LU86238A1 - Methode pour l'identification d'acides nucleiques - Google Patents

Methode pour l'identification d'acides nucleiques Download PDF

Info

Publication number: LU86238A1
Authority: LU; Luxembourg
Prior art keywords: hybridization; poly; probe; affinity pair; solution
Prior art date: 1985-01-02

Application number

LU86238A

Other languages

English (en)

French (fr)

Inventor

Hans Erik Soederlund

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-02

Filing date

1985-12-30

Publication date

1986-04-14

1985-12-30 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1986-04-14 Publication of LU86238A1 publication Critical patent/LU86238A1/fr

Links

238000000034 method Methods 0.000 title claims description 30
150000007523 nucleic acids Chemical class 0.000 title claims description 25
108020004707 nucleic acids Proteins 0.000 title claims description 23
102000039446 nucleic acids Human genes 0.000 title claims description 23
239000000523 sample Substances 0.000 claims description 51
238000009396 hybridization Methods 0.000 claims description 32
238000001514 detection method Methods 0.000 claims description 14
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 8
108010090804 Streptavidin Proteins 0.000 claims description 5
238000006243 chemical reaction Methods 0.000 claims description 5
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239000000126 substance Substances 0.000 claims description 5
229960002685 biotin Drugs 0.000 claims description 4
235000020958 biotin Nutrition 0.000 claims description 4
239000011616 biotin Substances 0.000 claims description 4
108090001008 Avidin Proteins 0.000 claims description 2
239000000427 antigen Substances 0.000 claims description 2
102000036639 antigens Human genes 0.000 claims description 2
108091007433 antigens Proteins 0.000 claims description 2
229910001385 heavy metal Inorganic materials 0.000 claims description 2
239000002773 nucleotide Substances 0.000 claims 1
125000003729 nucleotide group Chemical group 0.000 claims 1
125000004149 thio group Chemical group *S* 0.000 claims 1
239000000243 solution Substances 0.000 description 21
108020004414 DNA Proteins 0.000 description 19
239000013612 plasmid Substances 0.000 description 13
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
210000004027 cell Anatomy 0.000 description 12
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239000000203 mixture Substances 0.000 description 8
239000012634 fragment Substances 0.000 description 7
238000012360 testing method Methods 0.000 description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
239000000463 material Substances 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
239000001488 sodium phosphate Substances 0.000 description 5
229910000162 sodium phosphate Inorganic materials 0.000 description 5
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
241000701161 unidentified adenovirus Species 0.000 description 5
230000000694 effects Effects 0.000 description 4
239000000872 buffer Substances 0.000 description 3
239000007853 buffer solution Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
241000606153 Chlamydia trachomatis Species 0.000 description 2
108020003215 DNA Probes Proteins 0.000 description 2
239000003298 DNA probe Substances 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
229920002684 Sepharose Polymers 0.000 description 2
238000001042 affinity chromatography Methods 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
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238000007796 conventional method Methods 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
238000011534 incubation Methods 0.000 description 2
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238000011160 research Methods 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 2
238000005406 washing Methods 0.000 description 2
XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
BRLRJZRHRJEWJY-VCOUNFBDSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-[3-[3-(4-azido-2-nitroanilino)propyl-methylamino]propyl]pentanamide Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)NCCCN(C)CCCNC1=CC=C(N=[N+]=[N-])C=C1[N+]([O-])=O BRLRJZRHRJEWJY-VCOUNFBDSA-N 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
102000008857 Ferritin Human genes 0.000 description 1
108050000784 Ferritin Proteins 0.000 description 1
238000008416 Ferritin Methods 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
239000008118 PEG 6000 Substances 0.000 description 1
229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
JGQHTPYIIXRFLR-UHFFFAOYSA-N [2-(9h-fluoren-1-yl)-2-oxoethyl] acetate Chemical class C1C2=CC=CC=C2C2=C1C(C(=O)COC(=O)C)=CC=C2 JGQHTPYIIXRFLR-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
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230000001580 bacterial effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
244000309466 calf Species 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
238000010828 elution Methods 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
238000000605 extraction Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000011521 glass Substances 0.000 description 1
-1 heme compounds Chemical class 0.000 description 1
210000004408 hybridoma Anatomy 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229910052747 lanthanoid Inorganic materials 0.000 description 1
150000002602 lanthanoids Chemical class 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
239000003446 ligand Substances 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
238000007899 nucleic acid hybridization Methods 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108091008146 restriction endonucleases Proteins 0.000 description 1
239000012488 sample solution Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000009210 therapy by ultrasound Methods 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
238000013519 translation Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

LU86238A 1985-01-02 1985-12-30 Methode pour l'identification d'acides nucleiques LU86238A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI850004		1985-01-02
FI850004A FI72146C (fi)	1985-01-02	1985-01-02	Foerfarande foer identifiering av nukleinsyror.

Publications (1)

Publication Number	Publication Date
LU86238A1 true LU86238A1 (fr)	1986-04-14

Family

ID=8520136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86238A LU86238A1 (fr)	1985-01-02	1985-12-30	Methode pour l'identification d'acides nucleiques

Country Status (21)

Country	Link
JP (1)	JPH0669400B2 (fi)
AT (1)	AT397514B (fi)
AU (1)	AU561382B2 (fi)
BE (1)	BE903937A (fi)
CA (1)	CA1271705A (fi)
CH (1)	CH666696A5 (fi)
DE (1)	DE3546312A1 (fi)
DK (1)	DK164932C (fi)
FI (1)	FI72146C (fi)
FR (1)	FR2575493B1 (fi)
GB (1)	GB2169403B (fi)
HU (1)	HU196453B (fi)
IE (1)	IE58290B1 (fi)
IL (1)	IL77489A (fi)
IT (1)	IT1201514B (fi)
LU (1)	LU86238A1 (fi)
NL (1)	NL189427C (fi)
NO (1)	NO166743C (fi)
RO (1)	RO94651B (fi)
SE (1)	SE463212B (fi)
ZA (1)	ZA859895B (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5288609A (en) *	1984-04-27	1994-02-22	Enzo Diagnostics, Inc.	Capture sandwich hybridization method and composition
US6060237A (en) *	1985-02-26	2000-05-09	Biostar, Inc.	Devices and methods for optical detection of nucleic acid hybridization
IL79112A (en) *	1985-06-13	1992-01-15	Abbott Lab	Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
US4910300A (en) *	1985-12-11	1990-03-20	Chiron Corporation	Method for making nucleic acid probes
US4868105A (en) *	1985-12-11	1989-09-19	Chiron Corporation	Solution phase nucleic acid sandwich assay
US4882269A (en) *	1985-12-13	1989-11-21	Princeton University	Amplified hybridization assay
FI76119C (fi) *	1986-02-27	1988-09-09	Orion Yhtymae Oy	Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet.
AU622104B2 (en) *	1987-03-11	1992-04-02	Sangtec Molecular Diagnostics Ab	Method of assaying of nucleic acids, a reagent combination and kit therefore
JPH02503983A (ja) *	1987-06-26	1990-11-22	イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー	捕捉ビーズを用いる組み換えクローン化ｎａからの混入配列のアフイニテイ除去
AU623090B2 (en) *	1987-07-31	1992-05-07	Gen-Probe Incorporated	Assay for polynucleotides employing oligonucleotides to eliminate undesirable cross reactions
EP0305145A3 (en) *	1987-08-24	1990-05-02	Ortho Diagnostic Systems Inc.	Methods and probes for detecting nucleic acids
EP0304845A3 (en) *	1987-08-28	1991-03-06	Profile Diagnostic Sciences Inc.	Method and kit for assaying gene expressions
CA1325761C (en) *	1987-12-25	1994-01-04	Takanori Oka	Method of detecting an intended nucleic acid in a sample
DE3800644A1 (de) *	1988-01-12	1989-07-20	Boehringer Mannheim Gmbh	Verfahren zum hochspezifischen nachweis von nukleinsaeuren in loesung
US5104791A (en) *	1988-02-09	1992-04-14	E. I. Du Pont De Nemours And Company	Particle counting nucleic acid hybridization assays
WO1989010979A1 (en) *	1988-05-10	1989-11-16	E.I. Du Pont De Nemours And Company	Process for rapid nucleic acid detection
US5185243A (en) *	1988-08-25	1993-02-09	Syntex (U.S.A.) Inc.	Method for detection of specific nucleic acid sequences
US5858652A (en) *	1988-08-30	1999-01-12	Abbott Laboratories	Detection and amplification of target nucleic acid sequences
AU629845B2 (en) *	1988-08-30	1992-10-15	Abbott Laboratories	Detection and amplification of target nucleic acid sequences
GB2225112A (en) *	1988-11-22	1990-05-23	Ici Plc	Hybridisation probes
US5082935A (en) *	1988-12-15	1992-01-21	Amoco Corporation	Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination
WO1990008841A1 (en) *	1989-02-06	1990-08-09	Gene-Trak Systems	Probes and methods for the detection of listeria
ATE155821T1 (de) *	1989-03-10	1997-08-15	Vysis Inc	Interferenzverhinderung mit affinitätseinfangschemas
DE69017204T2 (de)	1989-03-10	1995-08-03	Amoco Corp	Immobilisierte oligonukleotidsonden und ihre verwendungen.
AU6075490A (en) *	1989-07-11	1991-02-06	Microprobe Corporation	Quantification of bacteria using a nucleic acid hybridization assay
US5334501A (en) *	1989-07-11	1994-08-02	Microprobe Corporation	Quantification of bacteria using a nucleic acid hybridization assay
GB8924989D0 (en) *	1989-11-06	1989-12-28	Scotgen Ltd	Method and device for the detection of antibiotic resistance
US5580970A (en) *	1989-12-01	1996-12-03	Amoco Corporation	Detection of HPV transcripts
AU7429591A (en) *	1990-04-18	1991-10-24	Gene-Trak Systems	Nucleic acid probes for the detection of giardia lamblia
WO1992015708A1 (en) *	1991-02-27	1992-09-17	Amoco Corporation	Methods for improving the sensitivity of hybridization assays
WO1993020234A1 (en) *	1992-03-31	1993-10-14	E.I. Du Pont De Nemours And Company	A rapid, high capacity nucleic acid based assay
US7713528B1 (en)	1993-02-18	2010-05-11	Enzo Therapeutics, Inc.	Method for in vivo delivery of active compounds using reagent conjugate
RU2146707C1 (ru) *	1996-04-11	2000-03-20	Куликова Валентина Филипповна	Способ выявления анализируемой последовательности нуклеиновых кислот
US5853993A (en) *	1996-10-21	1998-12-29	Hewlett-Packard Company	Signal enhancement method and kit
GB0016833D0 (en)	2000-07-07	2000-08-30	Lee Helen	Improved dipstick assays (2)
US7465540B2 (en)	2000-09-21	2008-12-16	Luminex Corporation	Multiple reporter read-out for bioassays
CN1303221C (zh) *	2003-01-27	2007-03-07	英科新创(厦门)科技有限公司	使用亲和放大的集成信号基团的靶核酸检测法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI63596C (fi) *	1981-10-16	1983-07-11	Orion Yhtymae Oy	Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
FR2518755B1 (fr) *	1981-12-23	1986-04-11	Pasteur Institut	Sonde contenant un acide nucleique modifie et reconnaissable par des anticorps specifiques et utilisation de cette sonde pour detecter et caracteriser une sequence d'adn homologue
GB8306426D0 (en) *	1983-03-09	1983-04-13	Malcolm A D B	Detecting polynucleotide sequence
CA1228811A (en) *	1983-05-05	1987-11-03	Robert G. Pergolizzi	Assay method utilizing polynucleotide sequences
CA1256005A (en) *	1983-09-26	1989-06-20	W. Peter Hansen	Sandwich hybridization method for nucleic acid detection
ZA849594B (en) *	1983-12-12	1985-08-28	Miles Lab	Nucleic acid hybridization assay employing antibodies to intercalation complexes
FR2558172B1 (fr) *	1984-01-16	1986-06-13	Inst Nat Sante Rech Med	Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue
CA1223222A (en) *	1984-02-22	1987-06-23	Nanibhushan Dattagupta	Immobilized nucleic acid-containing probes
FR2560298B1 (fr) *	1984-02-28	1988-07-15	Mors	Procede et dispositif de reglage avec precision de la chute de pression d'un fluide initialement sous pression elevee, tel qu'un fluide hydraulique par exemple alimentant un groupe hydraulique, et application du procede au dispositif dans un groupe ou une centrale hydraulique, en etant integre ou non, notamment a une table de machine ou a tout dispositif de support d'outillage
NZ211453A (en) *	1984-03-22	1989-01-06	Biotechnology Research Enterpr	Aryl azides, their preparation and use in the detection, localisation and isolation of polynucleotides
US4766062A (en) *	1984-05-07	1988-08-23	Allied Corporation	Displacement polynucleotide assay method and polynucleotide complex reagent therefor

1985
- 1985-01-02 FI FI850004A patent/FI72146C/fi not_active IP Right Cessation
- 1985-12-17 CH CH5378/85A patent/CH666696A5/de not_active IP Right Cessation
- 1985-12-20 GB GB08531414A patent/GB2169403B/en not_active Expired
- 1985-12-24 BE BE0/216059A patent/BE903937A/fr not_active IP Right Cessation
- 1985-12-27 NO NO855308A patent/NO166743C/no not_active IP Right Cessation
- 1985-12-27 JP JP60299797A patent/JPH0669400B2/ja not_active Expired - Lifetime
- 1985-12-29 HU HU855030A patent/HU196453B/hu unknown
- 1985-12-30 LU LU86238A patent/LU86238A1/fr unknown
- 1985-12-30 AT AT0376785A patent/AT397514B/de not_active IP Right Cessation
- 1985-12-30 DE DE19853546312 patent/DE3546312A1/de active Granted
- 1985-12-30 FR FR858519394A patent/FR2575493B1/fr not_active Expired - Lifetime
- 1985-12-30 ZA ZA859895A patent/ZA859895B/xx unknown
- 1985-12-30 RO RO121637A patent/RO94651B/ro unknown
- 1985-12-30 IT IT23408/85A patent/IT1201514B/it active
- 1985-12-31 NL NLAANVRAGE8503597,A patent/NL189427C/xx not_active IP Right Cessation
- 1985-12-31 IL IL77489A patent/IL77489A/xx not_active IP Right Cessation
- 1985-12-31 IE IE333385A patent/IE58290B1/en not_active IP Right Cessation
- 1985-12-31 AU AU51748/85A patent/AU561382B2/en not_active Expired
- 1985-12-31 CA CA000498834A patent/CA1271705A/en not_active Expired - Lifetime
1986
- 1986-01-02 DK DK000386A patent/DK164932C/da not_active IP Right Cessation
- 1986-01-02 SE SE8600011A patent/SE463212B/sv not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2575493B1 (fr)	1990-01-26
JPS61185200A (ja)	1986-08-18
IE58290B1 (en)	1993-08-25
FI72146C (fi)	1987-04-13
DE3546312C2 (fi)	1992-08-06
AU5174885A (en)	1986-07-17
DK164932C (da)	1993-01-25
HUT40166A (en)	1986-11-28
DK386D0 (da)	1986-01-02
HU196453B (en)	1988-11-28
DK386A (da)	1986-07-03
NL189427C (nl)	1993-04-01
NO166743C (no)	1991-08-28
NL8503597A (nl)	1986-08-01
SE8600011D0 (sv)	1986-01-02
JPH0669400B2 (ja)	1994-09-07
BE903937A (fr)	1986-04-16
FI72146B (fi)	1986-12-31
FI850004A0 (fi)	1985-01-02
DK164932B (da)	1992-09-07
RO94651B (ro)	1988-07-01
ZA859895B (en)	1986-08-27
IT8523408A0 (it)	1985-12-30
RO94651A (ro)	1988-06-30
GB2169403A (en)	1986-07-09
IL77489A (en)	1991-01-31
GB2169403B (en)	1988-06-08
GB8531414D0 (en)	1986-02-05
NL189427B (nl)	1992-11-02
CH666696A5 (de)	1988-08-15
AU561382B2 (en)	1987-05-07
CA1271705A (en)	1990-07-17
ATA376785A (de)	1993-09-15
IT1201514B (it)	1989-02-02
NO855308L (no)	1986-07-03
DE3546312A1 (de)	1986-07-10
SE8600011L (sv)	1986-07-03
IE853333L (en)	1986-07-02
AT397514B (de)	1994-04-25
FI850004L (fi)	1986-07-03
NO166743B (no)	1991-05-21
FR2575493A1 (fr)	1986-07-04
SE463212B (sv)	1990-10-22

Publication	Publication Date	Title
LU86238A1 (fr)	1986-04-14	Methode pour l'identification d'acides nucleiques
BE1003990A5 (fr)	1992-07-28	Methode pour le dosage d'acides nucleiques, combinaison de reactifs et trousse pour doser ces acides.
EP0486661B1 (fr)	1996-02-07	Procede de detection d'une sequence nucleotidique selon la technique d'hybridation sandwich
US4563417A (en)	1986-01-07	Nucleic acid hybridization assay employing antibodies to intercalation complexes
CA1272443A (en)	1990-08-07	Solution-phase dual hybridization assay for detecting polynucleotide sequences
KR0171617B1 (ko)	1999-05-01	단백질-핵산 프로브 및 그를 사용하는 면역분석법
CA1201670A (fr)	1986-03-11	Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines
FI86311B (fi)	1992-04-30	Hybridiseringsbestaemning av nukleinsyror medelst anvaendning av detekterbara antihybridantikroppar.
US4562159A (en)	1985-12-31	Diagnostic test for hepatitis B virus
CA2031659A1 (en)	1991-07-27	Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods
JPH05508323A (ja)	1993-11-25	蛍光分極によるｄｎａ／ｒｎａの検出
EP0146815B1 (en)	1990-08-16	Nucleic acid hybridization assay employing antibodies to intercalation complexes
Stark et al.	1996	Immunomagnetic separation and solid-phase detection of Bordetella pertussis
WO2020130627A1 (ko)	2020-06-25	황열 바이러스 ediii에 특이적으로 결합하는 dna 압타머 및 이의 용도
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JPS611388A (ja)	1986-01-07	ヌクレオチド雑種形成プローブ
JPH0531108B2 (fi)	1993-05-11
WO2019059643A1 (ko)	2019-03-28	Cfp10에 특이적으로 결합하는 dna 압타머 및 이의 용도
EP0401313B1 (en)	1995-05-10	Macromolecular conjugate
KR100274190B1 (ko)	2001-02-01	B형 간염 바이러스의 특이항원인 ubhbvcore 단백질의 발현
FR2840687A1 (fr)	2003-12-12	Procede de detection simultanee de reactions d'hybridation et immunologiques et ses utilisations en diagnostic