LT2958888T - Bicikliniai junginiai - Google Patents

Bicikliniai junginiai

Info

Publication number: LT2958888T
Authority: LT; Lithuania
Prior art keywords: bicyclic compounds; bicyclic; compounds
Prior art date: 2013-02-21

Application number

LTEP14709822.2T

Other languages

English (en)

Inventor

T. G. Murali Dhar

Hai-Yun Xiao

Alaric J. Dyckman

Eric J. Chan

Marta Dabros

Daniel Richard Roberts

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-02-21

Filing date

2014-02-21

Publication date

2017-02-10

2014-02-21 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2017-02-10 Publication of LT2958888T publication Critical patent/LT2958888T/lt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
- C07C25/18—Polycyclic aromatic halogenated hydrocarbons
- C07C25/22—Polycyclic aromatic halogenated hydrocarbons with condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
- C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
- C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

LTEP14709822.2T 2013-02-21 2014-02-21 Bicikliniai junginiai LT2958888T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201361767531P	2013-02-21	2013-02-21
PCT/US2014/017534 WO2014130752A2 (en)	2013-02-21	2014-02-21	Bicyclic compounds

Publications (1)

Publication Number	Publication Date
LT2958888T true LT2958888T (lt)	2017-02-10

Family

ID=50272738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP14709822.2T LT2958888T (lt)	2013-02-21	2014-02-21	Bicikliniai junginiai

Country Status (34)

Country	Link
US (3)	US9115054B2 (lt)
EP (1)	EP2958888B1 (lt)
JP (1)	JP6277210B2 (lt)
KR (1)	KR102242265B1 (lt)
CN (1)	CN105026362B (lt)
AR (1)	AR094851A1 (lt)
AU (1)	AU2014218883B2 (lt)
BR (1)	BR112015019919A2 (lt)
CA (1)	CA2902168C (lt)
CL (1)	CL2015002358A1 (lt)
CY (1)	CY1118641T1 (lt)
DK (1)	DK2958888T3 (lt)
EA (1)	EA025294B1 (lt)
ES (1)	ES2613262T3 (lt)
HR (1)	HRP20170247T1 (lt)
HU (1)	HUE031626T2 (lt)
IL (1)	IL240613B (lt)
LT (1)	LT2958888T (lt)
MA (1)	MA38425B1 (lt)
MX (1)	MX2015010347A (lt)
MY (1)	MY173990A (lt)
PE (1)	PE20151746A1 (lt)
PH (1)	PH12015501793B1 (lt)
PL (1)	PL2958888T3 (lt)
PT (1)	PT2958888T (lt)
RS (1)	RS55703B1 (lt)
SG (1)	SG11201506408TA (lt)
SI (1)	SI2958888T1 (lt)
SM (2)	SMT201700115T1 (lt)
TN (1)	TN2015000356A1 (lt)
TW (1)	TWI613182B (lt)
UY (1)	UY35338A (lt)
WO (1)	WO2014130752A2 (lt)
ZA (1)	ZA201506965B (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6617702B2 (ja)	2013-07-15	2019-12-11	ザリージェンツオブザユニバーシティオブカリフォルニア	Ｆｔｙ７２０のアザサイクリック拘束アナログ
AR101591A1 (es) *	2014-08-20	2016-12-28	Bristol Myers Squibb Co	Compuestos bicíclicos sustituidos
JP6853539B2 (ja)	2015-09-24	2021-03-31	ザリージェンツオブザユニバーシティオブカリフォルニアＴｈｅＲｅｇｅｎｔｓＯｆＴｈｅＵｎｉｖｅｒｓｉｔｙＯｆＣａｌｉｆｏｒｎｉａ	合成スフィンゴ脂質様分子、薬物、これらの合成方法、および処置方法
ES2859478T3 (es)	2016-09-02	2021-10-04	Bristol Myers Squibb Co	Compuestos heterocíclicos tricíclicos sustituidos
WO2019032632A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	ALKYLPHENYL COMPOUNDS
WO2019032631A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	Oxime ether compounds
WO2021062168A1 (en) *	2019-09-25	2021-04-01	The Regents Of The University Of California	Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
WO2025083549A1 (en)	2023-10-16	2025-04-24	Sun Pharma Advanced Research Company Limited	Methods and combinations of inhibitors of il-23 pathway and modulators of s1p signaling pathway for the treatment of autoimmune disorders

