PE20030336A1 - Utilizacion de sistemas de indan-1-ona sustituidos en c2 para la preparacion de medicamentos para la profilaxia o el tratamiento de la obesidad - Google Patents
Utilizacion de sistemas de indan-1-ona sustituidos en c2 para la preparacion de medicamentos para la profilaxia o el tratamiento de la obesidadInfo
- Publication number
- PE20030336A1 PE20030336A1 PE2002000807A PE2002000807A PE20030336A1 PE 20030336 A1 PE20030336 A1 PE 20030336A1 PE 2002000807 A PE2002000807 A PE 2002000807A PE 2002000807 A PE2002000807 A PE 2002000807A PE 20030336 A1 PE20030336 A1 PE 20030336A1
- Authority
- PE
- Peru
- Prior art keywords
- indan
- ona
- alkyl
- chloro
- obesity
- Prior art date
Links
- 208000008589 Obesity Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 235000020824 obesity Nutrition 0.000 title abstract 2
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 abstract 2
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 abstract 2
- -1 LEPTINE Chemical compound 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229940025084 amphetamine Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- XXEPPPIWZFICOJ-UHFFFAOYSA-N diethylpropion Chemical compound CCN(CC)C(C)C(=O)C1=CC=CC=C1 XXEPPPIWZFICOJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960004890 diethylpropion Drugs 0.000 abstract 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 abstract 1
- 229960002179 ephedrine Drugs 0.000 abstract 1
- XXVROGAVTTXONC-UHFFFAOYSA-N mefenorex Chemical compound ClCCCNC(C)CC1=CC=CC=C1 XXVROGAVTTXONC-UHFFFAOYSA-N 0.000 abstract 1
- 229960001468 mefenorex Drugs 0.000 abstract 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 abstract 1
- 229960000395 phenylpropanolamine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A UTILIZACION DE COMPUESTOS INDAN-1-ONA SUSTITUIDOS EN C2 DE FORMULA I DONDE R1, R2, R3, R4 SON H, F, Cl, Br, I, CN, N3, NO2, OH, O-ALQUILO C1-C8, O-CICLOALQUILO C3-C8, O-CH2-FENILO, O-FENILO, O-CO-ALQUILO C1-C8, ENTRE OTROS; X ES S, SO, SO2, Y ES (CH2)p; p ES 0-3; R5 ES CF3, ALQUILO C1-C18, CICLOALQUILO C3-C8, (CH2)rCOR6, CH2-CH(NHR7)-COR8, FENILO, ; r ES 1-6; R6 ES OH, O-ALQUILO C1-C6, NH2, CH2-CH(NHR7)-COR8; R7 ES H, CO-ALQUILO C1-C4, COO-ALQUILO C1-C4; R8 ES OH, O-ALQUILO C1-C6, NH2 PARA LA PREPARACION DE MEDICAMENTOS PARA EL TRATAMIENTO DE OBESIDAD. SON COMPUESTOS PREFERIDOS 5-CLORO-2-METILSULFANIL-INDAN-1-ONA; 5-CLORO-2-METANOSULFONIL-INDAN-1-ONA; 5-CLORO-2-FENILSULFANIL-INDAN-1-ONA, 2-BENCENOSULFONIL-5-CLORO-INDAN-1-ONA, 5-CLORO-2-METANOSULFONIL-INDAN-1-ONA. TAMBIEN SE REFIERE AL USO CON CATINA, FENILPROPANOLAMINA, AMFEPRAMONA, MEFENOREX, EFEDRINA, LEPTINA, DEXANFETAMINA, ANFETAMINA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10142668A DE10142668A1 (de) | 2001-08-31 | 2001-08-31 | Verwendung von C2-substituierten Indan-1-on-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030336A1 true PE20030336A1 (es) | 2003-05-19 |
Family
ID=7697238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000807A PE20030336A1 (es) | 2001-08-31 | 2002-08-22 | Utilizacion de sistemas de indan-1-ona sustituidos en c2 para la preparacion de medicamentos para la profilaxia o el tratamiento de la obesidad |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6946492B2 (es) |
