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NL300116I1 - Nieuwe osteoinductieve samenstellingen. - Google Patents

Nieuwe osteoinductieve samenstellingen.

Info

Publication number
NL300116I1
NL300116I1 NL300116C NL300116C NL300116I1 NL 300116 I1 NL300116 I1 NL 300116I1 NL 300116 C NL300116 C NL 300116C NL 300116 C NL300116 C NL 300116C NL 300116 I1 NL300116 I1 NL 300116I1
Authority
NL
Netherlands
Prior art keywords
osteoinductive compositions
new
new osteoinductive
compositions
bone
Prior art date
Application number
NL300116C
Other languages
English (en)
Other versions
NL300116I2 (nl
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/031,346 external-priority patent/US4877864A/en
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of NL300116I1 publication Critical patent/NL300116I1/nl
Publication of NL300116I2 publication Critical patent/NL300116I2/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/51Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043Mixtures of macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
NL300116C 1986-07-01 2003-02-24 Nieuwe osteoinductieve samenstellingen. NL300116I2 (nl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88077686A 1986-07-01 1986-07-01
US94333286A 1986-12-17 1986-12-17
US2828587A 1987-03-20 1987-03-20
US07/031,346 US4877864A (en) 1987-03-26 1987-03-26 Osteoinductive factors
PCT/US1987/001537 WO1988000205A1 (en) 1986-07-01 1987-06-30 Novel osteoinductive compositions

Publications (2)

Publication Number Publication Date
NL300116I1 true NL300116I1 (nl) 2003-05-01
NL300116I2 NL300116I2 (nl) 2003-06-02

Family

ID=27487661

Family Applications (1)

Application Number Title Priority Date Filing Date
NL300116C NL300116I2 (nl) 1986-07-01 2003-02-24 Nieuwe osteoinductieve samenstellingen.

Country Status (18)

