[go: up one dir, main page]

PE20010991A1 - Combinaciones de un inhibidor de cinasa de tirosina receptora con un compuesto organico capaz de enlazarse con glicoproteina acido-o1 - Google Patents

Combinaciones de un inhibidor de cinasa de tirosina receptora con un compuesto organico capaz de enlazarse con glicoproteina acido-o1

Info

Publication number
PE20010991A1
PE20010991A1 PE2000001393A PE0013932000A PE20010991A1 PE 20010991 A1 PE20010991 A1 PE 20010991A1 PE 2000001393 A PE2000001393 A PE 2000001393A PE 0013932000 A PE0013932000 A PE 0013932000A PE 20010991 A1 PE20010991 A1 PE 20010991A1
Authority
PE
Peru
Prior art keywords
glycoprotein
binding
phenyl
acid
organic compound
Prior art date
Application number
PE2000001393A
Other languages
English (en)
Inventor
Carlo Gambacorti-Passerini
Philipp Lecoutre
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20010991A1 publication Critical patent/PE20010991A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMBINACIONES QUE COMPRENDE UN INHIBIDOR DE TIROSINCINASA ab1, FACTOR DE CRECIMIENTO DERIVADO DE PLAQUETAS PDGF-R, RECEPTOR DE KIT COMO i)7H-PIRROLO-[2,3-d]PIRIMIDINA; ii)UN DERIVADO DE N-FENIL-2-PIRIMIDINAMINA; SON COMPUESTOS PREFERIDOS 1-(4-CLOROANILINO)-4-(4-PIRIDILMETIL)-FTALAZINA; (R)-6-(4-HIDROXIFENIL)-4-[(1-FENIL-ETIL)-AMINO]-7H-PIRROLO[2,3-d]PIRIMIDINA; 4-(4-METILPIPERAZIN-1-ILMETIL)-N-[4-METIL-3-(4-PIRIDIN-3-IL)PIRIMIDIN-2-ILAMINO)FENIL]-BENZAMIDA, ENTRE OTROS; b)UN COMPUESTO ORGANICO CAPAZ DE ENLAZARSE CON GLICOPROTEINA ACIDO-O1 COMO NICERGOLINA, PRAZOSINA, ALFENTANIL, CETAMINA, ETIDOCAINA, FENTANIL, MEPERIDINA, METADONA, ERITROMICINA, ESTAUROSPORINA, N-BENZOIL-ESTAUROSPORINA, FENILBUTAZONA, BUPIVACAINA, LIDOCAINA, QUINIDINA, VERAPAMIL, WARFARINA, FENITOINA, CARBAMAZEPINA, NAPROXENO, ALPRENOLOL, METOPROLOL, TRIAZOLAM, HEPARINA. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS, ENFERMEDADES TUMORALES
PE2000001393A 1999-12-27 2000-12-22 Combinaciones de un inhibidor de cinasa de tirosina receptora con un compuesto organico capaz de enlazarse con glicoproteina acido-o1 PE20010991A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI002711A ITMI992711A1 (it) 1999-12-27 1999-12-27 Composti organici

Publications (1)

Publication Number Publication Date
PE20010991A1 true PE20010991A1 (es) 2001-10-23

Family

ID=11384195

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001393A PE20010991A1 (es) 1999-12-27 2000-12-22 Combinaciones de un inhibidor de cinasa de tirosina receptora con un compuesto organico capaz de enlazarse con glicoproteina acido-o1

Country Status (18)

Country Link
US (2) US20030125343A1 (es)
EP (1) EP1250140B1 (es)
JP (1) JP2003523325A (es)
CN (1) CN1304005C (es)
AR (1) AR030179A1 (es)
AT (1) ATE432069T1 (es)
AU (1) AU2171901A (es)
BR (1) BR0016817A (es)
CA (1) CA2394944A1 (es)
CO (1) CO5271710A1 (es)
DE (1) DE60042283D1 (es)
ES (1) ES2326307T3 (es)
HK (1) HK1050993A1 (es)
IT (1) ITMI992711A1 (es)
PE (1) PE20010991A1 (es)
PT (1) PT1250140E (es)
TW (1) TWI246917B (es)
WO (1) WO2001047507A2 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041882A2 (en) * 2000-11-22 2002-05-30 Novartis Ag Combination comprising an agent decreasing vegf activity and an agent decreasing egf activity
AU2002315388A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel phenylamino-pyrimidines and uses thereof
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
US7323469B2 (en) 2001-08-07 2008-01-29 Novartis Ag 7H-pyrrolo[2,3-d]pyrimidine derivatives
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
NZ532418A (en) * 2001-10-25 2007-02-23 Novartis Ag Combinations comprising a selective cyclooxygenase-2 inhibitor and a microtubule interfering agent
GB0201508D0 (en) 2002-01-23 2002-03-13 Novartis Ag Organic compounds
WO2003080061A1 (en) * 2002-03-21 2003-10-02 Dana-Farber Cancer Institute, Inc. Inhibition of cell death responses induced by oxidative stress
GB0209265D0 (en) 2002-04-23 2002-06-05 Novartis Ag Organic compounds
AU2007201830C1 (en) * 2002-04-23 2017-09-07 Novartis Pharma Ag High drug load tablet
WO2004026930A2 (en) * 2002-06-26 2004-04-01 The Ohio State University Research Foundation The method for reducing inflammation using sti-571 or its salt
AU2003232376A1 (en) * 2002-07-24 2004-02-09 Novartis Ag 4-(4-methylpiperazin-1-ylmethyl)-n-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl)-benzamide for treating anaplastic thyroid cancer
US7585866B2 (en) * 2002-07-31 2009-09-08 Critical Outcome Technologies, Inc. Protein tyrosine kinase inhibitors
GB0222514D0 (en) 2002-09-27 2002-11-06 Novartis Ag Organic compounds
WO2004033446A1 (en) * 2002-10-09 2004-04-22 Danter Wayne R Protein tyrosine kinase inhibitors
AU2003268185A1 (en) * 2003-08-25 2005-04-11 Dana-Farber Cancer Institute Inc. Method of treating mixed lineage leukemia gene-rearranged acute lymphoblastic leukemias
EP1667719B1 (en) * 2003-09-19 2010-11-24 Novartis AG Treatment of gastrointestinal stromal tumors with imatinib and midostaurin
TW200517114A (en) * 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
EP1720853B2 (en) 2004-02-11 2023-06-28 Natco Pharma Limited Pharmaceutical compositions of the 2 crystalline form of imatinib mesylate for use in the treatment of chronic myelogenous leukemia
CA2572314A1 (en) 2004-06-29 2006-01-12 Christopher N. Farthing Pyrrolo[2,3-d]pyrimidines that modulate ack1 and lck activity
TW200615268A (en) * 2004-08-02 2006-05-16 Osi Pharm Inc Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds
AU2005322855B2 (en) 2004-12-30 2012-09-20 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
US20070059359A1 (en) * 2005-06-07 2007-03-15 Thomas Backensfeld Immediate-release and high-drug-load pharmaceutical formulations of non-micronised (4-chlorophenyl)[4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof
US20060275365A1 (en) * 2005-06-07 2006-12-07 Thomas Backensfeld Immediate-release and high-drug-load pharmaceutical formulations of micronised (4-chlorophenyl) [4-(4-pyridylmethyl)phthalazin-1-yl] and salts thereof
EP1951243B1 (en) * 2005-06-23 2010-08-04 Novartis AG Treatment of solid tumor diseases with combinations comprising imatinib and an efflux pump inhibitor
CA2633757A1 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
EP1971611B1 (en) 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
US7763731B2 (en) * 2005-12-21 2010-07-27 Abbott Laboratories Anti-viral compounds
MX2008013528A (es) * 2006-04-20 2008-10-29 Jannsen Pharmaceutica N V Metodo para inhibir la cinasa del c-kit.
AU2007269540B2 (en) * 2006-07-05 2013-06-27 Exelixis, Inc. Methods of using IGF1R and Abl kinase modulators
US8236950B2 (en) 2006-12-20 2012-08-07 Abbott Laboratories Anti-viral compounds
CA2673683C (en) 2007-01-11 2014-07-29 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
US20080248548A1 (en) * 2007-04-09 2008-10-09 Flynn Daniel L Modulation of protein functionalities
CA2700844A1 (en) 2007-09-25 2009-04-02 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US8466151B2 (en) * 2007-12-26 2013-06-18 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP2247596A2 (en) 2008-01-11 2010-11-10 Natco Pharma Limited Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
PT2300013T (pt) 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
EP2318406B1 (en) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
EP2381777A4 (en) 2008-12-12 2012-08-08 Ariad Pharma Inc AZAINDOL DERIVATIVES AS KINASEHEMMER
ITRM20090578A1 (it) * 2009-11-10 2011-05-11 Noi Per Voi Onlus Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
US20120115878A1 (en) 2010-11-10 2012-05-10 John Vincent Calienni Salt(s) of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide and processes of making thereof
TR201010618A2 (tr) * 2010-12-20 2012-07-23 Bi̇lgi̇ç Mahmut İmatinib içeren bir oral dozaj formu ve bu oral dozaj formunun üretimi
PL394169A1 (pl) 2011-03-09 2012-09-10 Adamed Spółka Z Ograniczoną Odpowiedzialnością Kompozycja farmaceutyczna metanosulfonianu imatinibu do napełniania jednostkowych postaci dawkowania oraz sposób jej wytwarzania
AU2012250517B2 (en) 2011-05-04 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
AU2013223749A1 (en) 2012-02-21 2014-09-11 Sun Pharmaceutical Industries Limited Stable dosage forms of imatinib mesylate
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Egfr発動性がんの細胞増殖阻害用化合物
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2017078647A1 (en) 2015-11-05 2017-05-11 Koçak Farma Ilaç Ve Kimya Sanayi Anonim Şirketi Pharmaceutical compositions of imatinib
EP3257499A1 (en) 2016-06-17 2017-12-20 Vipharm S.A. Process for preparation of imatinib methanesulfonate capsules
EP3914353A1 (en) 2019-01-23 2021-12-01 Novartis AG New crystalline forms of a succinate salt of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7h-pyrrolo[2,3-d]pyrimidine -6-carboxylic acid dimethylamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587459A (en) * 1994-08-19 1996-12-24 Regents Of The University Of Minnesota Immunoconjugates comprising tyrosine kinase inhibitors
US5750493A (en) * 1995-08-30 1998-05-12 Raymond F. Schinazi Method to improve the biological and antiviral activity of protease inhibitors
US20030069174A1 (en) * 1997-03-10 2003-04-10 Ludwig Pichler Use of human alpha1-acid glycoprotein for producing a pharmaceutical preparation
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
US6806266B1 (en) * 1999-07-13 2004-10-19 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
ATE380031T1 (de) * 1999-12-10 2007-12-15 Pfizer Prod Inc Pyrrolo 2,3-d pyrimidinderivate enthaltende zusammensetzungen

Also Published As

Publication number Publication date
EP1250140B1 (en) 2009-05-27
AU2171901A (en) 2001-07-09
CN1304005C (zh) 2007-03-14
JP2003523325A (ja) 2003-08-05
WO2001047507A2 (en) 2001-07-05
PT1250140E (pt) 2009-08-24
ITMI992711A0 (it) 1999-12-27
BR0016817A (pt) 2002-10-01
EP1250140A2 (en) 2002-10-23
AR030179A1 (es) 2003-08-13
TWI246917B (en) 2006-01-11
ITMI992711A1 (it) 2001-06-27
US20090221519A1 (en) 2009-09-03
HK1050993A1 (zh) 2003-07-18
DE60042283D1 (de) 2009-07-09
CN1414858A (zh) 2003-04-30
US20030125343A1 (en) 2003-07-03
CO5271710A1 (es) 2003-04-30
ATE432069T1 (de) 2009-06-15
WO2001047507A3 (en) 2002-04-04
ES2326307T3 (es) 2009-10-07
CA2394944A1 (en) 2001-07-05

Similar Documents

Publication Publication Date Title
PE20010991A1 (es) Combinaciones de un inhibidor de cinasa de tirosina receptora con un compuesto organico capaz de enlazarse con glicoproteina acido-o1
ECSP066773A (es) Intermediarios de quinolina como inhibidores de receptores de tirosina quinasas y la síntesis de los mismos
BRPI0414084A (pt) composto, mistura, e, composição
UY28970A1 (es) Compuestos moduladores de la actividad de c-kit y usos de los mismos
CR9716A (es) Bencimidazoles sustituidos como inhibidores de cinasa
UA87153C2 (ru) Энантиомерно чистые аминогетероарильные соединения как ингибиторы протеинкиназы
MA30076B1 (fr) Carbonylaminopyrrolopyrazoles servant de puissants inhibiteurs de kinases.
PE20060524A1 (es) Compuestos heterociclico fusionados como intermediarios en la preparacion de pirrolotriazinas inhibidoras de cinasa
EA200800727A1 (ru) Введение ингибиторов дипептидилпептидазы
DE60020595D1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
SE0101675D0 (sv) Novel composition
ATE430747T1 (de) 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren
ATE548363T1 (de) 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor- tyrosinkinasen eignen
ATE554087T1 (de) Neue kinaseinhibitoren
ATE302771T1 (de) Indolinon-derivative als protein-kinasehemmer
PE20070832A1 (es) Derivados de piridazinona como inhibidores de la tirosina quinasa
MXPA05013076A (es) Compuestos de isoindolina-1-ona como inhibidores de cinasa.
DE60023025D1 (de) 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
ATE528302T1 (de) 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind
PE20051171A1 (es) Inhibidores de proteina quinasas con estructura de 3-quinolincarbonitrilo
UA85394C2 (ru) Замещенные хинолины в качестве ингибиторов ферментов протеинтирозиновых киназ
PE20070795A1 (es) Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa
CO5390082A1 (es) Compuestos organicos
DE60015599D1 (de) 3,4-DIHYDRO-(1H)CHINAZOLIN-2-ON-VERBINDUNGEN ALS CSBP/p38-KINASE-INHIBITOREN
EA200600829A1 (ru) Новые кристаллические формы {2-[1-(3,5-бистрифторметилбензил)-5-пиридин-4-ил-1н-[1,2,3]триазол-4-ил]-пиридин-3-ил}-(2-хлорфенил)метанона

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed