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LU88248A1 - Derives de l'indole - Google Patents

Derives de l'indole Download PDF

Info

Publication number
LU88248A1
LU88248A1 LU88248A LU88248A LU88248A1 LU 88248 A1 LU88248 A1 LU 88248A1 LU 88248 A LU88248 A LU 88248A LU 88248 A LU88248 A LU 88248A LU 88248 A1 LU88248 A1 LU 88248A1
Authority
LU
Luxembourg
Prior art keywords
compound
compound according
metabolically labile
formula
salt
Prior art date
Application number
LU88248A
Other languages
English (en)
French (fr)
Inventor
Cugola Alfredo
Gaviraghi Giovanni
Original Assignee
Glaxo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Spa filed Critical Glaxo Spa
Publication of LU88248A1 publication Critical patent/LU88248A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
LU88248A 1992-04-16 1993-04-15 Derives de l'indole LU88248A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9208492 1992-04-16
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
LU88248A1 true LU88248A1 (fr) 1994-03-01

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
LU88248A LU88248A1 (fr) 1992-04-16 1993-04-15 Derives de l'indole

Country Status (41)

Country Link
US (4) US5374649A (hu)
EP (1) EP0568136A1 (hu)
JP (2) JPH07505407A (hu)
KR (1) KR100264114B1 (hu)
CN (1) CN1042331C (hu)
AP (1) AP480A (hu)
AT (1) AT403917B (hu)
AU (1) AU666927B2 (hu)
BE (1) BE1006343A5 (hu)
BG (1) BG62136B1 (hu)
BR (1) BR1100323A (hu)
CA (3) CA2094076A1 (hu)
CH (1) CH685630A5 (hu)
CY (1) CY2038B1 (hu)
CZ (1) CZ285799B6 (hu)
DK (1) DK169890B1 (hu)
ES (1) ES2105924B1 (hu)
FI (1) FI106198B (hu)
FR (1) FR2690919B1 (hu)
GB (2) GB9208492D0 (hu)
GE (1) GEP19991704B (hu)
GR (1) GR1001619B (hu)
HK (1) HK95797A (hu)
HU (2) HU217964B (hu)
IL (1) IL105412A (hu)
IS (1) IS3994A (hu)
IT (1) IT1265325B1 (hu)
LU (1) LU88248A1 (hu)
MX (1) MX9302195A (hu)
MY (1) MY112232A (hu)
NO (1) NO301879B1 (hu)
NZ (1) NZ247413A (hu)
OA (1) OA10103A (hu)
PL (1) PL176451B1 (hu)
RO (1) RO113242B1 (hu)
RU (1) RU2129544C1 (hu)
SE (1) SE504336C2 (hu)
SK (1) SK281941B6 (hu)
TW (1) TW224457B (hu)
WO (1) WO1993021153A1 (hu)
ZA (1) ZA932642B (hu)

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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
KR100314482B1 (ko) * 1993-05-27 2002-02-28 메렐 파마슈티칼스 인크. 3-(인돌-3-일)프로페노산유도체
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (hu) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
AU4416197A (en) * 1996-09-17 1998-04-14 Regents Of The University Of California, The Positive ampa receptor modulation to enhance brain neurotrophic factor expression
JP2001501221A (ja) * 1996-09-30 2001-01-30 ヘキスト・マリオン・ルセル・インコーポレイテツド Ｎｍｄａ（ｎ―メチル―ｄ―アスパラギン酸）アンタゴニスト
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
JP3714970B2 (ja) * 1998-03-26 2005-11-09 アステラス製薬株式会社 徐放性製剤
PL363870A1 (en) * 2000-07-31 2004-11-29 Dainippon Pharmaceutical Co, Ltd. Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
WO2003039540A2 (en) * 2001-11-09 2003-05-15 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
US7582657B2 (en) * 2001-12-10 2009-09-01 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
CA2528065A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
DE602004028150D1 (de) * 2003-11-26 2010-08-26 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
BRPI0418244A (pt) * 2003-12-29 2007-04-17 Sepracor Inc composto, métodos para aumentar a concentração de d-serina e/ou diminuir a concentração de produtos tóxicos da oxidação de d-serina pela daao em um mamìfero, para tratar a esquizofrenia, para tratar ou prevenir a perda de memória e/ou cognição associadas com o mal de alzheimer, para tratar a ataxia ou para prevenir a perda da função neuronal caracterìstica de doenças neurodegenerativas, para intensificar a aprendizagem, memória e/ou cognição e para tratar dor neuropática, e, composição farmacêutica
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
KR101381768B1 (ko) * 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
CA2636324C (en) 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
AU2008206039A1 (en) 2007-01-18 2008-07-24 Sepracor Inc. Inhibitors of D-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
KR101581289B1 (ko) 2007-05-31 2015-12-31 세프라코 아이엔시. 모노아민 재흡수 억제제로서 페닐 치환된 시클로알킬아민
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2010104093A1 (ja) 2009-03-10 2010-09-16 参天製薬株式会社 ４，６－ジクロロ－１ｈ－インドール－２－カルボン酸誘導体又はその塩を有効成分として含有する視神経障害の予防又は治療剤
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
KR102537686B1 (ko) 2014-04-30 2023-05-30 위펑 제인 쳉 D-아미노산 옥시다제 억제제로서 공지된 화합물의 용도
CN110234635B (zh) 2016-09-14 2023-03-10 宇凤·简·曾 作为d-胺基酸氧化酶(daao)抑制剂之新颖经取代苯并咪唑衍生物
AU2018284335A1 (en) 2017-06-12 2020-01-30 Glytech Llc. Treatment of depression with NMDA antagonists and D2/5HT2A or selective 5HT2A antagonists
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
JPH0347123A (ja) * 1989-05-05 1991-02-28 G D Searle & Co インドール―２―カルボキシレート化合物類を含有するｃｎｓ疾患治療用組成物
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US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
NZ247413A (en) 1995-12-21
PL176451B1 (pl) 1999-05-31
SK281941B6 (sk) 2001-09-11
GB2266091A (en) 1993-10-20
CN1085212A (zh) 1994-04-13
CY2038B1 (en) 1998-04-30
IL105412A (en) 1998-02-22
HUT70526A (en) 1995-10-30
GB9208492D0 (en) 1992-06-03
NO943913D0 (no) 1994-10-14
RO113242B1 (ro) 1998-05-29
CZ254394A3 (en) 1995-07-12
GEP19991704B (en) 1999-08-05
US5510367A (en) 1996-04-23
ZA932642B (en) 1994-01-10
JPH07505407A (ja) 1995-06-15
AT403917B (de) 1998-06-25
US5373018A (en) 1994-12-13
DK169890B1 (da) 1995-03-27
FI944800A0 (fi) 1994-10-12
IL105412A0 (en) 1993-08-18
CH685630A5 (fr) 1995-08-31
NO301879B1 (no) 1997-12-22
FR2690919A1 (fr) 1993-11-12
EP0568136A1 (en) 1993-11-03
SE504336C2 (sv) 1997-01-13
MX9302195A (es) 1994-03-31
US5374649A (en) 1994-12-20
HK95797A (en) 1997-08-08
KR100264114B1 (ko) 2000-11-01
CA2094075A1 (en) 1993-10-17
OA10103A (en) 1996-12-18
CA2094076A1 (en) 1993-10-17
JPH0649027A (ja) 1994-02-22
AP480A (en) 1996-03-22
ATA75293A (de) 1997-11-15
GR1001619B (el) 1994-07-29
BE1006343A5 (fr) 1994-07-26
HU9402975D0 (en) 1995-02-28
HU211826A9 (en) 1995-12-28
DK43193A (da) 1993-10-17
HU217964B (hu) 2000-05-28
SE9301241L (sv) 1993-10-17
CA2094073A1 (en) 1993-10-17
CZ285799B6 (cs) 1999-11-17
RU94045915A (ru) 1996-09-10
NO943913L (no) 1994-12-14
SE9301241D0 (sv) 1993-04-15
FI944800L (fi) 1994-10-12
AU666927B2 (en) 1996-02-29
IT1265325B1 (it) 1996-10-31
US5374648A (en) 1994-12-20
CN1042331C (zh) 1999-03-03
BG99111A (bg) 1995-05-31
SK124194A3 (en) 1995-05-10
FR2690919B1 (fr) 1995-05-05
IS3994A (is) 1993-10-17
MY112232A (en) 2001-05-31
WO1993021153A1 (en) 1993-10-28
ES2105924B1 (es) 1998-07-01
TW224457B (hu) 1994-06-01
ES2105924A1 (es) 1997-10-16
BG62136B1 (bg) 1999-03-31
BR1100323A (pt) 2000-06-27
ITRM930236A0 (it) 1993-04-15
AP9300524A0 (en) 1993-04-30
GB9307808D0 (en) 1993-06-02
DK43193D0 (da) 1993-04-15
RU2129544C1 (ru) 1999-04-27
FI106198B (fi) 2000-12-15
ITRM930236A1 (it) 1994-10-15
GB2266091B (en) 1995-08-09
AU3692393A (en) 1993-10-21

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