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PE20040694A1 - Derivados de benzoxazolinonas - Google Patents

Derivados de benzoxazolinonas

Info

Publication number
PE20040694A1
PE20040694A1 PE2003001147A PE2003001147A PE20040694A1 PE 20040694 A1 PE20040694 A1 PE 20040694A1 PE 2003001147 A PE2003001147 A PE 2003001147A PE 2003001147 A PE2003001147 A PE 2003001147A PE 20040694 A1 PE20040694 A1 PE 20040694A1
Authority
PE
Peru
Prior art keywords
hydroxy
alkyl
compounds
oxazin
ona
Prior art date
Application number
PE2003001147A
Other languages
English (en)
Inventor
Thierry Bouyssou
Frank Buettner
Ingo Konetzki
Sabine Pestel
Andreas Schnapp
Hermann W Schollenberger
Kurt Schromm
Claudia Heine
Klaus Rudolf
Philipp Lustenberger
Christoph Hoenke
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32185709&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20040694(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040694A1 publication Critical patent/PE20040694A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE AL USO DE LOS COMPUESTOS DE FORMULA I, EN DONDE n ES 1 O 2; R1 Y R2 SON H, ALQUILO(C1-C4), HALOGENO, OH U -O-ALQUILO(C1-C4); R3 ES H, ALQUILO(C1-C4), OH, HALOGENO, -O-ALQUILO(C1-C4), -O-ALQUILEN(C1-C4)-COOH U -O-ALQUILEN(C1-C4)-CO-O-ALQUILO(C1-C4). TAMBIEN SE REFIERE A COMPUESTOS DE LA FORMULA I QUE CUMPLEN LA CONDICION DE QUE CUANDO R1 Y R2 SON RESPECTIVAMENTE ORTO-METILO, R3 NO PUEDE SER SIMULTANEAMENTE OH. SON COMPUESTOS PREFERIDOS: 6-HIDROXI-8-{1-HIDROXI-2-[2-(4-METOXI-FENIL)-1,1-DIMETIL-ETILAMINO]-ETIL}-4H-BENZO[1,4]OXAZIN-3-ONA, 6-HIDROXI-8-{1-HIDROXI-2-[2-(4-FENOXI-ACIDO ACETICO)-1,1-DIMETIL-ETILAMINO]-ETIL}-4H-BENZO[1,4]OXAZIN-3-ONA, 8-{2-[2-(4-FLUORO-3-METIL-FENIL)-1,1-DIMETIL-ETILAMINO]-1-HIDROXI-ETIL}-6-HIDROXI-4H-BENZO[1,4]OXAZIN-3-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA FORMULACION FARMACEUTICA DE ADMINISTRACION POR INHALACION. ESTOS COMPUESTOS SON BETA MIMETICOS DE PROLONGADA EFICACIA Y PRESENTAN UNA ELEVADA SELECTIVIDAD AL ADRENOCEPTOR b2 Y SON UTILES PARA LA ELABORACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE LA EPOC (ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
PE2003001147A 2002-11-15 2003-11-13 Derivados de benzoxazolinonas PE20040694A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10253282A DE10253282A1 (de) 2002-11-15 2002-11-15 Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung

Publications (1)

Publication Number Publication Date
PE20040694A1 true PE20040694A1 (es) 2004-11-23

Family

ID=32185709

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001147A PE20040694A1 (es) 2002-11-15 2003-11-13 Derivados de benzoxazolinonas

Country Status (38)

Country Link
EP (2) EP1562603B3 (es)
JP (1) JP4317138B2 (es)
KR (1) KR101092247B1 (es)
CN (3) CN101817800A (es)
AR (2) AR041969A1 (es)
AT (1) ATE430569T1 (es)
AU (1) AU2003285326B2 (es)
BE (1) BE2014C016I2 (es)
BR (1) BRPI0316264B8 (es)
CA (1) CA2506082C (es)
CO (1) CO5570670A2 (es)
CY (2) CY1110500T1 (es)
DE (2) DE10253282A1 (es)
DK (1) DK1562603T3 (es)
EA (1) EA008665B1 (es)
EC (1) ECSP055774A (es)
ES (1) ES2326878T7 (es)
FR (1) FR14C0049I2 (es)
HR (1) HRP20050432B1 (es)
HU (1) HUS1400011I1 (es)
IL (1) IL167900A (es)
LT (1) LTC1562603I2 (es)
LU (1) LU92433I2 (es)
ME (1) ME00354B (es)
MX (1) MXPA05005081A (es)
MY (1) MY136034A (es)
NL (1) NL300650I2 (es)
NO (2) NO334314B1 (es)
NZ (1) NZ540661A (es)
PE (1) PE20040694A1 (es)
PL (1) PL212238B1 (es)
PT (1) PT1562603E (es)
RS (1) RS51607B (es)
SI (1) SI1562603T1 (es)
TW (1) TWI343812B (es)
UA (1) UA81276C2 (es)
WO (1) WO2004045618A2 (es)
ZA (1) ZA200502246B (es)

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Also Published As

Publication number Publication date
IL167900A (en) 2013-06-27
EA200500715A1 (ru) 2005-12-29
NO334314B1 (no) 2014-02-03
MXPA05005081A (es) 2005-07-01
KR101092247B1 (ko) 2011-12-12
CN101817800A (zh) 2010-09-01
CN1713914A (zh) 2005-12-28
LTC1562603I2 (lt) 2016-12-12
AU2003285326B2 (en) 2009-06-04
BR0316264A (pt) 2005-10-11
MY136034A (en) 2008-07-31
CO5570670A2 (es) 2005-10-31
EP2025338A1 (de) 2009-02-18
MEP53608A (en) 2011-05-10
NO20052883L (no) 2005-06-14
SI1562603T1 (sl) 2009-10-31
JP2006508140A (ja) 2006-03-09
BRPI0316264B1 (pt) 2019-04-09
CA2506082C (en) 2011-06-21
PL375270A1 (en) 2005-11-28
ME00354B (me) 2011-10-10
DE10253282A1 (de) 2004-05-27
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AR087241A2 (es) 2014-03-12
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RS51607B (sr) 2011-08-31
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CY2014032I2 (el) 2015-12-09
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BRPI0316264B8 (pt) 2021-05-25
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RS20050361A (sr) 2007-04-10
HUS1400011I1 (hu) 2022-02-28
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ES2326878T3 (es) 2009-10-21
WO2004045618A3 (de) 2004-09-30
NL300650I2 (nl) 2017-11-02
LU92433I2 (fr) 2014-06-24
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