-1-[(2s)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]ethanone Chemical compound C([C@@H](N(CC1)C(=O)COC=2C=CC(Cl)=CC=2)C)N1CC1=CC=C(F)C=C1 HQLNLEFFXBXJIW-HNNXBMFYSA-N 0.000 abstract 1
- KOEWNZKNNOOJSM-UHFFFAOYSA-N 2-(4-chlorophenoxy)-1-[2-ethyl-4-[(4-fluorophenyl)methyl]piperazin-1-yl]ethanone Chemical compound C1CN(C(=O)COC=2C=CC(Cl)=CC=2)C(CC)CN1CC1=CC=C(F)C=C1 KOEWNZKNNOOJSM-UHFFFAOYSA-N 0.000 abstract 1
- -1 AMINO Chemical class 0.000 abstract 1
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 abstract 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 abstract 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1a ES UNO O MAS SUSTITUYENTES SELECCIONADOS DE OXO, HALO, ALQUILO C1-C8, CICLOALQUILO C3-C10, ENTRE OTROS; R2 ES UNO O MAS SUSTITUYENTES SELECCIONADOS DE H, OH, HIDROXISULFONILO, HALO, ENTRE OTROS; R3 ES UN SISTEMA DE ANILLO CARBOCICLICO DE 3-15 MIEMBROS SUSTITUIDO POR UNO O MAS SUSTITUYENTES DE H, HIDROXI, MERCAPTO, ENTRE OTROS; R4 ES -O-, -N(R7), -C(R8)2- O ES UNA ENLACE; R5 ES ALQUILENO C1-C8, ALQUILIDENO C1-C8, O R4 Y R5 JUNTOS SON -HC=CH-, ENTRE OTROS; R6 ES -CO-, -C(S)-, -CH2- O ES UN ENLACE; R7 ES H, ALQUILO C1-C8, FENILO, ALCOXICARBONILO C1-C8, ENTRE OTROS; R8 ES H, FENILO O NAFTILO SUSTITUIDO O NO, AMINO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2S)-1-((4-CLOROFENOXI)METIL)CARBONIL-2-METIL-4-(4-FLUOROBENCIL)PIPERAZINA; 4-(4-FLUOROBENCIL)-1-((4-CLOROFENOXI)METIL)CARBONIL-2-ETILPIPERAZINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR 1 DE QUIMIOQUINA HUMANA "C-C" (CCR1), UTILES EN EL TRATAMIENTO DE ENDOMETRIOSIS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04090065 | 2004-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20051129A1 true PE20051129A1 (es) | 2006-02-16 |
Family
ID=34878280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000217A PE20051129A1 (es) | 2004-02-24 | 2005-02-24 | Piperazinas derivadas de urea para el tratamiento de la endometriosis |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20080119471A1 (es) |
| EP (1) | EP1727526A2 (es) |
| JP (1) | JP2007523126A (es) |
| KR (1) | KR20070033961A (es) |
| CN (1) | CN101090723A (es) |
| AR (1) | AR048068A1 (es) |
| AU (1) | AU2005215156A1 (es) |
| BR (1) | BRPI0507985A (es) |
| CA (1) | CA2556423A1 (es) |
| CR (1) | CR8584A (es) |
| EA (1) | EA200601514A1 (es) |
| EC (1) | ECSP066836A (es) |
| GT (1) | GT200500032A (es) |
| IL (1) | IL177406A0 (es) |
| NO (1) | NO20064298L (es) |
| PA (1) | PA8624501A1 (es) |
| PE (1) | PE20051129A1 (es) |
| SV (1) | SV2006002017A (es) |
| TW (1) | TW200539882A (es) |
| WO (1) | WO2005079769A2 (es) |
| ZA (1) | ZA200607970B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080943A1 (es) * | 2006-06-23 | 2008-09-27 | Smithkline Beecham Corp | Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8 |
| US8445674B2 (en) * | 2009-10-21 | 2013-05-21 | Hoffmann-La Roche Inc | Heterocyclyl compounds |
| ES2703176T3 (es) | 2010-03-11 | 2019-03-07 | Univ New York | Compuestos amido como moduladores de RORgammat y usos de los mismos |
| EA035256B1 (ru) | 2013-07-18 | 2020-05-21 | Новартис Аг | Ингибиторы аутотаксинов, содержащие гетероарил-бензил-амидное ядро |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| EP1534681A1 (en) * | 2002-06-27 | 2005-06-01 | Schering Aktiengesellschaft | Substituted quinoline ccr5 receptor antagonists |
-
2005
- 2005-02-23 EP EP05715567A patent/EP1727526A2/en not_active Withdrawn
- 2005-02-23 BR BRPI0507985-3A patent/BRPI0507985A/pt not_active Application Discontinuation
- 2005-02-23 GT GT200500032A patent/GT200500032A/es unknown
- 2005-02-23 US US11/064,116 patent/US20080119471A1/en not_active Abandoned
- 2005-02-23 AU AU2005215156A patent/AU2005215156A1/en not_active Abandoned
- 2005-02-23 EA EA200601514A patent/EA200601514A1/ru unknown
- 2005-02-23 KR KR1020067019708A patent/KR20070033961A/ko not_active Withdrawn
- 2005-02-23 JP JP2006553572A patent/JP2007523126A/ja active Pending
- 2005-02-23 CA CA002556423A patent/CA2556423A1/en not_active Abandoned
- 2005-02-23 WO PCT/EP2005/002036 patent/WO2005079769A2/en not_active Ceased
