PE20020487A1 - Terapia antitumoral comprendiendo la administracion de derivados de la distamicina - Google Patents
Terapia antitumoral comprendiendo la administracion de derivados de la distamicinaInfo
- Publication number
- PE20020487A1 PE20020487A1 PE2001000967A PE2001000967A PE20020487A1 PE 20020487 A1 PE20020487 A1 PE 20020487A1 PE 2001000967 A PE2001000967 A PE 2001000967A PE 2001000967 A PE2001000967 A PE 2001000967A PE 20020487 A1 PE20020487 A1 PE 20020487A1
- Authority
- PE
- Peru
- Prior art keywords
- cancer
- administration
- cicaplotino
- week
- refers
- Prior art date
Links
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- -1 MECLORETAMINE Chemical compound 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 abstract 1
- FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 abstract 1
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 206010062878 Gastrooesophageal cancer Diseases 0.000 abstract 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 abstract 1
- 229960002092 busulfan Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229960005243 carmustine Drugs 0.000 abstract 1
- 229960004630 chlorambucil Drugs 0.000 abstract 1
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 201000006974 gastroesophageal cancer Diseases 0.000 abstract 1
- 229960001101 ifosfamide Drugs 0.000 abstract 1
- HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229960001924 melphalan Drugs 0.000 abstract 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 abstract 1
- 229960003440 semustine Drugs 0.000 abstract 1
- 108010042747 stallimycin Proteins 0.000 abstract 1
- 229960004964 temozolomide Drugs 0.000 abstract 1
- 230000003442 weekly effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE REFIERE AL USO DE UN DERIVADO DE O-HALOGENO-ACRILOIL DISTAMICINA DE FORMULA I DONDE R ES Br, Cl, PARA LA PREAPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TUMORES GASTROINTESTINALES, CANCER COLORECTAL, CANCER GASTROESOFAGICO, CANCER DE HIGADO, QUE COMPRENDE LA INFUSION ENDOVENOSA POR 3-4 SEMANAS DE 0,85mg/m2 A 20mg/m2 DE AREA DE SUPERFICIECORPORAL O SEMANALMENTE POR 3 SEMANAS CONSECUTIVAS DE 0,3mg/m2/SEMANA A 7mg/m2/SEMANA; TAMBIEN SE REFIERE AL USO CON MELFALAN, CLORAMBUCIL, MECLORETAMINA, CICLOFOSFAMIDA, IFOSFAMIDA, BUSULFAN, CARMUSTINA, LORMUSTINA, SEMUSTINA, FOTEMUSTINA, DACARBAZIDA, TEMOZOLOMIDA, TIOPEDA, MITOMICINA C, CISPLATINO, CARBOPLATINO, OXALIPLATINO, NEDAPLATINO, CAMPTOTECINA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/676,770 US6576612B1 (en) | 2000-10-02 | 2000-10-02 | Antitumor therapy comprising distamycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020487A1 true PE20020487A1 (es) | 2002-05-23 |
Family
ID=24715919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000967A PE20020487A1 (es) | 2000-10-02 | 2001-09-28 | Terapia antitumoral comprendiendo la administracion de derivados de la distamicina |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6576612B1 (es) |
| EP (1) | EP1345604B1 (es) |
| JP (1) | JP2004510734A (es) |
| KR (1) | KR100827560B1 (es) |
| CN (1) | CN1468099A (es) |
| AT (1) | ATE339202T1 (es) |
| AU (2) | AU2162202A (es) |
| BR (1) | BR0114389A (es) |
| CA (1) | CA2424116A1 (es) |
| CZ (1) | CZ299686B6 (es) |
| DE (1) | DE60123117T2 (es) |
| EA (1) | EA006295B1 (es) |
| EE (1) | EE05241B1 (es) |
| ES (1) | ES2267841T3 (es) |
| HU (1) | HUP0301247A2 (es) |
| IL (1) | IL154755A0 (es) |
| MX (1) | MXPA03002824A (es) |
| MY (1) | MY134690A (es) |
| NO (1) | NO20031410D0 (es) |
| PE (1) | PE20020487A1 (es) |
| PL (1) | PL363926A1 (es) |
| SK (1) | SK5032003A3 (es) |
| WO (1) | WO2002028389A1 (es) |
| ZA (1) | ZA200303405B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
| US20070249651A1 (en) * | 2001-06-20 | 2007-10-25 | Nerviano Medical Sciences S.R.I. | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| US6969592B2 (en) * | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| CN1302777C (zh) * | 2002-04-02 | 2007-03-07 | 内尔维阿诺医学科学有限公司 | 包括取代的丙烯酰偏端霉素衍生物和放射治疗的抗肿瘤联合疗法 |
| AU2003288263A1 (en) * | 2002-10-16 | 2004-05-04 | Pharmacia Italia S.P.A. | Use of substituted acrylolyl distamycin derivatives in combination with demethylating agents, in the treatment of cancer |
| EP1975158B9 (en) * | 2005-12-27 | 2012-02-29 | Universidad Del Pais Vasco-Euskal Herriko Unibersitatea | Novel pyrrole derivatives with histone deacetylase inhibitor activity |
| MD36Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare |
| MD35Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare |
| MD23Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare |
| MD24Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8906709D0 (en) * | 1989-03-23 | 1989-05-10 | Creighton Andrew M | Acryloyl substituted pyrrole derivatives |
| GB9615692D0 (en) * | 1996-07-25 | 1996-09-04 | Pharmacia Spa | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9806689D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents |
| GB9928703D0 (en) * | 1999-12-03 | 2000-02-02 | Pharmacia & Upjohn Spa | Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents |
| US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
-
2000
- 2000-10-02 US US09/676,770 patent/US6576612B1/en not_active Expired - Lifetime
-
2001
- 2001-09-21 AU AU2162202A patent/AU2162202A/xx active Pending
- 2001-09-21 KR KR1020037004710A patent/KR100827560B1/ko not_active Expired - Fee Related
- 2001-09-21 EP EP01986259A patent/EP1345604B1/en not_active Expired - Lifetime
- 2001-09-21 CN CNA018167551A patent/CN1468099A/zh active Pending
- 2001-09-21 HU HU0301247A patent/HUP0301247A2/hu unknown
- 2001-09-21 CZ CZ20030909A patent/CZ299686B6/cs not_active IP Right Cessation
- 2001-09-21 AU AU2002221622A patent/AU2002221622B2/en not_active Ceased
- 2001-09-21 EA EA200300427A patent/EA006295B1/ru not_active IP Right Cessation
- 2001-09-21 EE EEP200300129A patent/EE05241B1/xx not_active IP Right Cessation
- 2001-09-21 IL IL15475501A patent/IL154755A0/xx not_active IP Right Cessation
- 2001-09-21 CA CA002424116A patent/CA2424116A1/en not_active Abandoned
- 2001-09-21 DE DE60123117T patent/DE60123117T2/de not_active Expired - Lifetime
- 2001-09-21 JP JP2002532214A patent/JP2004510734A/ja not_active Withdrawn
- 2001-09-21 US US10/381,272 patent/US7399748B2/en not_active Expired - Fee Related
- 2001-09-21 PL PL01363926A patent/PL363926A1/xx not_active Application Discontinuation
- 2001-09-21 MX MXPA03002824A patent/MXPA03002824A/es unknown
- 2001-09-21 ES ES01986259T patent/ES2267841T3/es not_active Expired - Lifetime
- 2001-09-21 BR BR0114389-1A patent/BR0114389A/pt not_active Application Discontinuation
- 2001-09-21 WO PCT/EP2001/010988 patent/WO2002028389A1/en not_active Ceased
- 2001-09-21 AT AT01986259T patent/ATE339202T1/de active
- 2001-09-21 SK SK503-2003A patent/SK5032003A3/sk unknown
- 2001-09-28 PE PE2001000967A patent/PE20020487A1/es not_active Application Discontinuation
- 2001-09-28 MY MYPI20014542A patent/MY134690A/en unknown
-
2003
- 2003-03-27 NO NO20031410A patent/NO20031410D0/no not_active Application Discontinuation
- 2003-05-02 ZA ZA200303405A patent/ZA200303405B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2162202A (en) | 2002-04-15 |
| EP1345604A1 (en) | 2003-09-24 |
| ES2267841T3 (es) | 2007-03-16 |
| US6576612B1 (en) | 2003-06-10 |
| ATE339202T1 (de) | 2006-10-15 |
| JP2004510734A (ja) | 2004-04-08 |
| EA200300427A1 (ru) | 2003-10-30 |
| PL363926A1 (en) | 2004-11-29 |
| NO20031410L (no) | 2003-03-27 |
| MXPA03002824A (es) | 2003-07-14 |
| DE60123117T2 (de) | 2007-02-08 |
| CZ2003909A3 (cs) | 2003-08-13 |
| EE05241B1 (et) | 2009-12-15 |
| EA006295B1 (ru) | 2005-10-27 |
| EP1345604B1 (en) | 2006-09-13 |
| IL154755A0 (en) | 2003-10-31 |
| US7399748B2 (en) | 2008-07-15 |
| CA2424116A1 (en) | 2002-04-11 |
| ZA200303405B (en) | 2004-05-03 |
| AU2002221622B2 (en) | 2007-05-17 |
| DE60123117D1 (de) | 2006-10-26 |
| WO2002028389A1 (en) | 2002-04-11 |
| CZ299686B6 (cs) | 2008-10-22 |
| HUP0301247A2 (hu) | 2003-09-29 |
| EE200300129A (et) | 2003-06-16 |
| SK5032003A3 (en) | 2003-08-05 |
| BR0114389A (pt) | 2004-02-03 |
| NO20031410D0 (no) | 2003-03-27 |
| MY134690A (en) | 2007-12-31 |
| KR100827560B1 (ko) | 2008-05-07 |
| US20040006023A1 (en) | 2004-01-08 |
| KR20030096222A (ko) | 2003-12-24 |
| CN1468099A (zh) | 2004-01-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |