[go: up one dir, main page]

PE20030712A1 - Indazolilpirrolotriazinas c-5 modificadas - Google Patents

Indazolilpirrolotriazinas c-5 modificadas

Info

Publication number
PE20030712A1
PE20030712A1 PE2002001102A PE2002001102A PE20030712A1 PE 20030712 A1 PE20030712 A1 PE 20030712A1 PE 2002001102 A PE2002001102 A PE 2002001102A PE 2002001102 A PE2002001102 A PE 2002001102A PE 20030712 A1 PE20030712 A1 PE 20030712A1
Authority
PE
Peru
Prior art keywords
indazol
triazin
heterocycle
benzyl
ilmetil
Prior art date
Application number
PE2002001102A
Other languages
English (en)
Inventor
Harold Mastalerz
James G Tarrant
Gregory D Vite
Guifen Zhang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20030712A1 publication Critical patent/PE20030712A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/009—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone characterised by the material treated
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B41/00—After-treatment of mortars, concrete, artificial stone or ceramics; Treatment of natural stone
    • C04B41/45—Coating or impregnating, e.g. injection in masonry, partial coating of green or fired ceramics, organic coating compositions for adhering together two concrete elements
    • C04B41/4584—Coating or impregnating of particulate or fibrous ceramic material
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00793—Uses not provided for elsewhere in C04B2111/00 as filters or diaphragms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Ceramic Engineering (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Abstract

SE REFIERE A DERIVADOS DE INDAZOLILPIRROLOTRIAZINAS C-5 MODIFICADAS, DE FORMULA I SUS ENANTIOMEROS, DIASTEREOMEROS, SALES DONDE R ES SR2, SOR2, OR2, NR3R4; R1 ES ARILO, HETEROCICLO, ENTRE OTROS; R2 ES H, ALQUILO, ARILO, ARALQUILO, HETEROCICLO; R3 Y R4 SON H, ALQUILO, ARILO, HETEROCICLO; R2 Y R3 JUNTOS FORMAN UN ANILLO CARBOCICLO, HETEROCICLO. SON COMPUESTOS PREFERIDOS (5-[1,4]DIAZEPAN-1-ILMETIL-PIRROLO[2,1-f][1,2,4]TRIAZIN-4-IL)-[1-(3-FLUOR-BENCIL)-1H-INDAZOL-5-IL]-AMINA, [1-(3-FLUOR-BENCIL)-1H-INDAZOL-5-IL]-(5-IMIDAZOL-1-ILMETIL-PIRROLO[2,1-f][1,2,4]TRIAZIN-5-ILMETIL}-PIPERIDIN-3-CARBOXILICO, AMIDA DEL ACIDO 1-{4-[1-(3-FLUORO-BENCIL)-1H-INDAZOL-5-ILAMINO]-PIRROLO[2,1-f][1,2,4]TRIAZIN-5-ILMETIL}-PIPERIDIN-3-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS INHIBEN LA ACTIVIDAD DE LA TIROSINA CINASA DE LOS RECEPTORES DEL FACTOR DE CRECIMIENTO TALES COMO HER1, HER2, HER4 Y SON UTILES COMO AGENTES ANTIPROLIFERATIVOS
PE2002001102A 2001-11-14 2002-11-14 Indazolilpirrolotriazinas c-5 modificadas PE20030712A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33301401P 2001-11-14 2001-11-14

Publications (1)

Publication Number Publication Date
PE20030712A1 true PE20030712A1 (es) 2003-08-21

Family

ID=23300880

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001102A PE20030712A1 (es) 2001-11-14 2002-11-14 Indazolilpirrolotriazinas c-5 modificadas

Country Status (24)

Country Link
US (2) US6908916B2 (es)
EP (1) EP1446401B1 (es)
JP (1) JP4301440B2 (es)
KR (1) KR20050044441A (es)
CN (1) CN1615306A (es)
AR (1) AR037368A1 (es)
AT (1) ATE524462T1 (es)
BR (1) BR0214112A (es)
CA (1) CA2467068A1 (es)
ES (1) ES2370709T3 (es)
HR (1) HRP20040422A2 (es)
HU (1) HUP0402566A3 (es)
IL (1) IL161616A0 (es)
IS (1) IS7243A (es)
MX (1) MXPA04004492A (es)
NO (1) NO20041983L (es)
NZ (1) NZ533034A (es)
PE (1) PE20030712A1 (es)
PL (1) PL368909A1 (es)
RU (1) RU2004117549A (es)
TW (1) TW200300350A (es)
UY (1) UY27540A1 (es)
WO (1) WO2003042172A2 (es)
ZA (1) ZA200403694B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670357B2 (en) * 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
JP4669225B2 (ja) 2002-04-23 2011-04-13 ブリストル−マイヤーズ スクイブ カンパニー キナーゼ阻害剤として有用なピロロトリアジンアニリン化合物
US7388009B2 (en) 2002-04-23 2008-06-17 Bristol-Myers Squibb Company Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
AU2003221753A1 (en) 2002-04-23 2003-11-10 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200401638A (en) * 2002-06-20 2004-02-01 Bristol Myers Squibb Co Heterocyclic inhibitors of kinases
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ES2281692T3 (es) 2002-08-23 2007-10-01 Sloan-Kettering Institute For Cancer Research Sintesis de epotilones, sus intermediarios, sus analogos y sus usos.
TW200420565A (en) * 2002-12-13 2004-10-16 Bristol Myers Squibb Co C-6 modified indazolylpyrrolotriazines
BRPI0407282A (pt) 2003-02-05 2006-01-31 Bristol Myers Squibb Co Processo para preparação de inibidores de pirrolotriazina cinase
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
US20060014741A1 (en) * 2003-12-12 2006-01-19 Dimarco John D Synthetic process, and crystalline forms of a pyrrolotriazine compound
MY145634A (en) 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
US7064203B2 (en) * 2003-12-29 2006-06-20 Bristol Myers Squibb Company Di-substituted pyrrolotriazine compounds
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7102002B2 (en) * 2004-06-16 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7173031B2 (en) 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
TW200600513A (en) 2004-06-30 2006-01-01 Bristol Myers Squibb Co A method for preparing pyrrolotriazine compounds
US7253167B2 (en) 2004-06-30 2007-08-07 Bristol-Myers Squibb Company Tricyclic-heteroaryl compounds useful as kinase inhibitors
US7102003B2 (en) * 2004-07-01 2006-09-05 Bristol-Myers Squibb Company Pyrrolotriazine compounds
US7504521B2 (en) 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
PE20060421A1 (es) 2004-08-12 2006-06-01 Bristol Myers Squibb Co Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
US7151176B2 (en) * 2004-10-21 2006-12-19 Bristol-Myers Squibb Company Pyrrolotriazine compounds
TW200635927A (en) * 2004-12-22 2006-10-16 Bristol Myers Squibb Co Synthetic process
EP1863792B1 (en) 2005-03-28 2009-01-21 Brystol-Myers Squibb Company Atp competitive kinase inhibitors
US7534882B2 (en) 2005-04-06 2009-05-19 Bristol-Myers Squibb Company Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7348325B2 (en) 2005-11-30 2008-03-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
PE20070855A1 (es) 2005-12-02 2007-10-14 Bayer Pharmaceuticals Corp Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas
CA2631741C (en) 2005-12-02 2014-01-28 Bayer Healthcare Llc Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
US8063208B2 (en) 2006-02-16 2011-11-22 Bristol-Myers Squibb Company Crystalline forms of (3R,4R)-4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol
DE102006030479A1 (de) * 2006-07-01 2008-03-20 Merck Patent Gmbh Indazolderivate
US8071779B2 (en) 2006-12-18 2011-12-06 Inspire Pharmaceuticals, Inc. Cytoskeletal active rho kinase inhibitor compounds, composition and use
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
CN102482281A (zh) * 2009-07-28 2012-05-30 宇部兴产株式会社 吡咯并[2，3-d]嘧啶衍生物
CN102627647A (zh) * 2012-03-20 2012-08-08 南京药石药物研发有限公司 4-氯-5-甲基-1H-吡咯并[2,1-f][1,2,4]三嗪的合成方法
US9447105B2 (en) 2013-01-24 2016-09-20 Council Of Scientific & Industrial Research Triazine compounds and a process for preparation thereof
WO2015054358A1 (en) 2013-10-11 2015-04-16 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2015081783A1 (zh) * 2013-12-06 2015-06-11 江苏奥赛康药业股份有限公司 吡咯并[2,1-f][1,2,4]三嗪类衍生物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4908056A (en) 1986-04-25 1990-03-13 E. I. Du Pont De Nemours And Company Heterocyclic acyl sulfonamides
DK0778277T3 (da) 1995-12-08 2003-10-27 Pfizer Substituerede heterocycliske derivater som CRF antagonister
CN1227554A (zh) 1996-08-28 1999-09-01 辉瑞大药厂 取代的6,5－杂二环衍生物
AU770377B2 (en) * 1999-05-21 2004-02-19 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
JP4623483B2 (ja) 1999-08-23 2011-02-02 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有するピロロトリアジン誘導体
US6867300B2 (en) * 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US20040082585A1 (en) * 2001-10-03 2004-04-29 Pharmacia Corporation Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
TW200300350A (en) * 2001-11-14 2003-06-01 Bristol Myers Squibb Co C-5 modified indazolylpyrrolotriazines
AU2003221753A1 (en) * 2002-04-23 2003-11-10 Bristol-Myers Squibb Company Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
TW200400034A (en) * 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases

Also Published As

Publication number Publication date
CN1615306A (zh) 2005-05-11
ATE524462T1 (de) 2011-09-15
CA2467068A1 (en) 2003-05-22
WO2003042172A2 (en) 2003-05-22
US6908916B2 (en) 2005-06-21
UY27540A1 (es) 2003-07-31
IS7243A (is) 2004-04-30
US20030186983A1 (en) 2003-10-02
WO2003042172A3 (en) 2004-01-29
AR037368A1 (es) 2004-11-03
BR0214112A (pt) 2004-09-14
US20050209235A1 (en) 2005-09-22
JP4301440B2 (ja) 2009-07-22
NZ533034A (en) 2004-11-26
RU2004117549A (ru) 2006-01-10
ZA200403694B (en) 2006-06-28
HUP0402566A2 (hu) 2005-03-29
PL368909A1 (en) 2005-04-04
EP1446401A4 (en) 2006-04-12
IL161616A0 (en) 2004-09-27
NO20041983D0 (no) 2004-05-13
HUP0402566A3 (en) 2009-01-28
MXPA04004492A (es) 2004-08-11
EP1446401A2 (en) 2004-08-18
KR20050044441A (ko) 2005-05-12
HRP20040422A2 (en) 2005-04-30
JP2005509030A (ja) 2005-04-07
ES2370709T3 (es) 2011-12-22
TW200300350A (en) 2003-06-01
NO20041983L (no) 2004-06-24
EP1446401B1 (en) 2011-09-14

Similar Documents

Publication Publication Date Title
PE20030712A1 (es) Indazolilpirrolotriazinas c-5 modificadas
PE20060374A1 (es) Inhibidores de cinasa heterociclicos fusionados
MX9203249A (es) Derivados del acido bencimidazolin-2-oxo-1-carboxilico y composiciones farmaceuticas que los contienen.
LU91162I2 (fr) Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables.
PE20041080A1 (es) Preparacion de medicamentos derivados de indolina sustituidos con heterociclos
EA200400981A1 (ru) Новые гетероциклические соединения, активные в качестве ингибиторов бета-лактамаз
ES2073398T3 (es) Nuevos derivados substituidos del acido bencilideno- y cinamilideno-malonico con actividad como inhibidores de la proliferacion celular.
ES2111654T3 (es) Derivados de piperazina como antagonistas de 5-ht1a.
PE20040698A1 (es) Derivados de isoindolina
GB1402498A (en) Triazine derivatives their production and their medicinal use
BG94282A (bg) 2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
DK163288D0 (da) 2-(4-(4-(4-((2-(2,4-difluorphenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)triazoloner
ES2045083T3 (es) Un procedimiento para preparar un compuesto quimico.
ES2039851T3 (es) Procedimiento para la obtencion de 3-(metano-sulfoniloxi) tiolano opticamente activo y sus analogos.
GB1374414A (en) 1-acyl-3-amino-alkyl-indoles and their preparation
ES8609277A1 (es) Procedimiento para la obtencion de 1-(bis-(4-fluorofenil)- metil)-4-(3-fenil-2-propenil)-hexahidro-1h-1, 4-diacepina
GB1495665A (en) Pyrimidines
GB1476949A (en) Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
ES2069967T3 (es) 5-piperazinilalquil-1,5-benzotiazepinonas utiles como antagonistas del calcio.
EA200200569A1 (ru) Арилоксипропаноламины для улучшения продуктивности домашнего скота
KR960704888A (ko) AMPA-수용체에 작용하는 알콕시-치환 β-카르보린 (Alkoxy-Substituted β-Carbolines Acting on The AMPA-Receptor)
PT1100800E (pt) Novos derivados acetais c-2 s/o e s/n de formaldeido de acidos carbapenem-3-carboxilicos e seu uso como antibioticos e inibidores de beta-lactamase
GB1292417A (en) 4-amino-2-(5-nitro-2-thienyl) quinazolines, their preparation, and compositions containing them
GB1481948A (en) 2-(disubstituted-amino)-4-phenyl-imidazolines and their use in pharmaceutical compositions
GB1147887A (en) Indole derivatives and a method for the production thereof

Legal Events

Date Code Title Description
FA Abandonment or withdrawal