[go: up one dir, main page]

LU91005I2 - Dibotermine alfa - Google Patents

Dibotermine alfa

Info

Publication number
LU91005I2
LU91005I2 LU91005C LU91005C LU91005I2 LU 91005 I2 LU91005 I2 LU 91005I2 LU 91005 C LU91005 C LU 91005C LU 91005 C LU91005 C LU 91005C LU 91005 I2 LU91005 I2 LU 91005I2
Authority
LU
Luxembourg
Prior art keywords
dibotermine
alfa
bone
research
factors
Prior art date
Application number
LU91005C
Other languages
English (en)
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/031,346 external-priority patent/US4877864A/en
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Publication of LU91005I2 publication Critical patent/LU91005I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043Mixtures of macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
LU91005C 1986-07-01 2003-01-29 Dibotermine alfa LU91005I2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88077686A 1986-07-01 1986-07-01
US94333286A 1986-12-17 1986-12-17
US2828587A 1987-03-20 1987-03-20
US07/031,346 US4877864A (en) 1987-03-26 1987-03-26 Osteoinductive factors
PCT/US1987/001537 WO1988000205A1 (fr) 1986-07-01 1987-06-30 Nouvelles compositions osteoinductives

Publications (1)

Publication Number Publication Date
LU91005I2 true LU91005I2 (en) 2003-03-31

Family

ID=27487661

Family Applications (1)

Application Number Title Priority Date Filing Date
LU91005C LU91005I2 (en) 1986-07-01 2003-01-29 Dibotermine alfa

Country Status (18)

Country Link
EP (3) EP0313578B1 (fr)
JP (3) JP2713715B2 (fr)
AT (3) ATE234921T1 (fr)
AU (1) AU613314B2 (fr)
CA (1) CA1341212C (fr)
DE (4) DE3752364T2 (fr)
DK (2) DK172275B1 (fr)
ES (1) ES2007625A6 (fr)
GR (1) GR871028B (fr)
IE (1) IE75881B1 (fr)
IL (1) IL83003A (fr)
LU (1) LU91005I2 (fr)
MX (1) MX170919B (fr)
MY (1) MY102505A (fr)
NL (1) NL300116I2 (fr)
NZ (1) NZ220894A (fr)
PT (1) PT85225B (fr)
WO (1) WO1988000205A1 (fr)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US5035901A (en) * 1987-10-09 1991-07-30 University Of Kansas Bone inducing agent from a human osteosarcoma cell line
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
DE68927153T2 (de) * 1988-04-08 1997-03-06 Stryker Corp., Kalamazoo, Mich. Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
WO1989010409A1 (fr) * 1988-04-08 1989-11-02 Genetics Institute, Inc. Compositions provoquant la formation d'os et de cartilage
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US4915301A (en) * 1988-11-15 1990-04-10 International Flavors & Fragrances, Inc. Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
JP3504259B2 (ja) 1989-03-28 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 骨誘導組成物
DE69031939T2 (de) * 1989-03-28 1998-09-10 Genetics Institute, Inc., Cambridge, Mass. Osteoinduktive zusammensetzungen
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (fr) * 1989-07-19 1991-01-20 Michael C. Kiefer Proteine morphogenetique des os
JPH05500503A (ja) * 1989-08-21 1993-02-04 セルトリックス ファーマシューティカルズ、インコーポレイテッド 骨特異的タンパク質
CA2024629C (fr) * 1989-09-06 2001-07-24 Taiheiyo Cement Corporation Proteine morphogenique osseuse dactylethre laevis, adn l'encodant et son utilisation
DK0448704T3 (da) * 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
ATE253589T1 (de) * 1990-09-26 2003-11-15 Inst Genetics Llc Bmp-5-derivate
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
CA2104678C (fr) 1991-03-11 2002-05-14 Charles M. Cohen Morphogenese induite par des proteines
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5739107A (en) * 1991-03-11 1998-04-14 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
JPH07500315A (ja) 1991-05-10 1995-01-12 セルトリックス ファーマシューティカルズ,インコーポレイテッド 骨成長因子の標的送達
ATE142460T1 (de) * 1991-06-21 1996-09-15 Genetics Inst Osteogene proteine enthaltende arzneimittel
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
NZ249113A (en) * 1992-02-12 1996-07-26 Bioph Biotech Entw Pharm Gmbh Recombinant dna encoding tgf-b, its production and pharmaceutical compositions thereof
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
WO1994006399A1 (fr) * 1992-09-15 1994-03-31 Creative Biomolecules, Inc. Regeneration tissulaire periodontique induite par des morphogenes
DE69325913T2 (de) * 1992-09-15 2001-05-17 Creative Biomolecules, Inc. Durch morphogen induzierte periodontolgeweberegeneration
EP1770161A3 (fr) * 1993-05-12 2008-04-23 Genetics Institute, LLC Compositions contenant la BMP-11
US6333168B1 (en) * 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
ATE319823T1 (de) 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
ATE245996T1 (de) * 1995-06-05 2003-08-15 Inst Genetics Llc Verwendung von knochenmorphogeneseproteinen zur heilung und reparatur von bindegewebebefestigung
JPH11510697A (ja) * 1995-08-08 1999-09-21 トーマス ジェファソン ユニバーシティー 組換え体c−プロテイナーゼ、ならびにそのプロセス、方法および使用
US5807981A (en) * 1995-12-13 1998-09-15 Fibrogen Inc. Peptides which are cleaved by C-proteinase
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
CA2272345A1 (fr) * 1996-11-22 1998-06-04 Akzo Nobel Nv Promoteur de bmp-4 et utilisation d'un tel promoteur pour selectionner des agents therapeutiques destines a la prevention et/ou au traitement de l'osteoporose
DE69814352T3 (de) * 1997-02-07 2009-08-13 Stryker Corp., Kalamazoo Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
JP5033276B2 (ja) 1997-05-05 2012-09-26 ストライカー コーポレイション 急性腎不全の治療
EP0985149A1 (fr) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Procedes pour evaluer la morphogenese des tissus et leur activite
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
DK2016951T3 (da) 1998-03-17 2012-09-24 Genentech Inc VEGF- og BMP1-homologe polypeptider
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6916783B2 (en) 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
ES2207258T3 (es) 1998-07-13 2004-05-16 University Of Southern California Procedimiento para acelerar el crecimiento oseo y del cartilago y su recuperacion.
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
AU770725B2 (en) 1998-10-06 2004-02-26 Howard An Method of chemonucleolysis
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
IL144523A0 (en) * 1999-02-01 2002-05-23 Genetics Inst Method and compositions for healing and repair of articular cartilage
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
WO2001016323A2 (fr) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions et procedes d'inhibition de l'infection due au virus de l'immunodeficience humaine a l'aide de genes cellulaires humains a regulation negative
WO2001016322A2 (fr) * 1999-09-01 2001-03-08 Subsidiary No. 3, Inc. Compositions et procedes d'inhibition de l'infection au virus de l'immunodeficience humaine, par regulation restrictive de genes cellulaires humains
