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PE20030134A1 - Derivados de oxazolidinonas como antibacterianos - Google Patents

Derivados de oxazolidinonas como antibacterianos

Info

Publication number
PE20030134A1
PE20030134A1 PE2002000572A PE2002000572A PE20030134A1 PE 20030134 A1 PE20030134 A1 PE 20030134A1 PE 2002000572 A PE2002000572 A PE 2002000572A PE 2002000572 A PE2002000572 A PE 2002000572A PE 20030134 A1 PE20030134 A1 PE 20030134A1
Authority
PE
Peru
Prior art keywords
alkyl
oxo
fluoro
halogen
phenyl
Prior art date
Application number
PE2002000572A
Other languages
English (en)
Inventor
Castillo Juan Carlos Del
Mancini Marisabel Mourelle
Clotet Juan Huguet
Rodriguez Jose De Calderon Hidalgo
Original Assignee
Vita Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Lab filed Critical Vita Lab
Publication of PE20030134A1 publication Critical patent/PE20030134A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE OXAZOLIDINONAS DE FORMULA I DONDE X ES CR6, N; R1 ES ALQUILO C1-C4, CICLOALQUILO C3-C6, ALQUENILO C2-C4, ENTRE OTROS; R2 ES H, ALQUILO C1-C4, FENILO; R3 ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; R4 ES H, HALO; R6 ES H, HALOGENO, ALQUILO C1-C4, ENTRE OTROS; R5 ES H, HALOGENO, OCH3, ALCOXI C1-C4, ENTRE OTROS; A ES -CH2-NH-R7, -CHOH-C=OH DONDE R7 ES ISOXAZOL, ENTRE OTROS; W ES EL GRUPO a, ENTRE OTROS; R10 ES H, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ACIDO 7-(4-{4-[5-(S)-(ACETILAMINO-METIL)-2-OXO-OXAZOLIDIN-3-IL]-2-FLUORO-FENIL}PIPERAZIN-1-IL)-1-CICLOPROPIL-6-FLUORO-4-OXO-1,4-DIHIDRO-QUINOLEIN-3-CARBOXILICO, ACIDO 7-(3-{4-[5-(S)-(ACETILAMINO-METIL)-2-OXO-OXAZOLIDIN-3-IL]-2-FLUORO-FENIL}-METIL-AMINO)-AZEPAN-1-IL]-1-CICLOPROPIL-6-FLUORO-4-OXO-1,4-DIHIDRO-QUINOLEIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS DERIVADOS FLUORQUINOLONICOS DE OXAZOLIDINONA SON UTILES COMO AGENTES ANTIBACTERIANOS
PE2002000572A 2001-06-27 2002-06-26 Derivados de oxazolidinonas como antibacterianos PE20030134A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101559A ES2186550B2 (es) 2001-06-27 2001-06-27 Nuevos derivados de oxazolidinonas como antibacterianos.

Publications (1)

Publication Number Publication Date
PE20030134A1 true PE20030134A1 (es) 2003-04-04

Family

ID=8498288

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000572A PE20030134A1 (es) 2001-06-27 2002-06-26 Derivados de oxazolidinonas como antibacterianos

Country Status (29)

Country Link
US (1) US20040147545A1 (es)
EP (1) EP1401834A1 (es)
JP (1) JP2004521147A (es)
KR (1) KR20040030712A (es)
CN (1) CN1520412A (es)
AP (1) AP2003002942A0 (es)
AR (1) AR035254A1 (es)
BG (1) BG108498A (es)
BR (1) BR0210667A (es)
CA (1) CA2450982A1 (es)
CO (1) CO5540387A2 (es)
CR (1) CR7195A (es)
CZ (1) CZ2004101A3 (es)
EA (1) EA200400086A1 (es)
EE (1) EE200400004A (es)
ES (1) ES2186550B2 (es)
HR (1) HRP20031063A2 (es)
HU (1) HUP0400370A2 (es)
IL (1) IL159434A0 (es)
IS (1) IS7088A (es)
MA (1) MA27046A1 (es)
MX (1) MXPA04000185A (es)
NO (1) NO20035791L (es)
NZ (1) NZ530206A (es)
OA (1) OA12639A (es)
PE (1) PE20030134A1 (es)
PL (1) PL365476A1 (es)
SK (1) SK572004A3 (es)
WO (1) WO2003002560A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
DE602004014361D1 (de) * 2003-04-30 2008-07-24 Morphochem Ag Komb Chemie Verwendung von oxazolidinon-chinolin-hybrid-antibiotika zur behandlung von anthrax und anderen infektionen
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US7304050B2 (en) * 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
WO2005051933A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited An improved process for the synthesis of 4-(4-benzyloxy-carbonylamino-2-fluorophenyl)-piperazine-1-carboxylic acid tert-butyl ester, a key intermediate for oxazolidinone antimicrobials and compounds prepared thereby
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
EP1557416A1 (en) * 2004-01-23 2005-07-27 Morphochem Aktiengesellschaft Für Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
JP2007516263A (ja) 2003-12-18 2007-06-21 モルフォケム アクチェンゲゼルシャフト フュア コンビナトリシェ ヘミー オキサゾリジノン−キノロンハイブリッド抗生物質
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
EP2009012B1 (en) 2006-03-31 2014-06-25 Research Foundation Itsuu Laboratory Novel compound having heterocyclic ring
JPWO2009044777A1 (ja) 2007-10-02 2011-02-10 財団法人乙卯研究所 ７員ヘテロ環を有するオキサゾリジノン誘導体
NZ589734A (en) * 2008-05-09 2012-11-30 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
AU2014273510B2 (en) 2013-05-28 2019-10-10 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibacterials for the parenteral treatment or prophylaxis of bacterial diseases
RU2675847C2 (ru) 2013-05-28 2018-12-25 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Комбинированные терапевтические средства, содержащие оксазолидинон-хинолоны, предназначенные для лечения бактериальных инфекций
CN107286111B (zh) * 2016-03-30 2020-06-19 广东赛法洛药业有限公司 一种噁唑烷酮化合物的制备方法
CN107286182A (zh) * 2016-04-12 2017-10-24 李靖 新型噁唑烷酮‑氟喹诺酮衍生物及用途
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid
GB201708606D0 (en) 2017-05-30 2017-07-12 King S College London Antibiotic resistance breakers
ES2952989T3 (es) * 2017-11-29 2023-11-07 Bugworks Res Inc Compuestos heterocíclicos antibacterianos y su síntesis
CN111087409B (zh) * 2018-10-24 2021-06-08 江阴安博生物医药有限公司 一种喹诺酮类化合物及其制备方法和应用
CN112940038A (zh) 2019-12-11 2021-06-11 华创合成制药股份有限公司 新型噁唑烷酮类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE444566B (sv) * 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
ATE123494T1 (de) * 1989-03-30 1995-06-15 Wakunaga Seiyaku Kk Chinolon-derivate und deren salze, verfahren zu deren herstellung und diese enthaltende antibakterielle wirkstoffe.
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
BR9509136A (pt) * 1994-10-26 1998-07-21 Upjohn Co Composto e uso do mesmo
AU713704B2 (en) * 1996-01-31 1999-12-09 Sankyo Company Limited Agents for the treatment and prevention of aids
DE69738457T2 (de) * 1996-04-11 2008-12-24 Pharmacia & Upjohn Co. Llc, Kalamazoo Verfahren zur Herstellung von Oxazolidinonen
GB9614236D0 (en) * 1996-07-06 1996-09-04 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
NZ530206A (en) 2005-07-29
JP2004521147A (ja) 2004-07-15
OA12639A (en) 2006-06-15
CO5540387A2 (es) 2005-07-29
CN1520412A (zh) 2004-08-11
AR035254A1 (es) 2004-05-05
EA200400086A1 (ru) 2004-06-24
NO20035791L (no) 2004-02-19
HUP0400370A2 (hu) 2004-08-30
CZ2004101A3 (cs) 2004-07-14
MXPA04000185A (es) 2004-03-18
EP1401834A1 (en) 2004-03-31
BR0210667A (pt) 2004-10-05
ES2186550B2 (es) 2003-11-16
IL159434A0 (en) 2004-06-01
EE200400004A (et) 2004-02-16
CA2450982A1 (en) 2003-01-09
CR7195A (es) 2004-03-05
SK572004A3 (en) 2004-08-03
ES2186550A1 (es) 2003-05-01
KR20040030712A (ko) 2004-04-09
MA27046A1 (fr) 2004-12-20
IS7088A (is) 2003-12-22
PL365476A1 (en) 2005-01-10
BG108498A (en) 2005-03-31
AP2003002942A0 (en) 2003-12-24
HRP20031063A2 (en) 2004-04-30
WO2003002560A1 (en) 2003-01-09
US20040147545A1 (en) 2004-07-29

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