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4200750A (en)	1977-01-07	1980-04-29	Westwood Pharmaceuticals Inc.	4-Substituted imidazo [1,2-a]quinoxalines
US6069143A (en)	1994-12-20	2000-05-30	Smithkline Beecham Corporation	Fibrinogen receptor antagonists
CA2472713C (en)	2002-01-18	2011-07-19	Merck & Co., Inc.	N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists
US20050070506A1 (en)	2002-01-18	2005-03-31	Doherty George A.	Selective s1p1/edg1 receptor agonists
DE60329073D1 (de)	2002-01-18	2009-10-15	Merck & Co Inc	Edg-rezeptoragonisten
EP1482895A4 (en)	2002-03-01	2005-04-27	Merck & Co Inc	AMINO ALKYL PHOSPHONATES AND RELATED COMPOUNDS AS EDG RECEPTOR AGONISTS
WO2003105771A2 (en)	2002-06-17	2003-12-24	Merck & Co., Inc.	1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
AR044402A1 (es)	2003-05-19	2005-09-14	Irm Llc	Compuestos heterociclicos y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
WO2005058848A1 (en)	2003-12-17	2005-06-30	Merck & Co., Inc.	(3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
TW200538433A (en)	2004-02-24	2005-12-01	Irm Llc	Immunosuppressant compounds and compositiions
EP1804793A4 (en)	2004-10-22	2010-03-31	Merck Sharp & Dohme	2- (ARYL) AZACYCLYLMETHYL-CARBOXYLATE, SULPHONATE, PHOSPHONATE, PHOSPHINATE AND HETEROCYCLES AS S1P RECEPTOR AGONISTS
CA2596990A1 (en)	2005-02-14	2006-08-24	University Of Virginia Patent Foundation	Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups
BRPI0607156A2 (pt)	2005-02-18	2009-08-11	Innodia Inc	composto, composição farmacêutica, uso do composto, kit farmacêutico, método para estimular a absorção de glicose por células de músculo e/ou célula de adipócito e método para estimular a secreção pancreática
JP2008532950A (ja)	2005-03-08	2008-08-21	バイオタサイエンティフィックマネージメントピーティーワイリミテッド	治療薬としての二環式ヌクレオシドおよび二環式ヌクレオチド
US7605269B2 (en)	2005-03-23	2009-10-20	Actelion Pharmaceuticals Ltd.	Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
NZ563522A (en)	2005-04-22	2010-01-29	Daiichi Sankyo Co Ltd	Heterocyclic compound with immunosuppressive activity
US20080306124A1 (en)	2005-06-08	2008-12-11	Rainer Albert	Polycyclic Oxadiazoles or I Soxazoles and Their Use as Sip Receptor Ligands
JP2009506046A (ja)	2005-08-23	2009-02-12	アイアールエム・リミテッド・ライアビリティ・カンパニー	免疫抑制剤化合物および組成物
AU2007205114B2 (en)	2006-01-06	2012-11-08	Sunovion Pharmaceuticals Inc.	Cycloalkylamines as monoamine reuptake inhibitors
RU2008134702A (ru)	2006-01-27	2010-03-10	Юниверсити Оф Вирждиния Пэтент Фаундейшн (Us)	Способ лечения невропатической боли
WO2007088450A2 (en)	2006-02-01	2007-08-09	Pfizer Products Inc.	Chromane antagonist of the h-3 receptor
US7790707B2 (en)	2006-03-21	2010-09-07	Epix Pharmaceuticals Inc.	S1P receptor modulating compounds and use thereof
CA2645639A1 (en)	2006-03-23	2007-10-04	Merck & Co. Inc.	Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2007116866A1 (ja)	2006-04-03	2007-10-18	Astellas Pharma Inc.	ヘテロ化合物
JP2009269819A (ja)	2006-08-25	2009-11-19	Asahi Kasei Pharma Kk	アミン化合物
CA2661315C (en)	2006-09-08	2015-11-24	Actelion Pharmaceuticals Ltd	Pyridin-3-yl derivatives as immunomodulating agents
US8217027B2 (en)	2006-12-21	2012-07-10	Abbott Laboratories	Sphingosine-1-phosphate receptor agonist and antagonist compounds
