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PE20011268A1 - Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com - Google Patents

Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com

Info

Publication number
PE20011268A1
PE20011268A1 PE2001000250A PE2001000250A PE20011268A1 PE 20011268 A1 PE20011268 A1 PE 20011268A1 PE 2001000250 A PE2001000250 A PE 2001000250A PE 2001000250 A PE2001000250 A PE 2001000250A PE 20011268 A1 PE20011268 A1 PE 20011268A1
Authority
PE
Peru
Prior art keywords
polymer
oxypropyl
indol
pyrrolidin
dihydroxy
Prior art date
Application number
PE2001000250A
Other languages
English (en)
Inventor
Walter C Babcock
Marshall D Crew
Dwayne Thomas Friesen
Ravi Mysore Shanker
Douglas Alan Lorenz
Chris Macri
James Alan Schriver Nightingale
Bruno Caspar Hancock
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011268A1 publication Critical patent/PE20011268A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA DISPERSION DE SOLIDO AMORFO DE 10% A 60% EN PESO DE [(1S)-BENCIL-(2R)-HIDROXI-3-((3R,4S)-DIHIDROXI-PIRROLIDIN-1-IL)-3-OXIPROPIL]AMIDA DEL ACIDO 5-CLORO-1H-INDOL-2-CARBOXILICO EN UN POLIMERO QUE AUMENTA LA CONCENTRACION DONDE DICHO POLIMERO ES UN POLIMERO IONIZABLE SELECCIONADO DE POLIMORES CELULOCICOS IONIZABLES, NO ISONIZABLES, TAL COMO HIDROXIPROPIL METILCELULOSA, HIDROXIPROPILCELULOSA, METILCELULOSA ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION DE LA COMPOSICION Y FORMAS DE DOSIFICACION DE LIBERACION INMEDIATA, RETRASADA, CONTROLADA O SOSTENIDAS LAS CUALES COMPRENDEN DICHAS DISPERSIONES SOLIDAS Y EXCIPIENTES. LAS COMPOSICION ACTUAN COMO INHIBIDOR DE LA GLUCOGENO FOSFORILASA Y ES UTIL PARA EL TRATAMIENTO DE DIABETES
PE2001000250A 2000-03-16 2001-03-15 Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com PE20011268A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19012500P 2000-03-16 2000-03-16

Publications (1)

Publication Number Publication Date
PE20011268A1 true PE20011268A1 (es) 2001-12-12

Family

ID=22700102

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000250A PE20011268A1 (es) 2000-03-16 2001-03-15 Composiciones farmaceuticas que comprenden una dispersion de solidos amorfos de [(1s)-bencil-(2r)-hidroxi-3-((3r,4s)-dihidroxi-pirrolidin-1-il)-3-oxipropil]amida del acido 5-cloro-1h-indol-2-carboxilico en un polimero que aumenta la concentracion com

Country Status (16)

Country Link
US (2) US20010053791A1 (es)
EP (1) EP1263433A2 (es)
JP (2) JP2003526666A (es)
AR (2) AR028253A1 (es)
AU (1) AU2001240978A1 (es)
CA (1) CA2403233A1 (es)
CO (1) CO5271644A1 (es)
GT (1) GT200100039A (es)
MX (1) MXPA02009098A (es)
PA (1) PA8513701A1 (es)
PE (1) PE20011268A1 (es)
SV (1) SV2002000342A (es)
TN (1) TNSN01041A1 (es)
TW (1) TW200304377A (es)
UY (1) UY26615A1 (es)
WO (1) WO2001068092A2 (es)

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US20030185891A1 (en) 2003-10-02
UY26615A1 (es) 2001-10-25
CA2403233A1 (en) 2001-09-20
US20010053791A1 (en) 2001-12-20
GT200100039A (es) 2001-12-31
US7235260B2 (en) 2007-06-26
TNSN01041A1 (fr) 2005-11-10
MXPA02009098A (es) 2003-03-12
EP1263433A2 (en) 2002-12-11
PA8513701A1 (es) 2002-10-24
AR028253A1 (es) 2003-04-30
JP2007182449A (ja) 2007-07-19
WO2001068092A3 (en) 2002-03-21
CO5271644A1 (es) 2003-04-30
WO2001068092A2 (en) 2001-09-20
AR040281A2 (es) 2005-03-23
SV2002000342A (es) 2002-07-16
AU2001240978A1 (en) 2001-09-24

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