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PE20040606A1 - 4-amino-1-(piridilmetil)piperidina sustituida y compuestos relacionados - Google Patents

4-amino-1-(piridilmetil)piperidina sustituida y compuestos relacionados

Info

Publication number
PE20040606A1
PE20040606A1 PE2003001087A PE2003001087A PE20040606A1 PE 20040606 A1 PE20040606 A1 PE 20040606A1 PE 2003001087 A PE2003001087 A PE 2003001087A PE 2003001087 A PE2003001087 A PE 2003001087A PE 20040606 A1 PE20040606 A1 PE 20040606A1
Authority
PE
Peru
Prior art keywords
alkyl
alkinyl
cycloalkyl
alkenyl
piperidine
Prior art date
Application number
PE2003001087A
Other languages
English (en)
Inventor
Trevor Mischki
Mathai Mammen
Craig Husfeld
Sarah Dunham
Li Li
Ioanna Stergiades
Yu-Hua Ji
Yan Chen
Adam Hughes
Richard Wilson
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PE20040606A1 publication Critical patent/PE20040606A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE W, X, Y y Z SON INDEPENDIENTEMENTE CH, CR4, N Y N--0, CON LA CONDICION DE QUE AL MENOS UNO Y NO MAS DE DOS SEA N O N--O, R1 ES UN -(CH2)a-(O)b-(CH2)c-; R2 ES H, ALQUILO(C1-C6), ALQUENILO O ALQUINILO(C2-C6), CICLOALQUILO(C3-C6), CH2R5 Y (CH2)xR6, OPCIONALMENTE SUSTITUIDOS POR FLUOR; R3 ES H, ALQUILO(C1-C6), ALQUENILO O ALQUINILO(C2-C6), CICLOALQUILO(C3-C6), CH2R7 Y (CH2)yR8, OPCIONALMENTE SUSTITUIDOS POR FLUOR; Ra Y Rb SON INDEPENDIENTEMENTE ALQUILO(C1-C4), ALQUENILO O ALQUINILO(C2-C4), CICLOALQUILO(C3-C6), CIANO, HALO, ORf, SRf, S(O)Rf Y NRgRh, O DOS GRUPOS Ra O Rb ADYACENTES; Rc Y Rd SON INDEPENDIENTEMENTE ALQUILO(C1-C4) Y FLUOR; Re ES H, ALQUILO(C1-C6), ALQUENILO O ALQUINILO(C2-C6), CICLOALQUILO(C3-C6), ENTRE OTROS O AMBOS Re SE UNEN JUNTO CON EL N FORMANDO UN HETEROCICLO(C3-C6), OPCIONALMENTE SUSTITUIDOS, SON COMPUESTOS PREFERIDOS: 4-{N-[7-(3-(S)-1-CARBAMOIL-1,1-DIFENILMETIL)PIRROLIDIN-1-IL)HEPT-1-IL]-N-(ISOPROPIL)AMINO}-1-(4-METOXIPIRID-3-ILMETIL)PIPERIDINA, 4-{N-[7-(3-(S)-1-CARBAMOIL-1,1-DIFENILMETIL)PIRROLIDIN-1-IL)HEPT-1-IL]-N-(ETIL)AMINO}-1-(2-METOXIPIRIDIN-3-ILMETIL)PIPERIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCESO DE ELABORACION. ESTOS COMPUESTOS Y SUS INTERMEDIOS SON INHIBIDORES SELECTIVOS DEL RECEPTOR DEL SUBTIPO M2 Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR RECEPTORES MUSCARINICOS COMO VEJIGA SUPERACTIVA, SINDROME DE INTESTINOS IRRITABLES, ASMA Y ENFERMEDAD OBSTRUCTIVA CRONICA
PE2003001087A 2002-10-30 2003-10-28 4-amino-1-(piridilmetil)piperidina sustituida y compuestos relacionados PE20040606A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42222902P 2002-10-30 2002-10-30
US48648303P 2003-07-11 2003-07-11

Publications (1)

Publication Number Publication Date
PE20040606A1 true PE20040606A1 (es) 2004-09-08

Family

ID=32314442

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001087A PE20040606A1 (es) 2002-10-30 2003-10-28 4-amino-1-(piridilmetil)piperidina sustituida y compuestos relacionados

Country Status (20)

Country Link
US (2) US7285564B2 (es)
EP (1) EP1556372B1 (es)
JP (2) JP4448492B2 (es)
KR (1) KR20050061504A (es)
AR (1) AR041855A1 (es)
AT (1) ATE363482T1 (es)
AU (1) AU2003285100A1 (es)
BR (1) BR0315778A (es)
CA (1) CA2500800A1 (es)
DE (1) DE60314170T2 (es)
EC (1) ECSP055762A (es)
ES (1) ES2287543T3 (es)
IS (1) IS7780A (es)
MX (1) MXPA05004507A (es)
NO (1) NO20052521L (es)
PE (1) PE20040606A1 (es)
PL (1) PL376716A1 (es)
RU (1) RU2005116239A (es)
TW (2) TWI295669B (es)
WO (1) WO2004041806A2 (es)

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TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
JP2007524641A (ja) * 2003-07-11 2007-08-30 セラヴァンス， インコーポレーテッド 置換４−アミノ−１−ベンジルピペリジン化合物
PE20050973A1 (es) * 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
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TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) * 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
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WO2009153649A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing 3-substituted pyrrolidine compounds
KR20120093859A (ko) * 2009-10-07 2012-08-23 머크 샤프 앤드 돔 코포레이션 베타 ３ 아드레날린 수용체 효능제 및 항무스카린제를 사용하는 조합 요법
US20110281853A1 (en) 2010-05-12 2011-11-17 Rishi Arora Compositions and methods for treating or preventing atrial fibrillation
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
PH12013500221A1 (en) * 2010-08-03 2017-08-23 Altherx Inc Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
SG11201404776PA (en) * 2012-02-09 2014-09-26 Altherx Inc Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder
KR20170086659A (ko) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법
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Also Published As

Publication number Publication date
AR041855A1 (es) 2005-06-01
MXPA05004507A (es) 2005-10-18
ATE363482T1 (de) 2007-06-15
RU2005116239A (ru) 2006-01-27
BR0315778A (pt) 2005-09-06
IS7780A (is) 2005-03-31
DE60314170D1 (de) 2007-07-12
JP4448492B2 (ja) 2010-04-07
JP2010059214A (ja) 2010-03-18
JP2006512408A (ja) 2006-04-13
CA2500800A1 (en) 2004-05-21
US20080091034A1 (en) 2008-04-17
TW200800953A (en) 2008-01-01
WO2004041806A2 (en) 2004-05-21
PL376716A1 (pl) 2006-01-09
KR20050061504A (ko) 2005-06-22
TW200418833A (en) 2004-10-01
AU2003285100A1 (en) 2004-06-07
US20040122014A1 (en) 2004-06-24
DE60314170T2 (de) 2008-01-24
ECSP055762A (es) 2005-07-06
US8030502B2 (en) 2011-10-04
ES2287543T3 (es) 2007-12-16
US7285564B2 (en) 2007-10-23
EP1556372A2 (en) 2005-07-27
NO20052521L (no) 2005-05-25
EP1556372B1 (en) 2007-05-30
TWI295669B (en) 2008-04-11
WO2004041806A3 (en) 2004-08-05

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