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PE20020839A1 - Difeniltioureas sustituidas con sulfonamida como antagonistas de receptores de il-8 - Google Patents

Difeniltioureas sustituidas con sulfonamida como antagonistas de receptores de il-8

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Publication number
PE20020839A1
PE20020839A1 PE2001000277A PE2001000277A PE20020839A1 PE 20020839 A1 PE20020839 A1 PE 20020839A1 PE 2001000277 A PE2001000277 A PE 2001000277A PE 2001000277 A PE2001000277 A PE 2001000277A PE 20020839 A1 PE20020839 A1 PE 20020839A1
Authority
PE
Peru
Prior art keywords
cyane
alkyl
sulfonamide
substituted
cyanoguanidine
Prior art date
Application number
PE2001000277A
Other languages
English (en)
Inventor
Hong Nie
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE20020839A1 publication Critical patent/PE20020839A1/es

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
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Abstract

SE REFIERE A DIFENILTIOUREAS SUSTITUIDAS CON SULFONAMIDA DE FORMULA I DONDE R ES CIANO, OR11, CONR15R16, R18, COOR11, COR11, SO2R17; R'R" SON H, NR6R7, OH, ORa, ALQUILO C1-C5, ENTRE OTROS; R"' ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10 HALOSUSTITUIDO, (CR8R8)qS(O)tRa, OH, ENTRE OTROS; R1 ES H, HALOGENO, NITRO, CIANO, ALQUILO C1-C10, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-(2-BROMOFENIL)-N'-[4-CLORO-2-HIDROXI-3-(N",N"-DIMETILAMINO-SULFONIL)FENIL]CIANOGUANIDINA, N-[4-CLORO-2-HIDROXI-3-(N",N"-DIMETILAMINOSULFONIL)FENIL]-N'-(2,3-DICLOROFENIL)-CIANOGUANIDINA, ENTRE OTROS. EL COMPUESTO I ES UN MEDIADOR DE QUIMIOQUINA QUE SE UNE AL RECEPTOR IL8 Y PUEDE SER UTIL PARA TRATAMIENTO DE PSORIASIS, DERMATITIS ATOPICA, OSTEOARTRITIS, ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, SINDROME DE INSUFICIENCIA RESPIRATORIA, ENFERMEDAD INTESTINAL INFLAMATORIA
PE2001000277A 2000-03-24 2001-03-23 Difeniltioureas sustituidas con sulfonamida como antagonistas de receptores de il-8 PE20020839A1 (es)

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AR029361A1 (es) * 1999-05-28 2003-06-25 Smithkline Beecham Corp Compuestos de guanidina ciclicas antagonistas de los receptores de la il- 8, composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
MXPA06013118A (es) 2004-05-12 2007-02-28 Schering Corp Antagonistas de cxcr1 y cxcr2 de quimocina.
EP1812008A4 (en) * 2004-10-20 2008-10-29 Smithkline Beecham Corp ANTAGONISTS OF THE IL-8 RECEPTOR
WO2007124424A2 (en) * 2006-04-21 2007-11-01 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2009534420A (ja) * 2006-04-21 2009-09-24 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
PE20080943A1 (es) * 2006-06-23 2008-09-27 Smithkline Beecham Corp Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
US20090131329A1 (en) * 2007-09-14 2009-05-21 Edmund John Miller Treatment for allograft rejection
CN106243023A (zh) * 2010-09-03 2016-12-21 福马Tm有限责任公司 用于抑制nampt的胍化合物和组合物
US8648070B2 (en) 2010-12-17 2014-02-11 Boehringer Ingelheim International Gmbh Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
PL2848612T3 (pl) * 2012-05-08 2017-12-29 Ishihara Sangyo Kaisha, Ltd. Sposób wytwarzania podstawionej pochodnej kwasu benzoesowego
WO2020161257A1 (en) 2019-02-07 2020-08-13 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors

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AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
CZ2001934A3 (cs) * 1998-09-23 2001-08-15 Tularik Inc. Arylsulfonanilidové močoviny
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EP1272175B1 (en) 2010-04-21
EA200201019A1 (ru) 2003-12-25
US6680317B2 (en) 2004-01-20
EP1272175A2 (en) 2003-01-08
AU2001249354A1 (en) 2001-10-08
CA2403787A1 (en) 2001-10-04
AR031101A1 (es) 2003-09-10
HUP0302614A2 (hu) 2003-11-28
EP1272175A4 (en) 2005-08-31
BR0108867A (pt) 2005-02-09
AP2002002599A0 (en) 2002-09-30
PL205103B1 (pl) 2010-03-31
DE60141896D1 (de) 2010-06-02
US20030216375A1 (en) 2003-11-20
DZ3333A1 (fr) 2001-10-04
MA25739A1 (fr) 2003-04-01
NO20024554D0 (no) 2002-09-23
BG107035A (bg) 2003-04-30
ES2344587T3 (es) 2010-09-01
MXPA02009355A (es) 2003-02-12
WO2001072960A3 (en) 2002-02-21
UY26627A1 (es) 2001-09-28
PL366315A1 (en) 2005-01-24
IL151210A0 (en) 2003-04-10
ZA200207576B (en) 2004-04-08
SK13682002A3 (sk) 2003-06-03
WO2001072960A2 (en) 2001-10-04
JP2004508287A (ja) 2004-03-18
AP1548A (en) 2006-01-16
MY128154A (en) 2007-01-31
HUP0302614A3 (en) 2005-05-30
KR20040014901A (ko) 2004-02-18
OA12235A (en) 2003-11-06
ATE464893T1 (de) 2010-05-15
CN1452483A (zh) 2003-10-29
HK1053789A1 (zh) 2003-11-07

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