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LT3551619T - Kompozicijos, apimančios metilfenidato provaistus, jų gamybos ir panaudojimo būdai - Google Patents

Kompozicijos, apimančios metilfenidato provaistus, jų gamybos ir panaudojimo būdai

Info

Publication number
LT3551619T
LT3551619T LTEPPCT/US2017/065482T LTUS2017065482T LT3551619T LT 3551619 T LT3551619 T LT 3551619T LT US2017065482 T LTUS2017065482 T LT US2017065482T LT 3551619 T LT3551619 T LT 3551619T
Authority
LT
Lithuania
Prior art keywords
promotions
manufacture
methods
compositions containing
containing methyl
Prior art date
Application number
LTEPPCT/US2017/065482T
Other languages
English (en)
Inventor
Travis Mickle
Sven M. GUENTHER
Guochen Chi
Original Assignee
Zevra Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zevra Therapeutics, Inc. filed Critical Zevra Therapeutics, Inc.
Publication of LT3551619T publication Critical patent/LT3551619T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4458Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
LTEPPCT/US2017/065482T 2016-12-11 2017-12-09 Kompozicijos, apimančios metilfenidato provaistus, jų gamybos ir panaudojimo būdai LT3551619T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662432675P 2016-12-11 2016-12-11
US201762519627P 2017-06-14 2017-06-14
US201762541695P 2017-08-05 2017-08-05
PCT/US2017/065482 WO2018107132A1 (en) 2016-12-11 2017-12-09 Compositions comprising methylphenidate-prodrugs, processes of making and using the same

Publications (1)

Publication Number Publication Date
LT3551619T true LT3551619T (lt) 2024-06-25

Family

ID=62491385

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2017/065482T LT3551619T (lt) 2016-12-11 2017-12-09 Kompozicijos, apimančios metilfenidato provaistus, jų gamybos ir panaudojimo būdai

Country Status (24)

Country Link
US (10) US10584113B2 (lt)
EP (2) EP3551619B1 (lt)
JP (1) JP6963614B2 (lt)
KR (1) KR102337138B1 (lt)
CN (1) CN110234636B (lt)
AU (2) AU2017371327B2 (lt)
BR (1) BR112019011640B1 (lt)
CA (1) CA3046486A1 (lt)
DK (1) DK3551619T3 (lt)
ES (1) ES2979262T3 (lt)
FI (1) FI3551619T3 (lt)
HR (1) HRP20240748T1 (lt)
HU (1) HUE067004T2 (lt)
IL (3) IL322584A (lt)
LT (1) LT3551619T (lt)
MX (1) MX390156B (lt)
NZ (1) NZ754751A (lt)
PL (1) PL3551619T3 (lt)
PT (1) PT3551619T (lt)
RS (1) RS65591B1 (lt)
SI (1) SI3551619T1 (lt)
SM (1) SMT202400217T1 (lt)
WO (1) WO2018107132A1 (lt)
ZA (1) ZA201903928B (lt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9653940B2 (en) 2015-06-02 2017-05-16 Voyetra Turtle Beach, Inc. Headset wireless charging dock
HUE067004T2 (hu) 2016-12-11 2024-10-28 Zevra Therapeutics Inc Metilfenidát prodrogokat tartalmazó készítmények, eljárások azok elõállítására és felhasználására
WO2019241020A1 (en) * 2018-06-15 2019-12-19 Kempharm, Inc. Serdexmethylphenidate conjugates, compositions and methods of use thereof
US11136295B2 (en) 2018-10-29 2021-10-05 Kempharm, Inc. D-amphetamine compounds, compositions, and processes for making and using the same
BR112022017133A2 (pt) * 2020-02-29 2022-10-11 Kempharm Inc Composições compreendendo pró-drogas de metilfenidato, processos de fabricação e uso das mesmas
US11805352B2 (en) 2021-05-28 2023-10-31 Plantronics, Inc. Wireless charging dock
US20250375436A1 (en) 2024-03-25 2025-12-11 Zevra Therapeutics, Inc. Serdexmethylphenidate for treatment of idiopathic hypersomnia

Family Cites Families (27)

* Cited by examiner, † Cited by third party
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US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5908850A (en) * 1995-12-04 1999-06-01 Celgene Corporation Method of treating attention deficit disorders with d-threo methylphenidate
US6622036B1 (en) 2000-02-09 2003-09-16 Cns Response Method for classifying and treating physiologic brain imbalances using quantitative EEG
US6210705B1 (en) 1997-12-15 2001-04-03 Noven Pharmaceuticals, Nc. Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate
AU2114199A (en) 1998-01-13 1999-08-02 Trustees Of The University Of Pennsylvania, The Novel dopamine re-uptake inhibitors and methods of synthesizing and using the same
US7060708B2 (en) 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US20020132793A1 (en) 2000-08-28 2002-09-19 Mel Epstein Use of methylphenidate compounds to enhance memory
JP2004507503A (ja) 2000-08-28 2004-03-11 センション,インコーポレイテッド 記憶を増強するためのトレオ−メチルフェニデートの使用
US7700561B2 (en) 2002-02-22 2010-04-20 Shire Llc Abuse-resistant amphetamine prodrugs
IL151251A0 (en) 2002-08-14 2003-04-10 Elta Systems Ltd Parallel processing platform with synchronous system halt-resume
US7247730B2 (en) 2003-03-07 2007-07-24 Isp Investments Inc. Process for the preparation of dexmethylphenidate hydrochloride
CN1816346B (zh) * 2003-05-29 2013-04-17 希拉有限责任公司 耐滥用的苯异丙胺化合物
EP1812390A2 (en) 2004-10-22 2007-08-01 Mark Froimowitz Methylphenidate analogs and methods of use thereof
EP1928881A2 (en) 2005-08-19 2008-06-11 Pharmacofore, Inc. Prodrugs of active agents
EP2053919B1 (en) * 2006-08-23 2013-12-25 The University Of Montana Method of reducing neuronal cell damage
US7772222B2 (en) 2007-02-08 2010-08-10 Mickle Travis C Polar hydrophilic prodrugs of amphetamine and other stimulants and processes for making and using the same
CA2672138A1 (en) 2006-12-11 2008-06-19 Kempharm, Inc. Non-standard amino acid conjugates of amphetamine and processes for making and using the same
CA2677241A1 (en) 2007-02-02 2008-08-14 Colucid Pharmaceuticals, Inc. Compounds that inhibit cholinesterase
US20100145057A1 (en) 2007-03-15 2010-06-10 Sun Pharma Advanced Research Company Ltd. Novel prodrugs
CN101679366B (zh) 2007-05-23 2013-08-07 默沙东公司 吡啶基哌啶食欲素受体拮抗剂
WO2009035473A2 (en) 2007-09-13 2009-03-19 Sanfilippo Louis C Method of treating binge eating disorder, obesity resulting from binge eating behavior and depressive disorders
CN107261148B (zh) * 2011-07-28 2021-07-13 凯姆制药公司 哌甲酯前药、其制备和使用方法
WO2013088255A1 (en) 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
US9088326B2 (en) 2012-07-18 2015-07-21 Rf Micro Devices, Inc. Front end radio architecture having a split band arrangement with co-banding
WO2018107131A1 (en) 2016-12-11 2018-06-14 Kempharm, Inc. Methylphenidate-prodrugs, processes of making and using the same
HUE067004T2 (hu) * 2016-12-11 2024-10-28 Zevra Therapeutics Inc Metilfenidát prodrogokat tartalmazó készítmények, eljárások azok elõállítására és felhasználására
WO2019241020A1 (en) * 2018-06-15 2019-12-19 Kempharm, Inc. Serdexmethylphenidate conjugates, compositions and methods of use thereof

Also Published As

Publication number Publication date
IL297652A (en) 2022-12-01
FI3551619T3 (fi) 2024-05-30
US20200181113A1 (en) 2020-06-11
SMT202400217T1 (it) 2024-07-09
CA3046486A1 (en) 2018-06-14
IL297652B1 (en) 2025-09-01
WO2018107132A1 (en) 2018-06-14
PL3551619T3 (pl) 2024-07-22
EP3551619B1 (en) 2024-03-06
US10584113B2 (en) 2020-03-10
RS65591B1 (sr) 2024-06-28
JP6963614B2 (ja) 2021-11-10
US10584112B2 (en) 2020-03-10
KR20190091461A (ko) 2019-08-06
US10954212B2 (en) 2021-03-23
HUE067004T2 (hu) 2024-10-28
BR112019011640A2 (pt) 2019-10-22
US20200016273A1 (en) 2020-01-16
US20200016272A1 (en) 2020-01-16
JP2020502091A (ja) 2020-01-23
NZ754751A (en) 2022-05-27
AU2020239746B2 (en) 2021-07-08
AU2017371327B2 (en) 2020-10-15
IL322584A (en) 2025-10-01
US11505537B2 (en) 2022-11-22
US20190284166A1 (en) 2019-09-19
ZA201903928B (en) 2023-03-29
MX390156B (es) 2025-03-20
PT3551619T (pt) 2024-06-14
US10759778B2 (en) 2020-09-01
SI3551619T1 (sl) 2024-08-30
US20200062731A1 (en) 2020-02-27
US20210130322A1 (en) 2021-05-06
US11021460B2 (en) 2021-06-01
ES2979262T3 (es) 2024-09-25
IL297652B2 (en) 2026-01-01
EP3551619A4 (en) 2020-07-22
EP4364802A3 (en) 2024-07-03
HRP20240748T1 (hr) 2024-09-13
US20200181114A1 (en) 2020-06-11
DK3551619T3 (da) 2024-06-10
BR112019011640B1 (pt) 2021-08-17
EP4364802A2 (en) 2024-05-08
US11021459B2 (en) 2021-06-01
US10954213B2 (en) 2021-03-23
US10858341B2 (en) 2020-12-08
US20190282559A1 (en) 2019-09-19
KR102337138B1 (ko) 2021-12-08
CN110234636A (zh) 2019-09-13
US20200061198A1 (en) 2020-02-27
AU2020239746A1 (en) 2020-10-22
EP3551619A1 (en) 2019-10-16
US20210253552A1 (en) 2021-08-19
MX2019006670A (es) 2019-12-16
IL267172A (en) 2019-08-29
CN110234636B (zh) 2022-09-20
AU2017371327A1 (en) 2019-07-11

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