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KR860007200A - 5- 플루오로벤조니트릴 유도체 및 그 약리학적으로 수용가능한 산 부가염으로 이루어지는 동물사료 조성물의 제조방법 - Google Patents

5- 플루오로벤조니트릴 유도체 및 그 약리학적으로 수용가능한 산 부가염으로 이루어지는 동물사료 조성물의 제조방법 Download PDF

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Publication number
KR860007200A
KR860007200A KR1019860002079A KR860002079A KR860007200A KR 860007200 A KR860007200 A KR 860007200A KR 1019860002079 A KR1019860002079 A KR 1019860002079A KR 860002079 A KR860002079 A KR 860002079A KR 860007200 A KR860007200 A KR 860007200A
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South Korea
Prior art keywords
fluoroacetophenone
bromo
cyano
fluorobenzonitrile
tert
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KR1019860002079A
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KR900003531B1 (ko
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아사토 고로
제임즈 벤틀리 테렌스
제임스 벤틀리 테렌스
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아메리칸 사이아나밋드 캄파니
죤 제이 헤이간
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음

Description

5-플루오로벤조니트릴 유도체 및 그 약리학적으로 수용가능한 산 부가염으로 이루어지는 동물사료 조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 2-아미노-5-플루오로아세토페논을 비양자성 용매 존재하에서 N-브로모숙신이미드와 반응시켜 2-아미노-3-브로모-5-플루오로아세토페논을 생성하고; 2-아미노-3-브로모-5-플루오로아세토페논을 산 존재하에서 질산 나트륨과 반응시켜 3-브로모-5-플루오로아세토 페논을 생성하고; 3-브로모-5-플루오로아세토페논을 환류온도에서 불활성 유기 용매 존재하에서, 시안화제일구리와 반응시켜 3-시아노-5-플루오로아세토페논을 전환시키고; 3-시아노-5-플루오로아세토 페논을 초산에 용해된 브롬화 수소산의 촉매량을 포함하는 염소화 탄화수소 용매에 분산시키고, 3-시아노-5-플루오로아세토 페논을 환류온도까지 가열하고, 브롬으로 처리하여 3-시아노-5-플루오로펜아실 브로마이드를 생성하고: 3-시아노-5-플루오로펜아실 브로마이드를 알코올에 분산시키고 촉매 존재하에서 환원제와 반응시켜 3-(2-브로모-1-히드록시에틸)-5-플루오로벤조니트릴을 생성하고; 3-(2-브로모-1-히드록시에틸)-5-플루오로벤조니트릴을 에틴올 존재하에서 3차-부틸아민 또는 이소프로필 아민과 반응시켜 3-[2-(3차-부틸아미노)-1-히드록시-에틸]-5-플루오로벤조니트릴 또는 3-플루오로-5-[1-히드록시-2-(이소프로필아미노)에틸]-벤조니트릴로 전환시키는 것으로 구성되는, 하기 구조식(I)의 화합물로 이루어지는 동물사료 조성물의 제조방법.
    상기식에서 R은 이소프로필 또는 3차-부틸이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002079A 1985-03-21 1986-03-20 5-플루오로벤조니트릴 유도체 및 그 약리학적으로 수용가능한 산 부가염으로 이루어지는 동물사료 조성물의 제조방법 Expired KR900003531B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US714,240 1985-03-21
US06/714,240 US4614746A (en) 1985-03-21 1985-03-21 5-fluorobenzonitrile derivatives for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals
US714240 1985-03-21

Publications (2)

Publication Number Publication Date
KR860007200A true KR860007200A (ko) 1986-10-08
KR900003531B1 KR900003531B1 (ko) 1990-05-21

Family

ID=24869266

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860002079A Expired KR900003531B1 (ko) 1985-03-21 1986-03-20 5-플루오로벤조니트릴 유도체 및 그 약리학적으로 수용가능한 산 부가염으로 이루어지는 동물사료 조성물의 제조방법

Country Status (15)

Country Link
US (1) US4614746A (ko)
EP (1) EP0195396B1 (ko)
JP (1) JPS61227557A (ko)
KR (1) KR900003531B1 (ko)
AT (1) ATE40990T1 (ko)
AU (1) AU592329B2 (ko)
CA (1) CA1260954A (ko)
DE (1) DE3662190D1 (ko)
DK (1) DK129286A (ko)
ES (1) ES8707924A1 (ko)
FI (1) FI83769C (ko)
IL (1) IL78208A0 (ko)
NO (1) NO164022C (ko)
NZ (1) NZ215521A (ko)
ZA (1) ZA862097B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3678252D1 (de) * 1985-10-17 1991-04-25 American Cyanamid Co Anthranilonitrilderivate und verwandte verbindungen als nuetzliche stoffe zur wachstumsbeschleunigung, zur verbesserung der futterqualitaet und zur steigerung des fleisch/fett-verhaeltnisses bei warmbluetigen tieren.
DK167136B1 (da) * 1985-11-27 1993-09-06 Lilly Co Eli Fremgangsmaade til foroegelse af fedtindholdet i colostrum eller maelk hos maelkegivende soeer
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
JP5507045B2 (ja) * 2006-12-15 2014-05-28 石原産業株式会社 アントラニルアミド系化合物の製造方法
WO2012161313A1 (ja) * 2011-05-26 2012-11-29 日産化学工業株式会社 １－（２－アミノ－置換フェニル）－２－ハロ－２，２－ジフルオロエタノン化合物及び１－（置換フェニル）－２－ハロ－２，２－ジフルオロエタノン化合物の製造方法
DE102016204794A1 (de) 2016-03-23 2017-09-28 Thyssenkrupp Ag Rotorsegment einer elektrischen Maschine
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2838923A1 (de) * 1978-09-07 1980-04-03 Thomae Gmbh Dr K Verwendung von phenylaethanolaminen als antiphlogistica
US4404222A (en) * 1980-08-25 1983-09-13 American Cyanamid Company Phenylethanolamine derivatives and acid addition salts thereof for enhancing the growth rate of meat-producing animals and improving the efficiency of feed utilization thereby
US4407819A (en) * 1980-08-25 1983-10-04 American Cyanamid Company Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals
US4432995A (en) * 1980-12-22 1984-02-21 American Cyanamid Company 5-[2-(Ethylamino)-1-hydroxylethyl] anthranilonitrile and the use thereof in meat producing animals
EP0103830A3 (de) * 1982-09-22 1985-07-31 Bayer Ag Wachstumsfördernde Phenylethylamin-Derivate

Also Published As

Publication number Publication date
AU592329B2 (en) 1990-01-11
NO861096L (no) 1986-09-22
KR900003531B1 (ko) 1990-05-21
AU5495886A (en) 1986-09-25
ES8707924A1 (es) 1987-09-01
FI83769C (fi) 1991-08-26
NZ215521A (en) 1989-06-28
DE3662190D1 (en) 1989-04-06
IL78208A0 (en) 1986-07-31
FI83769B (fi) 1991-05-15
ES553203A0 (es) 1987-09-01
NO164022C (no) 1990-08-22
FI861182A0 (fi) 1986-03-20
JPS61227557A (ja) 1986-10-09
DK129286A (da) 1986-09-22
US4614746A (en) 1986-09-30
EP0195396B1 (en) 1989-03-01
NO164022B (no) 1990-05-14
ZA862097B (en) 1986-11-26
ATE40990T1 (de) 1989-03-15
CA1260954A (en) 1989-09-26
FI861182L (fi) 1986-09-22
DK129286D0 (da) 1986-03-20
EP0195396A1 (en) 1986-09-24

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