PE20030890A1 - Cumarinas utiles como biomarcadores - Google Patents
Cumarinas utiles como biomarcadoresInfo
- Publication number
- PE20030890A1 PE20030890A1 PE2003000207A PE2003000207A PE20030890A1 PE 20030890 A1 PE20030890 A1 PE 20030890A1 PE 2003000207 A PE2003000207 A PE 2003000207A PE 2003000207 A PE2003000207 A PE 2003000207A PE 20030890 A1 PE20030890 A1 PE 20030890A1
- Authority
- PE
- Peru
- Prior art keywords
- noh
- cumarinas
- biomarkers
- useful
- formula
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen(.) Chemical compound [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
SE REFIERE AL COMPUESTO DE FORMULA (I), DONDE R1 Y R2 SON H, R3 Y R4 SON H, CH3, 11CH3, (CH2)nI, (CH2)n123I, (CH2)nOH, (CH2)nF, o (CH2)n18F, SIENDO n 2, 3 o 4, o R3 Y R4, JUNTO CON EL ATOMO DE NITROGENO CON EL QUE ESTAN UNIDOS FORMAN UN GRUPO DE FORMULA (II), DONDE R5 ES H, (CH2)nI, (CH2)n123I, (CH2)nOH, CH3, 11CH3, (CH2)nF o(CH2)n18F, SIENDO n COMO YA SE DEFINIO, O UNO DE R1 Y R2 ES H Y EL OTRO, JUNTO CON R3 FORMA UN PUENTE DE -(CH2)m-, DONDE m ES 2 o 3, Y R4 ES H, CH3, (CH2)nI, (CH2)n123I, (CH2)nOH, 11CH3, (CH2)nF o (CH2)n18F Y R ES UN GRUPO SELECCIONADO DE LAS FORMULAS (III), (IV) Y (V), DONDE X ES O, S o NR8, SIENDO R8 H, CH3, 11CH3, (CH2)nI, (CH2)n123I, (CH2)nOH, (CH2)nF o (CH2)n18F, Y ES CH o N, y R6 Y R7 SON INDEPENDIENTEMENTE H, NO2, F, 18F, O(CH2)nF, Cl, CN, 11CN, OCH3, O11CH3, I, 123I, O(CH2)nI o O(CH2)n123I, SIENDO n, EN AMBOS CASOS, COMO SE DEFINIO ANTERIORMENTE, EN FORMA DE BASE LIBRE O DE SAL DE ADICION DE ACIDO PARA UTILIZARSE COMO UN MARCADOR
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0205281.9A GB0205281D0 (en) | 2002-03-06 | 2002-03-06 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030890A1 true PE20030890A1 (es) | 2003-12-05 |
Family
ID=9932424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000207A PE20030890A1 (es) | 2002-03-06 | 2003-03-04 | Cumarinas utiles como biomarcadores |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7569337B2 (es) |
| EP (1) | EP1483262B1 (es) |
| JP (2) | JP4247123B2 (es) |
| KR (1) | KR20040095257A (es) |
| CN (1) | CN1628114A (es) |
| AR (1) | AR038723A1 (es) |
| AT (1) | ATE378333T1 (es) |
| AU (1) | AU2003210418A1 (es) |
| BR (1) | BR0308211A (es) |
| CA (1) | CA2472298A1 (es) |
| CO (1) | CO5611123A2 (es) |
| DE (1) | DE60317476T2 (es) |
| EC (1) | ECSP045255A (es) |
| ES (1) | ES2294304T3 (es) |
| GB (1) | GB0205281D0 (es) |
| MX (1) | MXPA04008570A (es) |
| NO (1) | NO20044174L (es) |
| PE (1) | PE20030890A1 (es) |
| PL (1) | PL370916A1 (es) |
| PT (1) | PT1483262E (es) |
| RU (1) | RU2004129733A (es) |
| TW (1) | TW200400049A (es) |
| WO (1) | WO2003074519A1 (es) |
| ZA (1) | ZA200405175B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| WO2005040337A2 (en) * | 2003-05-20 | 2005-05-06 | The Regents Of The University Of California | METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES |
| JP2007084526A (ja) * | 2004-11-26 | 2007-04-05 | Nagasaki Univ | アミロイド関連疾患診断用組成物 |
| JP4000353B2 (ja) | 2004-11-26 | 2007-10-31 | 国立大学法人 長崎大学 | アミロイド関連疾患診断用組成物 |
| TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
| US8303935B2 (en) * | 2006-05-19 | 2012-11-06 | Nihon Medi-Physics Co., Ltd. | Alkoxy substituted imidazo[1,2-a]pyridines having affinity for amyloid |
| TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
| KR20090025282A (ko) | 2006-06-21 | 2009-03-10 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물 |
| ES2421886T3 (es) | 2007-02-13 | 2013-09-06 | Nihon Mediphysics Co Ltd | Método para producción de un agente de representación de imágenes de diagnóstico por radiación |
| CN101903381A (zh) * | 2007-10-24 | 2010-12-01 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物 |
| AU2008319985A1 (en) * | 2007-10-30 | 2009-05-07 | Nihon Medi-Physics Co., Ltd. | Use of novel compound having affinity for amyloid, and process for production of the same |
| CN101909659A (zh) * | 2007-10-30 | 2010-12-08 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
| WO2013101974A1 (en) | 2011-12-30 | 2013-07-04 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| WO2013109972A2 (en) | 2012-01-20 | 2013-07-25 | Regents Of The University Of Minnesota | Therapeutic compounds |
| CA2862084C (en) | 2012-01-26 | 2021-05-11 | Ptc Therapeutics, Inc. | 1h-isochromen-1-one derivatives and compositions thereof for treating spinal muscular atrophy |
| EP3406252B1 (en) | 2012-02-10 | 2020-05-13 | PTC Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CN104302181B (zh) * | 2012-03-01 | 2017-09-15 | Ptc医疗公司 | 用于治疗脊髓性肌萎缩的化合物 |
| KR102109992B1 (ko) | 2012-03-23 | 2020-05-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| CN103420990B (zh) * | 2012-05-23 | 2016-04-20 | 复旦大学 | 7-氧、硫或氮杂取代香豆素及其衍生物和用途 |
| EP3082820B1 (en) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| EP4249472A3 (en) | 2015-05-30 | 2023-12-13 | PTC Therapeutics, Inc. | Methods for modulating rna splicing |
| EA201800367A1 (ru) | 2015-12-10 | 2019-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения болезни хантингтона |
| EP3544435A4 (en) | 2016-11-28 | 2020-11-04 | PTC Therapeutics, Inc. | RNA SPLICE MODULATION PROCESSES |
| EP4257596A3 (en) | 2016-12-22 | 2023-12-06 | Illumina Cambridge Limited | Coumarin compounds and their uses as fluorescent labels |
| CN108061725B (zh) * | 2017-02-16 | 2020-04-21 | 昆明医科大学 | 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用 |
| JP7376471B2 (ja) | 2017-06-05 | 2023-11-08 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
| WO2018232039A1 (en) | 2017-06-14 | 2018-12-20 | Ptc Therapeutics, Inc. | Methods for modifying rna splicing |
| BR112019027717A2 (pt) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics, Inc. | métodos para tratar a doença de huntington |
| US11395822B2 (en) | 2017-06-28 | 2022-07-26 | Ptc Therapeutics, Inc. | Methods for treating Huntington's disease |
| AU2019243048A1 (en) | 2018-03-27 | 2020-10-15 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| BR112020026534A2 (pt) | 2018-06-27 | 2021-03-23 | Ptc Therapeutics, Inc. | Compostos de heteroarila para o tratamento da doença de huntington |
| SI3814357T1 (sl) | 2018-06-27 | 2024-09-30 | Ptc Therapeutics, Inc. | Heterociklične in heteroarilne spojine za zdravljenje Huntingtonove bolezni |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| MX2020013384A (es) * | 2019-03-01 | 2021-04-28 | Illumina Cambridge Ltd | Compuestos de comarina sustituidos con amina exocíclica y sus usos como etiquetas fluorescentes. |
| CN112300201B (zh) * | 2020-12-07 | 2021-11-23 | 南京林业大学 | 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH390250A (de) * | 1958-06-19 | 1965-07-30 | Geigy Ag J R | Verfahren zur Herstellung von fluoreszierenden Farbstoffen |
| DE2030507C3 (de) * | 1970-06-20 | 1975-05-22 | Bayer Ag, 5090 Leverkusen | Oxazolyl-cumarine, deren Herstellung und Verwendung |
| JPS5529110B2 (es) * | 1972-12-25 | 1980-08-01 | ||
| DE2410634A1 (de) * | 1974-03-06 | 1975-09-18 | Basf Ag | 3-benzofurylcumarine |
| DE2411969A1 (de) * | 1974-03-13 | 1975-09-25 | Bayer Ag | Farbstofflaser |
| DE2525986A1 (de) * | 1975-06-11 | 1977-05-05 | Bayer Ag | Cumarinverbindungen |
| LU78311A1 (de) * | 1977-10-13 | 1979-06-01 | Ciba Geigy Ag | Neue cumarinfarbstoffe,deren herstellung und verwendung |
| US4892922A (en) * | 1987-11-30 | 1990-01-09 | Eastman Kodak Company | Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom |
| JPH01169327A (ja) * | 1987-12-25 | 1989-07-04 | Mitsui Toatsu Chem Inc | 紫外線検知用樹脂組成物 |
| JP2999841B2 (ja) * | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | 発光スクリーン用樹脂組成物 |
| DE69216498T2 (de) | 1991-08-13 | 1997-04-30 | Bayer Ag | Fluoreszierendes Etikett |
| JPH073179A (ja) * | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| JP4028155B2 (ja) * | 2000-04-11 | 2007-12-26 | 日本カーバイド工業株式会社 | 蛍光性再帰反射シート |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
-
2002
- 2002-03-06 GB GBGB0205281.9A patent/GB0205281D0/en not_active Ceased
-
2003
- 2003-03-04 PE PE2003000207A patent/PE20030890A1/es not_active Application Discontinuation
- 2003-03-04 TW TW092104534A patent/TW200400049A/zh unknown
- 2003-03-04 AR ARP030100711A patent/AR038723A1/es unknown
- 2003-03-05 RU RU2004129733/04A patent/RU2004129733A/ru not_active Application Discontinuation
- 2003-03-05 AT AT03743381T patent/ATE378333T1/de not_active IP Right Cessation
- 2003-03-05 MX MXPA04008570A patent/MXPA04008570A/es active IP Right Grant
- 2003-03-05 CN CNA038032163A patent/CN1628114A/zh active Pending
- 2003-03-05 EP EP03743381A patent/EP1483262B1/en not_active Expired - Lifetime
- 2003-03-05 JP JP2003572987A patent/JP4247123B2/ja not_active Expired - Fee Related
- 2003-03-05 ES ES03743381T patent/ES2294304T3/es not_active Expired - Lifetime
- 2003-03-05 KR KR10-2004-7013763A patent/KR20040095257A/ko not_active Ceased
- 2003-03-05 PL PL03370916A patent/PL370916A1/xx not_active Application Discontinuation
- 2003-03-05 PT PT03743381T patent/PT1483262E/pt unknown
- 2003-03-05 BR BR0308211-3A patent/BR0308211A/pt not_active IP Right Cessation
- 2003-03-05 WO PCT/EP2003/002251 patent/WO2003074519A1/en not_active Ceased
- 2003-03-05 CA CA002472298A patent/CA2472298A1/en not_active Abandoned
- 2003-03-05 DE DE60317476T patent/DE60317476T2/de not_active Expired - Fee Related
- 2003-03-05 US US10/506,381 patent/US7569337B2/en not_active Expired - Fee Related
- 2003-03-05 AU AU2003210418A patent/AU2003210418A1/en not_active Abandoned
-
2004
- 2004-06-29 ZA ZA200405175A patent/ZA200405175B/en unknown
- 2004-08-27 EC EC2004005255A patent/ECSP045255A/es unknown
- 2004-09-15 CO CO04091787A patent/CO5611123A2/es not_active Application Discontinuation
- 2004-09-30 NO NO20044174A patent/NO20044174L/no not_active Application Discontinuation
-
2008
- 2008-11-27 JP JP2008302570A patent/JP2009102322A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CO5611123A2 (es) | 2006-02-28 |
| CN1628114A (zh) | 2005-06-15 |
| GB0205281D0 (en) | 2002-04-17 |
| KR20040095257A (ko) | 2004-11-12 |
| NO20044174L (no) | 2004-09-30 |
| JP4247123B2 (ja) | 2009-04-02 |
| DE60317476D1 (de) | 2007-12-27 |
| US7569337B2 (en) | 2009-08-04 |
| PL370916A1 (en) | 2005-06-13 |
| JP2005526749A (ja) | 2005-09-08 |
| AU2003210418A1 (en) | 2003-09-16 |
| RU2004129733A (ru) | 2005-06-27 |
| EP1483262A1 (en) | 2004-12-08 |
| DE60317476T2 (de) | 2008-05-21 |
| CA2472298A1 (en) | 2003-09-12 |
| ECSP045255A (es) | 2004-09-28 |
| BR0308211A (pt) | 2004-12-21 |
| JP2009102322A (ja) | 2009-05-14 |
| PT1483262E (pt) | 2008-02-11 |
| AR038723A1 (es) | 2005-01-26 |
| MXPA04008570A (es) | 2004-12-06 |
| EP1483262B1 (en) | 2007-11-14 |
| US20050169837A1 (en) | 2005-08-04 |
| ZA200405175B (en) | 2005-06-21 |
| WO2003074519A1 (en) | 2003-09-12 |
| ES2294304T3 (es) | 2008-04-01 |
| TW200400049A (en) | 2004-01-01 |
| ATE378333T1 (de) | 2007-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |