PE20011115A1 - Etanos tri-aril-sustituidos inhibidores de pde4 - Google Patents
Etanos tri-aril-sustituidos inhibidores de pde4Info
- Publication number
- PE20011115A1 PE20011115A1 PE2001000258A PE2001000258A PE20011115A1 PE 20011115 A1 PE20011115 A1 PE 20011115A1 PE 2001000258 A PE2001000258 A PE 2001000258A PE 2001000258 A PE2001000258 A PE 2001000258A PE 20011115 A1 PE20011115 A1 PE 20011115A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- ethyl
- ethans
- tri
- substituted
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 abstract 2
- 102000011017 Type 4 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 2
- 108010037584 Type 4 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 229940122048 Leucotriene receptor antagonist Drugs 0.000 abstract 1
- 229940123391 Leucotriene synthesis inhibitor Drugs 0.000 abstract 1
- 229940126083 M3 antagonist Drugs 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/14—Antitussive agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
Abstract
SE REFIERE A ETANOS TRI-ARIL SUSTITUIDOS DE FORMULA I DONDE R1 ES ALQUILO C1-C6, CICLOALQUILO C3-C6; R2 ES ALQUILO C1-C6, CICLOALQUILO C3-C6; R3 ES ALQUILO C1-C4, CICLOALQUILO C3-C6, HETEROARILO, FENILO, ENTRE OTROS; R4 ES H, ALQUILO C1-C4 CON HALOGENO; RP ES H, HALOGENO, NITRILO, ALQUILO C1-C6, ENTRE OTROS; n ES 0-1; CUANDO R3 Y R4 ESTAN UNIDOS POR X SON ALQUILO Y X ES ALQUILO C0-C4. SON COMPUESTOS PREFERIDOS (+/-)-4-{2-[3,4-BIS(DIFLUOROMETOXI)FENIL]-2-[5-(2-(1-HIDROXI-1-METIL)ETIL)TIAZOLIL]ETIL}PIRIDINA N-OXIDO; QUIRAL-4-{2-[3,4-BIS(DIFLUOROMETOXI)FENIL]-2-[5-(2-(1-HIDROXI-1-METIL) ETIL)TIAZOLIL]ETIL}PIRIDINA N-OXIDO QUIRAL, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE ADEMAS UN ANTAGONISTA DE RECEPTORES DE LEUCOTRIENO, UN INHIBIDOR DE SINTESIS DE LEUCOTRIENO O UN ANTAGONISTA M2/M3. LOS COMPUESTOS DE FORMULA I SON INHIBIDORES DE LA FOSFODIESTERASA-4 (PDE-4) Y SON UTILES PARA EL TRATAMIENTO DE ASMA, BRONQUITIS, ENFERMEDAD OBSTRUCTIVA PULMONAR CRONICA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19166800P | 2000-03-23 | 2000-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011115A1 true PE20011115A1 (es) | 2001-10-29 |
Family
ID=22706424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000258A PE20011115A1 (es) | 2000-03-23 | 2001-03-20 | Etanos tri-aril-sustituidos inhibidores de pde4 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6399636B2 (es) |
| EP (1) | EP1272488B1 (es) |
| JP (1) | JP4944337B2 (es) |
| AR (1) | AR029240A1 (es) |
| AT (1) | ATE321043T1 (es) |
| AU (2) | AU4217201A (es) |
| CA (1) | CA2403423C (es) |
| DE (1) | DE60118165T2 (es) |
| DK (1) | DK1272488T3 (es) |
| ES (1) | ES2258521T3 (es) |
| JO (1) | JO2212B1 (es) |
| MY (1) | MY123585A (es) |
| PE (1) | PE20011115A1 (es) |
| PT (1) | PT1272488E (es) |
| TW (1) | TW575572B (es) |
| WO (1) | WO2001070738A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| US6639077B2 (en) * | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
| MY123585A (en) * | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
| US6699890B2 (en) | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7205320B2 (en) | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7153871B2 (en) | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| CA2450562A1 (en) * | 2001-06-22 | 2003-01-03 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP2005505570A (ja) * | 2001-09-19 | 2005-02-24 | アルタナ ファルマ アクチエンゲゼルシャフト | Ｐｄｅ阻害剤及びロイコトリエン受容体拮抗物質の複合薬 |
| AU2003281219A1 (en) * | 2002-07-02 | 2004-01-23 | Bernard Cote | Di-aryl-substituted-ethane pyridone pde4 inhibitors |
| WO2004009557A1 (en) | 2002-07-19 | 2004-01-29 | Memory Pharmaceuticals Corporation | 6-amino-1h-indazole and 4-aminobenzofuran compounds as phosphodiesterase 4 inhibitors |
| US7405230B2 (en) | 2002-07-19 | 2008-07-29 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| US6872724B2 (en) | 2002-07-24 | 2005-03-29 | Merck & Co., Inc. | Polymorphs with tyrosine kinase activity |
| EP1536794A2 (en) * | 2002-09-06 | 2005-06-08 | Merck & Co., Inc. | Treatment of rheumatoid arthritis by inhibition of pde4 |
| AU2003291418A1 (en) * | 2002-11-15 | 2004-06-15 | Merck And Co., Inc. | Use of pde4 inhibitors as adjunct therapy for psychiatric disorders |
| BR0315705A (pt) * | 2002-11-19 | 2005-09-06 | Memory Pharm Corp | Inibidores de fosfodiesterase-4 |
| US20060040981A1 (en) * | 2002-11-22 | 2006-02-23 | Daniel Dube | Use of phosphodiesterase-4 inhibitors as enhancers of cognition |
| EP1587474B1 (en) * | 2002-12-30 | 2009-11-18 | Celgene Corporation | Fluoroalkoxy-substituted 1, 3-dihydro-isoindolyl compounds and their pharmaceutical uses |
| US20060173028A1 (en) * | 2003-03-17 | 2006-08-03 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic and/or preventive agent for chronic skin disease |
| RU2006132043A (ru) * | 2004-02-06 | 2008-03-20 | МЕДА Фарма ГмбХ унд Ко.КГ (DE) | Комбинация и фармацевтический препарат для лечения ринита |
| RS53461B (sr) | 2006-07-05 | 2014-12-31 | Takeda Gmbh | Kombinacija inhibitora hmg-coa reduktaze atorvastatina ili simvastatina sa fosfodiesteraza 4 inhibitorom, kao što je roflumilast za lečenje inflamatornih pulmonarnih oboljenja |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| ES2989065T3 (es) * | 2020-05-28 | 2024-11-25 | Giiant Pharma Inc | Precursores del inhibidor de la PDE4 bioactivados de la microbiota intestinal |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212693D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9212673D0 (en) | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| EP0577024B1 (de) | 1992-07-01 | 1996-10-16 | Hoechst Aktiengesellschaft | 3,4,5-Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB9222253D0 (en) | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| GB9226830D0 (en) | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
| US5622977A (en) | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
| DE4306152A1 (de) | 1993-02-27 | 1994-09-01 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches Gemisch und damit hergestelltes Aufzeichnungsmaterial |
| GB9304919D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| US5455252A (en) | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| DE4318756A1 (de) | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE69433594T2 (de) | 1993-12-22 | 2004-08-05 | Celltech R&D Ltd., Slough | Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe |
| GB9326699D0 (en) | 1993-12-22 | 1994-03-02 | Celltech Ltd | Chemical compounds |
| GB9326173D0 (en) | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| EP0765867A1 (de) | 1995-09-27 | 1997-04-02 | Hoechst Aktiengesellschaft | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
| EP0873310A1 (en) * | 1995-12-15 | 1998-10-28 | Merck Frosst Canada Inc. | Diphenyl pyridyl ethane derivatives as pde iv inhibitors |
| GB9603723D0 (en) | 1996-02-22 | 1996-04-24 | Merck & Co Inc | Diphenyl pyridyl derivatives as pde iv inhibitors |
| US5710170A (en) | 1995-12-15 | 1998-01-20 | Merck Frosst Canada, Inc. | Tri-aryl ethane derivatives as PDE IV inhibitors |
| GB9526246D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526245D0 (en) | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| DE19622370A1 (de) | 1996-06-04 | 1997-12-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| GB9625184D0 (en) | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| TR199901305T2 (xx) | 1996-12-11 | 1999-08-23 | Basf Aktiengesellschaft | Calpain-�nleyicileri olarak ketonbenzamidler |
| IL138745A0 (en) | 1998-04-01 | 2001-10-31 | Janssen Pharmaceutica Nv | Pde iv inhibiting pyridine derivatives |
| MY123585A (en) * | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
-
2001
- 2001-03-13 MY MYPI20011169A patent/MY123585A/en unknown
- 2001-03-16 US US09/810,119 patent/US6399636B2/en not_active Expired - Fee Related
- 2001-03-19 AT AT01914905T patent/ATE321043T1/de active
- 2001-03-19 EP EP01914905A patent/EP1272488B1/en not_active Expired - Lifetime
- 2001-03-19 PT PT01914905T patent/PT1272488E/pt unknown
- 2001-03-19 CA CA2403423A patent/CA2403423C/en not_active Expired - Fee Related
- 2001-03-19 DK DK01914905T patent/DK1272488T3/da active
- 2001-03-19 DE DE60118165T patent/DE60118165T2/de not_active Expired - Lifetime
- 2001-03-19 ES ES01914905T patent/ES2258521T3/es not_active Expired - Lifetime
- 2001-03-19 AU AU4217201A patent/AU4217201A/xx active Pending
- 2001-03-19 AU AU2001242172A patent/AU2001242172B2/en not_active Ceased
- 2001-03-19 JP JP2001568939A patent/JP4944337B2/ja not_active Expired - Fee Related
- 2001-03-19 WO PCT/CA2001/000365 patent/WO2001070738A2/en not_active Ceased
- 2001-03-20 PE PE2001000258A patent/PE20011115A1/es not_active Application Discontinuation
- 2001-03-21 JO JO200136A patent/JO2212B1/en active
- 2001-03-21 TW TW90106613A patent/TW575572B/zh not_active IP Right Cessation
- 2001-03-22 AR ARP010101343A patent/AR029240A1/es unknown
-
2002
- 2002-03-20 US US10/102,552 patent/US6841564B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001242172B2 (en) | 2005-01-27 |
| US6841564B2 (en) | 2005-01-11 |
| WO2001070738A3 (en) | 2002-08-01 |
| DE60118165T2 (de) | 2006-12-14 |
| EP1272488A2 (en) | 2003-01-08 |
| AU4217201A (en) | 2001-10-03 |
| US6399636B2 (en) | 2002-06-04 |
| PT1272488E (pt) | 2006-07-31 |
| MY123585A (en) | 2006-05-31 |
| TW575572B (en) | 2004-02-11 |
| JO2212B1 (en) | 2004-10-07 |
| CA2403423A1 (en) | 2001-09-27 |
| US20020013347A1 (en) | 2002-01-31 |
| ATE321043T1 (de) | 2006-04-15 |
| WO2001070738A2 (en) | 2001-09-27 |
| DK1272488T3 (da) | 2006-07-17 |
| ES2258521T3 (es) | 2006-09-01 |
| JP4944337B2 (ja) | 2012-05-30 |
| EP1272488B1 (en) | 2006-03-22 |
| JP2003528099A (ja) | 2003-09-24 |
| DE60118165D1 (en) | 2006-05-11 |
| AR029240A1 (es) | 2003-06-18 |
| CA2403423C (en) | 2010-05-25 |
| US20020173661A1 (en) | 2002-11-21 |
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