Country Link
EP (3) EP0688869B1 (nl)
JP (3) JP2713715B2 (nl)
AT (3) ATE141928T1 (nl)
AU (1) AU613314B2 (nl)
CA (1) CA1341212C (nl)
DE (4) DE10399007I2 (nl)
DK (2) DK172275B1 (nl)
ES (1) ES2007625A6 (nl)
GR (1) GR871028B (nl)
IE (1) IE75881B1 (nl)
IL (1) IL83003A (nl)
LU (1) LU91005I2 (nl)
MX (1) MX170919B (nl)
MY (1) MY102505A (nl)
NL (1) NL300116I2 (nl)
NZ (1) NZ220894A (nl)
PT (1) PT85225B (nl)
WO (1) WO1988000205A1 (nl)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5035901A (en) * 1987-10-09 1991-07-30 University Of Kansas Bone inducing agent from a human osteosarcoma cell line
US6020313A (en) * 1987-10-09 2000-02-01 University Of Kansas Method for inducing bone formation using an extract of human osteosarcoma cell line SAOS-2
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
EP0714665B1 (en) 1988-04-08 2003-01-22 Stryker Corporation Osteogenic devices
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
JPH03503649A (ja) * 1988-04-08 1991-08-15 ジェネティックス・インスティテュート・インコーポレイテッド 硬骨および軟骨誘導組成物
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5344654A (en) * 1988-04-08 1994-09-06 Stryker Corporation Prosthetic devices having enhanced osteogenic properties
US5106626A (en) * 1988-10-11 1992-04-21 International Genetic Engineering, Inc. Osteogenic factors
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US4915301A (en) * 1988-11-15 1990-04-10 International Flavors & Fragrances, Inc. Container with sorbent member and microporous membrane for dispensing vapor from volatile liquid
JP3504259B2 (ja) 1989-03-28 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 骨誘導組成物
ES2113857T3 (es) * 1989-03-28 1998-05-16 Genetics Inst Composiciones osteoinductoras.
JPH03151877A (ja) * 1989-06-02 1991-06-28 Chiron Corp 骨カルシウム沈着因子
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
WO1991002744A1 (en) * 1989-08-21 1991-03-07 Celtrix Laboratories, Inc. Bone-specific protein
EP0416578B1 (en) * 1989-09-06 1996-07-31 Takeda Chemical Industries, Ltd. Protein, DNA and use thereof
DK0448704T3 (da) * 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
US5168050A (en) * 1990-05-24 1992-12-01 Genentech, Inc. Mammalian expression of the bone morphogenetic protein-2b using bmp2a/bmp2b fusion
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
ATE253589T1 (de) * 1990-09-26 2003-11-15 Inst Genetics Llc Bmp-5-derivate
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5318898A (en) * 1991-04-02 1994-06-07 Genetics Institute, Inc. Production of recombinant bone-inducing proteins
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
JPH07500315A (ja) 1991-05-10 1995-01-12 セルトリックス ファーマシューティカルズ,インコーポレイテッド 骨成長因子の標的送達
WO1993000050A1 (en) * 1991-06-21 1993-01-07 Genetics Institute, Inc. Pharmaceutical formulations of osteogenic proteins
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
AU674500B2 (en) 1991-11-04 1997-01-02 Genetics Institute, Llc Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
UA48105C2 (uk) * 1992-02-12 2002-08-15 Біофарм Гезельшафт Цур Біотехнологішен Ентвіклунг Вон Фармака Мбх ФРАГМЕНТ ДНК, ЯКИЙ КОДУЄ БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), РЕКОМБІНАНТНА МОЛЕКУЛА ДНК (ВАРІАНТИ), КЛІТИНА-ХАЗЯЇН (ВАРІАНТИ), СПОСІБ ОДЕРЖАННЯ БІЛКУ РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), БІЛОК РОДИНИ TGF-<font face="Symbol">b</font> (ВАРІАНТИ), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ (ВАРІАНТИ), АНТИТІЛО АБО ФРАГМЕНТ АНТИТІЛА (ВАРІАНТИ), МОЛЕКУЛА КДНК (ВАРІАНТИ)
IL106278A0 (en) * 1992-07-13 1993-11-15 Sumitomo Metal Ind Bone formation-inducing protein
DE69325913T2 (de) * 1992-09-15 2001-05-17 Creative Biomolecules, Inc. Durch morphogen induzierte periodontolgeweberegeneration
CA2144513C (en) * 1992-09-15 1998-12-15 Thangavel Kuberasampath Morphogen-induced periodontal tissue regeneration
EP1770161A3 (en) * 1993-05-12 2008-04-23 Genetics Institute, LLC BMP-11 compositions
US6333168B1 (en) 1993-05-20 2001-12-25 The Trustees Of Columbia University In The City Of New York Cloning, expression and uses of dorsalin-1
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
WO1995016035A2 (en) 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
DE69629294T2 (de) * 1995-06-05 2004-04-29 Genetics Institute, LLC, Cambridge Verwendung von knochenmorphogeneseproteinen zur heilung und reparatur von bindegewebebefestigung
CA2229044A1 (en) * 1995-08-08 1997-02-20 Thomas Jefferson University Recombinant c-proteinase and processes, methods and uses thereof
US5807981A (en) * 1995-12-13 1998-09-15 Fibrogen Inc. Peptides which are cleaved by C-proteinase
ATE493141T1 (de) 1996-03-22 2011-01-15 Stryker Corp Verfahren zur verbesserten funktionellen erholung der motorischen koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns
US6498142B1 (en) 1996-05-06 2002-12-24 Curis, Inc. Morphogen treatment for chronic renal failure
BR9713130A (pt) * 1996-11-22 2000-02-08 Akzo Nobel Nv Região promotora de bmp-4 e seus fragmentos, vetor compreendendo uma região promotora de bmp-4 ou seus fragmentos, célula hospedeira, processo para a identificação de agentes terapêuticos para a prevenção e/ou tratamento da osteoporose, e, uso de ici 164384.
DE69814352T3 (de) * 1997-02-07 2009-08-13 Stryker Corp., Kalamazoo Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
WO1999047677A2 (en) 1998-03-17 1999-09-23 Genentech, Inc. Polypeptides homologous to vegf and bmp1
ATE278414T1 (de) 1997-05-05 2004-10-15 Curis Inc Therapien zur behandlung von akutem nierenversagen
