LU87145A1 - METHOD FOR IMPROVING THE AESTHETIC APPEARANCE OF THE SKIN USING POLYVITAMIN MIXTURES - Google Patents

Abstract

Method for improving the aesthetic aspect of the skin comprises applying daily to the skin a cosmetic compsn contg a mixt of vitamins in a vehicle suitable for a topical applicn and administering orally and daily a prepn also contg a mixt of vehicles in a vehicle suitable for such administration, the method being continued until the desired result is reached. Pref. the method is effected: for 3-5 weeks and pref the compsn. contains a mixt of vitamins E A, B2, B5 and H, and pref. it also contains Vitamins F, D, B6 and/or folic acid.

Description

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The present invention relates to a method for improving the aesthetic appearance of the skin, in particular of the face, using polyvitamin combinations.

It is known that certain balanced combinations of vitamins make it possible to treat subjects with a deficiency in the general condition due to physical or intellectual fatigue, overwork or even an unbalanced diet. In addition, such vitamin-based treatments are particularly recommended during growth or pregnancy and during convalescence.

These mixtures of vitamins which can also be associated with mineral salts and trace elements contain, at therapeutically active doses, essentially the following vitamins: A, D2, Bl, B2, B5, B6, C and E as well as acid nicotinic (vitamin PP) and biotin (vitamin H).

It is also known, following numerous scientific studies, that the skin is a tissue particularly sensitive to nutritional deficiencies of vitamins. The deficiency of vitamins of group B, in particular of vitamins B1, B2 and B6 as well as the deficiency of vitamins C and A cause skin disorders which are manifested mainly by a rough appearance of the skin, an absence of elasticity and a lack of 'shine.

In order to remedy these manifestations, cosmetic compositions have been proposed based on certain fat-soluble as well as water-soluble vitamins insofar as these were sufficiently stable.

Pantothenic acid (vitamin B5) has also been proposed to have a beneficial effect on the skin, although there is no definite evidence of penetration through the epidermis.

These additional vitamin intakes, either orally or topically, are generally not sufficiently balanced in the various vitamins so that the treatments based on polyvitamin compositions do not make it possible to improve the aesthetic appearance of the skin, in particular of the face. .

Following numerous studies carried out in this field, it has been found, quite surprisingly and unexpectedly, that particularly favorable results with regard to the aesthetic appearance of the skin can be obtained by simultaneously combining treatment by topical route and by orally using certain appropriate mixtures of vitamins.

The results obtained in fact made it possible to demonstrate that the treatment according to the invention particularly significantly improved the appearance of the skin, the latter being smoother, softer and more supple on to touch.

Furthermore, it has been found that the people thus treated generally had a face with more radiance and that, moreover, the skin had better resistance to external aggressions.

A subject of the present invention is therefore a method for improving the aesthetic appearance of the skin, this method consisting in applying daily to the skin a cosmetic composition containing a mixture of vitamins in a vehicle suitable for topical application and in administering daily by oral route, a preparation also containing a mixture of vitamins in a vehicle suitable for such administration, said method being continued until the aesthetic appearance of the skin is improved,

The implementation of the method according to the invention does not imply any particular order of the two operations on the sole condition however that each of them is carried out daily during the treatment.

Particularly noticeable results both on sight and on touch are usually obtained after a period of three to five weeks.

In order not to lose the benefit of the effects obtained, it is particularly recommended to continue the treatment in the form of a maintenance treatment for a period of 3 to 4 weeks or less once a year and preferably 2 to 3 times per year.

The mixture of vitamins of the cosmetic composition administered topically, essentially consists of vitamins E, A, B2, B5 and H.

Vitamin A or retinol is present between 0.005 and. 0.5% by weight and preferably between 0.15 and 0.35%.

Vitamin E or ^ -tocopherol, preferably in the form of acetate of ^ -tocopherol, is generally present between 0.3 and 4% by weight and preferably between 1.5 and 3%.

Vitamin B2 or riboflavin, in the form of its sodium salt of the 5 * phosphate derivative, is present between 0.001 and 0.01% and preferably between 0.002 and 0.008%.

Vitamin B5 or pantothenic acid, preferably in the form of calcium or sodium D-pantothenate, is present between 0.5 and 3% and preferably between 1 and 2%.

Vitamin H or biotin is present between 0.01 and 0.05% and preferably between 0.015 and 0.03%.

These different percentages are here expressed relative to the total weight of the cosmetic composition.

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The studies that have been carried out have made it possible to highlight the importance of these various vitamins with a view to the desired cosmetic effect.

The cosmetic composition can be in various forms allowing convenient application of the composition to the skin, in particular to the face.

Thus this can be for example a cream, a milk or an emulsion of the oil-in-water or water-in-1 oil type.

It should be understood that the vehicle of the composition has no harmful effect on the stability of the mixture of vitamins.

The emulsifiers of these compositions are generally between 1 and 20% and preferably between 2 and 12% by weight relative to the total weight of the composition.

Among the various emulsifying agents which can be used, mention may in particular be made of: ethylene, polyoxyethylenated stearyl alcohol from 10 to 20 moles of ethylene oxide, polyglycerolated oleic alcohol to 4 moles of glycerol and synthetic fatty alcohols in CC. polyoxyethylenated from 5 to 10 moles of ethylene oxide and 15, alkyl sulphates oxyethylenated or not, such as sodium lauryl sulfate, ammonium lauryl sulfate, sodium cetyl stearyl sulfate, cetyl stearyl sulfate of triethanolamine, monoethanolamine lauryl sulfate, oxyethylenated sodium lauryl ether sulfate (with 2.2 moles of ethylene oxide for example) and oxyethylenated monoethanolamine lauryl ether sulfate (with 2.2 moles of oxide of ethylene for example), and soaps such as triethanolamine stearate.

One can also mention the emulsifying system consisting of magnesium lanolate and lanolin alcohol and / or hydrogenated lanolin.

The water phase of the emulsions may optionally contain gelling agents such as, for example, hydroxypropyl methylcellulose. The oil phase consisting of at least one oil and optionally at least one wax varies between approximately 8 and 50% by weight relative to the total weight of the composition.

Among the fatty products constituting the fatty phase of these compositions, there may be mentioned: -4- r - hydrocarbon oils such as paraffin oil, purcellin oil, perhydrosqualene and solutions of microcrystalline waxes in oils, - animal or vegetable oils such as sweet almond oil, avocado oil, calophyllum oil, lanolin, castor oil, horse oil, pork oil, sesame oil, olive oil, jojoba oil, shea oil, hoplostethus oil, sunflower oil, - mineral oils whose initial point of distillation at atmospheric pressure is about 250 ° C and the end point of the order of 410 ° C, - saturated or unsaturated esters such as alkyl myristates such as those of isopropyl, butyl or cetyl, hexadecyl stearate, ethyl or isopropyl palmitates, triglycerides of octanoic and decanoic acids and cetyl ricinoleate.

The cosmetic composition may also contain vitamins other than those listed, in particular vitamin F (essential fatty acids), vitamin D, vitamin B6, or even folic acid as well as other substances for the maintenance and improvement of the properties of the skin such as for example humectants, revitalizing agents and protein derivatives.

According to a particular embodiment, the cosmetic composition contains between 0.005 and 0.025% of folic acid and preferably between 0.0075 and 0.015%.

Certain vitamins, in particular water-soluble vitamins, can be incorporated into micro-dispersions of the liposome type.

Furthermore, the composition may also contain dyes, perfumes, sunscreens, antioxidants as well as preservatives such as methyl parahydroxybenzoate or propyl parahydroxybenzoate.

It is preferable to apply the cosmetic composition by carrying out a light massage in order to make it penetrate well, this application being preferably carried out in the evening so as to leave it to act well and to penetrate the composition during the night.

The following cosmetic compositions have been shown to be particularly favorable in the method for improving the aesthetic appearance of the skin according to the invention: r -5- l 1) Cream of the water-in-oil type Vitamin mixtures:

Vitamin E .............. 1.5%

Vitamin A ................................... 0.3%

Vitamin B2 .................................. 0.003%

Vitamin B5 .................................. 1%

Vitamin H ................................... 0.02%

Vitamin F ................................... 2%

Folic acid ................................ 0.008%

Magnesium lanolate ............................. 7%

Lanolin alcohol ................................ 3%

Isopropyl myristate ............................ 8%

Sunflower oil ................................ 30%

Vaseline .................. 10%

Methyl parahydroxybenzoate .................... 0.2%

Propyl parahydroxybenzoate .................... 0.1%

Water qs ........................................ 100% * 2) Emulsion of the type oil-in-water Mixtures of vitamins.

Vitamin E ................................... 3%

Vitamin A ................................... 0.2%

Vitamin B2 .................................. 0.007%

Vitamin B5 .................................. 2%

Vitamin H ................................... 0.03%

Folic acid, ............................... 0.015%

Perhydrosqualene .................................. 10%

Polyethylene glycol 400 ............................ 3%

Propylene glycol ................................... 4%

Triethanolamine ................................... 0.6%

Sweet almond oil .............................. 2%

Isopropyl myristate ............................ 1%

Esters of capric and caprylic acids and fatty alcohol C10-C10 ....................... 1% per io

Cetyl alcohol .................................. 0.5%

Stearic acid ................................... 3% -6- w l

Non-self-emulsifiable glycerol mono- and di-stearate .................................... 3%

Perfume ............................................ 0.1%

Preservatives ..................................... 0.2%

Water qs .............................. 100% 3) Oil-in-lt water type milk Vitamin mixtures .

Vitamin E ................................... 2%

Vitamin A ................................... 0.15%

Vitamin B2 ............. 0.002%

Vitamin B5 .................................. 2%

Vitamin H ................................... 0.015%

Shea oil ................................... 3%

Vaseline oil ................................. 8%

Glycerol stearate .............................. 2%

Sorbitan monostearate oxyethylenated with 20 moles of ethylene oxide (Tween 60) ..................... 1%

Stearic acid ................................... 1.4%

Sorted thano laminate ................................... 0.7%

Carbopol 940 (neutralized) ......................... 0.2%

Butylhydroxyanisol / butylhydroxytoluene (50/50) ...... 0.1%

Perfume ............................................ 1%

Water + preservatives q.s.p ....................... 100% 4) Milk of the oil-in-1 type water

Vitamin E ..., .............................. 2.50%

Vitamin A ............................... 0.35%

Vitamin B2 ........................ 0.008%

Vitamin B5 ................................. 1.50%

Vitamin H .................................. 0.02%

Sorbitan sesquioleate ...................... 2.00%

Oxyethylenated glycerol stearate with 20 moles of ethylene oxide ........ 2.00%

Cetyl alcohol ................................. 1.00%

Vaseline oil ............................ 10.00% τ -7- r

Jojoba oil ............. 2.00%

Carbopol 940 ..................................... 0.20%

Triethanolamine .................................. 0.20%

Perfume ........................... 1.00%

Methyl parahydroxybenzoate ................... 0.30%

Sterile demineralized water q.s.p .................. 100%

The polyvitamin preparation which is administered orally according to the method of the invention, essentially consists of a mixture of vitamins E, A, B2, B5, H, B1 and C.

As can be seen, the oral preparation and the cosmetic composition are essentially characterized by the presence of certain same vitamins, namely vitamins A, E, B2, B5 and H.

Vitamin A is preferably administered orally in the form of Provitamin A -carotene).

Vitamin B1 or thiamine is preferably administered in its hydrochloride or nitrate form and vitamin C or L-ascorbic acid in the form of its calcium or sodium salts or also in the form of ascorbyl palmitate.

The daily doses of these vitamins to be administered according to the method of the invention, in one or more doses, are as follows:

Provitamin A -carotene) .................. 1.2 to 7.2mg

Vitamin E .................................. 3.75 to 22.5mg

Vitamin B2 .................................. 0.3 to 2.5mg

Vitamin B5 .................................. 2.5 to 15mg

Vitamin H ................................... 0.075 to 0.45 mg

Vitamin B1 .................................. 0.3 to 2mg

Vitamin C ................................... 20 to 120mg

The oral preparation may also contain other vitamins, in particular vitamin PP, vitamin B6 (pyridoxine hydrochloride), as well as certain mineral elements and trace elements such as for example magnesium glycerophosphate, magnesium citrate, magnesium gluconate, ferrous phosphate, cupric citrate, cupric gluconate, zinc acetate, zinc gluconate, zinc chloride, selenite salts as well as seleniomethionine.

These oral compositions can be in various forms, in particular in the form of tablets, a powder, granules, pills, capsules, capsules or also in the form of a syrup, a suspension, or a solution.

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Among these different forms, those which are particularly preferred, according to the method of the invention, are capsules and capsules.

According to a preferred embodiment, the mixture of vitamins is associated with at least one edible vegetable oil such as for example safflower oil, wheat germ oil, evening primrose oil, borage oil , blackcurrant seed oil, peanut oil, soybean oil or an animal oil of marine origin rich in polyunsaturated fatty acids.

These oils are particularly recommended since they provide linoleic acid as well as% -linolenic acid (essential fatty acids).

The oral preparation can also contain various conventional ingredients such as, for example, fillers, sweeteners, etc.

The following preparations have been shown to be particularly suitable in the method for improving the aesthetic appearance of the skin according to the invention: A - Soft gelatin capsule of 462 mg Composition per capsule:

Peanut oil ............................. 103mg

Hydrogenated soybean oil ..................... 15.0mg

Safflower oil ............................ 85mg ^ -carotene 20% in oily suspension ..... 3.45mg ( 0.69 mg of carotene)

Vitamin E ................................... 7.5mg

Vitamin B1 .................................. 0.780mg

Vitamin B2 ........................ 0.863 mg

Vitamin B5 .................................. 5.0mg

Vitamin H ................................... 0.150mg

Vitamin C (ascorbic acid) ................. 25.0mg

Yeast ........................................ 70,0mg

In order to have the required doses of vitamins, two capsules of 462 mg per day are administered.

B - Soft gelatin capsule of 463mg Composition per capsule:

Wheat germ oil ....................... I68mg

Vitamin E ................................... 15.75mg 3 -carotene 20% in oily suspension. .... 13.8 mg (2.76 mg dej ^> -carotene)

Vitamin B1 .................................. 0.690mg r -9-

Vitamin B2 .................................. 0.660mg

Vitamin B5 ..........., ...................... 10mg

Vitamin H ................................... 0.150mg

Vitamin C (ascorbic acid) ................ 50mg

Folic acid ................................ 0.230mg

Vitamin B6 .................................. 1, Img

Vitamin PP .................................. 7.5mg Selenium (selenium yeast at 1000mcg / g) .. ..... 40mg (40mcg selenium) The administration of a capsule of 463mg per day provides the required doses of vitamins.

C - Suspension ^ -carotene at 20% in oily suspension .... Ij25g (0.25g deg -carotene)

Vitamin Bl, ................................. 0.065g

Vitamin B2 .................................. 0.105g

Vitamin B5 .................................. 0.55g

Vitamin C ................................... 2.5g

Vitamin E ................................... Ig

Vitamin H ................................... 0.005g

Blackcurrant seed oil q.s.p .............. 100ml The administration of 2ml of the suspension per day provides the required doses of vitamins.

Although the method for improving the aesthetic appearance of the skin has been described with reference to certain preferred embodiments, it goes without saying that it can be carried out using other embodiments without as much to leave neither its framework, nor its object.

The present invention also relates to a box, for the implementation of the method according to the invention, this consisting of two parts, the first part being constituted by the cosmetic composition and the second part by the preparation by oral, each part being present in quantities allowing the implementation of the m method for at least 15 days.

Claims (12)

1. Method for improving the aesthetic appearance of the skin, characterized in that it consists in applying daily to the skin a cosmetic composition containing a mixture of vitamins in a vehicle suitable for topical application and for daily administration by the oral preparation also containing a mixture of vitamins in a vehicle suitable for such administration, said method being continued until the appearance of the skin improves, 2. Method according to claim 1, characterized in that it is continued for 3 to 5 weeks due to a daily implementation. 3. Method according to claims 1 and 2, characterized in that the cosmetic composition contains a mixture of vitamins E, A, B2, B5 and H. 4. Method according to any one of claims 1 to 3, characterized in that the cosmetic composition contains the mixture of vitamins in the following weight proportions relative to the total weight of the composition: Vitamin E: between 0.3 and 4% and preferably between 1.5 and 3% Vitamin A: between 0.005 and 0.5% and preferably between 0.15 and 0.35% Vitamin B2: between 0.001 and 0.01% and preferably between 0.002 and 0.008% Vitamin B5: between 0.5 and 3% and preferably between 1 and 2% Vitamin H: between 0.01 and 0.05% and preferably between 0.015 and 0.03% 5. Method according to any one of the preceding claims, characterized in that the cosmetic composition also contains vitamin F, vitamin D, vitamin B6 and / or folic acid. 6. Method according to claim 5, characterized in that the cosmetic composition contains from 0.005 to 0.025% by weight of folic acid and preferably from 0.0075 to 0.015%. 7. Method according to any one of the preceding claims, 1 characterized in that the cosmetic composition is in the form of a cream, a milk or an emulsion. 8. Method according to claim 1, characterized in that the oral preparation contains a mixture of vitamins E, A (Q-carotene), B2, B5, H, B1 and C. 9. Method according to claim 1, characterized in that it consists in administering daily orally the mixture of vitamins in the following doses: '1 ty -n- Vitaraine E ........... ................... 3.75 to 22.5 mg Provitamin A (R -carotene) ............. 1.2 to 7.2mg Vitamin B2 ............................. 0.3 to 2.5mg Vitamin B5 ....... ...................... 2.5 to 15mg Vitamin H ..................... ......... 0.075 to 0.45 mg Vitamin B1 ............................. 0.3 to 2 mg Vitamin C .............................. 20 to 120mg 10. Method according to claim 8, characterized in that the oral preparation also contains vitamin PP and / or vitamin B6 as well as mineral elements and / or trace elements. 11. Method according to any one of claims 1 to 3 and 8 to 11, characterized in that the oral preparation is in the form of capsules or capsules. 12. Box for the implementation of the method according to any one of claims 1 to 11, characterized in that it is in the form of a packaging in two parts, the first part consisting of the cosmetic composition and the second part by the oral preparation, each part being present in amounts allowing the implementation of the method for at least 15 days.