AU6865100A (en) * 1999-09-02 2001-04-10 Mitsubishi Pharma Corporation Osteogenesis promoting agents
DK1223990T3 (da) 1999-10-15 2004-11-29 Inst Genetics Llc Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
US7371818B2 (en) 2000-12-28 2008-05-13 Shionogi & Co., Ltd. Polypeptide and DNA thereof
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
EP1399023B1 (fr) 2001-06-01 2008-04-30 Wyeth Compositions pour l'administration systemique de sequences codant pour des proteines morphogenetiques osseuses
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7160725B2 (en) 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
EP1448246B2 (fr) 2001-11-19 2015-09-09 Scil Technology GmbH Procede de production d'un dispositif a revetement homogene dote de proprietes osteoinductives et osteoconductrices
US7160994B2 (en) 2002-03-28 2007-01-09 Trustees Of The University Of Pennsylvania Osteoclast-specific genes and proteins and uses thereof
US8067557B2 (en) 2002-03-28 2011-11-29 The Trustees Of The University Of Pennsylvania OCL-2A3 compositions and uses thereof
JP4358741B2 (ja) 2002-09-10 2009-11-04 スキール テヒノロギー ゲーエムベーハー 低酸素濃度下において骨誘導性タンパク質で被覆された金属インプラント
CN101897974B (zh) 2003-09-12 2013-09-25 惠氏公司 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂
US8328876B2 (en) 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
EP1571159A1 (fr) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutéine d' une protéine morphogénétique osseuse et son utilisation
US8372419B2 (en) 2004-03-10 2013-02-12 Scil Technology Gmbh Coated implants, their manufacturing and use thereof
EP1763362B1 (fr) 2004-05-25 2011-07-06 Stryker Corporation Utilisation d'op-1s pour traiter les anomalies des cartilages
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
CN101365499A (zh) 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
CA2652549A1 (fr) 2006-05-17 2007-12-13 Stryker Corporation Procede pour traiter des defauts cartilagineux a l'aide d'uncomplexe de proteine morphogenique soluble
BRPI0716680A2 (pt) 2006-11-02 2013-09-24 Daniel J Capon "composto, multÍmero, composiÇço, mÉtodo de afetar a atividade de um alvo, complexo, processo de produÇço do composto, mÉtodo de produÇço de um extensço de aminoÁcidos consecutivos, processo de produÇço de uma extensço de aminoacidos consecutivos , processo para a produÇço de um composto , mÉtodo de produÇço de uma proteina e polipeptÍdeo"
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
ES2447516T3 (es) 2006-12-21 2014-03-12 Stryker Corporation Formulaciones de liberación sostenida que comprenden cristales BMP-7
WO2008157492A2 (fr) 2007-06-15 2008-12-24 Osteotech, Inc. Os spongieux déminéralisé ostéo-inducteur
EP3207948B1 (fr) 2007-06-15 2020-02-26 Warsaw Orthopedic, Inc. Compositions de matrice osseuse et méthodes
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
WO2009009688A1 (fr) 2007-07-10 2009-01-15 Osteotech, Inc. Système d'administration
WO2009020744A1 (fr) 2007-08-07 2009-02-12 Johnson & Johnson Regenerative Therapeutics, Llc Formules protéiniques comprenant le facteur gdf-5 dans une solution aqueuse acide
JP2011514331A (ja) 2008-02-13 2011-05-06 キース フルスカ, 血管硬化症の治療における使用のためのbmp−7
EP2276458A1 (fr) 2008-04-14 2011-01-26 Advanced Technologies and Regenerative Medicine, LLC Formulations liquides tamponnées de gdf-5
CN102369016A (zh) 2009-02-12 2012-03-07 史赛克公司 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用
SG173634A1 (en) 2009-02-12 2011-09-29 Stryker Corp COMPOSITIONS AND METHODS FOR MINIMALLY-INVASIVE SYSTEMIC DELIVERY OF PROTEINS INCLUDING TGF-ß SUPERFAMILY MEMBERS
US9011537B2 (en) 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
JP5749659B2 (ja) * 2009-03-12 2015-07-15 ハーゼ インベストメンツ ウーゲー Bmpアンタゴニスト感受性が低下した骨形成タンパク質2(bmp2)変異体
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US20120107413A1 (en) * 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
WO2011031856A1 (fr) 2009-09-09 2011-03-17 Stryker Corporation Bmp-7 à utiliser dans le traitement de la douleur induite par les lésions et les maladies d'articulation
EP2352750B1 (fr) 2009-09-17 2012-06-13 Stryker Corporation Tampons utilisés pour la régulation du ph des protéines morphogénétiques osseuses
JP2013514811A (ja) 2009-12-22 2013-05-02 ストライカー コーポレイション 免疫原性が抑制されたbmp−7変異体
US10836807B2 (en) 2016-12-30 2020-11-17 Biogend Therapeutics Co., Ltd. Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
EP0128041A3 (fr) * 1983-06-06 1986-12-03 David Jeston Baylink Polypeptides ayant une activité de facteur de croissance du squelette
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
NZ210699A (en) 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
DK518384A (da) 1984-01-31 1985-07-01 Idaho Res Found Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
AU599572B2 (en) 1984-07-06 1990-07-26 Novartis Ag Lymphokine production and purification
EP0169016B2 (fr) 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Facteur polypeptidique issu des os induisant le cartilage
ATE78515T1 (de) 1984-10-05 1992-08-15 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors

Also Published As

Publication number Publication date
NZ220894A (en) 1990-05-28
DE3751887D1 (de) 1996-10-02
DE3751887T2 (de) 1997-03-06
JP3093682B2 (ja) 2000-10-03
ATE141928T1 (de) 1996-09-15
EP0313578A4 (en) 1990-10-03
JPH06298800A (ja) 1994-10-25
EP1254956A3 (fr) 2002-11-13
ATE419349T1 (de) 2009-01-15
EP0313578B1 (fr) 1996-08-28
EP1254956B1 (fr) 2008-12-31
NL300116I1 (nl) 2003-05-01
MX170919B (es) 1993-09-22
GR871028B (fr) 1988-01-11
DE3752393D1 (de) 2009-02-12
IE871739L (en) 1988-01-01
JP2713715B2 (ja) 1998-02-16
IE970378L (en) 1988-01-01
DE3752364T2 (de) 2004-03-04
DK53497A (da) 1997-05-09
DE10399007I2 (de) 2006-03-16
EP0688869B1 (fr) 2003-03-19
ATE234921T1 (de) 2003-04-15
DK106288A (da) 1988-04-28
PT85225B (pt) 1990-03-30
DK172503B1 (da) 1998-10-26
PT85225A (en) 1987-08-01
DE10399007I1 (de) 2003-07-31
IL83003A0 (en) 1987-12-20
AU7783587A (en) 1988-01-29
DK106288D0 (da) 1988-02-29
ES2007625A6 (es) 1989-07-01
DE3752364D1 (de) 2003-04-24
EP0688869A1 (fr) 1995-12-27
JP2729222B2 (ja) 1998-03-18
AU613314B2 (en) 1991-08-01
CA1341212C (fr) 2001-04-10
JPH02500241A (ja) 1990-02-01
NL300116I2 (nl) 2003-06-02
MY102505A (en) 1992-07-31
WO1988000205A1 (fr) 1988-01-14
IL83003A (en) 1995-07-31
JPH1070989A (ja) 1998-03-17
EP1254956A2 (fr) 2002-11-06
EP0313578A1 (fr) 1989-05-03
DK172275B1 (da) 1998-02-16
IE75881B1 (en) 1997-09-24

Similar Documents

Publication Publication Date Title
LU91005I2 (en) Dibotermine alfa
EP0484401A4 (en) Production of vascular endothelial cell growth factor
GR880300077T1 (en) Galanthamine or analogues thereof for treating alzheimer's disease
IL91412A0 (en) Process and solution for the lyophilization of blood cells
GB2211192B (en) Composition and process for the treatment and care of the hair
EP0217004A3 (en) Process for controlling the cis-transconfiguration of the double bonds in polyalkenamers
EP0252479A3 (en) Method for surface treatment and treating material therefor
EP0294028A3 (en) Fluoxetine useful for the treatment of diabetes
HUT45564A (en) Process for producing hirudine variants
IL86849A0 (en) Promoters for the expression of foreign dna in methylotrophic bacteria,the obtaining thereof and the use thereof
EP0249094A3 (en) Method and plant for the treatment of laminated glass
DE3572441D1 (en) Use of interferon gamma (ifn-gamma) for the production of preparations for treating rheumatic diseases
NZ224348A (en) Tanning composition with al and ti
ATE94903T1 (de) Analoge des porcin-wachstumshormones.
GB2201157B (en) Processes and products for surface treatment
PT81774A (en) Improvememnts relating to the method for treating leather and similar products
HUT40312A (en) Process for producing protein concentrates and nutriments containing bioactive materials
EP0288901A3 (en) Recombinant human glutathione peroxidase, process for preparing the same and dna coding the same
SU1572563A1 (ru) Cпocoб лeчehия дeфektob potoглotkи и petpomoляphoй oблactи