PE20030432A1 - Derivados de imidazol-triazina como ligandos de los receptores gaba - Google Patents
Derivados de imidazol-triazina como ligandos de los receptores gabaInfo
- Publication number
- PE20030432A1 PE20030432A1 PE2002000616A PE2002000616A PE20030432A1 PE 20030432 A1 PE20030432 A1 PE 20030432A1 PE 2002000616 A PE2002000616 A PE 2002000616A PE 2002000616 A PE2002000616 A PE 2002000616A PE 20030432 A1 PE20030432 A1 PE 20030432A1
- Authority
- PE
- Peru
- Prior art keywords
- triazine derivatives
- ligands
- imidazole
- gaba receptors
- phenylimidazo
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- NBNOYIPKKPUGKE-UHFFFAOYSA-N 1h-imidazole;triazine Chemical class C1=CNC=N1.C1=CN=NN=C1 NBNOYIPKKPUGKE-UHFFFAOYSA-N 0.000 title 1
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- -1 (cyano)(fluoro)phenyl moiety Chemical group 0.000 abstract 1
- SKQCVELLWZOJOG-UHFFFAOYSA-N 7-phenylimidazo[1,2-b][1,2,4]triazine Chemical class C=1N=C2N=CC=NN2C=1C1=CC=CC=C1 SKQCVELLWZOJOG-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
SE REFIERE A DERIVADOS DE IMIDAZOL-TRIAZINA DE FORMULA I DONDE X1 ES H, F; R11 ES H, ALQUILO C1-C6, , HALO(ALQUILO C1-C6), (ALCOXI C2-C6)CARBONILO O -CR4=NOR5, ENTRE OTROS; R6 ES F; R4 ES H, ALQUILO C1-6; R5 ES H, ALQUILO C1-6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 4,2'-DIFLUORO-5´-[3-(1-FLUORO-1-METILETIL)IMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL]BIFENIL-2-CARBONITRILO; 5,2´-DIFLUORO-5´-(3-TRIFLUOROMETILIMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL)-BIFENIL-2-CARBONITRILO, 6,2´-DIFLUORO-5´-(3-(1-HIDROXI-1-METILETIL)IMIDAZO[1,2-b][1,2,4]TRIAZIN-7-IL)-BIFENIL-2-CARBONITRILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA . LOS COMPUESTOS MENCIONADOS SON LIGANDOS DE LOS RECEPTORES GABA Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0117277.4A GB0117277D0 (en) | 2001-07-16 | 2001-07-16 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030432A1 true PE20030432A1 (es) | 2003-05-17 |
Family
ID=9918561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000616A PE20030432A1 (es) | 2001-07-16 | 2002-07-10 | Derivados de imidazol-triazina como ligandos de los receptores gaba |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6617326B2 (es) |
| EP (1) | EP1409488B1 (es) |
| JP (1) | JP4373780B2 (es) |
| AT (1) | ATE310002T1 (es) |
| AU (1) | AU2002317957B2 (es) |
| CA (1) | CA2451445A1 (es) |
| DE (1) | DE60207416T2 (es) |
| ES (1) | ES2249598T3 (es) |
| GB (1) | GB0117277D0 (es) |
| PE (1) | PE20030432A1 (es) |
| WO (1) | WO2003008418A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1343788B1 (en) * | 2000-11-10 | 2005-11-23 | MERCK SHARP & DOHME LTD. | Imidazo-triazine derivatives as ligands for gaba receptors |
| GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0210124D0 (en) * | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0210127D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| US20070032553A1 (en) * | 2003-09-10 | 2007-02-08 | Mckernan Ruth | Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome |
| EP1723110A1 (en) * | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| JP2009513672A (ja) * | 2005-10-31 | 2009-04-02 | ブレインセルス，インコーポレイティド | 神経発生のｇａｂａ受容体媒介調節 |
| US20070244143A1 (en) * | 2006-03-08 | 2007-10-18 | Braincells, Inc | Modulation of neurogenesis by nootropic agents |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134077A2 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
| AU2007299920A1 (en) * | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| UA112028C2 (uk) * | 2012-12-14 | 2016-07-11 | Пфайзер Лімітед | Похідні імідазопіридазину як модулятори гамка-рецептора |
| CA2951497C (en) | 2014-06-12 | 2019-04-09 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity |
| US10079661B2 (en) | 2015-09-16 | 2018-09-18 | At&T Intellectual Property I, L.P. | Method and apparatus for use with a radio distributed antenna system having a clock reference |
| KR102482200B1 (ko) | 2016-01-27 | 2022-12-27 | 우니페르지타에트 취리히 | 가려움증 치료를 위한 ｇａｂａａ 수용체 조절인자의 용도 |
| KR102799156B1 (ko) * | 2018-04-18 | 2025-04-21 | 뉴로사이클 테라퓨틱스, 인크. | Gabaa 양성 알로스테릭 조절제 화합물, 이의 제조 방법 및 용도 |
| KR102805881B1 (ko) * | 2019-03-18 | 2025-05-12 | 뉴로사이클 테라퓨틱스, 인크. | 통증 치료를 위한 gabaa 수용체 조절제의 용도 |
| UY38930A (es) * | 2019-10-22 | 2021-05-31 | Neurocycle Therapeutics Inc | Compuestos moduladores alostéricos positivos para gabaa, métodos de fabricación y sus usos |
| EP4048266A4 (en) * | 2019-10-23 | 2024-07-10 | Neurocycle Therapeutics, Inc. | TREATMENT OF EPILEPTIC CONDITIONS WITH GABAa RECEPTOR MODULATORS |
| CN116693555B (zh) * | 2022-02-25 | 2025-07-04 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
| CN117069725A (zh) | 2022-05-10 | 2023-11-17 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3422194A (en) * | 1967-08-15 | 1969-01-14 | Smithkline Corp | The treatment of depression with imidazo(1,2-b)-as-triazines and compositions thereof |
| GB9702524D0 (en) | 1997-02-07 | 1997-03-26 | Merck Sharp & Dohme | Therapeutic agents |
| JP2003502405A (ja) * | 1999-06-22 | 2003-01-21 | ニューロサーチ、アクティーゼルスカブ | 新規ベンズイミダゾール誘導体及びこれらの化合物を含有する薬学的に容認された塩 |
| GB9921150D0 (en) | 1999-09-07 | 1999-11-10 | Merck Sharp & Dohme | Therapeutic agents |
| GB9927687D0 (en) | 1999-11-23 | 2000-01-19 | Merck Sharp & Dohme | Therapeutic agents |
| US6642229B2 (en) | 2000-05-24 | 2003-11-04 | Merck Sharp & Dohme Ltd. | 3-Phenyl-imidazo-pyrimidine derivatives as ligands for GABA receptors |
| GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| GB0027561D0 (en) | 2000-11-10 | 2000-12-27 | Merck Sharp & Dohme | Therapeutic agents |
| EP1343788B1 (en) | 2000-11-10 | 2005-11-23 | MERCK SHARP & DOHME LTD. | Imidazo-triazine derivatives as ligands for gaba receptors |
| TWI248936B (en) | 2001-03-21 | 2006-02-11 | Merck Sharp & Dohme | Imidazo-pyrimidine derivatives as ligands for GABA receptors |
-
2001
- 2001-07-16 GB GBGB0117277.4A patent/GB0117277D0/en not_active Ceased
-
2002
- 2002-07-08 AU AU2002317957A patent/AU2002317957B2/en not_active Ceased
- 2002-07-08 AT AT02747567T patent/ATE310002T1/de not_active IP Right Cessation
- 2002-07-08 JP JP2003513977A patent/JP4373780B2/ja not_active Expired - Fee Related
- 2002-07-08 DE DE60207416T patent/DE60207416T2/de not_active Expired - Fee Related
- 2002-07-08 EP EP02747567A patent/EP1409488B1/en not_active Expired - Lifetime
- 2002-07-08 CA CA002451445A patent/CA2451445A1/en not_active Abandoned
- 2002-07-08 WO PCT/GB2002/003114 patent/WO2003008418A1/en not_active Ceased
- 2002-07-08 ES ES02747567T patent/ES2249598T3/es not_active Expired - Lifetime
- 2002-07-10 PE PE2002000616A patent/PE20030432A1/es not_active Application Discontinuation
- 2002-07-15 US US10/195,274 patent/US6617326B2/en not_active Expired - Fee Related
-
2003
- 2003-06-17 US US10/463,025 patent/US6696444B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6617326B2 (en) | 2003-09-09 |
| US6696444B2 (en) | 2004-02-24 |
| GB0117277D0 (en) | 2001-09-05 |
| ATE310002T1 (de) | 2005-12-15 |
| JP2004536862A (ja) | 2004-12-09 |
| WO2003008418A1 (en) | 2003-01-30 |
| ES2249598T3 (es) | 2006-04-01 |
| EP1409488B1 (en) | 2005-11-16 |
| US20030216395A1 (en) | 2003-11-20 |
| US20030055060A1 (en) | 2003-03-20 |
| DE60207416T2 (de) | 2006-08-03 |
| CA2451445A1 (en) | 2003-01-30 |
| DE60207416D1 (de) | 2005-12-22 |
| EP1409488A1 (en) | 2004-04-21 |
| AU2002317957B2 (en) | 2007-10-25 |
| JP4373780B2 (ja) | 2009-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |