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LU90736I2 - Agenerase-amprenavir et ses d-riv-s pharmaceutiquement acceptables - Google Patents

Agenerase-amprenavir et ses d-riv-s pharmaceutiquement acceptables

Info

Publication number
LU90736I2
LU90736I2 LU90736C LU90736C LU90736I2 LU 90736 I2 LU90736 I2 LU 90736I2 LU 90736 C LU90736 C LU 90736C LU 90736 C LU90736 C LU 90736C LU 90736 I2 LU90736 I2 LU 90736I2
Authority
LU
Luxembourg
Prior art keywords
agenerase
amprenavir
pharmaceutically acceptable
acceptable derivatives
derivatives
Prior art date
Application number
LU90736C
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of LU90736I2 publication Critical patent/LU90736I2/fr

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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LU90736C 1992-09-08 2001-03-07 Agenerase-amprenavir et ses d-riv-s pharmaceutiquement acceptables LU90736I2 (fr)

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KR100296463B1 (ko) * 1992-08-25 2001-10-24 죤 에이치. 뷰센 레트로바이러스프로테아제저해제로서유용한히드록시에틸아미노술폰아미드
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5583132A (en) * 1992-10-30 1996-12-10 Vazquez; Michael L. Sulfonylalkanoylamino hydroxyethylamino sulfamic acids useful as retroviral protease inhibitors
ATE167669T1 (de) * 1992-10-30 1998-07-15 Searle & Co Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen
WO1994018192A1 (fr) * 1993-02-12 1994-08-18 Merck & Co., Inc. Derives de piperazine utiles comme inhibiteurs de la protease du vih
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JPH08501299A (ja) 1996-02-13
ES2200243T3 (es) 2004-03-01
IS2334B (is) 2008-02-15
PT885887E (pt) 2003-10-31
HK1023561A1 (en) 2000-09-15
DE10199024I2 (de) 2006-04-06
CA2143208A1 (fr) 1994-03-17
EP0885887B1 (fr) 2003-05-28
CA2143208C (fr) 2003-01-07
US6372778B1 (en) 2002-04-16
SK29395A3 (en) 1995-09-13
ATE178598T1 (de) 1999-04-15
US20100210603A1 (en) 2010-08-19
HU9500685D0 (en) 1995-04-28
NL300039I2 (nl) 2001-09-03
NO950876L (no) 1995-05-08
NZ314376A (en) 1998-10-28
BG62488B1 (bg) 1999-12-30
PH31251A (en) 1998-05-05
MY142901A (en) 2011-01-31
MXPA03010538A (es) 2011-12-16
ES2131589T3 (es) 1999-08-01
US5585397A (en) 1996-12-17
BR1100824A (pt) 1999-08-31
RU95109928A (ru) 1997-03-20
US20080293727A1 (en) 2008-11-27
NZ256238A (en) 1997-04-24
CZ289475B6 (cs) 2002-01-16
CN1061339C (zh) 2001-01-31
KR100262056B1 (ko) 2000-07-15
PL307858A1 (en) 1995-06-26
UA44694C2 (uk) 2002-03-15
DE69333012T2 (de) 2004-04-01
HU228198B1 (en) 2013-01-28
EP0659181B1 (fr) 1999-04-07
LTIP917A (en) 1994-11-25
NO303444B1 (no) 1998-07-13
DE69324369D1 (de) 1999-05-12
US7608632B2 (en) 2009-10-27
NO950876D0 (no) 1995-03-07
CN1087347A (zh) 1994-06-01
IL106927A0 (en) 1993-12-28
AU691160B2 (en) 1998-05-14
NO2001012I1 (no) 2001-07-23
IL106927A (en) 2001-01-11
RO118747B1 (ro) 2003-10-30
EP0885887A3 (fr) 1999-02-03
AP390A (en) 1995-08-02
EP0885887A2 (fr) 1998-12-23
DK0659181T3 (da) 1999-10-18
HK1012631A1 (en) 1999-08-06
LT3302B (en) 1995-06-26
US20030069222A1 (en) 2003-04-10
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CZ58795A3 (en) 1995-12-13
FI951059L (fi) 1995-04-18
US5856353A (en) 1999-01-05
SK281360B6 (sk) 2001-02-12
HUT71892A (en) 1996-02-28
GR3030719T3 (en) 1999-11-30
WO1994005639A1 (fr) 1994-03-17
AU4852093A (en) 1994-03-29
EP0659181A1 (fr) 1995-06-28
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PL185635B1 (pl) 2003-06-30
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SG43862A1 (en) 1997-11-14
DE69324369T2 (de) 1999-08-26
GEP20012579B (en) 2001-11-26
TW254927B (fr) 1995-08-21
CO4870779A1 (es) 1999-12-27
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DE69333012D1 (de) 2003-07-03
ATE241602T1 (de) 2003-06-15

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