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LT2804599T - Kombinuota terapija vėžio gydymui - Google Patents

Kombinuota terapija vėžio gydymui

Info

Publication number
LT2804599T
LT2804599T LTEP13738179.4T LT13738179T LT2804599T LT 2804599 T LT2804599 T LT 2804599T LT 13738179 T LT13738179 T LT 13738179T LT 2804599 T LT2804599 T LT 2804599T
Authority
LT
Lithuania
Prior art keywords
cancer
treatment
combination therapy
therapy
combination
Prior art date
Application number
LTEP13738179.4T
Other languages
English (en)
Inventor
Steven Hoffman
Original Assignee
Tyme, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/371,076 external-priority patent/US8481498B1/en
Application filed by Tyme, Inc. filed Critical Tyme, Inc.
Publication of LT2804599T publication Critical patent/LT2804599T/lt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37Coumarins, e.g. psoralen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP13738179.4T 2012-01-17 2013-01-16 Kombinuota terapija vėžio gydymui LT2804599T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261587420P 2012-01-17 2012-01-17
US13/371,076 US8481498B1 (en) 2012-01-17 2012-02-10 Pharmaceutical compositions and methods
US201261702994P 2012-09-19 2012-09-19
PCT/US2013/021714 WO2013109610A1 (en) 2012-01-17 2013-01-16 Pharmaceutical compositions and methods

Publications (1)

Publication Number Publication Date
LT2804599T true LT2804599T (lt) 2019-04-10

Family

ID=48799616

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP13738179.4T LT2804599T (lt) 2012-01-17 2013-01-16 Kombinuota terapija vėžio gydymui

Country Status (25)

Country Link
EP (2) EP3488848A1 (lt)
JP (4) JP6276707B2 (lt)
KR (1) KR102172658B1 (lt)
CN (2) CN107714684A (lt)
AU (4) AU2013209862A1 (lt)
BR (1) BR112014017613A2 (lt)
CA (1) CA2862689C (lt)
CY (1) CY1121450T1 (lt)
DK (1) DK2804599T3 (lt)
ES (1) ES2706070T3 (lt)
HR (1) HRP20190046T1 (lt)
HU (1) HUE045314T2 (lt)
IL (2) IL233681B (lt)
IN (1) IN2014DN06711A (lt)
LT (1) LT2804599T (lt)
MX (1) MX363579B (lt)
NZ (2) NZ721280A (lt)
PH (1) PH12014501639B1 (lt)
PL (1) PL2804599T3 (lt)
PT (1) PT2804599T (lt)
RS (1) RS58538B1 (lt)
SI (1) SI2804599T1 (lt)
SM (1) SMT201900024T1 (lt)
WO (1) WO2013109610A1 (lt)
ZA (1) ZA201405611B (lt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10272068B2 (en) 2012-01-17 2019-04-30 Tyme, Inc. Pharmaceutical compositions and methods
US20130183263A1 (en) 2012-01-17 2013-07-18 Steven Hoffman Pharmaceutical compositions and methods
US10646552B2 (en) 2012-01-17 2020-05-12 Tyme, Inc. Pharmaceutical compositions and methods
EP3488848A1 (en) * 2012-01-17 2019-05-29 Tyme, Inc. Tyrosine hydroxylase inhibitors for use in treating cancer
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
US9724657B2 (en) * 2013-10-22 2017-08-08 Tyme, Inc. High-speed centrifugal mixing devices and methods of use
KR20170117390A (ko) * 2014-12-23 2017-10-23 스티븐 호프만 경피 제형물
US9687528B2 (en) 2014-12-23 2017-06-27 Steven Hoffman Transdermal formulations
MX2018011101A (es) * 2016-03-15 2018-11-22 Tyme Inc Composiciones farmaceuticas para el tratamiento del cancer.
US20170333451A1 (en) * 2016-05-18 2017-11-23 Tyme, Inc. Dihydrotestosterone and dihydrotestosterone derivatives and promoters in the treatment of cancer
EP3541411A1 (en) * 2016-11-15 2019-09-25 Tyme, Inc. Pharmaceutical compositions and methods for the treatment of cancer
EP3548086A1 (en) * 2016-11-30 2019-10-09 Tyme, Inc. Tyrosine derivatives and compositions comprising them
JP7171611B2 (ja) * 2017-04-21 2022-11-15 スティーブン・ホフマン 網膜症を治療するための組成物及び方法
BR112021022784A2 (pt) * 2019-05-14 2022-03-22 Tyme Inc Composições e métodos para tratamento do câncer
WO2021076723A1 (en) * 2019-10-15 2021-04-22 Tyme, Inc. Alkylesters of alpha-methyl-dl-tyrosine for use in treating cancer
IL294803A (en) * 2020-01-17 2022-09-01 Tyme Inc Tyrosine derivatives for modulating cancer
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
US20240016815A1 (en) * 2020-12-02 2024-01-18 Hoffman Technologies Llc Compositions and methods for modulating cancer in non-human mammals

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
DE3823735A1 (de) * 1988-07-13 1989-03-02 Ernst Hajek Verwendung von d-leucin (rechtsdrehende (alpha)-amino-isocapronsaeure) als wirkstoff zur bekaempfung maligner tumoren des schleimhautepithels des gesamten intestinaltraktes einschliesslich pankreas und gallenblase
US5225435A (en) 1990-05-18 1993-07-06 Yale University Soluble melanin
IT1291633B1 (it) * 1997-04-22 1999-01-11 Pharmaconsult S A S Uso dell'alfa-metil-p-tirosina per inibire la produzione di melanina nei melanociti dell'iride
IL138214A0 (en) * 1998-03-09 2001-10-31 Zealand Pharmaceuticals As Pharmacolgically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
WO2000010507A2 (en) * 1998-08-21 2000-03-02 The Children's Medical Center Corporation Use of melanin for inhibition of angiogenesis and macular degeneration
JP2002128304A (ja) 2000-10-20 2002-05-09 Nec Eng Ltd 給紙装置
AU2003296176A1 (en) * 2002-12-26 2004-07-22 Ajinomoto Co., Inc. Inhibitor for liver cancer onset and progress
DE602005014442D1 (de) * 2005-03-11 2009-06-25 Gpc Biotech Ag Antiproliferative Kombinations-Therapie mit Satraplatin oder JM118 und Docetaxel
EP2056808A4 (en) * 2006-08-28 2009-12-23 Univ California Small molecule potentiator of hormonal therapy for breast cancer
JP5073541B2 (ja) 2007-05-09 2012-11-14 ルネサスエレクトロニクス株式会社 半導体記憶装置
US20100210535A1 (en) * 2007-09-11 2010-08-19 Dorian Bevec Therapeutic use of neuropeptide ei and acth 7-38 and compositions thereof
US8110578B2 (en) * 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
CN103025328A (zh) * 2010-04-16 2013-04-03 达沃斯生命科学有限公司 用于皮肤应用的至少一种维生素e成分和酪氨酸酶抑制剂协同相互作用
EP3488848A1 (en) 2012-01-17 2019-05-29 Tyme, Inc. Tyrosine hydroxylase inhibitors for use in treating cancer

Also Published As

Publication number Publication date
JP2020172521A (ja) 2020-10-22
CN104220057A (zh) 2014-12-17
JP2022095894A (ja) 2022-06-28
CA2862689A1 (en) 2013-07-25
SI2804599T1 (sl) 2019-05-31
AU2022202113A1 (en) 2022-04-14
EP2804599A4 (en) 2015-10-21
CN104220057B (zh) 2017-11-03
BR112014017613A2 (pt) 2017-07-04
AU2020201683A1 (en) 2020-03-26
IL233681B (en) 2019-07-31
ES2706070T3 (es) 2019-03-27
JP7095028B2 (ja) 2022-07-04
NZ721280A (en) 2017-08-25
CY1121450T1 (el) 2020-05-29
RS58538B1 (sr) 2019-04-30
EP3488848A1 (en) 2019-05-29
JP2018065848A (ja) 2018-04-26
IN2014DN06711A (lt) 2015-05-22
IL252566A0 (en) 2017-07-31
PH12014501639A1 (en) 2014-10-13
MX363579B (es) 2019-03-27
MX2014008640A (es) 2015-03-09
SMT201900024T1 (it) 2019-05-10
EP2804599A1 (en) 2014-11-26
CN107714684A (zh) 2018-02-23
JP6789916B2 (ja) 2020-11-25
ZA201405611B (en) 2015-06-24
KR20140135704A (ko) 2014-11-26
JP6276707B2 (ja) 2018-02-07
IL233681A0 (en) 2014-09-30
NZ628757A (en) 2016-07-29
CA2862689C (en) 2020-03-10
KR102172658B1 (ko) 2020-11-02
EP2804599B1 (en) 2018-10-17
AU2013209862A1 (en) 2014-09-04
HRP20190046T1 (hr) 2019-05-03
PH12014501639B1 (en) 2023-02-22
IL252566B (en) 2020-07-30
PL2804599T3 (pl) 2019-06-28
HUE045314T2 (hu) 2019-12-30
WO2013109610A1 (en) 2013-07-25
PT2804599T (pt) 2019-01-28
AU2018203026A1 (en) 2018-05-17
DK2804599T3 (en) 2019-02-04
JP2015509101A (ja) 2015-03-26

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