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PE20030599A1 - FERMENTO QUE PRODUCE y-GLUTAMILCISTEINA - Google Patents

FERMENTO QUE PRODUCE y-GLUTAMILCISTEINA

Info

Publication number
PE20030599A1
PE20030599A1 PE2002001125A PE2002001125A PE20030599A1 PE 20030599 A1 PE20030599 A1 PE 20030599A1 PE 2002001125 A PE2002001125 A PE 2002001125A PE 2002001125 A PE2002001125 A PE 2002001125A PE 20030599 A1 PE20030599 A1 PE 20030599A1
Authority
PE
Peru
Prior art keywords
residue
ferment
food
drink
mutation
Prior art date
Application number
PE2002001125A
Other languages
English (en)
Inventor
Hiroaki Nishiuchi
Reiko Sugimoto
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of PE20030599A1 publication Critical patent/PE20030599A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/24—Organic nitrogen compounds
    • A21D2/245—Amino acids, nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/28—Organic sulfur compounds
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D8/00—Methods for preparing or baking dough
    • A21D8/02—Methods for preparing dough; Treating dough prior to baking
    • A21D8/04—Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes
    • A21D8/047—Methods for preparing dough; Treating dough prior to baking treating dough with microorganisms or enzymes with yeasts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02003—Glutathione synthase (6.3.2.3)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

SE REFIERE A UN FERMENTO QUE PERTENECE AL GENERO DE SACCHAROMYCES O CANDIDA, QUE HOSPEDA UNA SINTETASA DE GLUTATION MUTANTE QUE TIENE UNA O AMBAS MUTACIONES SELECCIONADAS DE: i)UNA MUTACION PARA REEMPLAZAR UN RESIDUO DE TREONINA EN POSICION 47 CON UN RESIDUO DE ISOLEUCINA; Y, ii)UNA MUTACION PARA REEMPLAZAR UN RESIDUO DE GLICINA EN POSICION 387 CON UN RESIDUO DE ACIDO ASPARTICO Y QUE PRODUCE y-GLUTAMILCISTEINA. DICHO FERMENTO TIENE ADEMAS UNA MUTACION PARA REEMPLAZAR UN RESIDUO DE PROLINA EN POSICION 54 CON UN RESIDUO DE LEUCINA. SE REFIERE TAMBIEN A UN ALIMENTO O BEBIDA QUE COMPRENDE UN CULTIVO OBTENIDO CULTIVANDO EL FERMENTO DESCRITO. SE REFIERE TAMBIEN A UN METODO PARA PRODUCIR UN ALIMENTO O BEBIDA, QUE COMPRENDE: 1)CULTIVAR EL FERMENTO; 2)MEZCLAR EL CULTIVO CONTENIDO O SU PRODUCTO DE FRACCIONAMIENTO O EL MISMO SOMETIDO A UN TRATAMIENTO TERMICO CON UNA MATERIA PRIMA DE ALIMENTO O BEBIDA; Y, 3)PROCESAR LA MEZCLA EN UN ALIMENTO O BEBIDA
PE2002001125A 2001-11-26 2002-11-22 FERMENTO QUE PRODUCE y-GLUTAMILCISTEINA PE20030599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001359782A JP4273689B2 (ja) 2001-11-26 2001-11-26 γ−グルタミルシステイン産生酵母

Publications (1)

Publication Number Publication Date
PE20030599A1 true PE20030599A1 (es) 2003-09-09

Family

ID=19170726

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002001125A PE20030599A1 (es) 2001-11-26 2002-11-22 FERMENTO QUE PRODUCE y-GLUTAMILCISTEINA

Country Status (12)

