LU90011I2 - Remifentanil facultativement sous la forme d'un sel d'addition d'acide pharmaceutiquement acceptable y compris le chlorhydrate de remifentanil - Google Patents
Remifentanil facultativement sous la forme d'un sel d'addition d'acide pharmaceutiquement acceptable y compris le chlorhydrate de remifentanilInfo
- Publication number
- LU90011I2 LU90011I2 LU90011C LU90011C LU90011I2 LU 90011 I2 LU90011 I2 LU 90011I2 LU 90011 C LU90011 C LU 90011C LU 90011 C LU90011 C LU 90011C LU 90011 I2 LU90011 I2 LU 90011I2
- Authority
- LU
- Luxembourg
- Prior art keywords
- lower alkyl
- group
- alkoxy
- remifentanil
- member selected
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 title 1
- 229960003394 remifentanil Drugs 0.000 title 1
- WFBMIPUMYUHANP-UHFFFAOYSA-N remifentanil hydrochloride Chemical compound [Cl-].C1C[NH+](CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 WFBMIPUMYUHANP-UHFFFAOYSA-N 0.000 title 1
- 229960003011 remifentanil hydrochloride Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000000202 analgesic effect Effects 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 tri-substituted phenyl Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31131189A | 1989-02-15 | 1989-02-15 | |
| US07/448,497 US5019583A (en) | 1989-02-15 | 1989-12-11 | N-phenyl-N-(4-piperidinyl)amides useful as analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU90011I2 true LU90011I2 (fr) | 1997-03-11 |
Family
ID=26977841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU90011C LU90011I2 (fr) | 1989-02-15 | 1997-01-24 | Remifentanil facultativement sous la forme d'un sel d'addition d'acide pharmaceutiquement acceptable y compris le chlorhydrate de remifentanil |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5019583A (fr) |
| EP (1) | EP0383579B1 (fr) |
| JP (1) | JP2895145B2 (fr) |
| KR (1) | KR0160979B1 (fr) |
| AT (1) | ATE140451T1 (fr) |
| AU (1) | AU636330B2 (fr) |
| CA (1) | CA2010011C (fr) |
| CY (1) | CY2002A (fr) |
| CZ (1) | CZ402591A3 (fr) |
| DE (2) | DE69027794T2 (fr) |
| DK (1) | DK0383579T3 (fr) |
| ES (1) | ES2088961T4 (fr) |
| GR (1) | GR3020719T3 (fr) |
| HK (1) | HK78297A (fr) |
| IE (1) | IE77156B1 (fr) |
| LU (1) | LU90011I2 (fr) |
| MX (1) | MX9203024A (fr) |
| NL (1) | NL960030I2 (fr) |
| NZ (1) | NZ232542A (fr) |
| PT (1) | PT93137B (fr) |
| SG (1) | SG47967A1 (fr) |
| SK (1) | SK402591A3 (fr) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130321A (en) * | 1990-12-18 | 1992-07-14 | Glaxo Inc. | Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides |
| US5214148A (en) * | 1990-12-18 | 1993-05-25 | Glaxo Inc. | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides |
| GB9316863D0 (en) * | 1993-08-13 | 1993-09-29 | Glaxo Group Ltd | Chemical process |
| US5466700A (en) * | 1993-08-30 | 1995-11-14 | Glaxo Wellcome Inc. | Anesthetic use of N-phenyl-N-(4-piperidinyl)amides |
| US5866591A (en) * | 1996-09-11 | 1999-02-02 | Glaxo Wellcome Inc. | Stable formulations of remifentanil |
| ATE306472T1 (de) * | 1997-12-24 | 2005-10-15 | Ortho Mcneil Pharm Inc | (4)-(aryl(piperidin-4-yl) aminobenzamidderivate die an delta-opioid rezeptor binden |
| US6858018B1 (en) * | 1998-09-28 | 2005-02-22 | Vyteris, Inc. | Iontophoretic devices |
| US6436959B1 (en) | 1998-12-23 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)]aminobenzamides |
| US7074935B2 (en) | 1999-12-06 | 2006-07-11 | Mallinckrodt Inc. | Methods for the syntheses of alfentanil, sufentanil and remifentanil |
| WO2001068604A2 (fr) | 2000-03-14 | 2001-09-20 | Sepracor, Inc. | Piperidines 3-substituees comprenant un groupement uree et procedes d'utilisation de ces dernieres |
| ES2302742T5 (es) * | 2000-07-31 | 2011-10-10 | Nycomed Danmark Aps | Pulverizador nasal para suministrar una composición farmacéutica. |
| WO2002096351A2 (fr) | 2001-04-03 | 2002-12-05 | Aryx Therapeutics | Opioides a action ultrabreve pour application transdermique |
| AU2002361709A1 (en) * | 2001-12-17 | 2003-06-30 | Aryx Therapeutics | Analgesic delivery systems and methods of use |
| JPWO2005030722A1 (ja) * | 2003-09-29 | 2006-12-07 | 日本ケミファ株式会社 | Ｎ−置換−ｎ−（４−ピペリジニル）アミド誘導体 |
| MXPA06013917A (es) | 2004-06-18 | 2007-03-07 | Neurosearch As | Nuevos derivados de piperidina sustituidos con alquilo y su uso como inhibidores de la recaptacion del neurotransmisor monoamino. |
| US20090030041A1 (en) * | 2004-09-14 | 2009-01-29 | Toshihiro Takahashi | N-substituted N-(4-piperidinyl) Amide Derivative |
| EP1966140A1 (fr) * | 2005-11-17 | 2008-09-10 | Mallinckrodt, Inc. | Procede de synthetisation du remifentanil |
| JP2009524659A (ja) * | 2006-01-24 | 2009-07-02 | マリンクロッド・インコーポレイテッド | レミフェンタニルの合成方法 |
| CN101379032A (zh) * | 2006-02-03 | 2009-03-04 | 马林克罗特公司 | 瑞芬太尼盐酸盐的晶型 |
| EP1867635A1 (fr) * | 2006-06-15 | 2007-12-19 | Kern Pharma, S.L. | Procédé de préparation de remifentanil, ses produits intermédiaires, leur application et procédé pour leur préparation |
| GB0613693D0 (en) * | 2006-07-10 | 2006-08-16 | Cenes Ltd | Benzodiazepine salts (3) |
| RU2470935C2 (ru) | 2006-07-10 | 2012-12-27 | ПАЙОН ЮКей ЛИМИТЕД | Бензодиазепиновые соли кратковременного действия и их полиморфные формы |
| WO2008045192A2 (fr) * | 2006-10-05 | 2008-04-17 | Mallinckrodt Inc. | Procédé alternatif pour la préparation du remifentanil |
| AU2007325889A1 (en) * | 2006-11-29 | 2008-06-05 | Mallinckrodt Inc. | New process for remifentanil synthesis |
| MX2010010675A (es) | 2008-03-31 | 2010-11-25 | Gen Hospital Corp | Analogos de etomidato con propiedades farmacocineticas y farmacodinamicas mejoradas. |
| WO2010000282A1 (fr) * | 2008-07-03 | 2010-01-07 | Cilag Ag | Procédé de fabrication de sels de n-phényl-n-(4-pipéridinyl)amide |
| WO2010053944A1 (fr) * | 2008-11-04 | 2010-05-14 | Cambrex Charles City, Inc. | Procédé amélioré de fabrication de dérivés de la pipéridine |
| BR112012000606A2 (pt) | 2009-07-10 | 2016-11-22 | Brigham & Womens Hospital | análogos de etomidato que não inibem a síntese de esteróides adrenocorticais |
| EP2450039A1 (fr) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam) |
| IN2014DN06132A (fr) | 2012-01-13 | 2015-08-14 | Gen Hospital Corp | |
| KR20150065873A (ko) | 2012-10-08 | 2015-06-15 | 오클랜드 유니서비시즈 리미티드 | 케타민 유도체 |
| AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
| CN103728403B (zh) * | 2013-08-30 | 2015-10-07 | 宜昌人福药业有限责任公司 | 一种盐酸瑞芬太尼原料药中有关物质的检测方法 |
| EP3199523B1 (fr) | 2016-01-29 | 2018-08-15 | Bioka s. r.o. | Le nouveau procédé de production de n-phényl-n- (4-pipéridinyl) des dérivés d'amides tels que le rémifentanil et carfentanil |
| PL3643704T3 (pl) | 2018-10-26 | 2021-06-14 | Hameln Pharma Gmbh | Nowe produkty pośrednie do wytwarzania chlorowodorku remifentanilu |
| GB202010168D0 (en) | 2020-07-02 | 2020-08-19 | Johnson Matthey Plc | Process for preparing remifentanil hydrochloride |
| CN114262320A (zh) * | 2021-12-28 | 2022-04-01 | 宜昌人福药业有限责任公司 | 一种利用连续流微通道反应器制备苯胺基哌啶类药物的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL284196A (fr) * | 1961-10-10 | |||
| US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
| US3998834A (en) * | 1975-03-14 | 1976-12-21 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-n-phenylamides and -carbamates |
| US4179569A (en) * | 1975-03-14 | 1979-12-18 | Janssen Pharmaceutica N.V. | N-(4-piperidinyl)-N-phenylamides |
| US4167574A (en) * | 1978-03-13 | 1979-09-11 | Janssen Pharmaceutica, N.V. | N-phenyl-N-(4-piperidinyl)amides |
| US4584303A (en) * | 1984-04-09 | 1986-04-22 | The Boc Group, Inc. | N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds |
| US4801721A (en) * | 1984-08-16 | 1989-01-31 | Ryan James W | Stereospecific synthesis of carboxyalkyl peptides |
| CA1317940C (fr) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | N-(1-alkyl-3-hydroxy-4-piperidinyl) benzamides a substituant |
-
1989
- 1989-12-11 US US07/448,497 patent/US5019583A/en not_active Expired - Lifetime
-
1990
- 1990-02-14 SG SG1996005735A patent/SG47967A1/en unknown
- 1990-02-14 PT PT93137A patent/PT93137B/pt not_active IP Right Cessation
- 1990-02-14 KR KR1019900001796A patent/KR0160979B1/ko not_active Expired - Lifetime
- 1990-02-14 JP JP2031680A patent/JP2895145B2/ja not_active Expired - Lifetime
- 1990-02-14 IE IE53290A patent/IE77156B1/en not_active IP Right Cessation
- 1990-02-14 EP EP90301586A patent/EP0383579B1/fr not_active Expired - Lifetime
- 1990-02-14 DE DE69027794T patent/DE69027794T2/de not_active Expired - Lifetime
- 1990-02-14 AT AT90301586T patent/ATE140451T1/de active
- 1990-02-14 AU AU49731/90A patent/AU636330B2/en not_active Expired
- 1990-02-14 CA CA002010011A patent/CA2010011C/fr not_active Expired - Fee Related
- 1990-02-14 ES ES90301586T patent/ES2088961T4/es not_active Expired - Lifetime
- 1990-02-14 NZ NZ232542A patent/NZ232542A/en unknown
- 1990-02-14 DK DK90301586.5T patent/DK0383579T3/da active
- 1990-02-14 DE DE1996175028 patent/DE19675028I2/de active Active
-
1991
- 1991-12-23 SK SK4025-91A patent/SK402591A3/sk unknown
- 1991-12-23 CZ CS914025A patent/CZ402591A3/cs unknown
-
1992
- 1992-06-19 MX MX9203024A patent/MX9203024A/es unknown
-
1996
- 1996-08-02 GR GR960402083T patent/GR3020719T3/el unknown
- 1996-11-21 NL NL960030C patent/NL960030I2/nl unknown
-
1997
- 1997-01-24 LU LU90011C patent/LU90011I2/fr unknown
- 1997-06-12 HK HK78297A patent/HK78297A/en not_active IP Right Cessation
- 1997-12-05 CY CY200297A patent/CY2002A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3020719T3 (en) | 1996-11-30 |
| US5019583A (en) | 1991-05-28 |
| EP0383579B1 (fr) | 1996-07-17 |
| CA2010011A1 (fr) | 1990-08-15 |
| ATE140451T1 (de) | 1996-08-15 |
| ES2088961T4 (es) | 1996-12-01 |
| CZ402591A3 (en) | 1993-04-14 |
| IE77156B1 (en) | 1997-12-03 |
| AU4973190A (en) | 1990-08-23 |
| SK402591A3 (en) | 2000-09-12 |
| NL960030I2 (nl) | 1997-05-01 |
| DE19675028I2 (de) | 2002-11-07 |
| ES2088961T3 (es) | 1996-10-01 |
| KR0160979B1 (ko) | 1998-12-01 |
| HK78297A (en) | 1997-06-20 |
| CA2010011C (fr) | 1997-12-02 |
| AU636330B2 (en) | 1993-04-29 |
| MX9203024A (es) | 1992-07-01 |
| KR900012906A (ko) | 1990-09-03 |
| CY2002A (en) | 1997-12-05 |
| DE69027794T2 (de) | 1997-01-02 |
| DK0383579T3 (da) | 1996-10-14 |
| EP0383579A1 (fr) | 1990-08-22 |
| SG47967A1 (en) | 1998-04-17 |
| IE900532L (en) | 1990-08-15 |
| PT93137A (pt) | 1990-08-31 |
| JPH02300167A (ja) | 1990-12-12 |
| NL960030I1 (nl) | 1997-02-03 |
| NZ232542A (en) | 1992-06-25 |
| DE69027794D1 (de) | 1996-08-22 |
| JP2895145B2 (ja) | 1999-05-24 |
| PT93137B (pt) | 1996-02-29 |
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