CN101610674A (zh) *	2006-12-21	2009-12-23	艾博特公司	鞘氨醇-1-磷酸酯受体激动剂和拮抗剂化合物
GB0625648D0 (en)	2006-12-21	2007-01-31	Glaxo Group Ltd	Compounds
AR064650A1 (es) *	2006-12-21	2009-04-15	Abbott Lab	Compuestos agonistas y antagonistas del receptor de esfingosina-1-fosfato
CA2675221C (en)	2007-02-02	2016-02-23	F. Hoffmann-La Roche Ag	Novel 2-aminooxazolines as taar1 ligands
SI2125797T1 (sl)	2007-03-16	2014-03-31	Actelion Pharmaceuticals Ltd.	Derivati amino-piridina kot agonisti receptorja s1p1/edg1
BRPI0818457A2 (pt)	2007-10-04	2015-04-14	Merck Serono Sa	Derivados de oxadiazol
NZ585775A (en)	2007-11-01	2011-12-22	Actelion Pharmaceuticals Ltd	Novel pyrimidine derivatives
GB0725105D0 (en)	2007-12-21	2008-01-30	Glaxo Group Ltd	Compounds
US8153686B2 (en)	2008-04-01	2012-04-10	Theravance, Inc.	Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
US9181182B2 (en)	2008-10-17	2015-11-10	Akaal Pharma Pty Ltd	S1P receptors modulators
MX2011006560A (es)	2008-12-18	2011-08-03	Merck Serono Sa	Derivados heterociclicos fucionados con oxadiazola utiles para el tratamiento de esclerosis multiple.
EP2202232A1 (en)	2008-12-26	2010-06-30	Laboratorios Almirall, S.A.	1,2,4-oxadiazole derivatives and their therapeutic use
EP2210890A1 (en)	2009-01-19	2010-07-28	Almirall, S.A.	Oxadiazole derivatives as S1P1 receptor agonists
US8404672B2 (en)	2009-01-23	2013-03-26	Bristol-Meyers Squibb Company	Substituted heterocyclic compounds
JP2012515789A (ja)	2009-01-23	2012-07-12	ブリストル−マイヤーズスクイブカンパニー	スフィンゴシン−１−リン酸アゴニストとしてのピラゾール−１，２，４−オキサジアゾール誘導体
WO2010085581A1 (en)	2009-01-23	2010-07-29	Bristol-Myers Squibb Company	Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
EP2395986A1 (en)	2009-02-10	2011-12-21	Abbott Laboratories	Methods for preparing s1p receptor agonists and antagonists
US8399451B2 (en)	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
KR20130036171A (ko)	2009-10-29	2013-04-11	브리스톨-마이어스 스큅 컴퍼니	트리시클릭 헤테로시클릭 화합물
EP2560969B1 (en)	2010-04-23	2015-08-12	Bristol-Myers Squibb Company	4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists
CN102260177A (zh)	2010-05-25	2011-11-30	中国医学科学院药物研究所	丙二醇类衍生物、其制备方法和其药物组合物与用途
CN102260178A (zh)	2010-05-25	2011-11-30	中国医学科学院药物研究所	羟基丙二醇类衍生物、其制备方法和其药物组合物与用途
ES2539256T3 (es)	2010-07-20	2015-06-29	Bristol-Myers Squibb Company	Compuestos de 3-fenil-1,2,4-oxadiazol sustituidos
JP5869579B2 (ja)	2010-09-24	2016-02-24	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	置換オキサジアゾール化合物およびそれらのｓ１ｐ１アゴニストとしての使用
ES2525298T3 (es)	2010-11-03	2014-12-19	Bristol-Myers Squibb Company	Compuestos heterocíclicos como agonistas del S1P1 para el tratamiento de enfermedades autoinmunes y vasculares
EP2685971A4 (en)	2011-03-18	2014-01-22	Univ Virginia Patent Found	COMPOSITIONS AND METHODS FOR TISSUE PROCESSING AND CELL-BASED THERAPIES
WO2012147311A1 (ja)	2011-04-26	2012-11-01	パナソニック株式会社	暖房システム及び暖房システム制御方法
GB201107325D0 (en) *	2011-05-04	2011-06-15	Glaxosmithkline Llc	Novel compounds
JP6129159B2 (ja)	2011-05-13	2017-05-17	レセプトスエルエルシー	選択的複素環式スフィンゴシン１−リン酸受容体モジュレーター
WO2014018891A1 (en)	2012-07-27	2014-01-30	Biogen Idec Ma Inc.	Compounds that are s1p modulating agents and/or atx modulating agents