Country Link
US (1) US7569360B2 (es)
EP (1) EP1449913B1 (es)
JP (1) JP4273689B2 (es)
KR (1) KR100951069B1 (es)
CN (1) CN1326990C (es)
AT (1) ATE371720T1 (es)
BR (1) BRPI0214336B8 (es)
DE (1) DE60222167T2 (es)
MY (1) MY134675A (es)
PE (1) PE20030599A1 (es)
TW (1) TWI264466B (es)
WO (1) WO2003046155A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003159048A (ja) * 2001-11-26 2003-06-03 Ajinomoto Co Inc γ−グルタミルシステイン産生酵母とそのスクリーニング法
DE60323042D1 (de) 2002-12-13 2008-10-02 Ajinomoto Kk Verfahren für die Produktion von gamma-glutamylcystein
JP2005073638A (ja) 2003-09-02 2005-03-24 Ajinomoto Co Inc キャンディダ・ユティリスのグルタチオン合成酵素をコードする遺伝子
KR100771077B1 (ko) * 2006-06-02 2007-10-29 주식회사 홍재그린 발효 효모 배양 배지용 효모 영양제
JP5315600B2 (ja) * 2006-09-05 2013-10-16 味の素株式会社 γ−グルタミルシステイン生産酵母とその利用
WO2009102050A1 (ja) 2008-02-15 2009-08-20 Ajinomoto Co., Inc. 腸管免疫賦活剤
EP2251413A4 (en) 2008-03-04 2015-03-25 Ajinomoto Kk GAMMA GLUTAMYLCYSTEIN PRODUCING YEAST AND METHOD FOR PRODUCING A YEAST EXTRACT
EP2166075A1 (en) 2008-09-23 2010-03-24 The Procter and Gamble Company Cleaning composition
RU2009113205A (ru) 2009-04-08 2010-10-20 Федеральное государственное унитарное предприятие Государственный научно-исследовательский институт генетики и селекции промышленн Дрожжи, имеющие повышенное содержание серосодержащего соединения, способ скрининга таких дрожжей и способ их культивирования
JP5857973B2 (ja) * 2010-04-12 2016-02-10 味の素株式会社 γ−Ｇｌｕ−Ｘ又はγ−Ｇｌｕ−Ｘ−Ｇｌｙ含有酵母エキス及びその製造方法
CN103348014B (zh) 2010-10-05 2020-11-03 味之素株式会社 含有γ-Glu-Abu的酵母和酵母提取物以及它们的制备方法
DE102013209274A1 (de) 2013-05-17 2014-11-20 Wacker Chemie Ag Mikroorganismus und Verfahren zur fermentativen Überproduktion von Gamma-Glutamylcystein und Derivaten dieses Dipeptids
CN104328092B (zh) * 2014-09-28 2017-03-15 邦泰生物工程(深圳)有限公司 一种谷胱甘肽合成酶突变体、编码基因及应用
KR102100843B1 (ko) * 2018-08-08 2020-04-14 샘표식품 주식회사 항산화 활성을 갖는 펩타이드 및 이를 포함하는 조성물
KR102546738B1 (ko) * 2021-01-04 2023-06-22 씨제이제일제당 주식회사 글루타메이트-시스테인 리가아제 변이체 및 이를 이용한 글루타치온 생산방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206220A (en) * 1990-04-23 1993-04-27 Research Corporation Technologies, Inc. Soluble and stable sources of tyrosine, cysteine and glutamine for total parenteral nutrition
JPH0753102B2 (ja) * 1992-06-23 1995-06-07 アサヒビール株式会社 グルタチオン高含有酵母及びその製造法
JP3733585B2 (ja) * 1998-11-26 2006-01-11 味の素株式会社 食品の風味増強用素材の製造法
MY128920A (en) * 2000-05-25 2007-02-28 Ajinomoto Kk METHOD FOR PRODUCING y-GLUTAMYLCYSTEINE

Also Published As

Publication number Publication date
MY134675A (en) 2007-12-31
BRPI0214336B1 (pt) 2015-11-17
EP1449913A1 (en) 2004-08-25
EP1449913B1 (en) 2007-08-29
TW200300797A (en) 2003-06-16
BR0214336A (pt) 2004-09-14
US20050196836A1 (en) 2005-09-08
BRPI0214336B8 (pt) 2017-02-07
ATE371720T1 (de) 2007-09-15
TWI264466B (en) 2006-10-21
KR20040058327A (ko) 2004-07-03
US7569360B2 (en) 2009-08-04
KR100951069B1 (ko) 2010-04-07
CN1326990C (zh) 2007-07-18
EP1449913A4 (en) 2005-05-11
CN1592780A (zh) 2005-03-09
WO2003046155A1 (fr) 2003-06-05
DE60222167D1 (de) 2007-10-11
JP2003159049A (ja) 2003-06-03
JP4273689B2 (ja) 2009-06-03
DE60222167T2 (de) 2008-06-12

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