PE20000127A1 - BENZENOSULFONAMIDE DERIVATIVE - Google Patents
BENZENOSULFONAMIDE DERIVATIVEInfo
- Publication number
- PE20000127A1 PE20000127A1 PE1998001240A PE00124098A PE20000127A1 PE 20000127 A1 PE20000127 A1 PE 20000127A1 PE 1998001240 A PE1998001240 A PE 1998001240A PE 00124098 A PE00124098 A PE 00124098A PE 20000127 A1 PE20000127 A1 PE 20000127A1
- Authority
- PE
- Peru
- Prior art keywords
- alcoxy
- alkyl
- substituted
- carbamoyl
- carbonyl
- Prior art date
Links
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical class O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102000028517 Neuropeptide receptor Human genes 0.000 abstract 1
- 108070000018 Neuropeptide receptor Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical class O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE X ES S o NH, E "Y" y Z SON CADA UNO CH; o X ES NH Y UNA DE LAS VARIABLES Y y Z ES N, Y LA OTRA ES CH; R1 Y R2, EN FORMA INDEPENDIENTE, REPRESENTAN H, ALQUILO C1-C7, ALQUILO C1-C7 SUSTITUIDO POR HIDROXI, HALOGENO, ALCOXI C1-C7, CARBOXI, ALCOXI C1-C7-CARBONILO, CARBAMOILO, ALQUILO C1-C7 DE CARBONO-CARBOMOILO, DIALQUILO C1-C7-CARBAMOILO, CICLOALQUILO C3-C8, O POR CICLOALQUILO C3-C8 SUSTITUIDO POR ALCOXI C1-C7-CARBONILO, O REPRESENTA ALCANOILO C2-C7; MIENTRAS AL MENOS UNA DE LAS VARIABLES R1 o R2 SEA DIFERENTE DE HIDROGENO, EL GRUPO NR1R2 ES ALQUILENO C2-C6-AMINO LINEAL SUSTITUIDO O NO; EL ANILLO A, APARTE DE ESTAR SUSTITUIDO POR -SO2NR1R2 y -NH-, ESTA SUSTITUIDO o NO, UNA o MAS VECES POR ALQUILO C1-C7, ALCOXI C1-C7, ALCOXI C1-C7-ALCOXI DE C1-C7, HIDROXI, HALOGENO, Y CF3; EL ANILLO B ESTA SUSTITUIDO o NO, UNA o MAS VECES, MEDIANTE UNO DE SUS CARBONOS, POR HALOGENO, ALQUILO C1-C7, ALCOXI C1-C7, CARBOXI, ALCOXI C1-C7 DE CARBONO-CARBONILO, CARBAMOILO. TAMBIEN SE REFIERE AL USO DEL COMPUESTO DE FORMULA (I) PARA EL TRATAMIENTO DE LA OBESIDAD Y DESORDENES RELACIONADOS AL SER ANTAGONISTAS DEL SUBTIPO DE RECEPTOR DE NEUROPEPTIDO Y5REFERS TO A COMPOUND OF FORMULA (I), WHERE X IS S or NH, E "Y" AND Z ARE EACH CH; or X IS NH AND ONE OF THE VARIABLES Y and Z IS N, AND THE OTHER IS CH; R1 AND R2, INDEPENDENTLY, REPRESENT H, C1-C7 ALKYL, C1-C7 ALKYL SUBSTITUTED BY HYDROXY, HALOGEN, C1-C7 ALCOXY, CARBOXY, C1-C7-CARBONYL, CARBAMOYL-C7 CARBONYL, CARBAMOYL-C7 ALKYL , DIALKYL C1-C7-CARBAMOYL, CYCLOALKYL C3-C8, OR BY CYCLOALKYL C3-C8 SUBSTITUTED BY ALCOXY C1-C7-CARBONY, OR REPRESENTS ALKANOYL C2-C7; AS LONG AS AT LEAST ONE OF THE R1 or R2 VARIABLES IS DIFFERENT FROM HYDROGEN, THE NR1R2 GROUP IS C2-C6-LINEAR ALKYLENE SUBSTITUTED OR NOT; RING A, BESIDES BEING REPLACED BY -SO2NR1R2 and -NH-, IS SUBSTITUTED or NOT, ONE or MORE TIMES BY C1-C7 ALKYL, C1-C7 ALCOXY, C1-C7 ALCOXY-C1-C7 ALCOXY, HYDROXY, HALOGEN , And CF3; RING B IS SUBSTITUTED OR NOT, ONE OR MORE TIMES, THROUGH ONE OF ITS CARBONS, BY HALOGEN, C1-C7 ALKYL, C1-C7 ALCOXY, CARBOXI, CARBON-CARBONYL ALCOXY C1-C7, CARBAMOYL. IT ALSO REFERS TO THE USE OF THE FORMULA (I) COMPOUND FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS AS ANTAGONISTS OF THE Y5 NEUROPEPTIDE RECEPTOR SUBTYPE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19757248 | 1997-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20000127A1 true PE20000127A1 (en) | 2000-03-14 |
Family
ID=7853006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998001240A PE20000127A1 (en) | 1997-12-22 | 1998-12-17 | BENZENOSULFONAMIDE DERIVATIVE |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR014406A1 (en) |
| AU (1) | AU2415299A (en) |
| CO (1) | CO5011105A1 (en) |
| PE (1) | PE20000127A1 (en) |
| WO (1) | WO1999032466A1 (en) |
| ZA (1) | ZA9811705B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2350714A1 (en) | 1998-11-10 | 2000-05-18 | Merck & Co., Inc. | Spiro-indolines as y5 receptor antagonists |
| FR2792314B1 (en) * | 1999-04-15 | 2001-06-01 | Adir | NOVEL AMINOTRIAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| US6218408B1 (en) | 1999-06-30 | 2001-04-17 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
| US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| US6989379B1 (en) | 1999-04-22 | 2006-01-24 | H. Lundbick A/S | Selective NPY (Y5) antagonists |
| EP1183245B1 (en) * | 1999-04-22 | 2007-05-09 | H. Lundbeck A/S | Selective npy (y5) antagonists |
| US6225330B1 (en) | 1999-06-30 | 2001-05-01 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
| US6214853B1 (en) | 1999-06-30 | 2001-04-10 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (bicyclics) |
| US6222040B1 (en) | 1999-06-30 | 2001-04-24 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (tricyclics) |
| US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| DK1249233T3 (en) * | 1999-11-26 | 2008-11-17 | Shionogi & Co | NPYY5 receptor antagonists |
| JP2003525291A (en) * | 2000-03-01 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 2,4-disubstituted thiazolyl derivatives |
| FR2815346B1 (en) * | 2000-10-13 | 2004-02-20 | Servier Lab | NOVEL AMINOTRIAZOLONE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| WO2002078697A1 (en) * | 2001-03-29 | 2002-10-10 | Smithkline Beecham Corporation | Compounds and methods |
| CA2403307A1 (en) | 2001-10-23 | 2003-04-23 | Neurogen Corporation | Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| BRPI0409447A (en) * | 2003-04-14 | 2006-04-18 | Inst For Pharm Discovery Inc | substituted phenylalkanoic acids |
| EA200501710A1 (en) | 2003-04-30 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | SUBSTITUTED CARBON ACIDS |
| WO2006042215A1 (en) | 2004-10-08 | 2006-04-20 | Janssen Pharmaceutica, N.V. | 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives |
| GB0526257D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| US9353078B2 (en) * | 2013-10-01 | 2016-05-31 | New York University | Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof |
| EP4077290A1 (en) | 2019-12-20 | 2022-10-26 | Ikena Oncology, Inc. | 4-phenyl-n-(phenyl)thiazol-2-amine derivatives and related compounds as aryl hydrocarbon receptor (ahr) agonists for the treatment of e.g. angiogenesis implicated or inflammatory disorders |
| WO2025017207A1 (en) * | 2023-07-20 | 2025-01-23 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Inhibitors of smndc1 and their therapeutic use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3776765A (en) * | 1972-02-28 | 1973-12-04 | Cities Service Co | Process for protecting a substrate with an n{11 substituted aminoarylsulfonamide intumescent agent |
| FR2701480B1 (en) * | 1993-02-15 | 1995-05-24 | Sanofi Elf | Compounds with a sulfamoyl and amidino group, process for their preparation and pharmaceutical compositions containing them. |
| AU3201095A (en) * | 1994-07-27 | 1996-02-22 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
-
1998
- 1998-12-17 CO CO98075202A patent/CO5011105A1/en unknown
- 1998-12-17 PE PE1998001240A patent/PE20000127A1/en not_active Application Discontinuation
- 1998-12-18 AR ARP980106523A patent/AR014406A1/en unknown
- 1998-12-18 WO PCT/EP1998/008333 patent/WO1999032466A1/en not_active Ceased
- 1998-12-18 AU AU24152/99A patent/AU2415299A/en not_active Abandoned
- 1998-12-21 ZA ZA9811705A patent/ZA9811705B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9811705B (en) | 1999-09-07 |
| AU2415299A (en) | 1999-07-12 |
| CO5011105A1 (en) | 2001-02-28 |
| WO1999032466A1 (en) | 1999-07-01 |
| AR014406A1 (en) | 2001-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |