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MX2009006282A - Profarmacos solubles en agua de florfenicol y sus analogos. - Google Patents

Profarmacos solubles en agua de florfenicol y sus analogos.

Info

Publication number
MX2009006282A
MX2009006282A MX2009006282A MX2009006282A MX2009006282A MX 2009006282 A MX2009006282 A MX 2009006282A MX 2009006282 A MX2009006282 A MX 2009006282A MX 2009006282 A MX2009006282 A MX 2009006282A MX 2009006282 A MX2009006282 A MX 2009006282A
Authority
MX
Mexico
Prior art keywords
florfenicol
analogs
water
prodrug
prodrugs
Prior art date
Application number
MX2009006282A
Other languages
English (en)
Inventor
Tomasz W Glinka
Jason Zhang
Original Assignee
Schering Plough Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Plough Ltd filed Critical Schering Plough Ltd
Publication of MX2009006282A publication Critical patent/MX2009006282A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención describe ciertos profármacos novedosos de florfenicol y/o de análogos de florfenicol, incluyendo profármacos de sales farmacéuticamente aceptables de florfenicol y sus análogos, incluyendo ésteres que contienen nitrógeno del grupo alcohol secundario de florfenicol y de sus análogos, y sales farmacéuticamente aceptables de los mismos, composiciones que los contienen, y métodos para administrarlos a sujetos; en modalidades particulares, los profármacos son suficientemente solubles en agua para servir las funciones necesarias de un profármaco soluble en agua de florfenicol o de un profármaco soluble en agua de un análogo de florfenicol; una cierta subclase de los compuestos también posee la estabilidad hidrolítica necesaria para mantener el profármaco en solución el sistema del sujeto hasta que existan las condiciones apropiadas cuando el profármaco puede hidrolizar, liberando florfenicol o el análogo de floríenicol en cuestión.
MX2009006282A 2006-12-13 2007-12-11 Profarmacos solubles en agua de florfenicol y sus analogos. MX2009006282A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87486406P 2006-12-13 2006-12-13
PCT/US2007/025326 WO2008076259A1 (en) 2006-12-13 2007-12-11 Water-soluble prodrugs of florfenicol and its analogs

Publications (1)

Publication Number Publication Date
MX2009006282A true MX2009006282A (es) 2009-06-23

Family

ID=39304665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006282A MX2009006282A (es) 2006-12-13 2007-12-11 Profarmacos solubles en agua de florfenicol y sus analogos.

Country Status (6)

Country Link
US (1) US8084643B2 (es)
EP (1) EP2091909A1 (es)
CN (1) CN101605756A (es)
CA (1) CA2672586A1 (es)
MX (1) MX2009006282A (es)
WO (1) WO2008076259A1 (es)

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US8314252B2 (en) * 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2010107446A1 (en) * 2009-03-19 2010-09-23 Green Earth Fuels, Llc Biodiesel cold soak filtering system
MX2013012820A (es) 2011-05-02 2014-02-10 Zoetis Llc Cefalosporinas novedosas utiles como agentes antibacteriales.
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
CN110078729A (zh) * 2019-06-11 2019-08-02 石家庄学院 一种水溶性氟苯尼考前药及其制备方法
CN111393341A (zh) * 2020-05-07 2020-07-10 中国农业大学 一种水溶性氟苯尼考氨基酸盐的制备方法
CN112194788B (zh) * 2020-09-15 2022-08-02 石家庄学院 一种水溶性氟苯尼考及其制备方法
CN115286544A (zh) * 2022-10-08 2022-11-04 世华合创生物技术开发(山东)有限公司 一种氟苯尼考衍生物、制备方法及其在抗细菌感染的应用
CN115304526B (zh) * 2022-10-11 2023-08-01 世华合创生物技术开发(山东)有限公司 一种水溶性氟苯尼考前药及其制备方法
CN116178309B (zh) * 2023-02-20 2024-11-29 华中农业大学 一种水溶性良好的氟苯尼考衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
US20080188556A1 (en) 2008-08-07
US8084643B2 (en) 2011-12-27
CA2672586A1 (en) 2008-06-26
EP2091909A1 (en) 2009-08-26
WO2008076259A1 (en) 2008-06-26
CN101605756A (zh) 2009-12-16

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