2014
- 2014-02-20 UY UY0001035338A patent/UY35338A/es unknown
- 2014-02-20 TW TW103105719A patent/TWI613182B/zh not_active IP Right Cessation
- 2014-02-20 US US14/185,164 patent/US9115054B2/en active Active
- 2014-02-21 RS RS20170188A patent/RS55703B1/sr unknown
- 2014-02-21 WO PCT/US2014/017534 patent/WO2014130752A2/en not_active Ceased
- 2014-02-21 BR BR112015019919A patent/BR112015019919A2/pt not_active Application Discontinuation
- 2014-02-21 PL PL14709822T patent/PL2958888T3/pl unknown
- 2014-02-21 AU AU2014218883A patent/AU2014218883B2/en not_active Ceased
- 2014-02-21 HR HRP20170247TT patent/HRP20170247T1/hr unknown
- 2014-02-21 EA EA201591409A patent/EA025294B1/ru not_active IP Right Cessation
- 2014-02-21 KR KR1020157025410A patent/KR102242265B1/ko not_active Expired - Fee Related
- 2014-02-21 MY MYPI2015702746A patent/MY173990A/en unknown
- 2014-02-21 SM SM20170115T patent/SMT201700115T1/it unknown
- 2014-02-21 PT PT147098222T patent/PT2958888T/pt unknown
- 2014-02-21 JP JP2015558976A patent/JP6277210B2/ja not_active Expired - Fee Related
- 2014-02-21 AR ARP140100554A patent/AR094851A1/es unknown
- 2014-02-21 SI SI201430106A patent/SI2958888T1/sl unknown
- 2014-02-21 CA CA2902168A patent/CA2902168C/en not_active Expired - Fee Related
- 2014-02-21 MX MX2015010347A patent/MX2015010347A/es unknown
- 2014-02-21 SG SG11201506408TA patent/SG11201506408TA/en unknown
- 2014-02-21 LT LTEP14709822.2T patent/LT2958888T/lt unknown
- 2014-02-21 HU HUE14709822A patent/HUE031626T2/en unknown
- 2014-02-21 MA MA38425A patent/MA38425B1/fr unknown
- 2014-02-21 PE PE2015001795A patent/PE20151746A1/es active IP Right Grant
- 2014-02-21 DK DK14709822.2T patent/DK2958888T3/en active
- 2014-02-21 EP EP14709822.2A patent/EP2958888B1/en active Active
- 2014-02-21 ES ES14709822.2T patent/ES2613262T3/es active Active
- 2014-02-21 CN CN201480009497.1A patent/CN105026362B/zh not_active Expired - Fee Related
2015
- 2015-07-14 US US14/798,498 patent/US9359286B2/en active Active
- 2015-08-14 PH PH12015501793A patent/PH12015501793B1/en unknown
- 2015-08-17 IL IL240613A patent/IL240613B/en active IP Right Grant
- 2015-08-18 TN TN2015000356A patent/TN2015000356A1/en unknown
- 2015-08-21 CL CL2015002358A patent/CL2015002358A1/es unknown
- 2015-09-18 ZA ZA2015/06965A patent/ZA201506965B/en unknown
2016
- 2016-05-06 US US15/148,222 patent/US9487481B2/en active Active
2017
- 2017-02-16 CY CY20171100216T patent/CY1118641T1/el unknown
- 2017-02-21 SM SM201700115T patent/SMT201700115B/it unknown

