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PE20000131A1 - Derivados de acidos fenilaminoalquilcarboxilicos y composiciones farmaceuticas que los comprenden - Google Patents

Derivados de acidos fenilaminoalquilcarboxilicos y composiciones farmaceuticas que los comprenden

Info

Publication number
PE20000131A1
PE20000131A1 PE1998001241A PE00124198A PE20000131A1 PE 20000131 A1 PE20000131 A1 PE 20000131A1 PE 1998001241 A PE1998001241 A PE 1998001241A PE 00124198 A PE00124198 A PE 00124198A PE 20000131 A1 PE20000131 A1 PE 20000131A1
Authority
PE
Peru
Prior art keywords
group
atom
amino
alkylcarboxyl
phenylamine
Prior art date
Application number
PE1998001241A
Other languages
English (en)
Inventor
Tetsuro Tamai
Nobuyuki Tanaka
Hideyuki Muranaka
Akihito Hirabayashi
Masaaki Sato
Harunobu Mukaiyama
Masuo Akahane
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of PE20000131A1 publication Critical patent/PE20000131A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN DERIVADO DE ACIDO FENILAMINOALQUILCARBOXILICO SEGUN FORMULA GENERAL (I) EN LA CUAL : a) R1 REPRESENTA UN GRUPO HIDROXI, UN GRUPO ALCOXI INFERIOR, UN GRUPO ARALCOXI, UN GRUPO AMINO, UN GRUPO AMINO ALICICLICO O UN GRUPO MONO O DI(ALQUIL INFERIOR) AMINO QUE PUEDE TENER UN GRUPO HIDROXI O UN GRUPO ALCOXI INFERIOR COMO SUSTITUYENTE; b) R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR; c) R3 REPRESENTA UN ATOMO DE HIDROGENO O UN ATOMO DE HALOGENO; R4 Y R5 SON IGUALES O DIFERENTES Y CADA UNO REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO O UN GRUPO ALQUILO INFERIOR; d) A REPRESENTA UN GRUPO ALQUILENO INFERIOR; e) EL ATOMO MARCADO CON (R) REPRESENTA UN ATOMO DE CARBONO EN CONFIGURACION (R), Y EL ATOMO DE CARBONO MARCADO CON (S) REPRESENTA UN ATOMO DE CARBONO EN CONFIGURACION (S). EL COMPUESTO DE FORMULA GENERAL (I) O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO PUEDE SER USADO PARA PREVENIR O TRATAR LA OBESIDAD, LA HIPERGLICEMIA, LAS ENFERMEDADES CAUSADAS POR HIPERMOTILIDAD INTESTINAL, LA POLAQUIURIA, LA INCONTINENCIA URINARIA, LA DEPRESION O LAS ENFERMEDADES CAUSADAS POR CALCULOS BILIARES O HIPERMOTILIDAD DEL TRACTO BILIAR
PE1998001241A 1997-12-18 1998-12-17 Derivados de acidos fenilaminoalquilcarboxilicos y composiciones farmaceuticas que los comprenden PE20000131A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP37008797 1997-12-18

Publications (1)

Publication Number Publication Date
PE20000131A1 true PE20000131A1 (es) 2000-03-15

Family

ID=18496040

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001241A PE20000131A1 (es) 1997-12-18 1998-12-17 Derivados de acidos fenilaminoalquilcarboxilicos y composiciones farmaceuticas que los comprenden

Country Status (23)

Country Link
US (1) US6353025B1 (es)
EP (1) EP1043308B1 (es)
JP (1) JP4156799B2 (es)
KR (1) KR100545474B1 (es)
AR (1) AR017858A1 (es)
AT (1) ATE250570T1 (es)
AU (1) AU754317B2 (es)
CA (1) CA2315235C (es)
CO (1) CO5070654A1 (es)
CZ (1) CZ296433B6 (es)
DE (1) DE69818516T2 (es)
ES (1) ES2209226T3 (es)
HU (1) HUP0100102A3 (es)
IL (1) IL136612A (es)
MY (1) MY120466A (es)
NO (1) NO20003105L (es)
NZ (1) NZ505103A (es)
PE (1) PE20000131A1 (es)
PL (1) PL341221A1 (es)
SA (1) SA99191012B1 (es)
TW (1) TW503229B (es)
WO (1) WO1999031045A1 (es)
ZA (1) ZA9811655B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL138994A (en) * 1998-04-14 2004-02-19 Kissei Pharmaceutical 2-methylpropionic acid derivatives and medicinal compositions containing the same
AU2710301A (en) * 2000-01-28 2001-08-07 Asahi Kasei Kabushiki Kaisha Novel remedies with the use of beta3 agonist
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
WO2003042160A1 (en) 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
BR0316080A (pt) * 2002-11-07 2005-09-27 Astellas Pharma Inc Remédio para bexiga superativa compreendendo derivado de ácido acético anildo como o ingrediente ativo
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
WO2004106283A1 (ja) * 2003-05-28 2004-12-09 Kissei Pharmaceutical Co., Ltd. アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途
EP1765812B1 (en) 2004-07-02 2009-04-29 Bracco Imaging S.p.A Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
CA2737349A1 (en) 2008-10-09 2010-04-09 Asahi Kasei Pharma Corporation Indazole derivatives
WO2010041569A1 (ja) 2008-10-09 2010-04-15 旭化成ファーマ株式会社 インダゾール化合物
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
WO2011122524A1 (ja) 2010-03-29 2011-10-06 アステラス製薬株式会社 放出制御医薬組成物
US12097189B1 (en) 2024-02-09 2024-09-24 Astellas Pharma Inc. Pharmaceutical composition for modified release

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
EP0068669A1 (en) 1981-06-20 1983-01-05 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
DE3368258D1 (en) 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
ZA835126B (en) * 1982-07-16 1984-06-27 Beecham Group Plc Secondary amines
GB8528633D0 (en) 1985-11-21 1985-12-24 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
AU1506199A (en) 1999-07-05
HUP0100102A2 (hu) 2001-05-28
DE69818516T2 (de) 2004-07-08
US6353025B1 (en) 2002-03-05
EP1043308B1 (en) 2003-09-24
ES2209226T3 (es) 2004-06-16
NZ505103A (en) 2003-03-28
KR20010024747A (ko) 2001-03-26
CA2315235A1 (en) 1999-06-24
CZ296433B6 (cs) 2006-03-15
IL136612A (en) 2003-11-23
ZA9811655B (en) 1999-06-23
TW503229B (en) 2002-09-21
CO5070654A1 (es) 2001-08-28
ATE250570T1 (de) 2003-10-15
HUP0100102A3 (en) 2002-11-28
AR017858A1 (es) 2001-10-24
AU754317B2 (en) 2002-11-14
EP1043308A1 (en) 2000-10-11
SA99191012B1 (ar) 2006-07-03
KR100545474B1 (ko) 2006-01-24
DE69818516D1 (de) 2003-10-30
CZ20002244A3 (cs) 2000-11-15
IL136612A0 (en) 2001-06-14
NO20003105D0 (no) 2000-06-16
EP1043308A4 (en) 2001-11-14
PL341221A1 (en) 2001-03-26
WO1999031045A1 (en) 1999-06-24
JP4156799B2 (ja) 2008-09-24
CA2315235C (en) 2009-07-28
NO20003105L (no) 2000-08-17
MY120466A (en) 2005-10-31

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