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DE60314170D1 - Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten - Google Patents

Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten

Info

Publication number
DE60314170D1
DE60314170D1 DE60314170T DE60314170T DE60314170D1 DE 60314170 D1 DE60314170 D1 DE 60314170D1 DE 60314170 T DE60314170 T DE 60314170T DE 60314170 T DE60314170 T DE 60314170T DE 60314170 D1 DE60314170 D1 DE 60314170D1
Authority
DE
Germany
Prior art keywords
pyridylmethyl
piperidines
amino
substituted
receptor antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60314170T
Other languages
English (en)
Other versions
DE60314170T2 (de
Inventor
Mathai Mammen
Richard Wilson
Yan Chen
Sarah Dunham
Adam Hughes
Craig Husfeld
Yu-Hua Ji
Li Li
Trevor Mischki
Ioanna Stergiades
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoviva Inc
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of DE60314170D1 publication Critical patent/DE60314170D1/de
Application granted granted Critical
Publication of DE60314170T2 publication Critical patent/DE60314170T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE60314170T 2002-10-30 2003-10-29 Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten Expired - Lifetime DE60314170T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US42222902P 2002-10-30 2002-10-30
US422229P 2002-10-30
US48648303P 2003-07-11 2003-07-11
US486483P 2003-07-11
PCT/US2003/034444 WO2004041806A2 (en) 2002-10-30 2003-10-29 Substituted 4-amino-1-(pyridylmethyl) piperidine as muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
DE60314170D1 true DE60314170D1 (de) 2007-07-12
DE60314170T2 DE60314170T2 (de) 2008-01-24

Family

ID=32314442

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60314170T Expired - Lifetime DE60314170T2 (de) 2002-10-30 2003-10-29 Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten

Country Status (20)

Country Link
US (2) US7285564B2 (de)
EP (1) EP1556372B1 (de)
JP (2) JP4448492B2 (de)
KR (1) KR20050061504A (de)
AR (1) AR041855A1 (de)
AT (1) ATE363482T1 (de)
AU (1) AU2003285100A1 (de)
BR (1) BR0315778A (de)
CA (1) CA2500800A1 (de)
DE (1) DE60314170T2 (de)
EC (1) ECSP055762A (de)
ES (1) ES2287543T3 (de)
IS (1) IS7780A (de)
MX (1) MXPA05004507A (de)
NO (1) NO20052521L (de)
PE (1) PE20040606A1 (de)
PL (1) PL376716A1 (de)
RU (1) RU2005116239A (de)
TW (2) TWI295669B (de)
WO (1) WO2004041806A2 (de)

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TWI295669B (en) * 2002-10-30 2008-04-11 Theravance Inc Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
PE20050973A1 (es) * 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
WO2005087722A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
JP2007528418A (ja) * 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) * 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
WO2006058294A2 (en) * 2004-11-29 2006-06-01 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1863490A2 (de) 2005-03-28 2007-12-12 Vertex Pharmaceuticals Incorporated Muskarinische modulatoren
KR101495708B1 (ko) * 2007-02-23 2015-02-25 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 무스카린 수용체 안타고니스트로 유용한 4차 암모늄 디페닐메틸 화합물
WO2009153649A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing 3-substituted pyrrolidine compounds
JP5738871B2 (ja) * 2009-10-07 2015-06-24 メルク・シャープ・エンド・ドーム・コーポレイション β３アドレナリン作動性受容体アゴニスト及び抗ムスカリン剤を用いる併用療法
WO2011143457A2 (en) 2010-05-12 2011-11-17 Northwestern University Compositions and methods for treating or preventing atrial fibrillation
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
AU2011285928B9 (en) * 2010-08-03 2018-08-02 B3Ar Therapeutics, Inc. Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
AR089957A1 (es) * 2012-02-09 2014-10-01 Altherx Inc Combinaciones farmaceuticas, combinaciones sinergicas
EP3226849A4 (de) 2014-12-03 2018-05-09 Velicept Therapeutics, Inc. Zusammensetzungen und verfahren zur verwendung von solabegron mit modifizierter freisetzung für symptome der unteren harnwege
US10065922B2 (en) 2015-10-23 2018-09-04 Velicept Therapeutics, Inc. Solabegron zwitterion and uses thereof

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US3192206A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-aminoalkyl)-3, 3-disubstitutedn-hydrocarbon-2-pyrrolidinones and corresponding-2-thionpyrrolidinones
US3192221A (en) * 1961-12-04 1965-06-29 Robins Co Inc A H 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-pyrrolidinones and 4-(omega-substituted alkyl)-3, 3-disubstituted-1-substituted-2-thionpyrrolidinones and production thereof
GB1593851A (en) 1976-10-27 1981-07-22 Gallardo Antonio Sa N-(4-piperidyl)-benzamides and pharmaceutical compositions containing them
GB1507462A (en) 1974-03-21 1978-04-12 Gallardo Antonio Sa N-heterocyclic substituted benzamides methods for their preparation and compositions containing them
US3984557A (en) * 1974-12-26 1976-10-05 A. H. Robins Company, Incorporated Antiarrhythmia compositions and methods
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CH628885A5 (en) 1978-01-01 1982-03-31 Anphar Sa Piperidine derivative
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IL76583A (en) 1984-10-19 1988-08-31 Robins Co Inc A H 1-(aminoalkyl)-alpha'alpha-diaryl pyrrolidinyl,piperidino and homopiperidino acetamides and acetonitriles and pharmaceutical compositions containing them
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
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US5750540A (en) * 1995-04-28 1998-05-12 Banyu Pharmaceutical Co., Ltd. 1,4-di-substituted piperidine derivatives
EP0863141B1 (de) 1995-10-13 2001-09-12 Banyu Pharmaceutical Co., Ltd. Substituierte heteroaromatische derivate
PE92198A1 (es) 1996-08-01 1999-01-09 Banyu Pharma Co Ltd Derivados de 1,4-piperidina disustituida que contienen fluor
KR20010022147A (ko) 1997-07-24 2001-03-15 아사이 이페이 아미노시클로알칸 화합물
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UA73543C2 (uk) * 1999-12-07 2005-08-15 Тераванс, Інк. Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
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US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
PE20050973A1 (es) 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
JP2007528418A (ja) 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
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TW200540154A (en) 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds

Also Published As

Publication number Publication date
CA2500800A1 (en) 2004-05-21
PL376716A1 (pl) 2006-01-09
JP4448492B2 (ja) 2010-04-07
WO2004041806A3 (en) 2004-08-05
TWI295669B (en) 2008-04-11
WO2004041806A2 (en) 2004-05-21
IS7780A (is) 2005-03-31
ATE363482T1 (de) 2007-06-15
US8030502B2 (en) 2011-10-04
ECSP055762A (es) 2005-07-06
KR20050061504A (ko) 2005-06-22
TW200418833A (en) 2004-10-01
PE20040606A1 (es) 2004-09-08
JP2010059214A (ja) 2010-03-18
RU2005116239A (ru) 2006-01-27
NO20052521L (no) 2005-05-25
AU2003285100A1 (en) 2004-06-07
TW200800953A (en) 2008-01-01
BR0315778A (pt) 2005-09-06
US20040122014A1 (en) 2004-06-24
JP2006512408A (ja) 2006-04-13
AR041855A1 (es) 2005-06-01
US20080091034A1 (en) 2008-04-17
ES2287543T3 (es) 2007-12-16
EP1556372B1 (de) 2007-05-30
MXPA05004507A (es) 2005-10-18
US7285564B2 (en) 2007-10-23
EP1556372A2 (de) 2005-07-27
DE60314170T2 (de) 2008-01-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN