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PE20000472A1 - Compuestos triciclicos sustituidos - Google Patents

Compuestos triciclicos sustituidos

Info

Publication number
PE20000472A1
PE20000472A1 PE1999000321A PE00032199A PE20000472A1 PE 20000472 A1 PE20000472 A1 PE 20000472A1 PE 1999000321 A PE1999000321 A PE 1999000321A PE 00032199 A PE00032199 A PE 00032199A PE 20000472 A1 PE20000472 A1 PE 20000472A1
Authority
PE
Peru
Prior art keywords
phenyl
conh2
pyridyl
interfering
substitute
Prior art date
Application number
PE1999000321A
Other languages
English (en)
Inventor
David Mihelich Edward
Suarez Tulio
C R Smith Edward
Michael Morin Junior John
Wang Qiuping
James Bach Nicholas
Dean Kinnick Michael
Scott Sawyer Jason
Jon Sall Daniel
John Martinelli Michael
Michael Wilson Thomas
Wade Beight Douglas
Anne Bastian Jolie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20000472A1 publication Critical patent/PE20000472A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS TRICICLICOS I, DONDE A ES FENILO, PIRIDILO, EL N ESTA EN POSICION 5, 6, 7 o 8; B o D ES N Y EL OTRO ES C; Z ES CICLOHEXENILO, FENILO, PIRIDILO, EL N ESTA EN POSICION 1, 2 o 3; ANILLO HETEROCICLICO DE 6 MIEMBROS CON UN O, S EN LA POSICION 1, 2 o 3 Y EL N ESTA EN LA POSICION 1, 2, 3 o 4; R20 ES 1)-ALQUILO C5-C20, -ALQUENILO C5-C20, -ALQUINILO C5-C20, RADICALES CARBOCICLICOS O HETEROCICLICOS OPCIONALMENTE SUSTITUIDOS; 2)-(L)-R80; L ES UN GRUPO DE UNION DIVALENTE SELECCIONADO ENTRE i)C, H; ii)S; iii)O; iv)1-2 N, H; v)C, H, S; vi)C, H, O; R80 ES 1) DE R20; R21 ES UN SUSTITUYENTE NO INTERFERENTE; R1` ES -NHNH2, -NH2, -CONH2, R2' ES -OH, -O(CH2)tR5'; R5' ES H, -CN, -NH2, -CONH2, -CONR9R10, -NHSO2R15, -CONHSO2R15; R15 ES -ALQUILO C1-C6, -CF3, FENILO OPCIONALMENTE SUSTITUIDO; R3' ES UN SUSTITUYENTE NO INTERFERENTE, CARBOCICLOS, HETEROCICLOS; SOLO UNO DE A o Z ES UN ANILLO HETEROCICLICO; CUANDO D ES N, Z ES S, O EN LA POSICION 1-3; Y EL N EN LA POSICION 1-4. UN COMPUESTO PREFERIDO ES ACIDO (R,S)-(9-BENCIL-4-CARBAMOIL-1-OXO-3-TIA-1,2,3,4-TETRAHIDROCARBAZOL-5-IL)OXIACETICO, ENTRE OTROS. EL COMPUESTO I ES UN INHIBIDOR DE LA LIBERACION DE ACIDOS GRASOS MEDIADA POR sPLA2 O INHIBIENDO LA CASCADA DE ACIDO ARAQUIDONICO POR LO QUE PUEDE SER UTIL EN EL TRATAMIENTO DE SEPSIS, CHOQUE SEPTICO, ARTRITIS REUMATOIDE
PE1999000321A 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos PE20000472A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6216598A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
PE20000472A1 true PE20000472A1 (es) 2000-06-02

Family

ID=22040624

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000321A PE20000472A1 (es) 1998-04-17 1999-04-16 Compuestos triciclicos sustituidos

Country Status (27)

Country Link
EP (2) EP0950661B1 (es)
JP (1) JP4435325B2 (es)
KR (1) KR19990083234A (es)
CN (1) CN1235968A (es)
AR (1) AR018185A1 (es)
AT (2) ATE254128T1 (es)
AU (1) AU757454B2 (es)
BR (1) BR9901275A (es)
CA (1) CA2269256A1 (es)
CO (1) CO5080728A1 (es)
CZ (1) CZ137199A3 (es)
DE (2) DE69914951T2 (es)
EA (1) EA003129B1 (es)
ES (2) ES2213668T3 (es)
HU (1) HUP9901219A1 (es)
ID (1) ID23219A (es)
IL (1) IL129484A0 (es)
NO (1) NO991823L (es)
NZ (1) NZ335252A (es)
PE (1) PE20000472A1 (es)
PL (1) PL332564A1 (es)
SG (1) SG106035A1 (es)
SV (1) SV1999000052A (es)
TR (1) TR199900842A2 (es)
TW (1) TW555760B (es)
YU (1) YU19099A (es)
ZA (1) ZA992773B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610728B2 (en) * 1997-08-28 2003-08-26 Eli Lilly And Company Method for treatment of non-rheumatoid arthritis
AU2001244635A1 (en) * 2000-03-30 2001-10-15 Yamanouchi Pharmaceutical Co..Ltd. Hydrazide derivatives
WO2002005796A2 (en) * 2000-07-14 2002-01-24 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
CA2431721A1 (en) * 2000-12-18 2002-06-27 Eli Lilly And Company Tetracyclic derivatives as spla2 inhibitors
US6933313B2 (en) 2001-03-28 2005-08-23 Eli Lilly And Company Substituted carbazoles as inhibitors of sPLA2
DE60208065T2 (de) * 2001-08-09 2006-07-13 Eli Lilly And Co., Indianapolis Cyclohept'b! indolderivate als spla2-inhibitoren
EP1423366A1 (en) 2001-08-09 2004-06-02 Eli Lilly And Company Cyclopenta b ! indole derivatives as spla2 inhibitors
US6992100B2 (en) 2001-12-06 2006-01-31 Eli Lilly And Company sPLA2 inhibitors
US7608626B2 (en) 2004-11-01 2009-10-27 Wyeth Substituted indolizines and derivatives as CNS agents
ES2523580T3 (es) 2008-01-11 2014-11-27 Albany Molecular Research, Inc. Piridoindoles substituidos con (1-Azinona)
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
CA2830204C (en) * 2011-04-14 2019-04-09 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
DK2825542T3 (en) 2012-03-16 2017-01-09 Vitae Pharmaceuticals Inc LIVER-X-receptor modulators
SI2825541T1 (sl) 2012-03-16 2016-10-28 Vitae Pharmaceuticals, Inc. Modulatorji jetrnega receptorja X

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
JPH10505584A (ja) * 1994-07-21 1998-06-02 イーライ・リリー・アンド・カンパニー インドリジンｓＰＬＡ▲下２▼インヒビター
HUP9901984A3 (en) * 1995-12-13 2001-01-29 Lilly Co Eli Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds
BR9713261A (pt) * 1996-10-30 2000-03-28 Lilly Co Eli Tricìclicos substituìdos
CA2304482A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
WO1999025340A1 (en) * 1997-11-14 1999-05-27 Eli Lilly And Company Treatment for alzheimer's disease

Also Published As

Publication number Publication date
PL332564A1 (en) 1999-10-25
NO991823L (no) 1999-10-18
EA003129B1 (ru) 2003-02-27
CO5080728A1 (es) 2001-09-25
SG106035A1 (en) 2004-09-30
EP0950661A1 (en) 1999-10-20
NO991823D0 (no) 1999-04-16
ID23219A (id) 2000-03-30
AU757454B2 (en) 2003-02-20
EP0950661B1 (en) 2003-11-12
YU19099A (sh) 2001-09-28
SV1999000052A (es) 2000-03-14
EA199900304A2 (ru) 1999-10-28
HU9901219D0 (en) 1999-06-28
BR9901275A (pt) 2000-05-02
DE69914951T2 (de) 2004-12-23
CZ137199A3 (cs) 1999-11-17
EA199900304A3 (ru) 2000-04-24
EP1156050B1 (en) 2004-02-18
IL129484A0 (en) 2000-02-29
EP1156050A3 (en) 2001-11-28
AU2381899A (en) 1999-10-28
CN1235968A (zh) 1999-11-24
TR199900842A2 (xx) 2000-09-21
EP1156050A2 (en) 2001-11-21
JP4435325B2 (ja) 2010-03-17
HUP9901219A1 (hu) 2000-08-28
NZ335252A (en) 2000-11-24
ATE259818T1 (de) 2004-03-15
CA2269256A1 (en) 1999-10-17
DE69912670T2 (de) 2004-08-12
ATE254128T1 (de) 2003-11-15
KR19990083234A (ko) 1999-11-25
ES2213668T3 (es) 2004-09-01
ZA992773B (en) 2002-07-16
TW555760B (en) 2003-10-01
JPH11322745A (ja) 1999-11-24
DE69912670D1 (de) 2003-12-18
AR018185A1 (es) 2001-10-31
ES2210979T3 (es) 2004-07-01
DE69914951D1 (de) 2004-03-25

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed