LT3691692T - Aktyvuojami anti-cd71 antikūno-vaisto konjugatai ir jų panaudojimo būdai - Google Patents

Aktyvuojami anti-cd71 antikūno-vaisto konjugatai ir jų panaudojimo būdai

Info

Publication number: LT3691692T
Authority: LT; Lithuania
Prior art keywords: antibody; drug conjugates; activated anti; activated; conjugates
Prior art date: 2017-10-14

Application number

LTEP18797311.0T

Other languages

English (en)

Inventor

Shweta SINGH

Jennifer Hope RICHARDSON

Laura Patterson SERWER

Jonathan Alexander Terrett

Susan E. Morgan-Lappe

Tracy HENRIQUES

Sherry L. RALSTON

Marvin Robert Leanna

Ilaria BADAGNANI

Sahana Bose

Original Assignee

Abbvie Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-10-14

Filing date

2018-10-12

Publication date

2021-05-10

2018-10-12 Application filed by Abbvie Inc. filed Critical Abbvie Inc.

2021-05-10 Publication of LT3691692T publication Critical patent/LT3691692T/lt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

LTEP18797311.0T 2017-10-14 2018-10-12 Aktyvuojami anti-cd71 antikūno-vaisto konjugatai ir jų panaudojimo būdai LT3691692T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201762572467P	2017-10-14	2017-10-14
PCT/US2018/055733 WO2019075417A1 (en)	2017-10-14	2018-10-12	CONJUGATES OF MEDICAMENT ANTI-CD71 ACTIVATED ANTIBODIES AND METHODS OF USE

Publications (1)

Publication Number	Publication Date
LT3691692T true LT3691692T (lt)	2021-05-10

Family

ID=64110112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP18797311.0T LT3691692T (lt)	2017-10-14	2018-10-12	Aktyvuojami anti-cd71 antikūno-vaisto konjugatai ir jų panaudojimo būdai

Country Status (36)

Country	Link
US (3)	US20190111150A1 (lt)
EP (2)	EP3691692B8 (lt)
JP (2)	JP7374891B2 (lt)
KR (4)	KR20220045088A (lt)
CN (1)	CN111278467B (lt)
AR (1)	AR115178A1 (lt)
AU (1)	AU2018346969A1 (lt)
BR (1)	BR112020007302B1 (lt)
CA (1)	CA3077730A1 (lt)
CL (1)	CL2020000977A1 (lt)
CO (1)	CO2020005685A2 (lt)
CR (1)	CR20200206A (lt)
CY (1)	CY1123968T1 (lt)
DK (1)	DK3691692T3 (lt)
DO (1)	DOP2023000150A (lt)
EC (1)	ECSP20025198A (lt)
ES (1)	ES2864013T3 (lt)
HR (1)	HRP20210436T8 (lt)
HU (1)	HUE054037T2 (lt)
IL (1)	IL273586A (lt)
LT (1)	LT3691692T (lt)
MA (1)	MA50752B1 (lt)
MD (1)	MD3691692T2 (lt)
MX (1)	MX2020003723A (lt)
PE (1)	PE20210125A1 (lt)
PH (1)	PH12020550417A1 (lt)
PL (1)	PL3691692T3 (lt)
PT (1)	PT3691692T (lt)
RS (1)	RS61596B1 (lt)
RU (2)	RU2771292C2 (lt)
SG (1)	SG11202003378WA (lt)
SI (1)	SI3691692T1 (lt)
SM (1)	SMT202100184T1 (lt)
TW (2)	TW202330039A (lt)
UY (1)	UY37931A (lt)
WO (1)	WO2019075417A1 (lt)

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US20130116404A1 (en)	2011-11-08	2013-05-09	Case Western Reserve University	Targeted non-invasive imaging probes of egfr expressing cells
IL310251A (en)	2015-05-04	2024-03-01	Cytomx Therapeutics Inc	Anti-cd71 antibodies, activatable anti-cd71 antibodies, compositions comprising same and uses thereof
CN110809583A (zh)	2017-06-07	2020-02-18	瑞泽恩制药公司	用于内化酶的组合物和方法
WO2019075417A1 (en) *	2017-10-14	2019-04-18	Abbvie Inc.	CONJUGATES OF MEDICAMENT ANTI-CD71 ACTIVATED ANTIBODIES AND METHODS OF USE
KR20200118151A (ko)	2018-02-07	2020-10-14	리제너론 파마슈티칼스 인코포레이티드	치료 단백질 전달을 위한 방법 및 조성물
WO2019183633A1 (en)	2018-03-23	2019-09-26	Case Western Reserve Univeristy	Psma targeted conjugate compounds and uses thereof
CA3100021A1 (en)	2018-05-17	2019-11-21	Regeneron Pharmaceuticals, Inc.	Anti-cd63 antibodies, conjugates, and uses thereof
JP2023520821A (ja) *	2020-04-08	2023-05-19	アリアダセラピューティクス，インコーポレイテッド	血液脳関門送達のための組成物および方法
IL296634A (en) *	2020-04-09	2022-11-01	Cytomx Therapeutics Inc	Preparations containing activatable antibodies
JP2023535074A (ja) *	2020-07-23	2023-08-15	ダインセラピューティクス，インコーポレーテッド	筋標的化複合体およびそれらの使用
WO2023086833A1 (en)	2021-11-09	2023-05-19	Case Western Reserve University	Psma targeted conjugate compounds and uses thereof
US20260034230A1 (en) *	2022-07-29	2026-02-05	Regeneron Pharmaceuticals, Inc.	Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
WO2025024334A1 (en)	2023-07-21	2025-01-30	Marrow Therapeutics, Inc.	Hematopoietic cell targeting conjugates and related methods
WO2025133132A1 (en) *	2023-12-20	2025-06-26	Institut National De La Sante Et De La Recherche Medicale	Novel anti-tfr1 (cd71) antibodies for cancer treatment

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2018
- 2018-10-12 WO PCT/US2018/055733 patent/WO2019075417A1/en not_active Ceased
- 2018-10-12 MX MX2020003723A patent/MX2020003723A/es unknown
- 2018-10-12 MA MA50752A patent/MA50752B1/fr unknown
- 2018-10-12 TW TW111137633A patent/TW202330039A/zh unknown
- 2018-10-12 US US16/159,559 patent/US20190111150A1/en not_active Abandoned
- 2018-10-12 HU HUE18797311A patent/HUE054037T2/hu unknown
- 2018-10-12 KR KR1020227011264A patent/KR20220045088A/ko not_active Ceased
- 2018-10-12 CA CA3077730A patent/CA3077730A1/en active Pending
- 2018-10-12 DK DK18797311.0T patent/DK3691692T3/da active
- 2018-10-12 TW TW107136020A patent/TWI780237B/zh not_active IP Right Cessation
- 2018-10-12 KR KR1020227044475A patent/KR102529359B1/ko active Active
- 2018-10-12 SG SG11202003378WA patent/SG11202003378WA/en unknown
- 2018-10-12 JP JP2020520804A patent/JP7374891B2/ja active Active
- 2018-10-12 KR KR1020237014403A patent/KR20230070046A/ko not_active Withdrawn
- 2018-10-12 SI SI201830233T patent/SI3691692T1/sl unknown
- 2018-10-12 CR CR20200206A patent/CR20200206A/es unknown
- 2018-10-12 RU RU2020115713A patent/RU2771292C2/ru active
- 2018-10-12 CN CN201880069577.4A patent/CN111278467B/zh active Active
- 2018-10-12 PT PT187973110T patent/PT3691692T/pt unknown
- 2018-10-12 PE PE2020000380A patent/PE20210125A1/es unknown
- 2018-10-12 PH PH1/2020/550417A patent/PH12020550417A1/en unknown
- 2018-10-12 BR BR112020007302-4A patent/BR112020007302B1/pt active IP Right Grant
- 2018-10-12 PL PL18797311T patent/PL3691692T3/pl unknown
- 2018-10-12 EP EP18797311.0A patent/EP3691692B8/en active Active
- 2018-10-12 RU RU2022111211A patent/RU2022111211A/ru unknown
- 2018-10-12 ES ES18797311T patent/ES2864013T3/es active Active
- 2018-10-12 AR ARP180102966A patent/AR115178A1/es not_active Application Discontinuation
- 2018-10-12 AU AU2018346969A patent/AU2018346969A1/en not_active Abandoned
- 2018-10-12 EP EP20209320.9A patent/EP3834846A1/en not_active Withdrawn
- 2018-10-12 LT LTEP18797311.0T patent/LT3691692T/lt unknown
- 2018-10-12 SM SM20210184T patent/SMT202100184T1/it unknown
- 2018-10-12 RS RS20210341A patent/RS61596B1/sr unknown
- 2018-10-12 KR KR1020207013706A patent/KR102385495B1/ko not_active Expired - Fee Related
- 2018-10-12 MD MDE20200822T patent/MD3691692T2/ro unknown
- 2018-10-12 UY UY0001037931A patent/UY37931A/es not_active Application Discontinuation
- 2018-10-12 HR HRP20210436TT patent/HRP20210436T8/hr unknown
2020
- 2020-03-25 IL IL273586A patent/IL273586A/en unknown
- 2020-04-09 CL CL2020000977A patent/CL2020000977A1/es unknown
- 2020-05-07 CO CONC2020/0005685A patent/CO2020005685A2/es unknown
- 2020-05-13 EC ECSENADI202025198A patent/ECSP20025198A/es unknown
- 2020-11-25 US US17/105,402 patent/US20210145978A1/en not_active Abandoned
2021
- 2021-03-22 CY CY20211100239T patent/CY1123968T1/el unknown
2023
- 2023-05-19 US US18/320,869 patent/US20240115724A1/en not_active Abandoned
- 2023-07-27 DO DO2023000150A patent/DOP2023000150A/es unknown
- 2023-10-25 JP JP2023183034A patent/JP2024012366A/ja active Pending

Also Published As

Publication number	Publication date
EP3691692A1 (en)	2020-08-12
RU2771292C2 (ru)	2022-04-29
CN111278467A (zh)	2020-06-12
HRP20210436T1 (hr)	2021-04-30
AR115178A1 (es)	2020-12-09
US20240115724A1 (en)	2024-04-11
MA50752B1 (fr)	2021-03-31
ECSP20025198A (es)	2020-06-30
BR112020007302A2 (pt)	2020-09-29
KR102385495B1 (ko)	2022-04-15
CY1123968T1 (el)	2022-05-27
CN111278467B (zh)	2024-07-30
PL3691692T3 (pl)	2021-07-19
KR20220045088A (ko)	2022-04-12
MX2020003723A (es)	2020-07-22
DOP2023000150A (es)	2023-08-31
EP3691692B8 (en)	2021-05-26
WO2019075417A1 (en)	2019-04-18
MD3691692T2 (ro)	2021-05-31
TW201927815A (zh)	2019-07-16
RU2022111211A (ru)	2022-05-05
DK3691692T3 (da)	2021-03-22
EP3834846A1 (en)	2021-06-16
CA3077730A1 (en)	2019-04-18
CL2020000977A1 (es)	2020-09-11
SMT202100184T1 (it)	2021-05-07
KR20230004932A (ko)	2023-01-06
EP3691692B1 (en)	2020-12-30
KR102529359B1 (ko)	2023-05-09
CO2020005685A2 (es)	2020-05-15
RU2020115713A (ru)	2021-11-16
SI3691692T1 (sl)	2021-04-30
RU2020115713A3 (lt)	2022-02-25
PE20210125A1 (es)	2021-01-19
IL273586A (en)	2020-05-31
SG11202003378WA (en)	2020-05-28
JP2020537649A (ja)	2020-12-24
UY37931A (es)	2019-04-30
TWI780237B (zh)	2022-10-11
AU2018346969A1 (en)	2020-04-23
PT3691692T (pt)	2021-03-29
JP2024012366A (ja)	2024-01-30
US20190111150A1 (en)	2019-04-18
BR112020007302B1 (pt)	2023-01-31
KR20200070324A (ko)	2020-06-17
CR20200206A (es)	2021-02-18
HRP20210436T8 (hr)	2022-01-07
ES2864013T3 (es)	2021-10-13
PH12020550417A1 (en)	2021-04-12
KR20230070046A (ko)	2023-05-19
MA50752A (fr)	2020-08-12
HUE054037T2 (hu)	2021-08-30
TW202330039A (zh)	2023-08-01
JP7374891B2 (ja)	2023-11-07
US20210145978A1 (en)	2021-05-20
RS61596B1 (sr)	2021-04-29

Publication	Publication Date	Title
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IL278891A (en)	2021-01-31	Anti-HER2 drug-antibody conjugates, preparations containing them and their uses
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LT3423105T (lt)	2021-09-10	Antikūno-vaisto konjugatai eribulino pagrindu ir jų panaudojimo būdai
MA50755A (fr)	2019-10-23	Conjugués anticorps-médicaments mult-médicaments
SMT202400472T1 (it)	2025-01-14	Anticorpo anti-cdh6 e coniugato anticorpo anti-cdh6-farmaco
IL248961A0 (en)	2017-01-31	Oristatin histories and their conjugations
LT3558390T (lt)	2024-11-11	Amanitino ir antikūnų konjugatai
MA51778A (fr)	2019-12-11	Conjugués anticorps-médicament anti-ccr7
IL261493A (en)	2018-11-29	Napi2b-targeted antibody conjugates - drug and methods of using them
HUE049291T2 (hu)	2020-09-28	Antitest-hatóanyag konjugátumok és immuntoxinok
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PL3102606T3 (pl)	2019-05-31	Koniugaty przeciwciało-lek i immunotoksyny
HUE053287T2 (hu)	2021-06-28	PTK-7 elleni ellenanyag-drog konjugátumok
EP3612567C0 (en)	2024-09-11	ANTI-VTCN1 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES
DK3668874T3 (da)	2022-02-14	Pyrrolobenzodiazepin-konjugater
IL266112A (en)	2019-06-30	Antibodies against edb and antibody-drug conjugates
SG11202101517PA (en)	2021-03-30	Isoquinoline-steroid conjugates and uses thereof
PT3544637T (pt)	2021-02-03	Conjugados omv-antigénio nativos e sua utilização
PT3666787T (pt)	2024-03-21	Conjugados anticorpo-fármaco que incluem um derivado da hemiasterlina
GB201818562D0 (en)	2018-12-26	Pyrrolobenzodiazephones and conjugates thereof
GB201712101D0 (en)	2017-09-13	nOMV-ANTIGEN CONJUGATES AND USE THEREOF
GB201712096D0 (en)	2017-09-13	Immunogenic conjugates and use thereof
BR112016021717A2 (pt)	2018-07-10	anticorpos anti-egfr e conjugados anticorpo-fármaco
TH1601003590A (th)	2018-11-08	สารประกอบชนิดเปปติโดมิเมติกและคอนจูเกตแอนติบอดี-ยาของสิ่งนั้น