AR117177A1 - DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa - Google Patents
DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFaInfo
- Publication number
- AR117177A1 AR117177A1 ARP190103467A ARP190103467A AR117177A1 AR 117177 A1 AR117177 A1 AR 117177A1 AR P190103467 A ARP190103467 A AR P190103467A AR P190103467 A ARP190103467 A AR P190103467A AR 117177 A1 AR117177 A1 AR 117177A1
- Authority
- AR
- Argentina
- Prior art keywords
- infa
- pyrazolo
- pyrimidin
- methylamine
- carboxamide
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical compound N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proveen compuestos derivados de pirazolo[1,5-a]pirimidina que poseen actividad inhibitoria de la señalización de citocinas tales como IL-32 e INFa, composición farmacéutica que los comprende y un método para la preparación de la misma y la utilización de éstos compuestos para el tratamiento de enfermedades autoinmunes tales como la psoriasis y el lupus eritematoso sistémico. Reivindicación 1: Un compuesto de la fórmula (1), en donde R es un compuesto de fórmula (2) ó (3); o una sal de este aceptable desde el punto de vista farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862777395P | 2018-12-10 | 2018-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR117177A1 true AR117177A1 (es) | 2021-07-14 |
Family
ID=69006014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190103467A AR117177A1 (es) | 2018-12-10 | 2019-11-27 | DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12060356B2 (es) |
| EP (1) | EP3894412B1 (es) |
| JP (1) | JP7148728B2 (es) |
| CN (1) | CN113166163B (es) |
| AR (1) | AR117177A1 (es) |
| ES (1) | ES2939856T3 (es) |
| TW (1) | TWI800696B (es) |
| WO (1) | WO2020123225A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202108619SA (en) * | 2019-02-07 | 2021-09-29 | Ventyx Biosciences Inc | Tyk2 pseudokinase ligands |
| SG11202110523XA (en) | 2019-03-26 | 2021-10-28 | Ventyx Biosciences Inc | Tyk2 pseudokinase ligands |
| AU2020378345A1 (en) | 2019-11-08 | 2022-06-02 | Ventyx Biosciences, Inc. | TYK2 pseudokinase ligands |
| AR121251A1 (es) | 2020-02-12 | 2022-05-04 | Lilly Co Eli | Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida |
| ES2982561T3 (es) | 2020-02-12 | 2024-10-16 | Lilly Co Eli | Derivados de 7-(metilamino)pirazolo[1,5-a]pirimidin-3-carboxamida sustituida |
| KR102550713B1 (ko) * | 2021-01-18 | 2023-07-03 | (주)바이오액츠 | 히드록시 치환된 트리아진을 포함하는 형광 화합물 및 이의 제조방법 |
| US20240335443A1 (en) * | 2021-01-19 | 2024-10-10 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Imidazolopyridazine or pyrazolopyrimidine compounds and compositions |
| EP4308556A4 (en) | 2021-03-16 | 2025-02-19 | Anrui Biomedical Technology (Guangzhou) Co., Ltd. | Amino heteroaryl compounds and compositions |
| KR20240177341A (ko) * | 2023-06-19 | 2024-12-27 | 주식회사 에이조스바이오 | 신규 피라졸로 피리미딘계 화합물 및 이의 용도 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10223917A1 (de) | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Pyrazolopyrimidine |
| MXPA05002572A (es) | 2002-09-04 | 2005-09-08 | Schering Corp | Compuestos pirazolo[1,5-a]pirimidinas como inhibidores de cinasa depentes de ciclina. |
| CA2497440C (en) | 2002-09-04 | 2011-03-22 | Schering Corporation | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| WO2004076458A1 (en) * | 2003-02-28 | 2004-09-10 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyrimidine derivatives |
| EP1931675B1 (en) | 2005-10-06 | 2015-01-14 | Merck Sharp & Dohme Corp. | Pyrazolo(1, 5a) pyrimidines as protein kinase inhibitors |
| AR061793A1 (es) | 2006-07-05 | 2008-09-24 | Mitsubishi Tanabe Pharma Corp | Compuesto de pirazolo[1,5-a] pirimidina y composicion farmaceutica |
| PE20110828A1 (es) | 2008-10-31 | 2011-11-22 | Genentech Inc | Compuestos de pirazolopirimidina como inhibidores de jak |
| WO2010074284A1 (ja) * | 2008-12-26 | 2010-07-01 | 味の素株式会社 | ピラゾロピリミジン化合物 |
| MX385600B (es) | 2010-12-08 | 2025-03-18 | Us Health | Pirazolopirimidinas sustituidas como activadores de la glucocerebrosidasa. |
| JP6458038B2 (ja) | 2013-12-10 | 2019-01-23 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ＩＬ−１２、ＩＬ−２３および／またはＩＦＮα応答のモジュレーターとして有用なイミダゾピリダジン化合物 |
| EP3377496B1 (en) * | 2015-11-18 | 2020-09-16 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| WO2018067432A1 (en) | 2016-10-07 | 2018-04-12 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of il-12, il-23 and/or ifn alpha responses |
| ES2895107T3 (es) * | 2016-10-28 | 2022-02-17 | Bristol Myers Squibb Co | Compuestos heterobicíclicos útiles como moduladores de las respuestas de IL-12, IL-23 y/o IFN alfa |
| JP7012082B2 (ja) | 2016-11-17 | 2022-01-27 | ブリストル－マイヤーズ スクイブ カンパニー | Ｉｌ－１２、ｉｌ－２３および／またはｉｆｎ－アルファのイミダゾピリダジン調節剤 |
| PT3658557T (pt) | 2017-07-28 | 2024-09-11 | Nimbus Lakshmi Inc | Inibidores de tyk2 e usos dos mesmos |
| JP7179161B2 (ja) * | 2018-09-10 | 2022-11-28 | イーライ リリー アンド カンパニー | 乾癬および全身性エリテマトーデスの処置に有用なピラゾロ［１，５－ａ］ピリミジン－３－カルボキサミド誘導体 |
| AU2019360941B2 (en) | 2018-10-15 | 2025-02-27 | Takeda Pharmaceutical Company Limited | TYK2 inhibitors and uses thereof |
| AR121251A1 (es) * | 2020-02-12 | 2022-05-04 | Lilly Co Eli | Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida |
-
2019
- 2019-11-27 AR ARP190103467A patent/AR117177A1/es not_active Application Discontinuation
- 2019-11-27 TW TW108143067A patent/TWI800696B/zh active
- 2019-12-04 EP EP19828081.0A patent/EP3894412B1/en active Active
- 2019-12-04 JP JP2021531412A patent/JP7148728B2/ja active Active
- 2019-12-04 WO PCT/US2019/064427 patent/WO2020123225A1/en not_active Ceased
- 2019-12-04 ES ES19828081T patent/ES2939856T3/es active Active
- 2019-12-04 US US17/311,406 patent/US12060356B2/en active Active
- 2019-12-04 CN CN201980081444.3A patent/CN113166163B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3894412B1 (en) | 2023-02-08 |
| CN113166163B (zh) | 2023-04-07 |
| JP2022510357A (ja) | 2022-01-26 |
| EP3894412A1 (en) | 2021-10-20 |
| TW202039497A (zh) | 2020-11-01 |
| CN113166163A (zh) | 2021-07-23 |
| US12060356B2 (en) | 2024-08-13 |
| WO2020123225A1 (en) | 2020-06-18 |
| ES2939856T3 (es) | 2023-04-27 |
| US20220024933A1 (en) | 2022-01-27 |
| TWI800696B (zh) | 2023-05-01 |
| JP7148728B2 (ja) | 2022-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |