JP2003523325A - 受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せ - Google Patents

受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せ

Info

Publication number: JP2003523325A
Authority: JP; Japan
Prior art keywords: carbamoyl; group; lower alkyl; abl; tyrosine kinase
Prior art date: 1999-12-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2001548102A

Other languages

English (en)

Japanese (ja)

Other versions

JP2003523325A5 (es

Inventor

カルロ・ガムバコルティ−パッセリーニ

フィリップ・レコウトレ

Original Assignee

ノバルティスアクチエンゲゼルシャフト

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-27

Filing date

2000-12-22

Publication date

2003-08-05

2000-12-22 Application filed by ノバルティスアクチエンゲゼルシャフト filed Critical ノバルティスアクチエンゲゼルシャフト

2003-08-05 Publication of JP2003523325A publication Critical patent/JP2003523325A/ja

2008-02-14 Publication of JP2003523325A5 publication Critical patent/JP2003523325A5/ja

Status Pending legal-status Critical Current

Links

230000027455 binding Effects 0.000 title claims abstract description 65
229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 title claims abstract description 40
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102000012404 Orosomucoid Human genes 0.000 title 1
108010061952 Orosomucoid Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 88
230000002062 proliferating effect Effects 0.000 claims abstract description 49
102000003886 Glycoproteins Human genes 0.000 claims abstract description 43
108090000288 Glycoproteins Proteins 0.000 claims abstract description 43
239000002253 acid Substances 0.000 claims abstract description 40
239000000203 mixture Substances 0.000 claims abstract description 35
238000009472 formulation Methods 0.000 claims abstract description 22
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-1 7H-pyrrolo [2,3-d] pyrimidine compound Chemical class 0.000 claims description 107
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238000000034 method Methods 0.000 claims description 34
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Hematology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP2001548102A 1999-12-27 2000-12-22 受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せ Pending JP2003523325A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IT1999MI002711A ITMI992711A1 (it)	1999-12-27	1999-12-27	Composti organici
IT99A002711		1999-12-27
PCT/EP2000/013161 WO2001047507A2 (en)	1999-12-27	2000-12-22	Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound

Publications (2)

Publication Number	Publication Date
JP2003523325A true JP2003523325A (ja)	2003-08-05
JP2003523325A5 JP2003523325A5 (es)	2008-02-14

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ID=11384195

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JP2001548102A Pending JP2003523325A (ja)	1999-12-27	2000-12-22	受容体チロシンキナーゼ阻害剤とα１−酸性糖タンパク質結合性有機化合物との組合せ

Country Status (18)

Country	Link
US (2)	US20030125343A1 (es)
EP (1)	EP1250140B1 (es)
JP (1)	JP2003523325A (es)
CN (1)	CN1304005C (es)
AR (1)	AR030179A1 (es)
AT (1)	ATE432069T1 (es)
AU (1)	AU2171901A (es)
BR (1)	BR0016817A (es)
CA (1)	CA2394944A1 (es)
CO (1)	CO5271710A1 (es)
DE (1)	DE60042283D1 (es)
ES (1)	ES2326307T3 (es)
HK (1)	HK1050993A1 (es)
IT (1)	ITMI992711A1 (es)
PE (1)	PE20010991A1 (es)
PT (1)	PT1250140E (es)
TW (1)	TWI246917B (es)
WO (1)	WO2001047507A2 (es)

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JP2009051837A (ja) *	2002-01-23	2009-03-12	Novartis Ag	Ｎ−フェニル−２−ピリミジン−アミン誘導体のｎ−オキシド
JP2010031019A (ja) *	2002-04-23	2010-02-12	Novartis Ag	薬物高含量錠剤

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1999
- 1999-12-27 IT IT1999MI002711A patent/ITMI992711A1/it unknown
2000
- 2000-12-08 TW TW089126229A patent/TWI246917B/zh active
- 2000-12-22 DE DE60042283T patent/DE60042283D1/de not_active Expired - Lifetime
- 2000-12-22 ES ES00985244T patent/ES2326307T3/es not_active Expired - Lifetime
- 2000-12-22 BR BR0016817-3A patent/BR0016817A/pt not_active Application Discontinuation
- 2000-12-22 HK HK03101801.4A patent/HK1050993A1/zh unknown
- 2000-12-22 WO PCT/EP2000/013161 patent/WO2001047507A2/en not_active Ceased
- 2000-12-22 AR ARP000106887A patent/AR030179A1/es not_active Application Discontinuation
- 2000-12-22 EP EP00985244A patent/EP1250140B1/en not_active Expired - Lifetime
- 2000-12-22 JP JP2001548102A patent/JP2003523325A/ja active Pending
- 2000-12-22 US US10/169,035 patent/US20030125343A1/en not_active Abandoned
- 2000-12-22 PT PT00985244T patent/PT1250140E/pt unknown
- 2000-12-22 CO CO00097404A patent/CO5271710A1/es not_active Application Discontinuation
- 2000-12-22 AT AT00985244T patent/ATE432069T1/de active
- 2000-12-22 AU AU21719/01A patent/AU2171901A/en not_active Abandoned
- 2000-12-22 CN CNB008178976A patent/CN1304005C/zh not_active Expired - Fee Related
- 2000-12-22 PE PE2000001393A patent/PE20010991A1/es not_active Application Discontinuation
- 2000-12-22 CA CA002394944A patent/CA2394944A1/en not_active Abandoned
2009
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EP1250140A2 (en)	2002-10-23
TWI246917B (en)	2006-01-11
CN1304005C (zh)	2007-03-14
CA2394944A1 (en)	2001-07-05
ITMI992711A1 (it)	2001-06-27
ITMI992711A0 (it)	1999-12-27
ES2326307T3 (es)	2009-10-07
US20030125343A1 (en)	2003-07-03
DE60042283D1 (de)	2009-07-09
EP1250140B1 (en)	2009-05-27
PE20010991A1 (es)	2001-10-23
BR0016817A (pt)	2002-10-01
WO2001047507A3 (en)	2002-04-04
PT1250140E (pt)	2009-08-24
CN1414858A (zh)	2003-04-30
CO5271710A1 (es)	2003-04-30
AR030179A1 (es)	2003-08-13
WO2001047507A2 (en)	2001-07-05
HK1050993A1 (zh)	2003-07-18
AU2171901A (en)	2001-07-09
ATE432069T1 (de)	2009-06-15
US20090221519A1 (en)	2009-09-03

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