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ES2130079A1 - Resolucion de aminas - Google Patents

Resolucion de aminas

Info

Publication number
ES2130079A1
ES2130079A1 ES09701538A ES9701538A ES2130079A1 ES 2130079 A1 ES2130079 A1 ES 2130079A1 ES 09701538 A ES09701538 A ES 09701538A ES 9701538 A ES9701538 A ES 9701538A ES 2130079 A1 ES2130079 A1 ES 2130079A1
Authority
ES
Spain
Prior art keywords
enantiomer
salt
compound
dextrorotatory
resolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09701538A
Other languages
English (en)
Other versions
ES2130079B1 (es
Inventor
Antoni Torrens-Jover
Jordi Frigola-Constansa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009701538A priority Critical patent/ES2130079B1/es
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Priority to CA002295800A priority patent/CA2295800A1/en
Priority to AT98930811T priority patent/ATE250585T1/de
Priority to PCT/ES1998/000195 priority patent/WO1999002500A1/es
Priority to ES98930811T priority patent/ES2209158T3/es
Priority to EP98930811A priority patent/EP1024137B1/en
Priority to PT98930811T priority patent/PT1024137E/pt
Priority to DK98930811T priority patent/DK1024137T3/da
Priority to AU81117/98A priority patent/AU8111798A/en
Priority to DE69818495T priority patent/DE69818495T2/de
Priority to JP2000502028A priority patent/JP2001509505A/ja
Priority to US09/462,326 priority patent/US6187930B1/en
Publication of ES2130079A1 publication Critical patent/ES2130079A1/es
Priority to NO20000089A priority patent/NO314581B1/no
Application granted granted Critical
Publication of ES2130079B1 publication Critical patent/ES2130079B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gyroscopes (AREA)
  • Saccharide Compounds (AREA)

Abstract

Resolución de aminas. El procedimiento comprende hacer reaccionar la mezcla que comprende 2- [fenil (l-metil-1H-pirazol- 5-il)metoxil -N,N-dimetil- etanamina (I) con un enantiómero de un ácido ópticamente activo para formar una sal diastereoisómera, separar dicha sal y liberar el enantiómero de dicho compuesto (1). El enantiómero dextrorrotatorio de (I) puede obtenerse haciendo reaccionar una mezcla racémica o no racémica de (1) con ácido (+) -ditoluil-L- tartárico, opcionalmente mezclado con ácido p-toluensulfónico. El compuesto (I) tiene propiedades analgésicas y su enantiómero más activo es el dextrorrotatorio.
ES009701538A 1997-07-10 1997-07-10 Resolucion de aminas Expired - Fee Related ES2130079B1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ES009701538A ES2130079B1 (es) 1997-07-10 1997-07-10 Resolucion de aminas
JP2000502028A JP2001509505A (ja) 1997-07-10 1998-07-06 アミンの分割
PCT/ES1998/000195 WO1999002500A1 (es) 1997-07-10 1998-07-06 Resolucion de aminas
ES98930811T ES2209158T3 (es) 1997-07-10 1998-07-06 Resolucion de aminas.
EP98930811A EP1024137B1 (en) 1997-07-10 1998-07-06 Resolution of amines
PT98930811T PT1024137E (pt) 1997-07-10 1998-07-06 Resolucao de aminas
CA002295800A CA2295800A1 (en) 1997-07-10 1998-07-06 Resolution of amines
AU81117/98A AU8111798A (en) 1997-07-10 1998-07-06 Resolution of amines
DE69818495T DE69818495T2 (de) 1997-07-10 1998-07-06 Trennung von aminen
AT98930811T ATE250585T1 (de) 1997-07-10 1998-07-06 Trennung von aminen
US09/462,326 US6187930B1 (en) 1997-07-10 1998-07-06 Resolution of amines
DK98930811T DK1024137T3 (da) 1997-07-10 1998-07-06 Opspaltning af aminer
NO20000089A NO314581B1 (no) 1997-07-10 2000-01-07 Opplösning av aminer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701538A ES2130079B1 (es) 1997-07-10 1997-07-10 Resolucion de aminas

Publications (2)

Publication Number Publication Date
ES2130079A1 true ES2130079A1 (es) 1999-06-16
ES2130079B1 ES2130079B1 (es) 2000-01-16

Family

ID=8300022

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009701538A Expired - Fee Related ES2130079B1 (es) 1997-07-10 1997-07-10 Resolucion de aminas
ES98930811T Expired - Lifetime ES2209158T3 (es) 1997-07-10 1998-07-06 Resolucion de aminas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98930811T Expired - Lifetime ES2209158T3 (es) 1997-07-10 1998-07-06 Resolucion de aminas.

Country Status (12)

Country Link
US (1) US6187930B1 (es)
EP (1) EP1024137B1 (es)
JP (1) JP2001509505A (es)
AT (1) ATE250585T1 (es)
AU (1) AU8111798A (es)
CA (1) CA2295800A1 (es)
DE (1) DE69818495T2 (es)
DK (1) DK1024137T3 (es)
ES (2) ES2130079B1 (es)
NO (1) NO314581B1 (es)
PT (1) PT1024137E (es)
WO (1) WO1999002500A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5986135A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
US20040142929A1 (en) * 2001-07-06 2004-07-22 Ramon Merce-Vidal Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
US7182210B2 (en) 2003-08-19 2007-02-27 Rock-Tenn Shared Services, Llc Adjustable shelving system
TW200533657A (en) * 2004-02-17 2005-10-16 Esteve Labor Dr Substituted pyrazoline compounds, their preparation and use as medicaments
ES2244326B1 (es) * 2004-04-05 2007-02-16 Laboratorios Del Dr. Esteve, S.A. Combinacion de substancias activas.
EP1584335A3 (en) * 2004-04-05 2006-02-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising a carbinol composition and an opioid
US20060040924A1 (en) * 2004-06-22 2006-02-23 Laboratorios Dr. Esteve S.A. Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic
EP1671968A1 (en) 2004-12-17 2006-06-21 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
EP1671953A1 (en) 2004-12-17 2006-06-21 Laboratorios Del Dr. Esteve, S.A. Process for obtaining cizolirtine and its enantiomers
EP1674465A1 (en) 2004-12-27 2006-06-28 Laboratorios Del Dr. Esteve, S.A. Process for obtaining enantiomers of thienylazolylalcoxyethanamines
CA2604602A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
MX2007014129A (es) * 2005-05-10 2008-01-11 Teva Pharma Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico.
EP1743890A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments
EP1757587A1 (en) * 2005-07-15 2007-02-28 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
US7897589B2 (en) * 2005-07-15 2011-03-01 Laboratorios Del Dr. Esteve, S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
EP1743892A1 (en) * 2005-07-15 2007-01-17 Laboratorios del Dr. Esteve S.A. Substituted pyrazoline compounds, their preparation and use as medicaments
US7446220B2 (en) * 2005-09-19 2008-11-04 Teva Pharmaceutical Industries Ltd. Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid
EP1820502A1 (en) 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
EP2151234A1 (en) * 2008-07-28 2010-02-10 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion
WO2010123999A2 (en) * 2009-04-21 2010-10-28 Auspex Pharmaceuticals, Inc. 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor
JP2011057619A (ja) * 2009-09-10 2011-03-24 Tokai Univ 光学活性アミン化合物の製造方法、並びに、ジアステレオマー塩及びその製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020817A1 (fr) * 1995-12-06 1997-06-12 Laboratorios Del Dr. Esteve, S.A. Procede de separation de carbinols

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19601745C1 (de) * 1996-01-19 1997-10-09 Gruenenthal Gmbh Verfahren zur Racematspaltung von Tramadol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997020817A1 (fr) * 1995-12-06 1997-06-12 Laboratorios Del Dr. Esteve, S.A. Procede de separation de carbinols

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters, Vol. 3, no 2, paginas 269-272, 1993. J.A. HUESO-RODRIGUEZ et al. "Preparation of the enantiomers of the analgesic E-3710". Paginas 269-270. *
J. JACQUES et al. "Enantiomers, Racemates and Resolutions", 1991, Krieger Publishing Company. Florida (USA). Paginas 256-261,387-388. *

Also Published As

Publication number Publication date
NO314581B1 (no) 2003-04-14
CA2295800A1 (en) 1999-01-21
ATE250585T1 (de) 2003-10-15
ES2209158T3 (es) 2004-06-16
ES2130079B1 (es) 2000-01-16
DE69818495D1 (de) 2003-10-30
EP1024137B1 (en) 2003-09-24
DE69818495T2 (de) 2004-07-01
NO20000089L (no) 2000-02-22
PT1024137E (pt) 2004-01-30
AU8111798A (en) 1999-02-08
DK1024137T3 (da) 2003-12-22
WO1999002500A1 (es) 1999-01-21
JP2001509505A (ja) 2001-07-24
US6187930B1 (en) 2001-02-13
NO20000089D0 (no) 2000-01-07
EP1024137A1 (en) 2000-08-02

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