| EP (1) | EP1424999A1 (es) |
| JP (1) | JP4342306B2 (es) |
| AU (1) | AU2002336985B2 (es) |
| CA (1) | CA2458555A1 (es) |
| DE (1) | DE10142668A1 (es) |
| IL (2) | IL160607A0 (es) |
| MX (1) | MXPA04001853A (es) |
| PE (1) | PE20030336A1 (es) |
| WO (1) | WO2003020256A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010085811A2 (en) * | 2009-01-26 | 2010-07-29 | Taipei Medical University | Use of pterosin compounds for treating diabetes and obesity |
| CN103333144B (zh) * | 2013-06-17 | 2014-12-10 | 温州大学 | 一种2-硫基-3-卤代苯并呋喃化合物及其合成方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0009554B1 (de) * | 1978-07-27 | 1983-04-27 | Schering Aktiengesellschaft | Indanyl-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate |
| RU2073673C1 (ru) * | 1987-10-19 | 1997-02-20 | Пфайзер Инк. | Рацемические и оптические активные производные тетралина и 7-гидрокситетралина |
| ATE246668T1 (de) * | 1995-12-06 | 2003-08-15 | Venantius Ltd | Dimere indan verbindungen und ihre pharmazeutische verwendung |
| JP3071832B2 (ja) | 1996-01-17 | 2000-07-31 | ノボ ノルディスク アクティーゼルスカブ | 縮合した１，２，４−チアジアジン及び縮合した１，４−チアジン誘導体、これらの製造および使用 |
| PL192359B1 (pl) | 1996-08-30 | 2006-10-31 | Novo Nordisk As | Pochodna GLP-1(7-37) lub analogu GLP-1(7-37), środek farmaceutyczny oraz zastosowanie pochodnej GLP-1(7-37) lub analogu GLP-1(7-37) |
| CN1190434C (zh) | 1996-12-31 | 2005-02-23 | 雷迪实验室有限公司 | 新的杂环化合物、其制备方法和含有它们的药物组合物及其在治疗糖尿病和相关疾病中的应用 |
| IL133604A0 (en) | 1997-07-16 | 2001-04-30 | Novo Nordisk As | Fused 1, 2, 4-thiadiazine derivatives, their preparation and use |
| KR20010103786A (ko) * | 1999-03-01 | 2001-11-23 | 데이비드 존 우드 | 갑상선 수용체 리간드로서의 옥삼산 및 유도체 |
| FR2796070B1 (fr) * | 1999-07-06 | 2003-02-21 | Lipha | Derives de benzodiazepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparation |
| EP1078632A1 (en) | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
-
2001
- 2001-08-31 DE DE10142668A patent/DE10142668A1/de not_active Withdrawn
-
2002
- 2002-08-17 WO PCT/EP2002/009208 patent/WO2003020256A1/de not_active Ceased
- 2002-08-17 MX MXPA04001853A patent/MXPA04001853A/es active IP Right Grant
- 2002-08-17 AU AU2002336985A patent/AU2002336985B2/en not_active Ceased
- 2002-08-17 CA CA002458555A patent/CA2458555A1/en not_active Abandoned
- 2002-08-17 JP JP2003524565A patent/JP4342306B2/ja not_active Expired - Fee Related
- 2002-08-17 IL IL16060702A patent/IL160607A0/xx active IP Right Grant
- 2002-08-17 EP EP02772166A patent/EP1424999A1/de not_active Withdrawn
- 2002-08-22 PE PE2002000807A patent/PE20030336A1/es not_active Application Discontinuation
- 2002-08-30 US US10/231,162 patent/US6946492B2/en not_active Expired - Fee Related
-
2004
- 2004-02-26 IL IL160607A patent/IL160607A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003020256A1 (de) | 2003-03-13 |
| EP1424999A1 (de) | 2004-06-09 |
| IL160607A (en) | 2011-03-31 |
| JP2005503396A (ja) | 2005-02-03 |
| CA2458555A1 (en) | 2003-03-13 |
| AU2002336985B2 (en) | 2006-11-16 |
| MXPA04001853A (es) | 2004-06-15 |
| IL160607A0 (en) | 2004-07-25 |
| US20030134882A1 (en) | 2003-07-17 |
| DE10142668A1 (de) | 2003-03-20 |
| JP4342306B2 (ja) | 2009-10-14 |
| US6946492B2 (en) | 2005-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |