[go: up one dir, main page]

PE20050628A1 - DERIVADOS DE 2-AMINO-PIRIDINA COMO AGONISTAS ß-2 - Google Patents

DERIVADOS DE 2-AMINO-PIRIDINA COMO AGONISTAS ß-2

Info

Publication number
PE20050628A1
PE20050628A1 PE2004000553A PE2004000553A PE20050628A1 PE 20050628 A1 PE20050628 A1 PE 20050628A1 PE 2004000553 A PE2004000553 A PE 2004000553A PE 2004000553 A PE2004000553 A PE 2004000553A PE 20050628 A1 PE20050628 A1 PE 20050628A1
Authority
PE
Peru
Prior art keywords
amino
phenyl
pyridin
alkyl
pyridine derivatives
Prior art date
Application number
PE2004000553A
Other languages
English (en)
Inventor
Charlotte Alice Louise Lane
Russell Andrew Lewthwaite
Alan Daniel Brown
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20050628A1 publication Critical patent/PE20050628A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 2-AMINO-PIRIDINA DE FORMULA (I) DONDE EL GRUPO (CH2)n-C(=O)Q1 ESTA EN LA POSICION META O PARA; R1 Y R2 SON INDEPENDIENTEMENTE H Y ALQUILO(C1-C4), n ES DE 0 A 2, Q1 ES UN GRUPO DE FORMULA a), b), c) Y *-NR-Q2-A, DONDE p ES DE 1 A 3; q ES 1 O 2, Q2 ES UN ENLACE DIRECTO O ALQUILENO(C1-C4); R ES H, ALQUILO(C1-C4) O FENILO; A ES CICLOALQUILO(C3-C7), TETRAHIDROPIRANILO, PIPERIDINILO, O UN FENILO OPCIONALMENTE SUSTITUIDO CON H, ALQUILO(C1-C4), OR9, SR9, HALOGENO ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(3-{(2R)-2-[(2R)-2-(6-AMINO-PIRIDIN-3-IL)-2-HIDROXI-ETILAMINO]-PROPIL}-FENIL)-N-BENCIL-ACETAMIDA, 2-(4-{2-[(2R)-2-(6-AMINO-PIRIDIN-3-IL)-2-HIDROXI-ETILAMINO]-2-METIL-PROPIL]-FENIL)-N-(2,6-DIMETOXI-BENCIL)-ACETAMIDA, 3-(2-{(2R)-2-[6-(2,5-DIMETILPIRROL-1-IL)PIRIDIN-3-IL]-2-HIDROXIETILAMINO}-2-METILPROPIL)-N-(4'-HIDROXIBIFENIL-3-ILMETIL)BENZAMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE ELABORACION Y UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS TIENEN UNA ACTIVIDAD AGONISTA BETA-2, POR LOS QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES, TRANSTORNOS Y AFECCIONES INFLAMATORIAS ALERGICAS Y RESPIRATORIAS
PE2004000553A 2003-06-04 2004-06-01 DERIVADOS DE 2-AMINO-PIRIDINA COMO AGONISTAS ß-2 PE20050628A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0312832.9A GB0312832D0 (en) 2003-06-04 2003-06-04 2-amino-pyridine derivatives useful for the treatment of diseases

Publications (1)

Publication Number Publication Date
PE20050628A1 true PE20050628A1 (es) 2005-08-30

Family

ID=9959308

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000553A PE20050628A1 (es) 2003-06-04 2004-06-01 DERIVADOS DE 2-AMINO-PIRIDINA COMO AGONISTAS ß-2

Country Status (18)

Country Link
EP (1) EP1633715B1 (es)
JP (1) JP2006526613A (es)
AR (1) AR044475A1 (es)
AT (1) ATE372321T1 (es)
BR (1) BRPI0410946A (es)
CA (1) CA2527788A1 (es)
CL (1) CL2004001366A1 (es)
DE (1) DE602004008773T2 (es)
ES (1) ES2291882T3 (es)
GB (1) GB0312832D0 (es)
GT (1) GT200400116A (es)
MX (1) MXPA05012840A (es)
NL (1) NL1026329C2 (es)
PA (1) PA8604301A1 (es)
PE (1) PE20050628A1 (es)
TW (1) TW200524603A (es)
UY (1) UY28339A1 (es)
WO (1) WO2004108676A1 (es)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
UA87854C2 (en) * 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1799667B1 (en) 2004-09-20 2013-03-20 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
EP1804799B1 (en) 2004-09-20 2013-08-21 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1830837B1 (en) 2004-09-20 2013-09-04 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CN101084212A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途
CA2580845A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
CA2580855A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
CA2580856A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
GT200500281A (es) 2004-10-22 2006-04-24 Novartis Ag Compuestos organicos.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
MX2007015216A (es) 2005-06-03 2008-02-22 Xenon Pharmaceuticals Inc Derivados de aminotiazol y sus usos como agentes terapeuticos.
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
GB0516313D0 (en) 2005-08-08 2005-09-14 Argenta Discovery Ltd Azole derivatives and their uses
KR20080036632A (ko) 2005-08-08 2008-04-28 아젠터 디스커버리 리미티드 바이시클로[2.2.1]헵트-7-일아민 유도체 및 이들의 용도
EP2532678A1 (en) 2005-10-21 2012-12-12 Novartis AG Human antibodies against il13 and therapeutic uses
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
RU2457209C2 (ru) 2006-04-21 2012-07-27 Новартис Аг Производные пурина, предназначенные для применения в качестве агонистов аденозинового рецептора а2а
ES2392999T3 (es) * 2006-06-09 2012-12-17 Parion Sciences, Inc. Bloqueadores de canales de sodio pirazinoilguanidina sustituida con fenilo que tienen actividad agonista beta
EP2077262A4 (en) 2006-10-23 2011-12-28 Takeda Pharmaceutical IMINOPYRIDINE DERIVATIVE AND USE THEREOF
BRPI0811562A2 (pt) 2007-05-07 2014-12-09 Novartis Ag Compostos orgânicos
PT2444120T (pt) 2007-12-10 2018-01-03 Novartis Ag Análogos da amilorida espirocíclicos como bloqueadores de enac
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
WO2009150137A2 (en) 2008-06-10 2009-12-17 Novartis Ag Organic compounds
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
DE102008049675A1 (de) 2008-09-30 2010-04-01 Markus Dr. Heinrich Verfahren zur Herstellung von 3-Aminobiphenylen
MX2011007036A (es) 2008-12-30 2011-07-20 Pulmagen Therapeutics Inflammation Ltd Compuestos de sulfonamida para el tratamiento de trastornos respiratorios.
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
MX2012004792A (es) 2009-10-22 2013-02-01 Vertex Pharma Composiciones para el tratamiento de fibrosis quistica y otras enfermedades cronicas.
GB0918923D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminothiazole derivatives
GB0918924D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
GB0918922D0 (en) 2009-10-28 2009-12-16 Vantia Ltd Aminopyridine derivatives
WO2011098746A1 (en) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
EA201391230A1 (ru) 2011-02-25 2014-01-30 АйАрЭм ЭлЭлСи Соединения и композиции в качестве ингибиторов trk
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
WO2013038378A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
WO2013038386A1 (en) 2011-09-16 2013-03-21 Novartis Ag Heterocyclic compounds for the treatment of cystic fibrosis
WO2013038390A1 (en) 2011-09-16 2013-03-21 Novartis Ag N-substituted heterocyclyl carboxamides
WO2013038381A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine/pyrazine amide derivatives
WO2013038373A1 (en) 2011-09-16 2013-03-21 Novartis Ag Pyridine amide derivatives
US8809340B2 (en) 2012-03-19 2014-08-19 Novartis Ag Crystalline form
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
JP6433509B2 (ja) 2014-04-24 2018-12-05 ノバルティス アーゲー ホスファチジルイノシトール３−キナーゼ阻害薬としてのアミノピラジン誘導体
PL3134395T3 (pl) 2014-04-24 2018-07-31 Novartis Ag Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu
BR112016024484A2 (pt) 2014-04-24 2017-08-15 Novartis Ag derivados de aminopiridina como inibidores de fosfatidilinositol 3-quinase
MX2021015133A (es) 2019-06-10 2022-01-24 Novartis Ag Derivado de piridina y pirazina para el tratamiento de la fibrosis quistica, enfermedad pulmonar obstructiva cronica y bronquiectasia.
CR20220060A (es) 2019-08-28 2022-03-01 Novartis Ag Derivados de 1,3-fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358455A (en) * 1980-12-23 1982-11-09 Merck & Co., Inc. Aralkylamindethanol heterocyclic compounds
EP0824519A1 (en) * 1995-05-10 1998-02-25 Pfizer Inc. Beta-adrenergic agonists
ES2228413T3 (es) * 1999-07-23 2005-04-16 Pfizer Products Inc. Productos intermedios y un procedimiento para producir agonistas de receptores beta-adrenergicos.
TWI249515B (en) * 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
GB0217225D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
AP2005003283A0 (en) * 2002-10-11 2005-06-30 Pfizer Indole derivatives useful for the treatment os diseases

Also Published As

Publication number Publication date
WO2004108676A1 (en) 2004-12-16
AR044475A1 (es) 2005-09-14
PA8604301A1 (es) 2004-12-16
BRPI0410946A (pt) 2006-06-27
NL1026329A1 (nl) 2004-12-07
MXPA05012840A (es) 2006-02-13
UY28339A1 (es) 2005-01-31
TW200524603A (en) 2005-08-01
GT200400116A (es) 2005-03-03
CA2527788A1 (en) 2004-12-16
NL1026329C2 (nl) 2005-07-26
ES2291882T3 (es) 2008-03-01
CL2004001366A1 (es) 2005-05-06
DE602004008773D1 (de) 2007-10-18
ATE372321T1 (de) 2007-09-15
DE602004008773T2 (de) 2008-01-10
GB0312832D0 (en) 2003-07-09
EP1633715B1 (en) 2007-09-05
JP2006526613A (ja) 2006-11-24
EP1633715A1 (en) 2006-03-15

Similar Documents

Publication Publication Date Title
PE20050628A1 (es) DERIVADOS DE 2-AMINO-PIRIDINA COMO AGONISTAS ß-2
PE20081263A1 (es) DERIVADOS DE 4-(2-AMINO-1-HIDROXIETIL)FENOL COMO AGONISTAS DEL RECEPTOR ß2 ADRENERGICO
CL2023001738A1 (es) Inhibidores de prmt5
PE20090694A1 (es) Compuestos moduladores de sirtuinas
PE20060693A1 (es) Nuevos derivados de trifluorometansulfonanilida oxamida eter
JP2011513196A (ja) ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのｋｃｎｑカリウムチャネル開口薬の使用
RU2014113679A (ru) N-(2-амино-6,6-дифтор-4,4а,5,6,7,7а-гексагидро-циклопента[e][1,3]оксазин-4-ил)-фенил)-амиды в качестве ингибиторов бета-секретазы 1
PE20120305A1 (es) Compuestos heterociclicos derivados de benzotiazol y tetrahidroquinolina como inhbidores de bcl-2 y bcl-xl
PE20110852A1 (es) Antagonistas del receptor de orexina de isonicotinamida
PE20110588A1 (es) Derivados de benzotiazol como agentes anticancerigenos
PE20080061A1 (es) Compuestos derivados de amida como inhibidores de los canales de potasio task-1 y task-3
PE20091204A1 (es) Derivados de 2-aminoquinolina como antagonistas del receptor de 5-ht5a
PE20090547A1 (es) DERIVADOS DE PIRAZINONA COMO INHIBIDORES DE p38 QUINASA
PE20050874A1 (es) Compuestos de bencimidazolona que tienen actividad agonista del receptor 5-ht4
PE20121395A1 (es) Derivados de benzamida sustituidos con actividad sobre los receptores asociados a rastros de aminas
AR054799A1 (es) Derivados de oxindol
PE20091092A1 (es) Compuestos heterociclicos como inhibidores de la via hedgehog
UY29766A1 (es) Formas cristalinas delta y épsilon de mesilato de imatinib
ATE445609T1 (de) Substituierte thiophenderivate als glucagonrezeptorantagonisten, herstellung und therapeutische anwendungen
AR062299A1 (es) Derivados de bencimidazol
DE602006012725D1 (de) Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung
EA200700027A1 (ru) Антагонисты рецептора глюкагона, их получение и терапевтическое применение
NZ612544A (en) Heterocyclic compounds suitable for the treatment of dyslipidemia
PE20060357A1 (es) Compuestos y composiciones como moduladores de receptor activado de proliferador de peroxisoma (ppar)
PE20061163A1 (es) Compuestos de n-sulfonilaminofeniletil-2-fenoxiacetamida sustituidos

Legal Events

Date Code Title Description
FC Refusal