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LT2013104A - Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas - Google Patents

Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Info

Publication number
LT2013104A
LT2013104A LT2013104A LT2013104A LT2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A LT 2013104 A LT2013104 A LT 2013104A
Authority
LT
Lithuania
Prior art keywords
factor
preparation
stem cell
granulocyte colony
partners
Prior art date
Application number
LT2013104A
Other languages
English (en)
Other versions
LT6161B (lt
Inventor
Henrikas Pesliakas
Plečkaitytė
Mištinienė
Žvirblytė
Petreikytė
Leiva
Stirkė
Žvirblis
Original Assignee
Uab Profarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Profarma filed Critical Uab Profarma
Priority to LT2013104A priority Critical patent/LT6161B/lt
Priority to PCT/LT2014/000006 priority patent/WO2015047062A1/en
Priority to EP14727636.4A priority patent/EP3049433B1/en
Publication of LT2013104A publication Critical patent/LT2013104A/lt
Publication of LT6161B publication Critical patent/LT6161B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Išradime pateikiamas sulietų baltymų, konkrečiau granuliocitų kolonijas stimuliuojančio faktoriaus ir kamieninių ląstelių faktoriaus, sujungtų linkerine seka, heterodimerų gavimo būdas ir biologinės savybės. Išradimo multimerinės konstrukcijos gali būti naudojamos terapijoje, nes pasižymi sinergetiniu veikimu ir ilgesniu cirkuliacijos pusamžiu lyginant su kiekvienu iš monomerinių baltymų atskirai.
LT2013104A 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas LT6161B (lt)

Priority Applications (3)

Application Number Priority Date Filing Date Title
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas
PCT/LT2014/000006 WO2015047062A1 (en) 2013-09-27 2014-04-15 Fused proteins of granulocyte colony-stimulating factor with other partners of growth factor, preferably with stem cell factor, and method of preparation thereof
EP14727636.4A EP3049433B1 (en) 2013-09-27 2014-04-15 Fused proteins of granulocyte colony-stimulating factor with other partners of growth factor, preferably with stem cell factor, and method of preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Publications (2)

Publication Number Publication Date
LT2013104A true LT2013104A (lt) 2015-04-27
LT6161B LT6161B (lt) 2015-06-25

Family

ID=50877627

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2013104A LT6161B (lt) 2013-09-27 2013-09-27 Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas

Country Status (3)

Country Link
EP (1) EP3049433B1 (lt)
LT (1) LT6161B (lt)
WO (1) WO2015047062A1 (lt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108368162B (zh) * 2016-04-15 2021-11-12 江苏恒瑞医药股份有限公司 一种重组人粒细胞刺激因子的复性及纯化方法
WO2018176034A1 (en) * 2017-03-24 2018-09-27 Ohio State Innovation Foundation Modulators of notch signaling and methods of use thereof
CN109078617A (zh) * 2018-09-19 2018-12-25 生工生物工程（上海）股份有限公司 Gst纯化材料、制备方法和产品及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0992579B1 (en) 1989-10-16 2008-08-06 Amgen Inc. Stem cell factor
DE69129697T3 (de) * 1990-08-29 2004-01-29 Inst Genetics Llc Aus mehreren domänen bestehende hämatopoese-stimulatoren
JPH05502463A (ja) 1990-09-28 1993-04-28 オーソ・フアーマシユーチカル・コーポレーシヨン ハイブリツド成長因子
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
CA2234061A1 (en) 1995-10-05 1997-04-10 G.D. Searle & Co. Multi-functional hematopoietic receptor agonists
US6967092B1 (en) * 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
DE60040225D1 (en) * 1999-07-13 2008-10-23 Bolder Biotechnology Inc Erythropoietin immunglobulin fusionsproteine
AUPQ934100A0 (en) 2000-08-10 2000-08-31 Mathers, Norman Ian Torque wrench
BRPI0412427A (pt) 2003-07-09 2006-09-05 Cipla Ltd dispositivo inalador
KR101192136B1 (ko) 2003-07-29 2012-10-16 돔페 파르마 에스.피.에이. 혈액 줄기 세포의 동원에 유효한 ｇ-ｃｓｆ와 ｐｌｇｆ의조합 약제
US7220407B2 (en) 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
EP1527785A1 (en) 2003-10-27 2005-05-04 Ludwig-Maximilians-Universität München Use of G-CSF for treating ischemia
WO2006055260A2 (en) 2004-11-05 2006-05-26 Northwestern University Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders
CN100336907C (zh) * 2005-09-29 2007-09-12 南京大学 重组人血小板生成素/干细胞因子融合蛋白及其制备
EP1878739A1 (en) * 2006-07-14 2008-01-16 LEK Pharmaceuticals D.D. One step IMAC (MCAC) purification of proteins
CN102260343A (zh) * 2010-05-25 2011-11-30 健能隆医药技术（上海）有限公司 重组人g-csf二聚体在治疗神经损伤疾病中的用途
US9243049B2 (en) * 2011-08-09 2016-01-26 Uab Profarma Derivatives of recombinant proteins, homo-multimers of granulocyte colony-stimulating factor and method of preparation thereof

Also Published As

Publication number Publication date
EP3049433B1 (en) 2018-11-07
EP3049433A1 (en) 2016-08-03
WO2015047062A1 (en) 2015-04-02
WO2015047062A4 (en) 2015-05-21
LT6161B (lt) 2015-06-25

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