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PE11096A1 - Genes que codifican el complejo o-cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis - Google Patents

Genes que codifican el complejo o-cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis

Info

Publication number
PE11096A1
PE11096A1 PE1994245983A PE24598394A PE11096A1 PE 11096 A1 PE11096 A1 PE 11096A1 PE 1994245983 A PE1994245983 A PE 1994245983A PE 24598394 A PE24598394 A PE 24598394A PE 11096 A1 PE11096 A1 PE 11096A1
Authority
PE
Peru
Prior art keywords
branched
chain
ketoacide
dehydrogenase complex
production
Prior art date
Application number
PE1994245983A
Other languages
English (en)
Inventor
Kim Jonelle Stutzman-Engwall
Claudio Daniel Denoya
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE11096A1 publication Critical patent/PE11096A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/04—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with a disulfide as acceptor (1.2.4)
    • C12Y102/04004—3-Methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) (1.2.4.4), i.e. branched-chain-alpha-ketoacid dehydrogenase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UN SEGMENTO DE ADN AISLADO CON SECUENCIAS DE ACIDOS NUCLEICOS QUE CODIFICA UN COMPLEJO O CETOACIDO DESHIDROGENASA DE CADENA RAMIFICADA, QUE INCLUYE UNA REGION DE ADN QUE REGULA LA EXPRESION DE DICHO COMPLEJO EN UN MICROORGANISMO QUE PERTENECE AL GENERO STREPTOMICES ESPECIE AVERMITILIS. TAMBIEN SE REFIERE A NUEVOS PROCEDIMIENTOS DE POTENCIAR LA PRODUCCION DE AVERMECTINA NATURAL, A LA PRODUCCION DE UN MUTANTE bkd DE STREPTOMICES AVERMITILIS Y A LA PRODUCCION DE NUEVAS AVERMECTINAS POR FERMENTACION TAL COMO LAS QUE SE PRODUCEN ANADIENDO AL MEDIO: S-(+)-2-METIL BUTIRICO O ACIDO CICLOHEXANO CARBOXILICO
PE1994245983A 1993-12-16 1994-07-06 Genes que codifican el complejo o-cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis PE11096A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16860293A 1993-12-16 1993-12-16

Publications (1)

Publication Number Publication Date
PE11096A1 true PE11096A1 (es) 1996-04-12

Family

ID=22612168

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1994245983A PE11096A1 (es) 1993-12-16 1994-07-06 Genes que codifican el complejo o-cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis

Country Status (21)

Country Link
US (1) US5707839A (es)
EP (1) EP0734443A1 (es)
JP (1) JP2800921B2 (es)
KR (1) KR100209842B1 (es)
CN (2) CN1056189C (es)
AU (2) AU6805894A (es)
BR (1) BR9408337A (es)
CA (1) CA2177269A1 (es)
CO (1) CO4340655A1 (es)
CZ (1) CZ174496A3 (es)
EC (1) ECSP941123A (es)
EG (1) EG22869A (es)
FI (1) FI942725L (es)
HU (1) HUT76092A (es)
IL (3) IL109991A (es)
NO (2) NO962544L (es)
NZ (3) NZ329675A (es)
PE (1) PE11096A1 (es)
PL (1) PL178993B1 (es)
WO (1) WO1995016781A1 (es)
ZA (1) ZA944092B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5466102A (en) * 1993-12-16 1995-11-14 Kennametal Inc. System for coupling machine tools
JP2002503473A (ja) * 1998-02-13 2002-02-05 ファイザー・プロダクツ・インク Ｂ２：ｂ１アベルメクチンの比に関するストレプトミセス・アベルミティリス遺伝子
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
US6197591B1 (en) 1998-09-14 2001-03-06 Pfizer Inc. Streptomyces avermitilis regulatory genes for increased avermectin production
EA200200056A1 (ru) 1999-08-12 2002-06-27 Пфайзер Продактс Инк. Ген streptomyces avermitilis, направляющий соотношение авермектинов b2:b1
DE10356092B4 (de) * 2003-12-01 2008-04-03 Siemens Audiologische Technik Gmbh Hörgerät mit drahtlosem Übertragungssystem

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987003907A1 (en) * 1985-12-17 1987-07-02 Lubrizol Genetics, Inc. Isolation of genes for biosynthesis of polyketide antibiotics
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
US5077278A (en) * 1987-01-23 1991-12-31 Pfizer Inc. Non-natural demethylavermectins compositions and method of use
DE3881147T2 (de) * 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.

Also Published As

Publication number Publication date
PL178993B1 (pl) 2000-07-31
CN1056189C (zh) 2000-09-06
IL109991A (en) 2005-08-31
ECSP941123A (es) 1994-12-15
KR100209842B1 (ko) 1999-07-15
FI942725A7 (fi) 1995-06-17
HUT76092A (en) 1997-06-30
CN1210150A (zh) 1999-03-10
IL154162A0 (en) 2003-07-31
EG22869A (en) 2003-09-30
ZA944092B (en) 1995-12-11
NZ329675A (en) 1998-10-28
IL154161A0 (en) 2003-07-31
NZ329117A (en) 1998-04-27
CA2177269A1 (en) 1995-06-22
US5707839A (en) 1998-01-13
AU9421998A (en) 1999-03-04
WO1995016781A1 (en) 1995-06-22
NZ266526A (en) 1997-12-19
CN1137806A (zh) 1996-12-11
FI942725L (fi) 1995-06-17
AU6805894A (en) 1995-07-03
JP2800921B2 (ja) 1998-09-21
NO962544D0 (no) 1996-06-14
IL109991A0 (en) 1994-10-07
BR9408337A (pt) 1997-08-19
HU9601644D0 (en) 1996-08-28
CZ174496A3 (cs) 1999-05-12
FI942725A0 (fi) 1994-06-09
CO4340655A1 (es) 1996-07-30
NO20070802L (no) 1996-06-14
EP0734443A1 (en) 1996-10-02
JPH09500283A (ja) 1997-01-14
PL314977A1 (en) 1996-09-30
NO962544L (no) 1996-06-14

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