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KR900007803A - 3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체 - Google Patents

3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체 Download PDF

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Publication number
KR900007803A
KR900007803A KR1019890016381A KR890016381A KR900007803A KR 900007803 A KR900007803 A KR 900007803A KR 1019890016381 A KR1019890016381 A KR 1019890016381A KR 890016381 A KR890016381 A KR 890016381A KR 900007803 A KR900007803 A KR 900007803A
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KR
South Korea
Prior art keywords
dimethyl
methoxy
carried out
reaction
formula
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Withdrawn
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KR1019890016381A
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English (en)
Inventor
바우만 칼
Original Assignee
페터 자이델, 클라우스 로덴
씨엘 파마 아크티엔 게젤샤프트
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Publication of KR900007803A publication Critical patent/KR900007803A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

내용 없음

Description

3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 불활성 희석제 존재하에, 구조식(Ⅱ)의 3,5-디메틸-4-메톡시-2-시아노피리딘을 촉매 수소화반응시켜 구조식(Ⅲ)의 3,5-디메틸-4-메톡시-2-아미노메틸 피리딘을 수득한 다음, 산성 수용액 중에서 아질산 나트륨과 반응시켜 3,5-디메틸-4-메톡시-2-하이드록시 메틸피리딘을 수득하고, 경우에 따라, 후자를 티오닐 클로라이드와 반응시켜 3,5-디메틸-4-메톡시-2-클로로메틸피리딘을 수득함을 특징으로 하여, 일반식(Ⅰ)의 화합물을 제조하는 방법.
    상기식에서, X는 OH 또는 CI라디칼이다.
  2. 제1항에 있어서, 촉매로서 라니(Raney)니켈, 또는 활성탄상의 백금을 사용하여 촉매 수소화반응을 수행함을 특징으로 하는 방법.
  3. 제1항에 있어서, NH3와의 배합물로 된 라니 니켈, 또는 광산 또는 톨루엔-설폰산과의 배합물로 된 활성탄상의 백금을 사용하여 촉매 수소화 반응을 수행함을 특징으로 하는 방법.
  4. 제1항에 있어서, NH3와의 배합물로 된 라니 니켈을 사용하여 촉매 수소화반응을 수행함을 특징으로 하는 방법.
  5. 제1항에 있어서, 희석제로서 메탄올 존재하에 수소화반응을 수행함을 특징으로 하는 방법.
  6. 제1항에 있어서, 9 : 1 내지 1 : 1비율의 물 및 빙초산 존재하에서 3,5-디메틸-4-메톡시-2-아미노메틸 피리딘의 반응을 수행함을 특징으로 하는 방법.
  7. 제1항에 있어서, 반응시 형성된 중간체인 3,5-디메틸-4-메톡시-2-아미노메틸피리딘 및 3,5-디메틸-4-메톡시-2-하이드록시메틸피리딘을 분리시키지 않고 반응시켜, 일반식(Ⅰ)(여기서, X는 CI 라디칼이다)의 화합물을 수득함을 특징으로 하는 방법.
  8. 3,5-디메틸-4-메톡시-2-아미노메틸피리딘.
  9. 3,5-디메틸-4-메톡시-2-하이드록시메틸피리딘 및 3,5-디메틸-4-메톡시-2-클로로메틸피리딘을 제조하기 위한 3,5-디메틸-4-메톡시-2-아미노메틸피리딘의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890016381A 1988-11-15 1989-11-13 3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체 Withdrawn KR900007803A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0278988A AT391693B (de) 1988-11-15 1988-11-15 Verfahren zur herstellung von 3-5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer
ATA2789/88 1988-11-15

Publications (1)

Publication Number Publication Date
KR900007803A true KR900007803A (ko) 1990-06-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890016381A Withdrawn KR900007803A (ko) 1988-11-15 1989-11-13 3,5-디메틸-4-메톡시피리딘 유도체의 제조방법 및 이를 제조하기 위한 중간체

Country Status (24)

Country Link
US (1) US5066810A (ko)
EP (1) EP0369208B1 (ko)
JP (1) JPH02180868A (ko)
KR (1) KR900007803A (ko)
CN (1) CN1042705A (ko)
AT (2) AT391693B (ko)
AU (1) AU628100B2 (ko)
CA (1) CA2002757A1 (ko)
CS (1) CS276357B6 (ko)
DD (1) DD284877A5 (ko)
DE (2) DE3840372A1 (ko)
DK (1) DK568989A (ko)
ES (1) ES2053906T3 (ko)
FI (1) FI895389A7 (ko)
GR (1) GR3007391T3 (ko)
HU (1) HU207995B (ko)
IL (1) IL92152A (ko)
NO (1) NO894410L (ko)
NZ (1) NZ231252A (ko)
PH (1) PH25813A (ko)
PT (1) PT92307B (ko)
SU (1) SU1745121A3 (ko)
YU (1) YU216389A (ko)
ZA (1) ZA898273B (ko)

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DE4411657A1 (de) * 1994-04-02 1995-10-05 Basf Ag Verfahren zur Herstellung von 6-Hydroxymethylchinolinen
ES2097089B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Procedimiento para la preparacion de 2-hidroximetil-3,5-dimetil-4-metoxipiridina.
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CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
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IL154014A0 (en) 2000-08-25 2003-07-31 Bayer Cropscience Sa Process for the preparation of 2-aminoethylpyridines
EP1422221A1 (en) * 2002-11-20 2004-05-26 Bayer CropScience SA Novel process for the preparation of 2-aminomethylpyridine derivative
WO2008092939A2 (en) 2007-01-31 2008-08-07 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation
CN101648912B (zh) * 2009-09-14 2012-07-04 南京第一农药集团有限公司 一种4-硝基-3,5-二甲基吡啶-n-氧化物的连续化制备方法
CN101648907B (zh) * 2009-09-14 2011-08-03 南京第一农药集团有限公司 2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐的纯化方法
CN102603620B (zh) * 2012-01-13 2014-10-29 江苏中邦制药有限公司 一种氯甲基吡啶或其吡啶衍生物盐酸盐的合成方法
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CN114805193B (zh) * 2022-04-19 2023-06-20 南京红太阳医药研究院有限公司 一种奥美拉唑中间体的制备方法

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Also Published As

Publication number Publication date
CA2002757A1 (en) 1990-05-15
CN1042705A (zh) 1990-06-06
ATE86978T1 (de) 1993-04-15
AU4465789A (en) 1990-05-24
DE3840372A1 (de) 1990-05-31
NO894410L (no) 1990-05-16
DK568989D0 (da) 1989-11-14
YU216389A (en) 1991-02-28
HUT52480A (en) 1990-07-28
SU1745121A3 (ru) 1992-06-30
IL92152A0 (en) 1990-07-12
EP0369208A1 (de) 1990-05-23
AT391693B (de) 1990-11-12
DK568989A (da) 1990-05-16
ZA898273B (en) 1990-07-25
GR3007391T3 (ko) 1993-07-30
HU207995B (en) 1993-07-28
PT92307A (pt) 1990-05-31
ATA278988A (de) 1990-05-15
PH25813A (en) 1991-11-05
JPH02180868A (ja) 1990-07-13
AU628100B2 (en) 1992-09-10
FI895389A0 (fi) 1989-11-13
HU895899D0 (en) 1990-02-28
CS643889A3 (en) 1992-01-15
DD284877A5 (de) 1990-11-28
FI895389A7 (fi) 1990-05-16
EP0369208B1 (de) 1993-03-17
NO894410D0 (no) 1989-11-06
CS276357B6 (en) 1992-05-13
NZ231252A (en) 1991-05-28
PT92307B (pt) 1995-07-18
IL92152A (en) 1993-05-13
DE58903808D1 (de) 1993-04-22
US5066810A (en) 1991-11-19
ES2053906T3 (es) 1994-08-01

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