JO2312B1 - Imidazo-pyrimidine derivative as ligands for gaba receptors - Google Patents
Imidazo-pyrimidine derivative as ligands for gaba receptorsInfo
- Publication number
- JO2312B1 JO2312B1 JO200223A JOP20020023A JO2312B1 JO 2312 B1 JO2312 B1 JO 2312B1 JO 200223 A JO200223 A JO 200223A JO P20020023 A JOP20020023 A JO P20020023A JO 2312 B1 JO2312 B1 JO 2312B1
- Authority
- JO
- Jordan
- Prior art keywords
- ligands
- imidazo
- phenyl ring
- pyrimidine derivative
- gaba receptors
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- 150000005237 imidazopyrimidines Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A class of 3-phenylimidazo[1,2-alpha]pyrimidine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a -NH- linkage, and further substituted on the phenyl ring by alkyl, trifluoromethyl, alkoxy or one or two halogen atoms, especially fluoro, are selective ligands for GABAA receptors, in particular having good affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107134A GB0107134D0 (en) | 2001-03-21 | 2001-03-21 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO2312B1 true JO2312B1 (en) | 2005-09-12 |
Family
ID=9911291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO200223A JO2312B1 (en) | 2001-03-21 | 2002-03-13 | Imidazo-pyrimidine derivative as ligands for gaba receptors |
Country Status (3)
| Country | Link |
|---|---|
| GB (1) | GB0107134D0 (en) |
| JO (1) | JO2312B1 (en) |
| ZA (1) | ZA200307023B (en) |
-
2001
- 2001-03-21 GB GB0107134A patent/GB0107134D0/en not_active Ceased
-
2002
- 2002-03-13 JO JO200223A patent/JO2312B1/en active
-
2003
- 2003-09-09 ZA ZA200307023A patent/ZA200307023B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200307023B (en) | 2004-06-28 |
| GB0107134D0 (en) | 2001-05-09 |
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