PE20030835A1 - COMBINACION FARMACEUTICA QUE COMPRENDE UN AGONISTA DEL RECEPTOR DE ADENOSINA A2a Y UN AGONISTA DEL RECEPTOR ß2-ADRENERGICO - Google Patents
COMBINACION FARMACEUTICA QUE COMPRENDE UN AGONISTA DEL RECEPTOR DE ADENOSINA A2a Y UN AGONISTA DEL RECEPTOR ß2-ADRENERGICOInfo
- Publication number
- PE20030835A1 PE20030835A1 PE2002001166A PE2002001166A PE20030835A1 PE 20030835 A1 PE20030835 A1 PE 20030835A1 PE 2002001166 A PE2002001166 A PE 2002001166A PE 2002001166 A PE2002001166 A PE 2002001166A PE 20030835 A1 PE20030835 A1 PE 20030835A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- phenyl
- receptor agonist
- cycloalkyl
- adenosine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMBINACION INHALADA DE a) UN AGONISTA DEL RECEPTOR DE ADENOSINA A2a DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6 CON FENILO, NAFTILO; R2 ES H, ALQUILO C1-C6; A ES ALQUILENO C1-C6; R3 ES H, ALQUILO C1-C6, -COOR4, CN, -CONR4R4, CICLOALQUILO C3-C8, FENILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, FENILO; R5 ES ALQUILO C1-C6, CICLOALQUILO C1-C6, FENILO; R6 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, FENILO, ENTRE OTROS; R7 ES ALQUILO C1-C6, CICLOALQUILO C3-C8, FENILO, NAFTILO, HET; m ES 0-2. EL COMPUESTO DE FORMULA I ES 9-[(2R,3R, 4S, 5R)-3,4-DIHIDROXI-5-(HIDROXIMETIL)-TETRAHIDRO-2-FURANIL]-6-[(2,2-IFENILETIL)AMINO]-N-[2-(1-PIPERIINIL)ETIL]-9H-PURINA-2-CARBOXAMIDA O UNA DE SUS SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES Y b) UN AGONISTA DEL RECEPTOR ß2-ADRENERGICO COMO SALMETEROL. LA COMBINACION ES UTIL PARA EL TRATAMIENTO DE UNA ENFERMEDAD OBSTRUCTIVA DE LAS VIAS RESPIRATORIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0129397.6A GB0129397D0 (en) | 2001-12-07 | 2001-12-07 | Pharmaceutical combination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030835A1 true PE20030835A1 (es) | 2003-10-08 |
Family
ID=9927249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001166A PE20030835A1 (es) | 2001-12-07 | 2002-12-03 | COMBINACION FARMACEUTICA QUE COMPRENDE UN AGONISTA DEL RECEPTOR DE ADENOSINA A2a Y UN AGONISTA DEL RECEPTOR ß2-ADRENERGICO |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030109485A1 (es) |
| AR (1) | AR037709A1 (es) |
| AU (1) | AU2002347532A1 (es) |
| GB (1) | GB0129397D0 (es) |
| GT (1) | GT200200261A (es) |
| HN (1) | HN2002000355A (es) |
| PA (1) | PA8560401A1 (es) |
| PE (1) | PE20030835A1 (es) |
| SV (1) | SV2004001429A (es) |
| TW (1) | TW200303754A (es) |
| UY (1) | UY27565A1 (es) |
| WO (1) | WO2003047628A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| CN105473133A (zh) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | 干粉制剂及使用方法 |
| WO2019059953A2 (en) | 2017-09-22 | 2019-03-28 | Otitopic Inc. | DRY POWDER COMPOSITIONS CONTAINING MAGNESIUM STEARATE |
| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1547636A1 (en) * | 1995-04-14 | 2005-06-29 | SmithKline Beecham Corporation | Metered dose inhaler for salmeterol |
| GB9913932D0 (en) * | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
| GB0003960D0 (en) * | 2000-02-18 | 2000-04-12 | Pfizer Ltd | Purine derivatives |
-
2001
- 2001-12-07 GB GBGB0129397.6A patent/GB0129397D0/en not_active Ceased
-
2002
- 2002-11-28 AU AU2002347532A patent/AU2002347532A1/en not_active Abandoned
- 2002-11-28 WO PCT/IB2002/005046 patent/WO2003047628A1/en not_active Ceased
- 2002-12-02 US US10/307,727 patent/US20030109485A1/en not_active Abandoned
- 2002-12-03 PE PE2002001166A patent/PE20030835A1/es not_active Application Discontinuation
- 2002-12-04 TW TW091135153A patent/TW200303754A/zh unknown
- 2002-12-05 AR ARP020104715A patent/AR037709A1/es not_active Application Discontinuation
- 2002-12-05 UY UY27565A patent/UY27565A1/es not_active Application Discontinuation
- 2002-12-05 HN HN2002000355A patent/HN2002000355A/es unknown
- 2002-12-06 SV SV2002001429A patent/SV2004001429A/es not_active Application Discontinuation
- 2002-12-06 PA PA20028560401A patent/PA8560401A1/es unknown
- 2002-12-06 GT GT200200261A patent/GT200200261A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SV2004001429A (es) | 2004-05-07 |
| GT200200261A (es) | 2003-07-11 |
| TW200303754A (en) | 2003-09-16 |
| PA8560401A1 (es) | 2003-12-10 |
| US20030109485A1 (en) | 2003-06-12 |
| WO2003047628A1 (en) | 2003-06-12 |
| HN2002000355A (es) | 2003-02-21 |
| UY27565A1 (es) | 2003-07-31 |
| GB0129397D0 (en) | 2002-01-30 |
| AR037709A1 (es) | 2004-12-01 |
| AU2002347532A1 (en) | 2003-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |