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KR900009638A - 신규 화합물들 - Google Patents

신규 화합물들 Download PDF

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Publication number
KR900009638A
KR900009638A KR1019890019276A KR890019276A KR900009638A KR 900009638 A KR900009638 A KR 900009638A KR 1019890019276 A KR1019890019276 A KR 1019890019276A KR 890019276 A KR890019276 A KR 890019276A KR 900009638 A KR900009638 A KR 900009638A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
general formula
acceptable salt
compound
chx
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019890019276A
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English (en)
Inventor
스튜어트 해들리 마이클
에이드리언 와이먼 폴
시드니 오어럭 배리
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Publication of KR900009638A publication Critical patent/KR900009638A/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Photoreceptors In Electrophotography (AREA)

Abstract

내용 없음

Description

신규 화합물들
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반구조식(Ⅰ) 화합물 또는 이들의 제약학적으로 허용 가능한 염.
  2. (±) 엑소-3-(3-에틸-1,2,4-옥사디아졸-5-일)-1-아자비시클로[2.2.1]헵탄 또는 이들의 제약학적으로 허용가능한 염.
  3. (±) 엑소-3-(3-에틸-1,2,4-옥사디아졸-5-일)-1-아자비시클로[2.2.1]헵탄 또는 이들의 제약학적으로 허용가능한 염.
  4. (±) 엑소-3-(3-에틸-1,2,4-옥사디아졸-5-일)-1-아자비시클로[2.2.1]헵탄 또는 이들의 제약학적으로 허용가능한 염.
  5. (a) 하기 일반식(Ⅱ) 화합물
    (상기식에서, R10은 수소 또는 N-보호기이며, C는 -(CH2)2-,-CH2- 및 -CHX'-CH2-(여기서 X'는 X 또는 이들로 전환할수 있는 기이며 이때 X는 3-에틸-1,2,4-옥사디아졸-5-일임) 또는 이들로 전환할수 있는 기중 하나이며, D는 다른 하나이며 E는 그 나머지하니이며 L'은 이탈기이거나 C는 -(CH2)2- 및 -CH2- 또는 이들로 전환할수 있는 기중 하나이며 E는 다른 하나이며 D는 -CHX" -CH2-이며, 여기서 X"와 L'는 함께 -COO-를 나타냄)을 고리화시킨후, 임의로 또는 필요하다면 임의의 적당한 순서로, C,D 및 E를 -(CH2)2-, -CH2- 및 -CHX'-CH2-로 전환시키고 임의의 R10보호기를 제거시키고, X'를 X로 전환시키고 입체 이성질체 형태를 분리하고/거나 제약학적으로 허용가능한 염을 형성하거나,(b) 하기 일반구조식(Ⅲ) 화합물,
    (상기식에서 Y4는 -(CH2)m-W 이며 Y3은 -(CO)gL2이며 이때 W는 전자 끄는 기이며 L2는 이탈기 이며 m은 2이며 g은 0이거나 m 및 g는 1임)을 고리화시킨후, 임의로 또는 필요하다면, 임의의 적당한 순서로, 고리화생성물을 가수분해시키고 탈카르 복실화시킨후 카르보닐기를 CHX'(여기서 X'는 X또는 이들로 전환할 수 있는 기이며, 이때 X는 상기한 바와 같음)로 전환시키고 W를 정의된 X'로 전환시키고 X'를 X로 전환시키고 입체 이성질체 형태로 분리하고/ 거나 제약학적으로 허용가능한 염을 형성하는 것으로 구성된, 제1항에 정의된 일반구조식(Ⅰ) 화합물 또는 이들의 제약학적으로 허용 가능한 염의 제조방법.
  6. 제1항에 정의된 일반구조식(Ⅰ)화합물 또는 이들의 제약학적으로 허용가능한 염, 및 제약학적으로 허용가능한 담체로 구성된 제약학적 조성물.
  7. 활성 치료 물질로서 사용하기 위한, 제1항에 정의된 일반구조식(Ⅰ)화합물 또는 이들의 제약학적으로 허용가능한 염.
  8. 치매의 치료 및/ 또는 예방에 사용하기 위한 제1항에 정의된 일반구조식(Ⅰ) 화합물 또는 이들의 제약학적으로 허용가능한 염.
  9. 치매의 치료 및/ 또는 예방을 위한 약제의 제조에 제1항에 정의된 일반구조식(Ⅰ) 화합물 또는 이들의 제약학적으로 허용가능한 염의 사용.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890019276A 1988-12-23 1989-12-22 신규 화합물들 Withdrawn KR900009638A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8830226.0 1988-12-23
GB888830226A GB8830226D0 (en) 1988-12-23 1988-12-23 Novel compounds

Publications (1)

Publication Number Publication Date
KR900009638A true KR900009638A (ko) 1990-07-05

Family

ID=10649157

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890019276A Withdrawn KR900009638A (ko) 1988-12-23 1989-12-22 신규 화합물들

Country Status (13)

Country Link
US (1) US5043342A (ko)
EP (1) EP0375450B1 (ko)
JP (1) JPH02215782A (ko)
KR (1) KR900009638A (ko)
AT (1) ATE122352T1 (ko)
AU (1) AU620957B2 (ko)
CA (1) CA2006436A1 (ko)
DE (1) DE68922596T2 (ko)
DK (1) DK656889A (ko)
GB (1) GB8830226D0 (ko)
NZ (1) NZ231970A (ko)
PT (1) PT92668B (ko)
ZA (1) ZA899821B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100441404B1 (ko) * 2002-01-24 2004-07-23 한국과학기술연구원 신규한 알케닐 아자 두 고리 화합물 및 그 제조방법

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0427390B1 (en) * 1989-10-07 1996-03-27 Beecham Group Plc Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658067A (en) * 1953-11-03 Substituted carbamic acdj esters
GB1053085A (ko) * 1964-03-26
US3501471A (en) * 1966-09-21 1970-03-17 American Cyanamid Co Novel 2,3-heterocyclic fused quinuclidines,and 3-substituted quinuclidine-2-carboxylate derivatives
US3681363A (en) * 1970-08-20 1972-08-01 Univ Temple Spiro(imidazolidine-4,3{40 -quinuclidine)-2,5-diones
US4038402A (en) * 1974-03-05 1977-07-26 Mikhail Emmanuilovich Kaminka Method of effecting antihistaminic, antiserotonin and antiallergic actions
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
GB8314391D0 (en) * 1983-05-24 1983-06-29 Kefalas As Heterocyclic compounds
JPS6191185A (ja) * 1984-10-11 1986-05-09 Sumitomo Seiyaku Kk 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
ES2061502T3 (es) * 1986-06-27 1994-12-16 Beecham Group Plc Nuevos n-heterociclos biciclicos puenteados.
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
ES2053748T3 (es) * 1987-09-10 1994-08-01 Merck Sharp & Dohme Oxazoles y tiazoles para el tratamiento de la demencia senil.
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100441404B1 (ko) * 2002-01-24 2004-07-23 한국과학기술연구원 신규한 알케닐 아자 두 고리 화합물 및 그 제조방법

Also Published As

Publication number Publication date
US5043342A (en) 1991-08-27
NZ231970A (en) 1992-01-29
EP0375450B1 (en) 1995-05-10
GB8830226D0 (en) 1989-02-22
ATE122352T1 (de) 1995-05-15
PT92668B (pt) 1995-09-12
EP0375450A2 (en) 1990-06-27
AU620957B2 (en) 1992-02-27
JPH02215782A (ja) 1990-08-28
PT92668A (pt) 1990-06-29
DE68922596T2 (de) 1995-09-28
DK656889D0 (da) 1989-12-21
CA2006436A1 (en) 1990-06-23
ZA899821B (en) 1990-12-28
DE68922596D1 (de) 1995-06-14
AU4706489A (en) 1990-06-28
EP0375450A3 (en) 1991-07-31
DK656889A (da) 1990-06-24

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19891222

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid