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PE20020977A1 - Composicion farmaceutica que comprende al menos un fosfolipido zwitterionico y un difosfonato - Google Patents

Composicion farmaceutica que comprende al menos un fosfolipido zwitterionico y un difosfonato

Info

Publication number
PE20020977A1
PE20020977A1 PE2001000324A PE2001000324A PE20020977A1 PE 20020977 A1 PE20020977 A1 PE 20020977A1 PE 2001000324 A PE2001000324 A PE 2001000324A PE 2001000324 A PE2001000324 A PE 2001000324A PE 20020977 A1 PE20020977 A1 PE 20020977A1
Authority
PE
Peru
Prior art keywords
diphosphonate
pharmaceutical composition
zwitterionic phospholipid
composition including
phosphatidyl
Prior art date
Application number
PE2001000324A
Other languages
English (en)
Inventor
Lenard Lichtenberger
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of PE20020977A1 publication Critical patent/PE20020977A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE AL MENOS UN FOSFOLIPIDO ZWITTERIONICO (ION HIBRIDO) Y b) DE 0.1 mg A 1000mg DE UN DIFOSFONATO DE FORMULA I DONDE R' ES H, OH, Cl Y R ES ALQUILO C1-C6, AMINO, ALQUILAMINO, DIALQUILAMINO C1-C5, HALOGENO, ARILTIO, ENTRE OTROS. EL DIFOSFONATO SE SELECCIONA DE RISEDRONATO, ALENDRONATO, PAMIDRONATO UTIL PARA REDUCIR LA RESORCION DE LOS HUESOS Y EL FOSFOLIPIDO ZWITTERIONICO ES SELECCIONADO DE FOSFATIDIL COLINAS, ETANOLAMINAS FOSFATIDIL UTIL PARA REDUCIR LA TOXICIDAD GASTROINTESTINAL DEL DIFOSFONATO
PE2001000324A 2000-04-07 2001-04-10 Composicion farmaceutica que comprende al menos un fosfolipido zwitterionico y un difosfonato PE20020977A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19556200P 2000-04-07 2000-04-07

Publications (1)

Publication Number Publication Date
PE20020977A1 true PE20020977A1 (es) 2002-12-15

Family

ID=22721882

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000324A PE20020977A1 (es) 2000-04-07 2001-04-10 Composicion farmaceutica que comprende al menos un fosfolipido zwitterionico y un difosfonato

Country Status (13)

Country Link
US (2) US6943155B2 (es)
EP (1) EP1267890A2 (es)
JP (1) JP2004517800A (es)
KR (1) KR20010090767A (es)
CN (1) CN1446093A (es)
AR (1) AR049854A1 (es)
AU (1) AU2001251432A1 (es)
BR (1) BR0110316A (es)
CA (1) CA2405360A1 (es)
CO (1) CO5280096A1 (es)
MX (1) MXPA02009924A (es)
PE (1) PE20020977A1 (es)
WO (1) WO2001076577A2 (es)

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Publication number Publication date
CN1446093A (zh) 2003-10-01
JP2004517800A (ja) 2004-06-17
BR0110316A (pt) 2005-01-18
US20020022603A1 (en) 2002-02-21
WO2001076577A3 (en) 2002-06-13
WO2001076577A2 (en) 2001-10-18
MXPA02009924A (es) 2004-08-19
US6943155B2 (en) 2005-09-13
US20030176397A1 (en) 2003-09-18
KR20010090767A (ko) 2001-10-19
US7354912B2 (en) 2008-04-08
AU2001251432A1 (en) 2001-10-23
CA2405360A1 (en) 2001-10-18
AR049854A1 (es) 2006-09-13
CO5280096A1 (es) 2003-05-30
EP1267890A2 (en) 2003-01-02

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