[go: up one dir, main page]

LV12000B - Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana - Google Patents

Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana Download PDF

Info

Publication number
LV12000B
LV12000B LVP-97-200A LV970200A LV12000B LV 12000 B LV12000 B LV 12000B LV 970200 A LV970200 A LV 970200A LV 12000 B LV12000 B LV 12000B
Authority
LV
Latvia
Prior art keywords
thr
lys
ser
leu
glu
Prior art date
Application number
LVP-97-200A
Other languages
English (en)
Latvian (lv)
Other versions
LV12000A (lv
Inventor
Daniel Caput
Pascual Ferrara
Jean-Claude Guillemot
Mourad Kaghad
Richard Legoux
Gerard Loison
Elizabeth Larbre
Johannes Lupker
Pascal Leplatois
Marc Salome
Patrick Laurent
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8909550A external-priority patent/FR2649720A1/fr
Priority claimed from FR8917466A external-priority patent/FR2656530B1/fr
Application filed by Sanofi filed Critical Sanofi
Publication of LV12000A publication Critical patent/LV12000A/xx
Publication of LV12000B publication Critical patent/LV12000B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
    • C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Saccharide Compounds (AREA)
  • Glass Compositions (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
LVP-97-200A 1989-07-13 1997-10-15 Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana LV12000B (lv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8909550A FR2649720A1 (en) 1989-07-13 1989-07-13 Recombinant gene which encodes a protein such as urate oxidase
FR8917466A FR2656530B1 (fr) 1989-12-29 1989-12-29 Gene recombinant pour une expression dans les cellules eucaryotes d'une proteine telle que l'urate oxydase.
FR9001368A FR2657785A2 (fr) 1989-12-29 1990-02-06 Gene recombinant pour une expression dans les cellules animales d'une proteine telle que l'urate oxydage.

Publications (2)

Publication Number Publication Date
LV12000A LV12000A (lv) 1998-03-20
LV12000B true LV12000B (lv) 1998-06-20

Family

ID=27251947

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-97-200A LV12000B (lv) 1989-07-13 1997-10-15 Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana

Country Status (23)

Country Link
EP (1) EP0408461B1 (pt)
JP (1) JP2664804B2 (pt)
AT (1) ATE144282T1 (pt)
AU (1) AU636637B2 (pt)
BR (1) BR9006855A (pt)
CA (1) CA2035900C (pt)
DE (2) DE69028884T2 (pt)
DK (1) DK0408461T3 (pt)
ES (1) ES2095243T3 (pt)
FI (1) FI105047B (pt)
GR (1) GR3022085T3 (pt)
HU (1) HU215948B (pt)
IE (1) IE77158B1 (pt)
IL (1) IL95057A (pt)
LU (1) LU90781I2 (pt)
LV (1) LV12000B (pt)
MC (1) MC2145A1 (pt)
NL (1) NL300046I2 (pt)
NO (1) NO2001018I2 (pt)
NZ (1) NZ234453A (pt)
PT (1) PT94680B (pt)
RU (1) RU2105812C1 (pt)
WO (1) WO1991000909A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2971218B2 (ja) * 1991-12-04 1999-11-02 協和醗酵工業株式会社 ウリカーゼ遺伝子およびウリカーゼの製造法
US5691188A (en) 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
PL190041B1 (pl) * 1996-09-13 2005-10-31 Transkaryotic Therapies Zastosowanie ludzkiej komórki, cząsteczka DNA, konstrukt ekspresji, hodowana ludzka komórka, klonujący szczep komórek, klonująca linia komórek, białko, sposób wytwarzania glikozylowanej ludzkiej alfa-galaktozydazy A, oczyszczona glikozylowana ludzkaalfa-galaktozydaza A, sposób oczyszczania ludzkiej alfa-galaktozydazy A, zastosowanie oczyszczonej glikozylowanej ludzkiej alfa-galaktozydazy A, kompozycja terapeutyczna i sposób oczyszczania ludzkiej alfa-galaktozydazy A z próbki
HU226294B1 (en) * 1998-08-06 2008-08-28 Mountain View Pharmaceuticals Peg-urate oxidase conjugates and use thereof
CA2728907C (en) 1998-08-06 2015-11-24 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1310560A4 (en) 2000-08-17 2005-07-13 Ajinomoto Kk METHOD FOR MODIFICATION OF TRANSGLUTAMINASE OF MICROORGANISMS (MTG)
NZ536361A (en) 2002-04-25 2008-05-30 Shire Human Genetic Therapies Treatment of alpha-galactosidase a deficiency
PT3321359T (pt) 2005-04-11 2021-03-11 Horizon Pharma Rheumatology Llc Formas variantes de urato-oxidase e a sua utilização
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
RU2435847C2 (ru) 2005-04-11 2011-12-10 Савиент Фармасьютикалз, Инк. Вариантная форма урат-оксидазы и ее использование
KR101288027B1 (ko) * 2006-04-12 2013-07-22 새비언트 파마수티컬즈 인크. 양이온 계면활성제를 이용한 단백질 정제 방법
RU2443426C2 (ru) * 2008-11-07 2012-02-27 Мунтэн Вью Фармасьютикэлз, Инк. Конъюгаты уратоксидазы, фармацевтическая композиция для снижения уровней мочевой кислоты и способ получения вышеупомянутых конъюгатов
EP2446260B1 (en) 2009-06-25 2018-12-26 Horizon Pharma Rheumatology LLC Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
JP2019535819A (ja) 2016-11-11 2019-12-12 ホライゾン ファーマ リューマトロジー リミテッド ライアビリティ カンパニーＨｏｒｉｚｏｎ Ｐｈａｒｍａ Ｒｈｅｕｍａｔｏｌｏｇｙ Ｌｌｃ プレドニゾンおよびウリカーゼ分子の併用療法ならびにその使用
CN109223707B (zh) * 2018-09-13 2020-12-08 中国药科大学 一种尿酸酶外用凝胶制剂、其制备方法及用途
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR6301M (pt) * 1967-03-29 1968-09-09
SU457723A1 (ru) * 1973-04-09 1977-08-05 Всесоюзный Научно-Исследовательский Витаминный Институт Штамм 313-152 - продуцент уратоксидазы
EP0173378B1 (en) * 1984-07-27 1991-06-12 Unilever N.V. Process for preparing a polypeptide by culturing a transformed microorganism, a transformed microorganism suitable therefor and dna sequences suitable for preparing such microorganism
WO1988008450A1 (en) * 1987-05-01 1988-11-03 Birdwell Finlayson Gene therapy for metabolite disorders
JPH0671428B2 (ja) * 1988-08-17 1994-09-14 サッポロビール株式会社 ウリカーゼのｄｎａ配列および製法

Also Published As

Publication number Publication date
JP2664804B2 (ja) 1997-10-22
FI911212A0 (fi) 1991-03-12
IE902559A1 (en) 1991-02-27
DE10199042I2 (de) 2003-10-23
ATE144282T1 (de) 1996-11-15
NZ234453A (en) 1993-01-27
HK1000099A1 (en) 1997-11-21
DK0408461T3 (da) 1997-03-24
DE10199042I1 (de) 2002-01-10
ES2095243T3 (es) 1997-02-16
CA2035900A1 (fr) 1991-01-14
LU90781I2 (fr) 2001-07-23
IE77158B1 (en) 1997-12-03
EP0408461A1 (fr) 1991-01-16
BR9006855A (pt) 1991-08-06
DE69028884T2 (de) 1997-05-07
EP0408461B1 (fr) 1996-10-16
NL300046I2 (nl) 2001-12-01
DE69028884D1 (de) 1996-11-21
GR3022085T3 (en) 1997-03-31
CA2035900C (fr) 2000-01-11
AU6052390A (en) 1991-02-06
IL95057A0 (en) 1991-06-10
PT94680A (pt) 1991-04-18
RU2105812C1 (ru) 1998-02-27
WO1991000909A1 (fr) 1991-01-24
FI105047B (fi) 2000-05-31
HUT56884A (en) 1991-10-28
HU906046D0 (en) 1991-07-29
LV12000A (lv) 1998-03-20
NO2001018I2 (no) 2006-05-01
PT94680B (pt) 1997-04-30
NL300046I1 (nl) 2001-09-03
JPH04501807A (ja) 1992-04-02
IL95057A (en) 1997-07-13
HU215948B (hu) 1999-03-29
MC2145A1 (fr) 1992-02-18
AU636637B2 (en) 1993-05-06

Similar Documents

Publication Publication Date Title
LV12000B (lv) Olbaltumviela ar urātoksidāzes aktivitāti un tās iegūšana
KR0159107B1 (ko) 우레이트 산화효소 활성 단백질, 이 단백질을 암호화하는 재조합 유전자, 발현 벡터, 미생물 및 형질전환세포
EP0293357B1 (fr) Expression de la proapolipoprotéine A-I humaine
FR2594846A1 (fr) Procede de preparation de la serum albumine humaine mature
EP0198745B1 (fr) Procédé de préparation microbiologique de la sérum-albumine humaine
JPH09512423A (ja) エラスターゼ阻害活性を有するα−１−アンチキモトリプシンアナログ
JPS6193128A (ja) 遺伝子工学で処理した微生物から精製成長ホルモンを回収する方法
Varga et al. Pigment-protein complexes from Rhodopseudomonas palustris: isolation, characterization, and reconstitution into liposomes
JP4372421B2 (ja) 細胞からタンパク質を抽出するための方法および組成物
Lehman et al. Large-scale purification and characterization of recombinant tick anticoagulant peptide
CN103989707B (zh) 一种猪血有限酶解提取后分离的猪血抑菌剂及其制备方法
Keen The structure of clathrin-coated membranes: assembly and disassembly
CN1055009A (zh) 人的碱性fgf突变蛋白质的制备
CN114908074A (zh) 水溶液稳定性碱性蛋白酶2709突变体及其制备方法和应用
EP0435776A1 (fr) Promoteur artificiel pour l'expression de protéines dans la levure
JPH0662867A (ja) アルギニンデイミナーゼ発現ベクター、形質転換微生物およびアルギニンデイミナーゼの製造法
RU2337966C2 (ru) Препарат рекомбинантного человеческого сывороточного альбумина и способ его получения
Maezawa et al. Determination of the regions of the clathrin molecule inducing membrane fusion
FR2667612A1 (fr) Production stable de polypeptide actif m-csf.
CN108070574A (zh) 灰盖鬼伞来源的过氧化物酶的突变体及其编码基因和应用
HK1000099B (en) Protein with urate oxidase activity, recombinant gene coding therefor, expression vector, micro-organisms and transformed cells
CN120590511A (zh) 一种马血清白蛋白及其制备方法和应用
EP0475842A1 (fr) Cassette d'expression d'un précurseur de l'endothiapepsine dans Cryphonectria parasitica
FR2649720A1 (en) Recombinant gene which encodes a protein such as urate oxidase
TW201343911A (zh) 生產成熟型人類酪胺酸酶的大腸桿菌表現系統及其生產方法