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PE17895A1 - Antagonista triciclico diacepinico de vasopresina y antagonista de oxitocina - Google Patents

Antagonista triciclico diacepinico de vasopresina y antagonista de oxitocina

Info

Publication number
PE17895A1
PE17895A1 PE1994247526A PE24752694A PE17895A1 PE 17895 A1 PE17895 A1 PE 17895A1 PE 1994247526 A PE1994247526 A PE 1994247526A PE 24752694 A PE24752694 A PE 24752694A PE 17895 A1 PE17895 A1 PE 17895A1
Authority
PE
Peru
Prior art keywords
antagonist
oxytokine
diacepine
vasopresin
tricyclic
Prior art date
Application number
PE1994247526A
Other languages
English (en)
Inventor
Guillermo Delos Santos Efren
Fred Reich Marvin
Donald Albright Jay
Sum Fuk-Wah
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of PE17895A1 publication Critical patent/PE17895A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE: 1) Y ES -CH(ALQUILO C1-C3)-, -CO-, -(CH2)n, VARIANDO n DE 0 A 2; 2) A-B SE SELECCIONA DE -(CH2)m-N(R3)-, -N(R3)-(CH2)m, VARIANDO m DE 1 A 2; 3) LA PORCION QUE CONTIENE A Z PUEDE SER UN FENILO FUSIONADO, UN ANILLO HETEROCICLICO AROMATICO DE 5 A 6 MIEMBROS CON 2 ATOMOS DE NITROGENO o UN ANILLO DE 5 MIEMBROS CON NITROGENO, OXIGENO o AZUFRE; 4) D, E, F PUEDEN SER CARBONO o NITROGENO Y EL ANILLO PUEDE ESTAR SUSTITUIDO; 5) R3 ES -CO-ARILO, SIENDO EL ARILO UN FENILO, INDOL o HETEROCICLO DE 5 MIEMBROS OPCIONALMENTE SUSTITUIDO; EL CUAL PUEDE SER ANTAGONISTA DE VASOPRESINA Y OXITOCINA
PE1994247526A 1993-07-29 1994-07-26 Antagonista triciclico diacepinico de vasopresina y antagonista de oxitocina PE17895A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10000493A 1993-07-29 1993-07-29

Publications (1)

Publication Number Publication Date
PE17895A1 true PE17895A1 (es) 1995-07-18

Family

ID=22277643

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994247526A PE17895A1 (es) 1993-07-29 1994-07-26 Antagonista triciclico diacepinico de vasopresina y antagonista de oxitocina

Country Status (28)

Country Link
US (2) US5516774A (es)
EP (1) EP0636625B1 (es)
JP (1) JP3782475B2 (es)
KR (1) KR100347479B1 (es)
CN (2) CN1039908C (es)
AT (1) ATE176234T1 (es)
AU (1) AU683660B2 (es)
BR (1) BR1100563A (es)
CA (1) CA2128956C (es)
CZ (1) CZ291322B6 (es)
DE (1) DE69416211T2 (es)
DK (1) DK0636625T3 (es)
EC (1) ECSP941137A (es)
ES (1) ES2129090T3 (es)
FI (3) FI110944B (es)
GR (1) GR3030069T3 (es)
HU (1) HU220707B1 (es)
IL (1) IL110435A (es)
LV (1) LV12497B (es)
NO (1) NO301827B1 (es)
NZ (1) NZ264115A (es)
PE (1) PE17895A1 (es)
PH (1) PH31469A (es)
PL (1) PL178563B1 (es)
RU (1) RU2126006C1 (es)
SG (1) SG47522A1 (es)
SK (1) SK280836B6 (es)
ZA (1) ZA945603B (es)

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NO942816D0 (no) 1994-07-28
LV12497A (en) 2000-06-20
CA2128956A1 (en) 1995-01-30
ZA945603B (en) 1995-03-09
PH31469A (en) 1998-11-03
RU94027583A (ru) 1996-07-20
FI943543L (fi) 1995-01-30
US5624923A (en) 1997-04-29
CZ179994A3 (en) 1995-02-15
DE69416211D1 (de) 1999-03-11
EP0636625A2 (en) 1995-02-01
HU9402219D0 (en) 1994-09-28
PL178563B1 (pl) 2000-05-31
CN1039908C (zh) 1998-09-23
IL110435A (en) 2003-11-23
LV12497B (lv) 2000-09-20
FI20011206L (fi) 2001-06-07
FI110944B (fi) 2003-04-30
NO942816L (no) 1995-01-30
NZ264115A (en) 1997-10-24
SK280836B6 (sk) 2000-08-14
US5516774A (en) 1996-05-14
JPH07157486A (ja) 1995-06-20
FI113868B (fi) 2004-06-30
RU2126006C1 (ru) 1999-02-10
HU220707B1 (hu) 2002-04-29
IL110435A0 (en) 1994-10-21
DE69416211T2 (de) 1999-09-02
EP0636625A3 (en) 1995-05-17
ATE176234T1 (de) 1999-02-15
CN1205335A (zh) 1999-01-20
CN1106812A (zh) 1995-08-16
AU683660B2 (en) 1997-11-20
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EP0636625B1 (en) 1999-01-27
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