LU86950A1 - Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 - Google Patents

Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 Download PDF

Info

Publication number: LU86950A1
Authority: LU; Luxembourg
Prior art keywords: formula; group; residue; methyl; aza
Prior art date: 1986-07-30

Application number

LU86950A

Other languages

English (en)

French (fr)

Inventor

Moise Azria

Karl-Heinz Buchheit

Keith Arnold Dixon

Gunther Engel

Rudolf K A Giger

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-30

Filing date

1987-07-24

Publication date

1988-02-02

1986-07-30 Priority claimed from GB868618614A external-priority patent/GB8618614D0/en

1987-07-24 Application filed by Sandoz Sa filed Critical Sandoz Sa

1988-02-02 Publication of LU86950A1 publication Critical patent/LU86950A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/12—Oxygen atoms acylated by aromatic or heteroaromatic carboxylic acids, e.g. cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

LU86950A 1986-07-30 1987-07-24 Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3 LU86950A1 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB8618614		1986-07-30
GB868618614A GB8618614D0 (en)	1986-07-30	1986-07-30	Treatment of psychiatric disorders
DE3626703		1986-08-07
DE3626703		1986-08-07

Publications (1)

Publication Number	Publication Date
LU86950A1 true LU86950A1 (fr)	1988-02-02

Family

ID=25846334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU86950A LU86950A1 (fr)	1986-07-30	1987-07-24	Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3

Country Status (26)

Country	Link
US (1)	US5561149A (de)
JP (1)	JP2632858B2 (de)
KR (1)	KR950014445B1 (de)
AU (2)	AU642210B2 (de)
BE (1)	BE1005921A4 (de)
CA (1)	CA1327750C (de)
CH (1)	CH675072A5 (de)
CY (2)	CY1753A (de)
DE (1)	DE3724059A1 (de)
DK (1)	DK392487A (de)
ES (2)	ES2010227A6 (de)
FI (1)	FI873280L (de)
FR (1)	FR2602142B1 (de)
GB (3)	GB2193633B (de)
GR (1)	GR871212B (de)
HK (3)	HK2694A (de)
HU (2)	HU202108B (de)
IE (1)	IE61103B1 (de)
IL (2)	IL83363A (de)
IT (1)	IT1218150B (de)
LU (1)	LU86950A1 (de)
MY (1)	MY101863A (de)
NL (1)	NL8701682A (de)
NO (1)	NO873133L (de)
NZ (1)	NZ221226A (de)
SE (2)	SE504184C2 (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE385517T1 (de) *	1985-03-14	1991-07-25	Beecham Group p.l.c., Brentford, Middlesex	Arzneimittel zur behandlung von erbrechen.
GB8518658D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Medicaments
US5198447A (en) *	1986-11-21	1993-03-30	Glaxo Group Limited	Medicaments
DE3777805D1 (de) *	1986-11-21	1992-04-30	Glaxo Group Ltd	Arzneimittel zur behandlung oder vorbeugung des entzugssyndromes.
GB8627909D0 (en) *	1986-11-21	1986-12-31	Glaxo Group Ltd	Medicaments
US4973594A (en) *	1986-12-17	1990-11-27	Glaxo Group Limited	Medicaments
US5190954A (en) *	1986-12-17	1993-03-02	Glaxo Group Limited	Methods for the treatment of cognitive disorders
AU618520B2 (en) *	1986-12-17	1992-01-02	Glaxo Group Limited	Medicaments
GB8630071D0 (en) *	1986-12-17	1987-01-28	Glaxo Group Ltd	Medicaments
ATE124865T1 (de) *	1986-12-17	1995-07-15	Glaxo Group Ltd	Verwendung von heterocyclischen verbindungen zur behandlung von bewusstseinsstörungen.
US5244909A (en) *	1986-12-17	1993-09-14	Glaxo Group Limited	Methods for the treatment of cognitive disorders
US5246941A (en) *	1986-12-17	1993-09-21	Glaxo Group Limited	Method for the treatment of depression
US5200414A (en) *	1986-12-17	1993-04-06	Glaxo Group Limited	Methods for the treatment of cognitive disorders
NZ227841A (en) *	1988-02-12	1991-08-27	Merck Sharp & Dohme	Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808433D0 (en) *	1988-04-11	1988-05-11	Merck Sharp & Dohme	Therapeutic agents
IT1226389B (it) *	1988-07-12	1991-01-15	Angeli Inst Spa	Nuovi derivati ammidinici e guanidinici
US5221687A (en) *	1988-09-01	1993-06-22	Glaxo Group Limited	Medicaments
US5229407A (en) *	1988-09-01	1993-07-20	Glaxo Group Limited	Medicaments
GB8904551D0 (en) *	1989-02-28	1989-04-12	Glaxo Group Ltd	Chemical compounds
US5530008A (en) *	1989-04-21	1996-06-25	Sandoz Ltd.	Use of 5-HT3 receptor antagonists in treating panic disorders or obsessive compulsive disorders
ATE97803T1 (de)	1989-04-21	1993-12-15	Sandoz Ag	Therapeutische verwendung von 5-ht3-rezeptorantagonisten.
CA2017621A1 (en) *	1989-06-23	1990-12-23	Masayuki Kato	Indole derivatives and processes for preparation thereof
GB8917556D0 (en) *	1989-08-01	1989-09-13	Glaxo Group Ltd	Medicaments
GB8917557D0 (en) *	1989-08-01	1989-09-13	Glaxo Group Ltd	Medicaments
CA2030051C (en) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Indole derivatives
US5225407A (en) *	1990-02-22	1993-07-06	Glaxo Group Limited	5-HT3 receptor antagonists for the treatment of autism
US5187166A (en) *	1990-07-31	1993-02-16	Nisshin Flour Milling Co., Ltd.	Azabicyclo derivatives and their use as antiemetics
GB9020927D0 (en) *	1990-09-26	1990-11-07	Beecham Group Plc	Pharmaceuticals
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
EP0492020A1 (de) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Verwendung von bestimmten Estern von Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-on und verwandter Verbindungen zur Behandlung von kognitiven Erkrankungen
EP0564650B1 (de) *	1990-12-28	1995-09-20	Kyowa Hakko Kogyo Co., Ltd.	Chinolinderivat
JP3026845B2 (ja) *	1991-02-20	2000-03-27	日清製粉株式会社	ピペリジン誘導体
DE4115215A1 (de) *	1991-05-10	1992-11-12	Merck Patent Gmbh	Indolderivate
US5955470A (en) *	1991-06-11	1999-09-21	Merrell Pharmaceuticals, Inc.	Derivatives of amide analogs of certain methano bridged quinolizines
WO1993000074A1 (en) *	1991-06-26	1993-01-07	Sepracor, Inc.	Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
GB9121170D0 (en) *	1991-10-05	1991-11-20	Smithkline Beecham Plc	Pharmaceuticals
US5344831A (en) *	1992-01-31	1994-09-06	Nisshin Flour Milling Co., Ltd.	Diazabicyclo derivatives
IT1254469B (it) *	1992-02-25	1995-09-25	Recordati Chem Pharm	Derivati benzopiranici e benzotiopiranici
US5605896A (en) *	1992-02-25	1997-02-25	Recordati S.A., Chemical And Pharmaceutical Company	Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities
US5474994A (en) *	1992-05-26	1995-12-12	Recordati S.A., Chemical And Pharmaceutical Company	Bicyclic heterocyclic derivatives having α1 -adrenergic and 5HT1A
JP2699794B2 (ja) *	1992-03-12	1998-01-19	三菱化学株式会社	チエノ〔３，２−ｂ〕ピリジン誘導体
JPH05310732A (ja) *	1992-03-12	1993-11-22	Mitsubishi Kasei Corp	シンノリン−３−カルボン酸誘導体
IT1258315B (it) *	1992-04-10	1996-02-22	Recordati Chem Pharm	Derivati del flavone
US5840903A (en)	1992-07-27	1998-11-24	G. D. Searle & Co.	4-aminomethyl-1-azaadamantane derived benzamides
ES2062921B1 (es) *	1992-11-06	1995-06-16	Merck Patent Gmbh	3-(indol-2-carboxiamido)quinuclidinas.
US5330986A (en) *	1992-11-24	1994-07-19	Hoechst-Roussel Pharmaceuticals Inc.	Indole-7-carboxamide derivatives
US5354757A (en) *	1992-12-15	1994-10-11	G. D. Searle & Co.	Azanoradamantanes
US5399562A (en) *	1994-02-04	1995-03-21	G. D. Searle & Co.	Indolones useful as serotonergic agents
US5530018A (en) *	1994-02-04	1996-06-25	G. D. Searle & Co.	Meso-azanoradamantanes
FR2747386B1 (fr) *	1996-04-12	1998-05-15	Synthelabo	Derives de 3-[(1,2,3,4-tetrahydroisoquinolein-2-yl)methyl] -8-azabicyclo [3.2.1] octane, leur preparation et leur application en therapeutique
USD402434S (en)	1997-11-05	1998-12-08	Ergodyne Corporation	Lateral patient transfer mechanism
US6150420A (en) *	1998-06-01	2000-11-21	Theramax, Inc.	Method for enhanced brain delivery of bupropion
WO2000003701A1 (en) *	1998-07-16	2000-01-27	Massachusetts Institute Of Technology	Composition for treatment of stress
US6579899B1 (en)	1998-07-16	2003-06-17	Massachusetts Institute Of Technology	Composition for treatment of stress
WO2000051582A2 (en)	1999-03-01	2000-09-08	Sepracor Inc.	Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
US6492385B2 (en)	2000-08-18	2002-12-10	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease
US6479510B2 (en)	2000-08-18	2002-11-12	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
US6486172B2 (en)	2000-08-18	2002-11-26	Pharmacia & Upjohn Company	Quinuclidine-substituted aryl compounds for treatment of disease
WO2002015662A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists
WO2002017358A2 (en)	2000-08-21	2002-02-28	Pharmacia & Upjohn Company	Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists)
PE20021019A1 (es)	2001-04-19	2002-11-13	Upjohn Co	Grupos azabiciclicos sustituidos
US20030044356A1 (en) *	2001-04-20	2003-03-06	Jin Auh	Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one)
AR036041A1 (es) *	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
US6562816B2 (en)	2001-08-24	2003-05-13	Pharmacia & Upjohn Company	Substituted-heteroaryl-7-aza[2.2.1]bicycloheptanes for the treatment of disease
JP2005504059A (ja) *	2001-08-24	2005-02-10	ファルマシアアンドアップジョンカンパニーリミティドライアビリティーカンパニー	疾患を処置するための置換アリール７−アザ［２．２．１］ビシクロヘプタン
EP1425286B1 (de) *	2001-09-12	2007-02-28	Pharmacia & Upjohn Company LLC	Substituierte 7-aza-[2.2.1]bicycloheptane für die behandlung von krankheiten
DK1432707T3 (da)	2001-10-02	2012-06-11	Pharmacia & Upjohn Co Llc	Azabicyklisk-substituerede kondenserede heteroarylforbindelser til behandling af sygdomme
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
CA2464194A1 (en) *	2001-10-26	2003-05-08	Pharmacia & Upjohn Company	N-azabicyclo-substituted hetero-bicyclic carboxamides as nachr agonists
MXPA04004464A (es) *	2001-11-08	2004-08-11	Upjohn Co	Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
WO2003042210A1 (en)	2001-11-09	2003-05-22	Pharmacia & Upjohn Company	Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
DE10156719A1 (de)	2001-11-19	2003-05-28	Bayer Ag	Heteroarylcarbonsäureamide
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
EP1480977A2 (de)	2002-02-15	2004-12-01	PHARMACIA & UPJOHN COMPANY	Substituierte arylverbindungen zur behandlung von krankheiten
WO2003070731A2 (en) *	2002-02-19	2003-08-28	Pharmacia & Upjohn Company	Azabicyclic compounds for the treatment of disease
WO2003070732A1 (en) *	2002-02-19	2003-08-28	Pharmacia & Upjohn Company	Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
CA2475773A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
GB0217920D0 (en) *	2002-04-23	2002-09-11	Aventis Pharm Prod Inc	Interleukin-4 Gene Expression inhibitors
DE10234424A1 (de)	2002-07-29	2004-02-12	Bayer Ag	Benzothiophen-, Benzofuran- und Indolharnstoffe
WO2004013137A1 (en) *	2002-08-01	2004-02-12	Pharmacia & Upjohn Company Llc	1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity
DE10241407A1 (de) *	2002-09-06	2004-03-18	Elbion Ag	Behandlung nicht allergischer Rhinitis durch selektive Phosphodiesterase 4-Hemmstoffe
EE05516B1 (et)	2002-09-25	2012-02-15	Memory@Pharmaceuticals@Corporation	Indasoolid bensotiasoolid ja bensoisotiasoolid nende valmistamine ning kasutamine
CA2503786A1 (en) *	2002-11-01	2004-05-13	Pharmacia & Upjohn Company Llc	Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
KR20060120694A (ko) *	2003-12-22	2006-11-27	메모리 파마슈티칼스 코포레이션	인돌, 1ｈ-인다졸, 1,2-벤즈이속사졸 및1,2-벤즈이소티아졸, 및 이들의 제법 및 용도
TW200533348A (en) *	2004-02-18	2005-10-16	Theravance Inc	Indazole-carboxamide compounds as 5-ht4 receptor agonists
CA2560741C (en)	2004-03-25	2013-08-06	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US7728006B2 (en) *	2004-04-07	2010-06-01	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US8309575B2 (en)	2004-04-07	2012-11-13	Theravance, Inc.	Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en)	2004-04-07	2011-11-01	Theravance Inc	Quinolinone-carboxamide compounds as 5-ht4 recepto
EP1742944B1 (de) *	2004-04-22	2010-11-10	Memory Pharmaceuticals Corporation	Indole, 1h-indazole, 1,2-benzisoxazole, 1,2-benzoisothiazole, deren herstellung und verwendungen
EP1745046B1 (de) *	2004-05-07	2011-04-13	Memory Pharmaceuticals Corporation	1h-indazole, benzothiazole, 1,2-benzisoxazole, 1,2-benzisothiazole und chromone und deren herstellung und verwendungen
EP1807422B1 (de) *	2004-11-05	2009-09-02	Theravance, Inc.	5-HT4-Rezeptoragonistenverbindungen
WO2006052889A2 (en) *	2004-11-05	2006-05-18	Theravance, Inc.	Quinolinone-carboxamide compounds
ES2342675T3 (es) *	2004-12-22	2010-07-12	Memory Pharmaceuticals Corporation	Ligandos del receptor alfa-7 nicotinico contra enfermedades relacionadas con el snc.
KR20070091665A (ko) *	2004-12-22	2007-09-11	세라밴스 인코포레이티드	인다졸－카르복사미드 화합물
BRPI0608392A2 (pt) *	2005-03-02	2009-12-29	Theravance Inc	compostos de quinolinona como agonistas do receptor 5-ht4
DE602006003227D1 (de) *	2005-07-06	2008-11-27	Inke Sa	Verfahren zur gewinnung der pharmazeutisch aktivendavon und verfahren zu deren gewinnung
ES2264901B1 (es) *	2005-07-06	2007-12-01	Inke, S.A.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo, sus intermedios de sintesis y procedimiento para la obtencion de los mismos.
US8106066B2 (en) *	2005-09-23	2012-01-31	Memory Pharmaceuticals Corporation	Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
ES2363998T3 (es)	2007-03-23	2011-08-22	Abbott Laboratories	Derivados ester y carbamato de azaadamantano y métodos de uso de los mismos.
EP2217597B1 (de) *	2007-10-01	2011-03-30	Comentis, Inc.	1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit
PE20110711A1 (es)	2008-11-19	2011-10-11	Envivo Pharmaceuticals Inc	Tratamiento de trastornos cognitivos con (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y sales farmaceuticamente aceptables de la misma
EP2429518A1 (de) *	2009-05-11	2012-03-21	Envivo Pharmaceuticals, Inc.	Behandlung von kognitiven erkrankungen mit bestimmten alpha-7-nikotinsäure-rezeptoren in kombination mit acetylcholinesterase-inhibitoren
US20100298397A1 (en) *	2009-05-19	2010-11-25	Singh Nikhilesh N	Method of treatment of obsessive compulsive disorder with ondansetron
CN102844313B (zh)	2010-01-28	2016-10-05	哈佛大学校长及研究员协会	提高蛋白酶体活性的组合物和方法
MX2012013345A (es)	2010-05-17	2013-02-11	Envivo Pharmaceuticals Inc	Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin- 3-il)benzo[b]tiofeno-2-carboxamida monohidratado.
WO2012154967A1 (en)	2011-05-12	2012-11-15	Proteostasis Therapeutics, Inc.	Proteostasis regulators
RU2635522C2 (ru)	2012-05-08	2017-11-13	Форум Фармасьютикалз, Инк.	Способы поддержания, лечения или улучшения когнитивной функции
US9849135B2 (en)	2013-01-25	2017-12-26	President And Fellows Of Harvard College	USP14 inhibitors for treating or preventing viral infections
US9050325B2 (en) *	2013-04-08	2015-06-09	Abdul Zahir	Ondansetron nasal spray composition
WO2015073528A1 (en)	2013-11-12	2015-05-21	Proteostasis Therapeutics, Inc.	Proteasome activity enhancing compounds
US9434724B2 (en)	2014-07-11	2016-09-06	Alpharmagen, Llc	Quinuclidines for modulating alpha 7 activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB214772A (en) *	1923-02-17	1924-05-01	James Walter Henry Dew	Improved clothes-dryer applicable for other purposes
IL59004A0 (en) *	1978-12-30	1980-03-31	Beecham Group Ltd	Substituted benzamides their preparation and pharmaceutical compositions containing them
FR2493848B2 (fr) *	1980-11-07	1986-05-16	Delalande Sa	Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
FI74707C (fi) *	1982-06-29	1988-03-10	Sandoz Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara alkylenoeverbryggade piperidylestrar eller -amider av bicykliska karboxylsyror.
FR2529548A1 (fr) *	1982-07-02	1984-01-06	Delalande Sa	Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique
EP0099194A3 (de) *	1982-07-03	1984-04-11	Beecham Group Plc	Benzamide
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
WO1985001048A1 (en) *	1983-08-26	1985-03-14	Sandoz Ag	Aromatic esters or amides of carboxylic acid and sulfonic acid
DE3445377A1 (de) *	1983-12-23	1985-07-04	Sandoz-Patent-GmbH, 7850 Lörrach	Carbocylische und heterocyclische carbonsaeureester und -amide von ueberbrueckten und nicht ueberbrueckten cyclischen stickstoffhaltigen aminen oder alkoholen
NO164025C (no) *	1984-01-25	1990-08-22	Glaxo Group Ltd	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-imidazolylmetyl-tetrahydrokarbazolon-derivater.
AU583343B2 (en) *	1985-01-23	1989-04-27	Glaxo Group Limited	Heterocyclic compounds
DE385517T1 (de) *	1985-03-14	1991-07-25	Beecham Group p.l.c., Brentford, Middlesex	Arzneimittel zur behandlung von erbrechen.
GB8525913D0 (en) *	1985-10-21	1985-11-27	Beecham Group Plc	Compounds
DE3650772T2 (de) *	1985-04-27	2003-04-03	F. Hoffmann-La Roche Ag, Basel	Derivate von Indazole-3-carboxamide und -3-carboxylsäure
GB8518658D0 (en) *	1985-07-24	1985-08-29	Glaxo Group Ltd	Medicaments
GB8520616D0 (en) *	1985-08-16	1985-09-25	Beecham Group Plc	Compounds
ES2053451T3 (es) *	1986-01-07	1994-08-01	Beecham Group Plc	Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
EP0235878A3 (de) *	1986-01-16	1989-06-14	Beecham Group Plc	Neue Verbindungen

1987
- 1987-07-16 NL NL8701682A patent/NL8701682A/nl not_active Application Discontinuation
- 1987-07-16 HU HU873252D patent/HU202108B/hu not_active IP Right Cessation
- 1987-07-16 HU HU895334A patent/HU895334D0/hu not_active IP Right Cessation
- 1987-07-21 DE DE19873724059 patent/DE3724059A1/de not_active Ceased
- 1987-07-22 FR FR8710519A patent/FR2602142B1/fr not_active Expired - Fee Related
- 1987-07-23 IT IT48211/87A patent/IT1218150B/it active
- 1987-07-23 CH CH2831/87A patent/CH675072A5/de not_active IP Right Cessation
- 1987-07-23 BE BE8700818A patent/BE1005921A4/fr not_active IP Right Cessation
- 1987-07-24 LU LU86950A patent/LU86950A1/fr unknown
- 1987-07-27 GB GB8717768A patent/GB2193633B/en not_active Expired - Lifetime
- 1987-07-27 NO NO873133A patent/NO873133L/no unknown
- 1987-07-28 ES ES8702207A patent/ES2010227A6/es not_active Expired
- 1987-07-28 SE SE8702980A patent/SE504184C2/sv not_active IP Right Cessation
- 1987-07-28 NZ NZ221226A patent/NZ221226A/xx unknown
- 1987-07-28 IL IL8783363Q patent/IL83363A/xx unknown
- 1987-07-28 GR GR871212A patent/GR871212B/el unknown
- 1987-07-28 DK DK392487A patent/DK392487A/da not_active Application Discontinuation
- 1987-07-28 FI FI873280A patent/FI873280L/fi not_active Application Discontinuation
- 1987-07-29 CA CA000543271A patent/CA1327750C/en not_active Expired - Fee Related
- 1987-07-29 KR KR1019870008247A patent/KR950014445B1/ko not_active Expired - Fee Related
- 1987-07-29 IE IE205187A patent/IE61103B1/en not_active IP Right Cessation
- 1987-07-29 JP JP62193629A patent/JP2632858B2/ja not_active Expired - Lifetime
- 1987-09-25 MY MYPI87001945A patent/MY101863A/en unknown
- 1987-12-31 IL IL8783363A patent/IL83363A0/xx unknown
1989
- 1989-03-31 ES ES8901137A patent/ES2016440A6/es not_active Expired - Lifetime
1990
- 1990-04-10 GB GB9008068A patent/GB2231264B/en not_active Expired - Lifetime
- 1990-04-10 GB GB9008069A patent/GB2231265B/en not_active Expired - Lifetime
1991
- 1991-02-27 AU AU71946/91A patent/AU642210B2/en not_active Ceased
- 1991-03-14 AU AU72910/91A patent/AU637878B2/en not_active Ceased
1993
- 1993-03-24 SE SE19939300978A patent/SE9300978D0/xx not_active Application Discontinuation
1994
- 1994-01-13 HK HK26/94A patent/HK2694A/xx not_active IP Right Cessation
- 1994-01-13 HK HK29/94A patent/HK2994A/xx not_active IP Right Cessation
- 1994-01-20 HK HK46/94A patent/HK4694A/xx not_active IP Right Cessation
- 1994-06-03 CY CY175394A patent/CY1753A/en unknown
- 1994-06-03 CY CY175494A patent/CY1754A/en unknown
1995
- 1995-03-14 US US08/403,620 patent/US5561149A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI873280A7 (fi)	1988-01-31
ES2010227A6 (es)	1989-11-01
DK392487A (da)	1988-01-31
IE61103B1 (en)	1994-10-05
SE9300978A0 (sv)	1993-03-24
IL83363A0 (en)	1987-12-31
AU642210B2 (en)	1993-10-14
DE3724059A1 (de)	1988-02-18
FI873280L (fi)	1988-01-31
HU895334D0 (en)	1990-01-28
SE8702980D0 (sv)	1987-07-28
GB2231265B (en)	1991-04-24
IL83363A (en)	1993-07-08
CH675072A5 (de)	1990-08-31
KR880001291A (ko)	1988-04-22
GR871212B (en)	1987-12-15
HU202108B (en)	1991-02-28
NZ221226A (en)	1990-07-26
NO873133L (no)	1988-02-01
GB2193633A (en)	1988-02-17
US5561149A (en)	1996-10-01
ES2016440A6 (es)	1990-11-01
CA1327750C (en)	1994-03-15
AU7194691A (en)	1991-05-09
MY101863A (en)	1992-01-31
GB2231265A (en)	1990-11-14
AU7291091A (en)	1991-05-16
FI873280A0 (fi)	1987-07-28
IE872051L (en)	1988-01-30
JP2632858B2 (ja)	1997-07-23
SE8702980L (sv)	1988-04-28
BE1005921A4 (fr)	1994-03-15
HK2994A (en)	1994-01-21
SE9300978D0 (sv)	1993-03-24
DK392487D0 (da)	1987-07-28
HK4694A (en)	1994-01-28
CY1754A (en)	1994-06-03
IT1218150B (it)	1990-04-12
GB8717768D0 (en)	1987-09-03
GB2231264A (en)	1990-11-14
GB9008069D0 (en)	1990-06-06
FR2602142B1 (fr)	1996-07-05
IT8748211A0 (it)	1987-07-23
GB2193633B (en)	1991-04-17
AU7619087A (en)	1988-02-04
JPS6341429A (ja)	1988-02-22
GB2231264B (en)	1991-04-24
FR2602142A1 (fr)	1988-02-05
KR950014445B1 (ko)	1995-11-28
NL8701682A (nl)	1988-02-16
HUT45895A (en)	1988-09-28
CY1753A (en)	1994-06-03
AU610074B2 (en)	1991-05-16
GB9008068D0 (en)	1990-06-06
SE504184C2 (sv)	1996-12-02
AU637878B2 (en)	1993-06-10
NO873133D0 (no)	1987-07-27
HK2694A (en)	1994-01-21

Publication	Publication Date	Title
LU86950A1 (fr)	1988-02-02	Utilisation en therapeutique des antagonistes des recepteurs serotoninergiques 5ht3
CA2226784C (en)	2003-07-08	Use of cgmp-phosphodiesterase inhibitors to treat impotence
LU87314A1 (fr)	1989-03-08	Nouvelles piperidines pontees,leur preparation et leur utilisation comme medicaments
SK3898A3 (en)	1998-11-04	Cyclic gmp-specific phosphodiesterase inhibitors
HUE034347T2 (en)	2018-02-28	N-heteroaryl compounds with a cyclic bridge unit for the treatment of parasitic diseases
HU218654B (hu)	2000-10-28	Triciklusos vegyületek, ezeket hatóanyagként tartalmazó gyógyászati készítmények és eljárás előállításukra
US12291528B2 (en)	2025-05-06	Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions
US9192605B2 (en)	2015-11-24	Compositions and methods for treating parkinson's disease
CA2362918A1 (en)	2000-09-14	Methods and compositions for treating erectile dysfunction
JP4339679B2 (ja)	2009-10-07	Ｐｄｅ５阻害剤としてのカルボリン誘導体
JPH0269417A (ja)	1990-03-08	精神分裂病治療用組成物
CN112118891A (zh)	2020-12-22	作为流感病毒复制抑制剂的稠和多环吡啶酮化合物
EA020328B1 (ru)	2014-10-30	Способ лечения алкогольной зависимости
US4024259A (en)	1977-05-17	3-Anilino-2,4-diazabicyclo[3.2.1]octenes
PT85429B (pt)	1995-03-01	Processo para a preparacao de composicoes farmaceuticas
JPH05503084A (ja)	1993-05-27	イミダゾキノキサリン化合物、その製造及び使用
CY1755A (en)	1994-06-03	Pharmaceutical compositions containing antiserotonin indolyl derivatives
IL96797A (en)	1994-12-29	Manufacture of pharmaceutical compositions containing 1,2,3,9- tetrahydro-3-((1H-imidazol-1-YL)methyl)-4H-carbazol-4-one for treatment of impaired approach oriented behavior in stressful situations, for increasing vigilance and for treatment of rhinitis or lung embolism
JPWO1997030703A1 (ja)	1999-03-26	１，２−エタンジオール誘導体またはその塩を含有する脳機能改善剤
HK1005363B (en)	2006-12-01	Use of cgmp - phosphodiesterase inhibitors to treat impotence

Legal Events

Date	Code	Title	Description
1987-07-24	DT	Application date
1991-06-28	TA	Annual fee