EP1988395A1 (en) 1997-05-30 2008-11-05 Curis, Inc. Methods for evaluating tissue morphogenesis and morphogenic activity
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
CA2328871C (en) 1998-07-13 2002-10-01 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US6916783B2 (en) 1998-07-13 2005-07-12 University Of Southern California Methods for accelerating bone and cartilage growth and repair
US7572440B2 (en) 1999-07-30 2009-08-11 Stryker Corporation Method for repairing a defect in an intervertebral disc
CA2343698C (en) 1998-10-06 2014-05-20 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
US6958149B2 (en) 1998-10-06 2005-10-25 Stryker Corporation Repair of larynx, trachea, and other fibrocartilaginous tissues
JP3786533B2 (ja) 1998-11-12 2006-06-14 善彦 西村 ペプチド及び骨形成促進剤
HUP0105312A3 (en) * 1999-02-01 2003-12-29 Genetics Inst Llc Cambridge Methods and compositions for healing and repair of articular cartilage
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
JP2003510033A (ja) * 1999-09-01 2003-03-18 サブサイダリー ナンバースリー インコーポレイテッド ヒト細胞遺伝子をダウンレギュレートすることにより、ヒト免疫不全ウイルス感染を阻止するための組成物および方法
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
AU6865100A (en) * 1999-09-02 2001-04-10 Mitsubishi Pharma Corporation Osteogenesis promoting agents
EP2286847A1 (en) 1999-10-15 2011-02-23 Genetics Institute, LLC Formulations of hyaluronic acid for delivery of osteogenic proteins
US7371818B2 (en) 2000-12-28 2008-05-13 Shionogi & Co., Ltd. Polypeptide and DNA thereof
TWI329129B (en) 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
ES2305246T3 (es) 2001-06-01 2008-11-01 Wyeth Composiciones para la administracion sistemica de secuencias que codifican proteinas oseas morfogeneticas.
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7160725B2 (en) 2001-11-13 2007-01-09 Curis, Inc. Hedgehog signaling promotes the formation of three dimensional cartilage matrices
BR0214275A (pt) 2001-11-19 2004-09-21 Scil Technology Gmbh Dispositivo tendo propriedades osteocondutora e osteoindutora
US8067557B2 (en) 2002-03-28 2011-11-29 The Trustees Of The University Of Pennsylvania OCL-2A3 compositions and uses thereof
US7160994B2 (en) 2002-03-28 2007-01-09 Trustees Of The University Of Pennsylvania Osteoclast-specific genes and proteins and uses thereof
DE60304584T2 (de) 2002-09-10 2007-04-26 Scil Technology Gmbh Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat
EP1675608B1 (en) 2003-09-12 2007-03-21 Wyeth Injectable calcium phosphate solid rods for delivery of osteogenic proteins
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
EP1571159A1 (en) * 2004-03-04 2005-09-07 Bayerische Julius-Maximilians-Universität Würzburg Mutein of a bone morphogenetic protein and use thereof
EP1737734B1 (en) 2004-03-10 2010-08-18 Scil Technology GmbH Coated implants, their manufacturing and use thereof
ES2369629T3 (es) 2004-05-25 2011-12-02 Stryker Corporation Uso de op-1 para tratar defectos del cartílago.
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
CN101365499A (zh) 2005-11-01 2009-02-11 骨骼技术股份有限公司 骨基质组合物和方法
EP2035030A2 (en) 2006-05-17 2009-03-18 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
NZ576445A (en) 2006-11-02 2012-03-30 Daniel J Capon Hybrid immunoglobulins with moving parts
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CA2671925A1 (en) 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
CA2695697A1 (en) 2007-08-07 2009-02-12 Advanced Technologies And Regenerative Medicine, Llc Protein formulations comprising gdf-5 in aqueous acidic solution
EP2268302B1 (en) 2008-02-13 2014-04-09 Keith Hruska Bmp-7 for use in treating neointimal hyperplasia
WO2009129101A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
JP5819734B2 (ja) 2009-02-12 2015-11-24 ストライカー コーポレイションStryker Corporation TGF−βスーパーファミリーメンバー含有タンパク質の最小に侵襲性の全身送達のための組成物および方法
SG173632A1 (en) 2009-02-12 2011-09-29 Stryker Corp Peripheral administration of proteins including tgf-beta superfamily members for systemic treatment of disorders and disease
WO2010093959A2 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
JP5749659B2 (ja) * 2009-03-12 2015-07-15 ハーゼ インベストメンツ ウーゲー Bmpアンタゴニスト感受性が低下した骨形成タンパク質2(bmp2)変異体
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US20120107413A1 (en) * 2009-07-23 2012-05-03 Singapore Health Services Pte Ltd Pre-natal mesenchymal stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
AU2010295509A1 (en) 2009-09-17 2012-04-19 Stryker Corporation Buffers for controlling the pH of bone morphogenetic proteins
JP2013514811A (ja) 2009-12-22 2013-05-02 ストライカー コーポレイション 免疫原性が抑制されたbmp−7変異体
NZ754942A (en) 2016-12-30 2023-02-24 Biogend Therapeutics Co Ltd Recombinant polypeptides, compositions, and methods thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
EP0128041A3 (en) * 1983-06-06 1986-12-03 David Jeston Baylink Polypeptides exhibiting skeletal growth factor activity
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
NZ210699A (en) 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
DK518384A (da) 1984-01-31 1985-07-01 Idaho Res Found Vektor til fremstilling af et gen-produkt i insektceller, fremgangsmaade til dens fremstilling samt dens anvendelse
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
JP2540509B2 (ja) 1984-07-06 1996-10-02 サンド・アクチエンゲゼルシヤフト リンホカインの生産および精製
EP0169016B2 (en) 1984-07-16 2004-04-28 Celtrix Pharmaceuticals, Inc. Polypeptide cartilage-inducing factors found in bone
DE3586386T2 (de) 1984-10-05 1993-01-14 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors

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DK106288A (da) 1988-04-28
EP0313578A1 (en) 1989-05-03
MY102505A (en) 1992-07-31
DE3752393D1 (de) 2009-02-12
IE75881B1 (en) 1997-09-24
ATE419349T1 (de) 2009-01-15
ATE234921T1 (de) 2003-04-15
NL300116I2 (nl) 2003-06-02
CA1341212C (en) 2001-04-10
IE970378L (en) 1988-01-01
JP2713715B2 (ja) 1998-02-16
JPH1070989A (ja) 1998-03-17
DK53497A (da) 1997-05-09
EP0313578A4 (en) 1990-10-03
JPH06298800A (ja) 1994-10-25
NZ220894A (en) 1990-05-28
IL83003A (en) 1995-07-31
WO1988000205A1 (en) 1988-01-14
EP0688869A1 (en) 1995-12-27
PT85225A (en) 1987-08-01
AU613314B2 (en) 1991-08-01
DE3751887D1 (de) 1996-10-02
PT85225B (pt) 1990-03-30
JP3093682B2 (ja) 2000-10-03
EP1254956A3 (en) 2002-11-13
GR871028B (nl) 1988-01-11
JP2729222B2 (ja) 1998-03-18
EP1254956B1 (en) 2008-12-31
AU7783587A (en) 1988-01-29
ATE141928T1 (de) 1996-09-15
LU91005I2 (en) 2003-03-31
DK106288D0 (da) 1988-02-29
DK172503B1 (da) 1998-10-26
IL83003A0 (en) 1987-12-20
EP0313578B1 (en) 1996-08-28
EP0688869B1 (en) 2003-03-19
MX170919B (es) 1993-09-22
JPH02500241A (ja) 1990-02-01
DE3752364D1 (de) 2003-04-24
ES2007625A6 (es) 1989-07-01
IE871739L (en) 1988-01-01
DE10399007I1 (de) 2003-07-31
DE10399007I2 (de) 2006-03-16
DE3752364T2 (de) 2004-03-04
DK172275B1 (da) 1998-02-16
EP1254956A2 (en) 2002-11-06
DE3751887T2 (de) 1997-03-06

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