PE20040909A1 - Derivados fluoroglicosidos aromaticos con afinidad por el receptor sglt2 - Google Patents
Derivados fluoroglicosidos aromaticos con afinidad por el receptor sglt2Info
- Publication number
- PE20040909A1 PE20040909A1 PE2003001250A PE2003001250A PE20040909A1 PE 20040909 A1 PE20040909 A1 PE 20040909A1 PE 2003001250 A PE2003001250 A PE 2003001250A PE 2003001250 A PE2003001250 A PE 2003001250A PE 20040909 A1 PE20040909 A1 PE 20040909A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- replaced
- ring
- saturated
- sglt2
- Prior art date
Links
- 108091006269 SLC5A2 Proteins 0.000 title 1
- 102000058081 Sodium-Glucose Transporter 2 Human genes 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 abstract 1
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A DERIVADOS FLUOROGLICOSIDOS AROMATICOS DE FORMULA I, INCLUYENDO SUS SALES FARMACEUTICAMENTE ACEPTABLES, EN DONDE, R1 Y R2 SON OH, F o H, o R1 Y R2 SON F, EXCLUYENDO LAS TRES COMBINACIONES a) R1 ES F y R2, OH; b) R1 ES OH y R2, F; y c) R1 Y R2 SON OH; R3 ES OH o F, EN EL QUE AL MENOS UNO DE LOS RADICALES R1, R2, R3 DEBE SER F; A ES O, NH, CH2, S o UN ENLACE; R4, R5 Y R6 SON H, F, Cl, Br, I, OH, NO2, CN, COOH, ENTRE OTROS; B ES ALCANDIILO C0-C15, SIENDO POSIBLE QUE UNO O MAS C EN EL RADICAL ALCANDIILO ESTEN SUSTITUIDOS POR O, (C=O), CH=CH, CºC, S, CH(OH), ENTRE OTROS; n ES 0-4; Cyc1 ES UN ANILLO DE 3-7 MIEMBROS SATURADO, PARCIALMENTE SATURADO O INSATURADO, EN DONDE EL ATOMO 1C PUEDE ESTAR SUSTITUIDO POR O, N o S; R7, R8 Y R9 SON H, F, Cl, Br, I, OH, CF3, ENTRE OTROS; O R8 Y R9 FORMAN JUNTO CON LOS C QUE LOS SOPORTAN UN ANILLO Cyc2 DE 5-7 MIEMBROS SATURADO, PARCIALMENTE O COMPLETAMENTE INSATURADO, SIENDO POSIBLE QUE 1 o 2 ATOMOS DE C EN EL ANILLO ESTEN SUSTITUIDOS POR N, O o S, Y QUE EL Cyc2 PUEDE ESTAR SUSTITUIDO CON ALQUILO C1-C6, ALQUENILO C2-C5, ALQUINILO C2-C5, ENTRE OTROS. TAMBIEN SE REFIERE A UN MEDICAMENTO Y UN PROCESO DE PRODUCCION. ESTOS COMPUESTOS AUMENTAN EL EFECTO SOBRE SGLT Y SON UTILES PARA PREVENIR Y/O TRATAR LA DIABETES MELLITUS TIPO I Y TIPO II
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10258007A DE10258007B4 (de) | 2002-12-12 | 2002-12-12 | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040909A1 true PE20040909A1 (es) | 2005-01-03 |
Family
ID=32477574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001250A PE20040909A1 (es) | 2002-12-12 | 2003-12-10 | Derivados fluoroglicosidos aromaticos con afinidad por el receptor sglt2 |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US7288528B2 (es) |
| EP (1) | EP1572707B1 (es) |
| JP (1) | JP4806192B2 (es) |
| KR (1) | KR101059705B1 (es) |
| CN (1) | CN100368420C (es) |
| AR (1) | AR042438A1 (es) |
| AT (1) | ATE321769T1 (es) |
| AU (1) | AU2003298149B2 (es) |
| BR (1) | BR0316605A (es) |
| CA (1) | CA2508024C (es) |
| CY (1) | CY1105617T1 (es) |
| DE (2) | DE10258007B4 (es) |
| DK (1) | DK1572707T3 (es) |
| ES (1) | ES2259777T3 (es) |
| GT (1) | GT200300269A (es) |
| HN (1) | HN2003000407A (es) |
| HR (1) | HRP20050531B1 (es) |
| IL (1) | IL168924A (es) |
| JO (1) | JO2354B1 (es) |
| MA (1) | MA27559A1 (es) |
| MX (1) | MXPA05005825A (es) |
| MY (1) | MY139303A (es) |
| NO (1) | NO330376B1 (es) |
| PA (1) | PA8592201A1 (es) |
| PE (1) | PE20040909A1 (es) |
| PL (1) | PL210848B1 (es) |
| PT (1) | PT1572707E (es) |
| RS (1) | RS50775B (es) |
| RU (1) | RU2340622C2 (es) |
| SI (1) | SI1572707T1 (es) |
| SV (1) | SV2004001691A (es) |
| TW (1) | TWI320043B (es) |
| UY (1) | UY28123A1 (es) |
| WO (1) | WO2004052902A1 (es) |
| ZA (1) | ZA200503364B (es) |
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| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
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| US8785403B2 (en) | 2003-08-01 | 2014-07-22 | Mitsubishi Tanabe Pharma Corporation | Glucopyranoside compound |
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| UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
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| WO2010066643A1 (de) * | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | Verfahren zur herstellung von 4-fluoro-4-desoxy-alpha-d-glucopyranoside |
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