Also Published As

Publication number	Publication date
EP2958888B1 (en)	2016-11-23
CL2015002358A1 (es)	2016-02-26
US20150315128A1 (en)	2015-11-05
CN105026362B (zh)	2017-07-14
HUE031626T2 (en)	2017-07-28
WO2014130752A2 (en)	2014-08-28
EP2958888A2 (en)	2015-12-30
ES2613262T3 (es)	2017-05-23
PE20151746A1 (es)	2015-12-02
JP6277210B2 (ja)	2018-02-07
ZA201506965B (en)	2017-08-30
SMT201700115T1 (it)	2017-03-08
PT2958888T (pt)	2017-02-03
AR094851A1 (es)	2015-09-02
TN2015000356A1 (en)	2017-01-03
DK2958888T3 (en)	2017-03-06
TWI613182B (zh)	2018-02-01
MY173990A (en)	2020-03-03
PL2958888T3 (pl)	2017-07-31
SMT201700115B (it)	2017-03-08
US9359286B2 (en)	2016-06-07
TW201444786A (zh)	2014-12-01
MA38425A1 (fr)	2017-12-29
CA2902168C (en)	2019-01-08
SI2958888T1 (sl)	2017-01-31
CY1118641T1 (el)	2017-07-12
US9115054B2 (en)	2015-08-25
CN105026362A (zh)	2015-11-04
KR102242265B1 (ko)	2021-04-19
WO2014130752A3 (en)	2014-10-23
AU2014218883A1 (en)	2015-10-15
EA025294B1 (ru)	2016-12-30
US9487481B2 (en)	2016-11-08
MA38425B1 (fr)	2019-03-29
JP2016513124A (ja)	2016-05-12
UY35338A (es)	2014-08-29
EA201591409A1 (ru)	2015-12-30
BR112015019919A2 (pt)	2017-07-18
AU2014218883B2 (en)	2017-05-11
PH12015501793A1 (en)	2015-11-09
HK1218111A1 (en)	2017-02-03
IL240613A0 (en)	2015-10-29
HRP20170247T1 (hr)	2017-04-07
MX2015010347A (es)	2015-11-16
IL240613B (en)	2018-06-28
RS55703B1 (sr)	2017-07-31
SG11201506408TA (en)	2015-09-29
KR20150119352A (ko)	2015-10-23
US20140235591A1 (en)	2014-08-21
US20160251309A1 (en)	2016-09-01
CA2902168A1 (en)	2014-08-28
PH12015501793B1 (en)	2015-11-09

Publication	Publication Date	Title
GB201309085D0 (en)	2013-07-03	Compounds
AP2015008713A0 (en)	2015-09-30	Tetrahydropyrrolothiazine compounds
GB201302927D0 (en)	2013-04-03	Compounds
GB201310542D0 (en)	2013-07-31	Compounds
GB201311951D0 (en)	2013-08-14	Compounds
GB201309508D0 (en)	2013-07-10	Compounds
GB201317619D0 (en)	2013-11-20	Compounds
GB201319363D0 (en)	2013-12-18	Compounds
ZA201506965B (en)	2017-08-30	Bicyclic compounds
GB201320636D0 (en)	2014-01-08	Compounds
GB201311953D0 (en)	2013-08-14	Compounds
AP3850A (en)	2016-09-30	Azetidinyloxyphenylpyrrolidine compounds
GB201312901D0 (en)	2013-09-04	Compounds
EP2948457A4 (en)	2016-09-07	COMPOUNDS
GB201306794D0 (en)	2013-05-29	Compounds
GB201318461D0 (en)	2013-12-04	Compounds
GB201316014D0 (en)	2013-10-23	Compounds
GB201310460D0 (en)	2013-07-24	Compounds
GB201321553D0 (en)	2014-01-22	Compounds
GB201321283D0 (en)	2014-01-15	Compounds
GB201318323D0 (en)	2013-11-27	Compounds
GB201318143D0 (en)	2013-11-27	Compounds
GB201317118D0 (en)	2013-11-06	Compounds
GB201316717D0 (en)	2013-11-06	Compounds
GB201315947D0 (en)	2013-10-23	Compounds