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PE20030697A1 - Derivados de tetrahidrobenzofluoreno - Google Patents

Derivados de tetrahidrobenzofluoreno

Info

Publication number
PE20030697A1
PE20030697A1 PE2002001231A PE2002001231A PE20030697A1 PE 20030697 A1 PE20030697 A1 PE 20030697A1 PE 2002001231 A PE2002001231 A PE 2002001231A PE 2002001231 A PE2002001231 A PE 2002001231A PE 20030697 A1 PE20030697 A1 PE 20030697A1
Authority
PE
Peru
Prior art keywords
alkyl
derivatives
hydroxy
tetrahidrobenzofluoreno
alkenyl
Prior art date
Application number
PE2002001231A
Other languages
English (en)
Inventor
Hubert Jan Jozef Loozen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20030697A1 publication Critical patent/PE20030697A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A DERIVADOS DE TETRAHIDROBENZOFLUORENO DE FORMULA I DONDE EL SUSTITUYENTE O-(CH2)n-N(R1R2) EN EL ANILLO PUEDE ESTAR EN POSICION META O PARA; n ES 2-4; Re Y Re' SON OH, R1 Y R2 SON ALQUILO, ALQUENILO, HIDROXI-ALQUILO, ALCOXI-ALQUILO, ARILO-ALQUILO O JUNTO A N FORMA UN HETEROCICLO OPCIONALMENTE SUSTITUIDO CON ALQUILO, ALQUENILO, HIDROXI-ALQUILO, ALCOXI-ALQUILO, ARILO. LOS COMPUESTOS SON ANTAGONISTAS DE RECEPTORES DE ESTROGENOS ß Y PUEDEN SER UTILES PARA ALIVIAR LOS MALESTARES TIPICOS ASOCIADOS CON LA MENOPAUSIA
PE2002001231A 2001-12-21 2002-12-13 Derivados de tetrahidrobenzofluoreno PE20030697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01205206 2001-12-21

Publications (1)

Publication Number Publication Date
PE20030697A1 true PE20030697A1 (es) 2003-08-18

Family

ID=8181558

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001231A PE20030697A1 (es) 2001-12-21 2002-12-13 Derivados de tetrahidrobenzofluoreno

Country Status (11)

Country Link
US (2) US7304155B2 (es)
EP (1) EP1458743B1 (es)
JP (1) JP5054882B2 (es)
AR (1) AR038035A1 (es)
AT (1) ATE382628T1 (es)
AU (1) AU2002358715A1 (es)
DE (1) DE60224441T2 (es)
ES (1) ES2298414T3 (es)
PE (1) PE20030697A1 (es)
TW (1) TW200408385A (es)
WO (1) WO2003053994A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200408385A (en) * 2001-12-21 2004-06-01 Akzo Nobel Nv Tetrahydrobenzfluorene derivatives
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9078888B2 (en) 2007-01-22 2015-07-14 Gtx, Inc. Nuclear receptor binding agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5147880A (en) * 1991-07-22 1992-09-15 Eli Lilly And Company Benzo[a]fluorene compounds
AU2001254710A1 (en) 2000-03-27 2001-10-08 Akzo Nobel N.V. Non-steroidal, tetracyclic compounds for estrogen-related treatments
TW200408385A (en) * 2001-12-21 2004-06-01 Akzo Nobel Nv Tetrahydrobenzfluorene derivatives

Also Published As

Publication number Publication date
JP2005518387A (ja) 2005-06-23
DE60224441D1 (de) 2008-02-14
ES2298414T3 (es) 2008-05-16
DE60224441T2 (de) 2008-12-11
WO2003053994A1 (en) 2003-07-03
US7304155B2 (en) 2007-12-04
EP1458743A1 (en) 2004-09-22
ATE382628T1 (de) 2008-01-15
JP5054882B2 (ja) 2012-10-24
US7655653B2 (en) 2010-02-02
EP1458743B1 (en) 2008-01-02
US20080058361A1 (en) 2008-03-06
AU2002358715A1 (en) 2003-07-09
TW200408385A (en) 2004-06-01
US20050119264A1 (en) 2005-06-02
AR038035A1 (es) 2004-12-22

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Legal Events

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