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PE20041000A1 - Pirazolopirimidinas como inhibidores de la quinasa dependientes de ciclina - Google Patents

Pirazolopirimidinas como inhibidores de la quinasa dependientes de ciclina

Info

Publication number
PE20041000A1
PE20041000A1 PE2003000900A PE2003000900A PE20041000A1 PE 20041000 A1 PE20041000 A1 PE 20041000A1 PE 2003000900 A PE2003000900 A PE 2003000900A PE 2003000900 A PE2003000900 A PE 2003000900A PE 20041000 A1 PE20041000 A1 PE 20041000A1
Authority
PE
Peru
Prior art keywords
kinase inhibitors
cycline
pyrazolopyrimidines
dependent kinase
alkyl
Prior art date
Application number
PE2003000900A
Other languages
English (en)
Inventor
Ronald J Doll
Viyyoor M Girijavallabhan
Tin-Yau Chan
Kamil Paruch
Chad Knutson
Ray Anthony James
Lawrence W Dillard
Michael P Dwyer
Thierry O Fischmann
Vincent Madison
Vinh D Tran
Haengsoon Park
Zhen Min He
Timothy J Guzi
Carmen S Alvarez
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of PE20041000A1 publication Critical patent/PE20041000A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Cardiology (AREA)
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  • Communicable Diseases (AREA)
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  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
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  • Psychology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R ES ARILO, SUSTITUIDO O NO; R2 ES ALQUINILALQUILO, CN, ALQUILO, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO, ENTRE OTROS; R4 ES H, HALO, ALQUILO. SON COMPUESTOS PREFERIDOS: A, B, C, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA SIENDO INHIBIDORES DE CINASA DE PROTEINAS UTILES EN EL TRATAMIENTO DE CANCER, INFLAMACION, ARTRITIS, ENFERMEDADES VIRALES Y ENFERMEDADES NEURODEGENERATIVAS, CARDIOVASCULARES Y FUNGICAS
PE2003000900A 2002-09-04 2003-09-04 Pirazolopirimidinas como inhibidores de la quinasa dependientes de ciclina PE20041000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40802902P 2002-09-04 2002-09-04

Publications (1)

Publication Number Publication Date
PE20041000A1 true PE20041000A1 (es) 2004-12-29

Family

ID=32030632

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000900A PE20041000A1 (es) 2002-09-04 2003-09-04 Pirazolopirimidinas como inhibidores de la quinasa dependientes de ciclina

Country Status (18)

Country Link
US (2) US7067661B2 (es)
EP (1) EP1534712B1 (es)
JP (2) JP4790265B2 (es)
KR (1) KR20050033659A (es)
CN (1) CN1701073B (es)
AR (1) AR041133A1 (es)
AT (1) ATE362474T1 (es)
AU (1) AU2003298571B2 (es)
CA (1) CA2497544C (es)
DE (1) DE60313872T2 (es)
ES (1) ES2283868T3 (es)
MX (1) MXPA05002572A (es)
MY (2) MY137843A (es)
NZ (1) NZ539161A (es)
PE (1) PE20041000A1 (es)
TW (1) TWI329645B (es)
WO (1) WO2004026229A2 (es)
ZA (1) ZA200501846B (es)

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CN1701073A (zh) 2005-11-23
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