- 2005-02-23 CN CNA2005800129365A patent/CN101090723A/zh active Pending
- 2005-02-24 AR ARP050100664A patent/AR048068A1/es unknown
- 2005-02-24 PA PA20058624501A patent/PA8624501A1/es unknown
- 2005-02-24 SV SV2005002017A patent/SV2006002017A/es not_active Application Discontinuation
- 2005-02-24 PE PE2005000217A patent/PE20051129A1/es not_active Application Discontinuation
- 2005-02-24 TW TW094105516A patent/TW200539882A/zh unknown
-
2006
- 2006-08-10 IL IL177406A patent/IL177406A0/en unknown
- 2006-08-30 CR CR8584A patent/CR8584A/es not_active Application Discontinuation
- 2006-09-11 EC EC2006006836A patent/ECSP066836A/es unknown
- 2006-09-22 ZA ZA200607970A patent/ZA200607970B/xx unknown
- 2006-09-22 NO NO20064298A patent/NO20064298L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL177406A0 (en) | 2006-12-10 |
| EA200601514A1 (ru) | 2007-02-27 |
| PA8624501A1 (es) | 2006-07-03 |
| US20080119471A1 (en) | 2008-05-22 |
| CA2556423A1 (en) | 2005-09-01 |
| KR20070033961A (ko) | 2007-03-27 |
| JP2007523126A (ja) | 2007-08-16 |
| GT200500032A (es) | 2005-10-31 |
| CN101090723A (zh) | 2007-12-19 |
| SV2006002017A (es) | 2006-05-09 |
| AU2005215156A1 (en) | 2005-09-01 |
| WO2005079769A2 (en) | 2005-09-01 |
| ZA200607970B (en) | 2008-12-31 |
| WO2005079769A3 (en) | 2007-01-04 |
| CR8584A (es) | 2007-08-28 |
| EP1727526A2 (en) | 2006-12-06 |
| NO20064298L (no) | 2006-11-24 |
| AR048068A1 (es) | 2006-03-29 |
| ECSP066836A (es) | 2006-11-24 |
| TW200539882A (en) | 2005-12-16 |
| BRPI0507985A (pt) | 2007-05-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY27976A1 (es) | Piperazinas heterocíclicas sustituídas para el tratamiento de la esquizofrenia | |
| ECSP066976A (es) | 4-fenilamino-quinazolin-6-il-amidas | |
| PE20080277A1 (es) | Derivados de azaindol espirociclicos y sustituidos | |
| PE20081800A1 (es) | NUEVOS DERIVADOS DE 3-([1,2,4]TRIAZOLO[4,3-a]PIRIDIN-7-IL)BENZAMIDA | |
| PE20071023A1 (es) | Azaciclilaminas-n-sustituidas como antagonistas de histamina-3 | |
| PE20121050A1 (es) | Compuestos de n-(1-(4-(1h-pirazol-5-il)ftalazin-1-il)piperidin-4-il)-benzamida sustituidos como antagonistas de la trayectoria hedgehog | |
| PE20090816A1 (es) | Derivados de pirrolopirimidinona como agentes ligandos de los receptores p2x3 | |
| JO2355B1 (en) | Hereditary calcitonin polypeptide receptor antagonists | |
| PE20091689A1 (es) | DERIVADOS DE 4-AMINOCICLOHEXANO SUSTITUIDO CON ACTIVIDAD SOBRE RECEPTORES µ Y ORL-1 | |
| NO20072435L (no) | CGRP-reseptorantagonister | |
| PE20070108A1 (es) | Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n-[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida | |
| UA86957C2 (ru) | Производные азепиноиндола в качестве фармацевтического средства | |
| PE20120593A1 (es) | Derivados fusionados de pirimidin-4-ona como antagonistas del receptor de angiotensina ii y como agonistas del receptor ppar gamma | |
| PE20090741A1 (es) | Derivados de 1,1,1-trifluor-2-hidroxi-3-fenilpropano | |
| AR063393A1 (es) | Derivados de benzoil amino heterociclilos utiles en el tratamiento de enfermedades originadas por la glk | |
| AR065772A1 (es) | Compuestos de indolobenzazepina para el tratamiento de la hepatitis c. composiciones farmaceuticas. | |
| PE20081409A1 (es) | Antagonistas del receptor de progesterona | |
| TW200510429A (en) | Heterocyclic MCHR1 antagonists | |
| ECSP056115A (es) | ANTAGONISTAS DEL RECEPTOR A2a DE 2-ALQUINIL- Y 2-ALQUENIL-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PIRIMIDINA ADENOSINA | |
| NO20080670L (no) | Substituerte piperaziner som metabotrofiske glutamatreseptorantagonister | |
| AR058587A1 (es) | Compuestos de pirrolo-1,5-naftiridinona,su uso como agentes antibacterianos, composiciones farmaceuticas que los contienen y compuestos intermediarios para preparar dichos compuestos | |
| ATE433454T1 (de) | Pyrazoloä1,5-aüpyrimidine als antagonisten des adenosin-a2a-rezeptors | |
| TW200508207A (en) | New benzimidazole derivatives | |
| PE20140792A1 (es) | Composiciones farmaceuticas | |
| PE20081665A1 (es) | Antagonistas del receptor de dopamina 2 de rapida disociacion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |