[go: up one dir, main page]

KR910004603A - 신규 화합물 - Google Patents

신규 화합물 Download PDF

Info

Publication number
KR910004603A
KR910004603A KR1019900012252A KR900012252A KR910004603A KR 910004603 A KR910004603 A KR 910004603A KR 1019900012252 A KR1019900012252 A KR 1019900012252A KR 900012252 A KR900012252 A KR 900012252A KR 910004603 A KR910004603 A KR 910004603A
Authority
KR
South Korea
Prior art keywords
compound according
compound
treatment
general formula
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019900012252A
Other languages
English (en)
Inventor
모리스 에반스 존
스탬프 제프리
캐시디 프레드릭
버렐 고오든
Original Assignee
데이빗 로버츠
비이참 그루우프 피이엘시이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 데이빗 로버츠, 비이참 그루우프 피이엘시이 filed Critical 데이빗 로버츠
Publication of KR910004603A publication Critical patent/KR910004603A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Sub-Exchange Stations And Push- Button Telephones (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

내용 없음.

Description

신규 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 락탐 및 OH 부위가 트란스인 하기일반식(I)의 화합물의 (3S,4R) 이성질체.
  2. 하기 일반식(II) :
    (여기서 Ra는 에릴 또는 이것으로 전환가능한 기 또는 원자이다)의 화합물을 i) 피페리디논 음이온의 형태의 하기 일반식(III) :
    의 화합물과; 또는 ii) 하기 일반식(V) :
    여기서 L1및 L2는 이탈기이다)의 화합물로 연속적으로 아실화되는 하기 일반식(IV) ;
    의 트란스 아미노를 생성키 위해 암모니아와 반응하고; 그런뒤 필요하다면 결과화합물을 고리화하고; 그런뒤 Ra(에틸이외의 것인 경우)를 에틸로 전환하는 것으로 구성된, 제1항에 따른 화합물의 제조방법.
  3. 3,4-디히드로-2,2-디메틸-6-에테닐-4R-(2-옥소피페리딘-1-일)-2-1-벤조피란-3S-올.
  4. 제1항에 따른 화합물 및 제약학적으로 허용가능한 담체로 구성되는 제약학적 조성물.
  5. 고혈압 및/또는 기도 질환의 치료를 받을 필요가 있는 포유동물에게 제1항에 따른 화합물의 효과적인 량을 투여하는 것으로 구성된 포유동물내 고혈압 및/또는 기도질환의 치료방법.
  6. 활성 치료 물질로서 사용하기 위한 제1항에 따른 화합물.
  7. 평활근 수착과 관련된 질환의 치료에서 칼륨 채널 활성제로서 사용하기 위한 제1항에 따른 화합물.
  8. 고혈압 및/또는 기도질환의 치료에 사용하기 위한 제1항에 따른 화합물.
  9. 평활근 수축과 관련된 질환의 치료에서 칼륨 채널 활성제로서 사용하기 위한 약조 제조에서 제1항에 따른 화합물의 사용.
  10. 고혈압 및/또는 기도질환의 치료에 사용하기 위한 약제 제조에서 제1항에 따른 화합물의 사용.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012252A 1989-08-10 1990-08-09 신규 화합물 Withdrawn KR910004603A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898918298A GB8918298D0 (en) 1989-08-10 1989-08-10 Novel compounds
GB89182984 1989-08-10

Publications (1)

Publication Number Publication Date
KR910004603A true KR910004603A (ko) 1991-03-29

Family

ID=10661454

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900012252A Withdrawn KR910004603A (ko) 1989-08-10 1990-08-09 신규 화합물

Country Status (18)

Country Link
EP (1) EP0412760B1 (ko)
JP (1) JPH03218373A (ko)
KR (1) KR910004603A (ko)
CN (1) CN1049342A (ko)
AT (1) ATE114308T1 (ko)
AU (2) AU6080090A (ko)
DE (1) DE69014256T2 (ko)
FI (1) FI903950A7 (ko)
GB (1) GB8918298D0 (ko)
HU (1) HUT58727A (ko)
IE (1) IE902871A1 (ko)
IL (1) IL95313A0 (ko)
MA (1) MA21929A1 (ko)
NO (1) NO903488L (ko)
NZ (1) NZ234811A (ko)
PT (1) PT94950A (ko)
ZA (1) ZA906252B (ko)
ZW (1) ZW12890A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
TW244350B (ko) * 1991-12-14 1995-04-01 Hoechst Ag
US8785192B2 (en) 2010-07-07 2014-07-22 Cellular Dynamics International, Inc. Endothelial cell production by programming

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos

Also Published As

Publication number Publication date
ZA906252B (en) 1991-08-28
HUT58727A (en) 1992-03-30
PT94950A (pt) 1991-04-18
NZ234811A (en) 1993-01-27
IE902871A1 (en) 1991-02-27
GB8918298D0 (en) 1989-09-20
FI903950A7 (fi) 1991-02-11
FI903950A0 (fi) 1990-08-09
EP0412760B1 (en) 1994-11-23
JPH03218373A (ja) 1991-09-25
EP0412760A2 (en) 1991-02-13
NO903488D0 (no) 1990-08-08
EP0412760A3 (en) 1991-07-31
ATE114308T1 (de) 1994-12-15
MA21929A1 (fr) 1991-04-01
CN1049342A (zh) 1991-02-20
AU6080090A (en) 1991-02-14
AU5216593A (en) 1994-02-17
HU904936D0 (en) 1991-01-28
DE69014256T2 (de) 1995-03-30
DE69014256D1 (de) 1995-01-05
ZW12890A1 (en) 1991-05-08
NO903488L (no) 1991-02-11
IL95313A0 (en) 1991-06-30

Similar Documents

Publication Publication Date Title
UA41446C2 (uk) Застосування фумагілолу та його похідних для одержання ліків, призначених для боротьби з кишковими інфекціями, та фармацевтична композиція на їх основі
KR900014367A (ko) 피롤리딘 유도체
EA200101005A1 (ru) Высокоэффективные композиции, содержащие дигидроэрготамин
DE69713526D1 (de) Lösliche prodrugs von paclitaxel
HUT47217A (en) Process for producing pharmaceutical compositions containing indol derivatives as active components
PT977564E (pt) Forscolina para promocao da massa corporal magra
DK0975595T3 (da) Kokainanaloger
KR890700601A (ko) 펩티딜아미노디올
RU99105213A (ru) Применение хелатирующего агента клиохинола для производства фармацевтической композиции для лечения болезни альцгеймера
KR910009242A (ko) 치근막 질환 치료용 서방성 조성물
KR960700061A (ko) 니코틴 의존상태 치료를 위한 약리학적 제형 (pharmaceutical composition for treating nicotine dependence)
UA45942A (uk) 1,3-оксатіолан, його похідні, спосіб (варіанти) його одержання та фармацевтична композиція
EA200000057A1 (ru) (+)-норцисаприд, пригодный для лечения нарушений, опосредованных 5-нт3 и 5-нт4 (рецепторами)
KR950007848A (ko) (S)-(-)-α-에틸-2-옥소-1-피롤리딘아세트아미드를 사용한 불안치료방법
KR950016727A (ko) 트롬보모듈린 발현을 증가시키는 방법
GEP20012389B (en) Benzoxazinone Dopamine D4 Receptor Antagonists, Pharmaceutical Composition Containing the Same and Method for Treatment of Psychosis or Schizophrenia
KR950701623A (ko) 치환된 헥사하이드로벤조페난트리딘
HU9303000D0 (en) Aryl-morpholine-derivatives and pharmaceutical compositions containing it and process for production thereof
DE60026883D1 (de) Methoden und zusammensetzungen zur behandlung von schmerzen
KR910004603A (ko) 신규 화합물
KR890012942A (ko) 5-치환된 오르니틴 유도체
KR910004609A (ko) 아미노케톤 유도체 및 그의 용도
KR880004810A (ko) 소화성 궤양 치료제
KR890700131A (ko) 신규 화합물
FR2701952B1 (fr) Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19900809

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid