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KR900004700A - 아릴렌디아민 치환 피리미딘 - Google Patents

아릴렌디아민 치환 피리미딘 Download PDF

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Publication number
KR900004700A
KR900004700A KR1019890013422A KR890013422A KR900004700A KR 900004700 A KR900004700 A KR 900004700A KR 1019890013422 A KR1019890013422 A KR 1019890013422A KR 890013422 A KR890013422 A KR 890013422A KR 900004700 A KR900004700 A KR 900004700A
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KR
South Korea
Prior art keywords
alkyl
hydrogen
phenyl
cycloalkyl
substituted
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KR1019890013422A
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KR0120735B1 (ko
Inventor
록우드 윌러 에드워드
허버트바로우 프랭클린
존 프랭코 로버트
Original Assignee
아이.제이.크라코워
유니로얄 케미칼 컴페니 인코포레이티드
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Publication of KR900004700A publication Critical patent/KR900004700A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3442—Heterocyclic compounds having nitrogen in the ring having two nitrogen atoms in the ring
    • C08K5/3462—Six-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아릴렌디아민 치환 피리미딘
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(I)의 화합물:
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3는 수소, 페닐 또는 C1-C11알킬(R1이 수소일때); R4는 수소 또는 C1-C8알킬; R5는 수소 또는 C1-C8알킬; R6는 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7
    R7은 C1-C12R8은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬;C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  2. 불포화 폴리마 및 내붕궤성에 유효한 양의 하기 구조식(I)의 화합물을 포함하는, 내붕궤성 조성물:
    여기서, X는
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3은 수소, 페닐 또는 C1-C11알킬(R1이 수소일 때); R4은 수소, C1-C11알킬; R5는 수소 또는 C1-C8알킬; R6은 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7,
    R7은 C1-C12R7은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬; C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  3. 내붕궤성에 유효한 양의 하기 구조식(I)의 화합물이 내부에 첨합되어 있는 불포화 폴리마를 포함하는, 엘라스토마 제품:
    여기서, X는
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3은 수소, 페닐 또는 C1-C11알킬(R1이 수소일 때); R4은 수소 또는 C1-C8알킬; R5는 수소 또는 C1-C8알킬; R6은 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7,
    R7은 C1-C12R8은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬; C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  4. 하기 단계를 포함하는, 2,4,6-트리스(N-치환-파라-페닐렌디아미노)피리미딘의 제조방법. 용매내에서 N-치환-p-페닐렌디아민을 트리-할로피리미딘과 반응시켜, 2,4,6-트리스(N-치환-p-페닐렌디아미노)-피리미딘 트리히드로할라이드를 내포하고 있는 반응 혼합물을 형성하고; 및 상기 2,4,6-트리스(N-치환-p-페닐렌디아미노)-피리미딘 트리히드로할라이드를 염기로 중화하여 2,4,6-트리스(N-치환-p-페닐렌디아미노)피리미딘을 형성.
  5. 2,4,6-트리스(N-알킬-파라-페닐렌디아미노)피리미딘.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013422A 1988-09-21 1989-09-19 아릴렌디아민 치환 피리미딘 Expired - Fee Related KR0120735B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US247,143 1988-09-21
US07/247,143 US4946956A (en) 1988-09-21 1988-09-21 Arylenediamine substituted pyrimidines

Publications (2)

Publication Number Publication Date
KR900004700A true KR900004700A (ko) 1990-04-12
KR0120735B1 KR0120735B1 (ko) 1997-10-30

Family

ID=22933755

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013422A Expired - Fee Related KR0120735B1 (ko) 1988-09-21 1989-09-19 아릴렌디아민 치환 피리미딘

Country Status (7)

Country Link
US (1) US4946956A (ko)
EP (1) EP0363002B1 (ko)
KR (1) KR0120735B1 (ko)
AT (1) ATE107635T1 (ko)
BR (1) BR8904702A (ko)
CA (1) CA1339846C (ko)
DE (1) DE68916359T2 (ko)

Families Citing this family (30)

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Publication number Priority date Publication date Assignee Title
ES2274634T3 (es) 1998-08-29 2007-05-16 Astrazeneca Ab Compuestos de pirimidina.
ATE336484T1 (de) 1998-08-29 2006-09-15 Astrazeneca Ab Pyrimidine verbindungen
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
CA2404121C (en) * 2000-03-21 2009-10-06 Flexsys America L.P. Pyrimidine derivatives as hardness stabilizers
US6465604B2 (en) 2000-03-21 2002-10-15 Flexsys America L.P. Pyrimidine derivatives as hardness stabilizers
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US20040127502A1 (en) * 2001-01-31 2004-07-01 Synaptic Pharmaceutical Corporation Use of GAL3 antagonist for treatment of depression
US7081470B2 (en) * 2001-01-31 2006-07-25 H. Lundbeck A/S Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
HUP0401858A3 (en) * 2001-01-31 2009-06-29 Lundbeck & Co As H Gal3 receptor antagonist pyrimidine and indolone-derivatives and their use for preparation of pharmaceutical compositions suitable for the treatment of depression and/or anxiety
WO2002060392A2 (en) * 2001-01-31 2002-08-08 Synaptic Pharmaceutical Corporation Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
WO2003076434A1 (en) 2002-03-09 2003-09-18 Astrazeneca Ab 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205688D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
US6936607B2 (en) * 2002-08-07 2005-08-30 H. Lunobeck A/S 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
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US4650867A (en) * 1985-03-26 1987-03-17 Ciba-Geigy Corporation Process for the preparation of 2,4,6-tris(aminophenylamino)triazines
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US4794134A (en) * 1987-08-28 1988-12-27 Uniroyal Chemical Company, Inc. Ozone resistant elastomeric articles
JPH033982A (ja) * 1989-05-31 1991-01-10 Matsushita Electric Works Ltd エアーポンプ

Also Published As

Publication number Publication date
DE68916359D1 (de) 1994-07-28
KR0120735B1 (ko) 1997-10-30
CA1339846C (en) 1998-04-28
US4946956A (en) 1990-08-07
EP0363002B1 (en) 1994-06-22
EP0363002A1 (en) 1990-04-11
DE68916359T2 (de) 1994-10-27
BR8904702A (pt) 1990-05-01
ATE107635T1 (de) 1994-07-15

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